LOCUS       HSKCC                   3722 bp    mRNA    linear   HUM 06-JUL-1996
DEFINITION  Human K-Cl cotransporter (hKCC1) mRNA, complete cds.
ACCESSION   U55054
VERSION     U55054.1
KEYWORDS    bumetanide, furosemide, K-Cl cotransporter, membrane transport,
            transmembrane protein.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3722)
  AUTHORS   Gillen,C.M., Brill,S., Payne,J.A. and Forbush,B. III.
  TITLE     Molecular cloning and functional expression of the K-Cl
            cotransporter from rabbit, rat, and human. A new member of the
            cation-chloride cotransporter family
  JOURNAL   J. Biol. Chem. 271 (27), 16237-16244 (1996)
   PUBMED   8663127
REFERENCE   2  (bases 1 to 3722)
  AUTHORS   Gillen,C.M.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-APR-1996) Christopher M. Gillen, Cellular and
            Molecular Physiology, Yale University School of Medicine, 333 Cedar
            St., New Haven, CT 06520, USA
FEATURES             Location/Qualifiers
     source          1..3722
                     /db_xref="H-InvDB:HIT000220334"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
                     /note="Reported sequence is a composite from complete
                     sequencing of IMAGE consortium EST cDNA clones #154000
                     (R67622, R67622), #159363 (H15821, H161129), #34953
                     (R19769, R45189), #151758 (H02923, H04227), and from a
                     reverse transcriptase PCR product from human embryonic
                     kidney tissue culture cells (HEK 293)"
     gene            1..3722
                     /gene="hKCC1"
     CDS             56..3313
                     /gene="hKCC1"
                     /note="ion cotransport protein"
                     /codon_start=1
                     /product="K-Cl cotransporter"
                     /protein_id="AAC50563.1"
                     /translation="MPHFTVVPVDGPRRGDYDNLEGLSWVDYGERAELDDSDGHGNHR
                     ESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEA
                     ESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLIC
                     CCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYIL
                     GAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKF
                     ASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETV
                     ATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVE
                     KHGLPSADAPSLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKS
                     IPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIV
                     IGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAE
                     LGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMS
                     LCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEE
                     GPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYG
                     EAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYG
                     WRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGG
                     MLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEVVEMH
                     NSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEEDE
                     SAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIV
                     TRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS"
BASE COUNT          712 a         1088 c         1126 g          796 t
ORIGIN      
        1 acgaggcagc ggcgggcggc tgggacggcg ggtgcggcgg ggccgagccc gcacgatgcc
       61 tcacttcacc gtggtgccag tggacgggcc gaggcgcggc gactatgaca acctcgaggg
      121 gctcagttgg gtggactacg gggagcgcgc cgagctggat gactcggacg gacatggcaa
      181 ccacagagag agcagccctt ttctttcccc cttggaggct tccagaggaa ttgactacta
      241 tgacaggaac ctggcactgt ttgaggaaga gctggacatc cgcccaaagg tatcgtctct
      301 tctgggaaag ctcgtcagct acaccaacct cacccagggc gccaaagagc atgaggaggc
      361 cgagagtggg gagggcaccc gccggagggc agccgaggca cccagcatgg gcaccctcat
      421 gggggtgtac ctgccctgcc tgcagaatat ctttggggtt atcctcttcc tgcggctgac
      481 ctggatggtg ggcacagcag gtgtgctaca ggccctcctc atcgtgctta tctgctgctg
      541 ttgtaccctg ctgacggcca tctccatgag tgccatcgcc accaacggtg tggttccagc
      601 tgggggctcc tatttcatga tctctcgttc actggggcca gaatttggag gtgctgtggg
      661 cctgtgcttc tacctgggaa caacattcgc agcagccatg tacatcctgg gggccatcga
      721 gatcttgctg acctacattg ccccaccagc tgccattttt tacccatcgg gtgctcatga
      781 cacgtcgaat gccactttga acaatatgcg tgtgtatggg accattttcc tgaccttcat
      841 gaccctggtg gtgtttgtgg gggtcaagta tgtgaacaaa tttgcctcgc tcttcctggc
      901 ctgtgtgatc atctccatcc tctccatcta tgctgggggc ataaagtcta tatttgaccc
      961 tcccgtgttt ccggtatgca tgctgggcaa caggaccctg tcccgggacc agtttgacat
     1021 ctgtgccaag acagctgtag tggacaatga gacagtggcc acccagctat ggagtttctt
     1081 ctgccacagc cccaacctta cgaccgactc ctgtgacccc tacttcatgc tcaacaatgt
     1141 gaccgagatc cctggcatcc ccggggcagc tgctggtgtg ctccaggaaa acctgtggag
     1201 cgcctacctg gagaagggtg acatcgtgga gaagcatggg ctgccctccg cagatgcccc
     1261 gagcctgaag gagagcctgc ctctgtacgt ggtcgctgac atcgccacat ccttcaccgt
     1321 gctggtcggc atcttcttcc cttctgtaac aggcatcatg gctggctcaa accgctctgg
     1381 ggaccttcgt gacgcccaga agtctatccc tgtggggacc attctggcca tcattacaac
     1441 ttccctcgtg tacttcagca gtgtggttct ctttggtgcc tgcattgagg gtgtggttct
     1501 ccgggacaag tatggcgatg gtgtcagcag gaacttggtg gtgggcacac tggcctggcc
     1561 ttcaccctgg gtcatcgtca tcggctcctt cttttcaacg tgtggcgctg gcctccagag
     1621 cctcacaggg gcaccacgcc tattgcaggc cattgccaag gacaacatca tccccttcct
     1681 ccgggtgttt ggccacggga aggtgaatgg tgaacccaca tgggcactcc tcctgacggc
     1741 actcatcgcc gagctgggca tcctcatcgc ctccctcgac atggtggccc ccatcttatc
     1801 catgttcttt ctgatgtgct acctgttcgt gaacctcgcc tgtgcggtgc agacactcct
     1861 gaggaccccc aactggcggc cccggttcaa gtactatcac tgggcgctgt ccttcctggg
     1921 catgagtctc tgcctggccc ttatgtttgt ctcctcctgg tactatgccc tggtggccat
     1981 gctcatcgcc ggcatgatct acaaatacat cgagtaccaa ggggctgaga aggagtgggg
     2041 tgacgggatc cgaggcctgt ccctgagcgc tgcccgctac gcgctgttgc ggctggagga
     2101 ggggcctcct cacaccaaga actggcggcc gcagctgctg gtgctgctga agctggacga
     2161 ggacctccac gtgaagtacc cgcggctcct caccttcgcc tcccagctca aggctggcaa
     2221 gggcctgacc attgttggtt ctgtcatcca ggggagcttc ttggagagct atggcgaggc
     2281 tcaggccgcc gagcagacca tcaagaacat gatggaaatt gagaaggtga agggcttctg
     2341 ccaggtggtg gtggccagca aggtgcggga ggggctggcc cacctcatcc agtcctgtgg
     2401 cctgggaggc atgcggcata actccgtggt gctgggctgg ccctacggct ggcgacagag
     2461 cgaggacccc cgtgcctgga agaccttcat tgacaccgtg cgctgcacta cggctgccca
     2521 cctggccctg ctcgtgccca agaacatcgc cttctacccc agcaaccacg agcgctacct
     2581 ggagggccac atagacgtgt ggtggatcgt gcacgatggt ggcatgctca tgcttctgcc
     2641 cttcctgctg cgccagcata aggtctggag gaagtgccgg atgcgcatct tcacagtggc
     2701 ccagatggat gacaacagca tccagatgaa gaaggacctg gctgtctttc tgtaccatct
     2761 gcgccttgag gccgaggtgg aggtggtgga gatgcataac agtgacatct ctgcatacac
     2821 ctacgagcgg acgctgatga tggagcagcg gtcgcagatg ctgcggcaga tgagactgac
     2881 caagactgag cgggagcgag aagcccagct ggtcaaggat cggcactcgg ccctgcggct
     2941 ggagagcctg tactcggacg aggaagatga gtctgcagtg ggggctgaca agatccagat
     3001 gacgtggacc agggacaagt acatgactga gacctgggac cccagccatg cccctgacaa
     3061 tttccgggag ctggtgcaca ttaagccgga ccaatccaat gtgcggcgca tgcacactgc
     3121 tgtgaagctc aatgaagtca ttgtcacgcg ctcccacgac gcccgcctgg ttctcctaaa
     3181 catgcctggc ccacccagga acagtgaggg cgacgagaac tacatggagt tcctcgaggt
     3241 gctgaccgag ggccttgagc gggtgctgtt ggtgcgcggt ggtggccgtg aagtcatcac
     3301 catctactcc tgagcccagt gtcatcttgt ggcctggagt cgaggtcttg gccaggacat
     3361 aacaagctgt ggtctggggt aacagcctct tcccagcacc cacctgccag ccctgcttgc
     3421 ctggccctgt cctggaccca gctttgctag gtctccttgg aaaccaggcc tgggcctcaa
     3481 aatggagatg gatcccaggt cttgtgggac cctgggatgt ttggggactt tactatctag
     3541 caccccagta ggcctgtcct ggccagagaa gactggtagg ggccgagtgg ggtttgaagg
     3601 cagccggccc ggcccagccc aggagcgcta tttattgcat atttattgtt tggatgtcac
     3661 catcagagac gaagggaagg gtagccaggg agggagtcca gcccagctgc ctgcaggaag
     3721 at
//