LOCUS HSKCC 3722 bp mRNA linear HUM 06-JUL-1996 DEFINITION Human K-Cl cotransporter (hKCC1) mRNA, complete cds. ACCESSION U55054 VERSION U55054.1 KEYWORDS bumetanide, furosemide, K-Cl cotransporter, membrane transport, transmembrane protein. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3722) AUTHORS Gillen,C.M., Brill,S., Payne,J.A. and Forbush,B. III. TITLE Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family JOURNAL J. Biol. Chem. 271 (27), 16237-16244 (1996) PUBMED 8663127 REFERENCE 2 (bases 1 to 3722) AUTHORS Gillen,C.M. TITLE Direct Submission JOURNAL Submitted (15-APR-1996) Christopher M. Gillen, Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar St., New Haven, CT 06520, USA FEATURES Location/Qualifiers source 1..3722 /db_xref="H-InvDB:HIT000220334" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="16" /map="16q22.1" /note="Reported sequence is a composite from complete sequencing of IMAGE consortium EST cDNA clones #154000 (R67622, R67622), #159363 (H15821, H161129), #34953 (R19769, R45189), #151758 (H02923, H04227), and from a reverse transcriptase PCR product from human embryonic kidney tissue culture cells (HEK 293)" gene 1..3722 /gene="hKCC1" CDS 56..3313 /gene="hKCC1" /note="ion cotransport protein" /codon_start=1 /product="K-Cl cotransporter" /protein_id="AAC50563.1" /translation="MPHFTVVPVDGPRRGDYDNLEGLSWVDYGERAELDDSDGHGNHR ESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEA ESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLIC CCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYIL GAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKF ASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETV ATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVE KHGLPSADAPSLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKS IPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIV IGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAE LGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMS LCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEE GPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYG EAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYG WRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGG MLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEVVEMH NSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEEDE SAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIV TRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS" BASE COUNT 712 a 1088 c 1126 g 796 t ORIGIN 1 acgaggcagc ggcgggcggc tgggacggcg ggtgcggcgg ggccgagccc gcacgatgcc 61 tcacttcacc gtggtgccag tggacgggcc gaggcgcggc gactatgaca acctcgaggg 121 gctcagttgg gtggactacg gggagcgcgc cgagctggat gactcggacg gacatggcaa 181 ccacagagag agcagccctt ttctttcccc cttggaggct tccagaggaa ttgactacta 241 tgacaggaac ctggcactgt ttgaggaaga gctggacatc cgcccaaagg tatcgtctct 301 tctgggaaag ctcgtcagct acaccaacct cacccagggc gccaaagagc atgaggaggc 361 cgagagtggg gagggcaccc gccggagggc agccgaggca cccagcatgg gcaccctcat 421 gggggtgtac ctgccctgcc tgcagaatat ctttggggtt atcctcttcc tgcggctgac 481 ctggatggtg ggcacagcag gtgtgctaca ggccctcctc atcgtgctta tctgctgctg 541 ttgtaccctg ctgacggcca tctccatgag tgccatcgcc accaacggtg tggttccagc 601 tgggggctcc tatttcatga tctctcgttc actggggcca gaatttggag gtgctgtggg 661 cctgtgcttc tacctgggaa caacattcgc agcagccatg tacatcctgg gggccatcga 721 gatcttgctg acctacattg ccccaccagc tgccattttt tacccatcgg gtgctcatga 781 cacgtcgaat gccactttga acaatatgcg tgtgtatggg accattttcc tgaccttcat 841 gaccctggtg gtgtttgtgg gggtcaagta tgtgaacaaa tttgcctcgc tcttcctggc 901 ctgtgtgatc atctccatcc tctccatcta tgctgggggc ataaagtcta tatttgaccc 961 tcccgtgttt ccggtatgca tgctgggcaa caggaccctg tcccgggacc agtttgacat 1021 ctgtgccaag acagctgtag tggacaatga gacagtggcc acccagctat ggagtttctt 1081 ctgccacagc cccaacctta cgaccgactc ctgtgacccc tacttcatgc tcaacaatgt 1141 gaccgagatc cctggcatcc ccggggcagc tgctggtgtg ctccaggaaa acctgtggag 1201 cgcctacctg gagaagggtg acatcgtgga gaagcatggg ctgccctccg cagatgcccc 1261 gagcctgaag gagagcctgc ctctgtacgt ggtcgctgac atcgccacat ccttcaccgt 1321 gctggtcggc atcttcttcc cttctgtaac aggcatcatg gctggctcaa accgctctgg 1381 ggaccttcgt gacgcccaga agtctatccc tgtggggacc attctggcca tcattacaac 1441 ttccctcgtg tacttcagca gtgtggttct ctttggtgcc tgcattgagg gtgtggttct 1501 ccgggacaag tatggcgatg gtgtcagcag gaacttggtg gtgggcacac tggcctggcc 1561 ttcaccctgg gtcatcgtca tcggctcctt cttttcaacg tgtggcgctg gcctccagag 1621 cctcacaggg gcaccacgcc tattgcaggc cattgccaag gacaacatca tccccttcct 1681 ccgggtgttt ggccacggga aggtgaatgg tgaacccaca tgggcactcc tcctgacggc 1741 actcatcgcc gagctgggca tcctcatcgc ctccctcgac atggtggccc ccatcttatc 1801 catgttcttt ctgatgtgct acctgttcgt gaacctcgcc tgtgcggtgc agacactcct 1861 gaggaccccc aactggcggc cccggttcaa gtactatcac tgggcgctgt ccttcctggg 1921 catgagtctc tgcctggccc ttatgtttgt ctcctcctgg tactatgccc tggtggccat 1981 gctcatcgcc ggcatgatct acaaatacat cgagtaccaa ggggctgaga aggagtgggg 2041 tgacgggatc cgaggcctgt ccctgagcgc tgcccgctac gcgctgttgc ggctggagga 2101 ggggcctcct cacaccaaga actggcggcc gcagctgctg gtgctgctga agctggacga 2161 ggacctccac gtgaagtacc cgcggctcct caccttcgcc tcccagctca aggctggcaa 2221 gggcctgacc attgttggtt ctgtcatcca ggggagcttc ttggagagct atggcgaggc 2281 tcaggccgcc gagcagacca tcaagaacat gatggaaatt gagaaggtga agggcttctg 2341 ccaggtggtg gtggccagca aggtgcggga ggggctggcc cacctcatcc agtcctgtgg 2401 cctgggaggc atgcggcata actccgtggt gctgggctgg ccctacggct ggcgacagag 2461 cgaggacccc cgtgcctgga agaccttcat tgacaccgtg cgctgcacta cggctgccca 2521 cctggccctg ctcgtgccca agaacatcgc cttctacccc agcaaccacg agcgctacct 2581 ggagggccac atagacgtgt ggtggatcgt gcacgatggt ggcatgctca tgcttctgcc 2641 cttcctgctg cgccagcata aggtctggag gaagtgccgg atgcgcatct tcacagtggc 2701 ccagatggat gacaacagca tccagatgaa gaaggacctg gctgtctttc tgtaccatct 2761 gcgccttgag gccgaggtgg aggtggtgga gatgcataac agtgacatct ctgcatacac 2821 ctacgagcgg acgctgatga tggagcagcg gtcgcagatg ctgcggcaga tgagactgac 2881 caagactgag cgggagcgag aagcccagct ggtcaaggat cggcactcgg ccctgcggct 2941 ggagagcctg tactcggacg aggaagatga gtctgcagtg ggggctgaca agatccagat 3001 gacgtggacc agggacaagt acatgactga gacctgggac cccagccatg cccctgacaa 3061 tttccgggag ctggtgcaca ttaagccgga ccaatccaat gtgcggcgca tgcacactgc 3121 tgtgaagctc aatgaagtca ttgtcacgcg ctcccacgac gcccgcctgg ttctcctaaa 3181 catgcctggc ccacccagga acagtgaggg cgacgagaac tacatggagt tcctcgaggt 3241 gctgaccgag ggccttgagc gggtgctgtt ggtgcgcggt ggtggccgtg aagtcatcac 3301 catctactcc tgagcccagt gtcatcttgt ggcctggagt cgaggtcttg gccaggacat 3361 aacaagctgt ggtctggggt aacagcctct tcccagcacc cacctgccag ccctgcttgc 3421 ctggccctgt cctggaccca gctttgctag gtctccttgg aaaccaggcc tgggcctcaa 3481 aatggagatg gatcccaggt cttgtgggac cctgggatgt ttggggactt tactatctag 3541 caccccagta ggcctgtcct ggccagagaa gactggtagg ggccgagtgg ggtttgaagg 3601 cagccggccc ggcccagccc aggagcgcta tttattgcat atttattgtt tggatgtcac 3661 catcagagac gaagggaagg gtagccaggg agggagtcca gcccagctgc ctgcaggaag 3721 at //