LOCUS HSU56387 2844 bp mRNA linear HUM 20-JUL-2000
DEFINITION Homo sapiens protease PC6 isoform A (PCSK5) mRNA, complete cds.
ACCESSION U56387
VERSION U56387.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2844)
AUTHORS Miranda,L., Wolf,J., Pichuantes,S., Duke,R. and Franzusoff,A.
TITLE Isolation of the human PC6 gene encoding the putative host protease
for HIV-1 gp160 processing in CD4+ T lymphocytes
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 93 (15), 7695-7700 (1996)
PUBMED 8755538
REFERENCE 2 (bases 1 to 2760)
AUTHORS Franzusoff,A., Miranda,L., Wolf,J., Pichuantes,S. and Duke,R.
TITLE Direct Submission
JOURNAL Submitted (23-APR-1996) Cellular and Structural Biology, University
of Colorado Health Sciences Center, 4200 East Ninth Avenue, Box
B-111, Denver, CO 80262, USA
REFERENCE 3 (bases 1 to 2844)
AUTHORS Franzusoff,A., Miranda,L., Wolf,J., Pichuantes,S., Lu,Y. and
Duke,R.
TITLE Direct Submission
JOURNAL Submitted (20-JUL-2000) Cellular and Structural Biology, University
of Colorado Health Sciences Center, 4200 East Ninth Avenue, Box
B-111, Denver, CO 80262, USA
REMARK Sequence update by submitter
COMMENT On Jul 20, 2000 this sequence version replaced U56387.1.
FEATURES Location/Qualifiers
source 1..2844
/db_xref="H-InvDB:HIT000220447"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="CEM human T cell"
gene 1..2844
/gene="PCSK5"
/gene_synonym="PC6"
CDS 13..2754
/gene="PCSK5"
/gene_synonym="PC6"
/note="KEX2-like protease"
/codon_start=1
/product="protease PC6 isoform A"
/protein_id="AAC50643.2"
/translation="MDWESRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIA
GGFPEANRIASKYGFINIGQIGALKDYYHFYHSRTIKRSVISSRGTHSFISMEPKVEW
IQQQVVKKRTKRDYDSSRVQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGY
TGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAG
EVAAAANNSHCTVGIAFNAKIGGVRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDD
DGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTIS
ISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIITTDLRQRCTDNHTGTSASAPMA
AGIIALALEANPFLTWRDVQHVIVRTSRAGHLNANDWKTNAAGFKVSHLYGFGLMDAE
AMVMEAEKWTTVPRQHVCVESTDRQIKTIRPNSAVRSIYKASGCSDNPNRHVNYLEHV
VVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAG
DWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVRPYSPTNEFPKVERFRYSRVEDPT
DDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHYHAD
KKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKC
SENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQDCQPCHRFCATCAGAGAD
GCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSC
PSGYLLDLGMCQMGAICKDATEESWAEGGFCMLVKKNNLCQRKVLQQLCCKTCTFQG"
BASE COUNT 775 a 708 c 751 g 610 t
ORIGIN
1 agcgtcggga ccatggattg ggagagccgc tgctgctgcc caggacgttt ggacctgctg
61 tgcgtgctgg cgctgctcgg gggctgcctg ctccccgtgt gtcggacgcg cgtctacacc
121 aaccactggg cagtcaaaat cgccgggggc ttcccggagg ccaaccgtat cgccagcaag
181 tacggattca tcaacatagg acagataggg gccctgaagg actactacca cttctaccat
241 agcaggacga ttaaaaggtc agttatctcg agcagaggga cccacagttt catttcaatg
301 gaaccaaagg tggaatggat ccaacagcaa gtggtaaaaa agcggacaaa gagggattat
361 gactccagtc gtgtccagtc tacctatttc aatgatccca agtggcccag catgtggtat
421 atgcactgca gtgacaatac acatccctgc cagtctgaca tgaatatcga aggagcctgg
481 aagagaggct acacgggaaa gaacattgtg gtcactatcc tggatgacgg aattgagaga
541 acccatccag atctgatgca aaactacgat gctctggcaa gttgcgacgt gaatgggaat
601 gacttggacc caatgcctcg ttatgatgca agcaacgaga acaagcatgg gactcgctgt
661 gctggagaag tggcagccgc tgcaaacaat tcgcactgca cagtcggaat tgctttcaac
721 gccaagatcg gaggagtgcg aatgctggac ggagatgtca cggacatggt tgaagcaaaa
781 tcagttagct tcaaccccca gcacgtgcac atttacagcg ccagctgggg cccggatgat
841 gatggcaaga ctgtggacgg accagccccc ctcacccggc aagcctttga aaacggcgtt
901 agaatggggc ggagaggcct cggctctgtg tttgtttggg catctggaaa tggtggaagg
961 agcaaagacc actgctcctg tgatggctac accaacagca tctacaccat ctccatcagc
1021 agcactgcag aaagcggaaa gaaaccttgg tacctggaag agtgttcatc cacgctggcc
1081 acaacctaca gcagcgggga gtcctacgat aagaaaatca tcactacaga tctgaggcag
1141 cgttgcacgg acaaccacac tgggacgtca gcctcagccc ccatggctgc aggcatcatt
1201 gcgctggccc tggaagccaa tccgtttctg acctggagag acgtacagca tgttattgtc
1261 aggacttccc gtgcgggaca tttgaacgct aatgactgga aaaccaatgc tgctggtttt
1321 aaggtgagcc atctttatgg atttggactg atggacgcag aagccatggt gatggaggca
1381 gagaagtgga ccaccgttcc ccggcagcac gtgtgtgtgg agagcacaga ccgacaaatc
1441 aagacaatcc gccctaacag tgcagtgcgc tccatctaca aagcttcagg ctgctcggat
1501 aaccccaacc gccatgtcaa ctacctggag cacgtcgttg tgcgcatcac catcacccac
1561 cccaggagag gagacctggc catctacctg acctcgccct ctggaactag gtctcagctt
1621 ttggccaaca ggctatttga tcactccatg gaaggattca aaaactggga gttcatgacc
1681 attcattgct ggggagaaag agctgctggt gactgggtcc ttgaagttta tgatactccc
1741 tctcagctaa ggaactttaa gactccaggt aaattgaaag aatggtcttt ggtcctctac
1801 ggcacctccg tgcggccata ttcaccaacc aatgaatttc cgaaagtgga acggttccgc
1861 tatagccgag ttgaagaccc cacagacgac tatggcacag aggattatgc aggtccctgc
1921 gaccctgagt gcagtgaggt tggctgtgac gggccaggac cagaccactg caatgactgt
1981 ttgcactact actacaagct gaaaaacaat accaggatct gtgtctccag ctgcccccct
2041 ggccactacc acgccgacaa gaagcgctgc aggaagtgtg cccccaactg tgagtcctgc
2101 tttgggagcc atggtgacca atgcatgtcc tgcaaatatg gatactttct gaatgaagaa
2161 accaacagct gtgttactca ctgccctgat gggtcatatc aggataccaa gaaaaatctt
2221 tgccggaaat gcagtgaaaa ctgcaagaca tgtactgaat tccataactg tacagaatgt
2281 agggatgggt taagcctgca gggatcccgg tgctctgtct cctgtgaaga tggacggtat
2341 ttcaacggcc aggactgcca gccctgccac cgcttctgcg ccacttgtgc tggggcagga
2401 gctgatgggt gcattaactg cacagagggc tacttcatgg aggatgggag atgcgtgcag
2461 agctgtagta tcagctatta ctttgaccac tcttcagaga atggatacaa atcctgcaaa
2521 aaatgtgata tcagttgttt gacgtgcaat ggcccaggat tcaagaactg tacaagctgc
2581 cctagtgggt atctcttaga cttaggaatg tgtcaaatgg gagccatttg caaggatgca
2641 acggaagagt cctgggcgga aggaggcttc tgtatgcttg tgaaaaagaa caatctgtgc
2701 caacggaagg ttcttcaaca actttgctgc aaaacatgta catttcaagg ctgagcagcc
2761 atcttagatt tctttgttcc tgtagactta tagattattc catattatta aaaagaaaaa
2821 aaaaagccaa aaaaaaaaaa aaaa
//