LOCUS AH003673 5509 bp DNA linear HUM 10-JUN-2016
DEFINITION Homo sapiens chromosome 12 C-lectin type II protein (NKG2-A) gene,
complete cds.
ACCESSION AH003673 U54782 U54783 U54784 U54785 U54786
VERSION AH003673.2
KEYWORDS cell surface receptor; lectin; supergene family.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5509)
AUTHORS Plougastel,B., Jones,T. and Trowsdale,J.
TITLE Genomic structure, chromosome location, and alternative splicing of
the human NKG2A gene
JOURNAL Immunogenetics 44 (4), 286-291 (1996)
PUBMED 8753859
REFERENCE 2 (bases 1 to 5509)
AUTHORS Plougastel,B.
TITLE Direct Submission
JOURNAL Submitted (11-APR-1996) Beatrice Plougastel, Human Immunogenetic,
Imperial Cancer research Fund., 44 lincoln's Inn Field, London,
WC2A 3PX, UK
COMMENT On or before Jun 10, 2016 this sequence version replaced U54782.1,
U54783.1, U54784.1, U54785.1, U54786.1, AH003673.1.
FEATURES Location/Qualifiers
source 1..5509
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="p12.3-p13.1"
/cell_line="4X Cell line GM1416B"
gene 1..4982
/gene="NKG2-A"
mRNA join(<1..133,855..1072,1463..1558,2079..2132,2815..2966,
3545..3645,4361..4982)
/gene="NKG2-A"
exon <1..133
/gene="NKG2-A"
/number=1
intron 134..>153
/gene="NKG2-A"
/number=1
gap 154..253
/estimated_length=unknown
intron <254..854
/gene="NKG2-A"
/number=1
exon 855..1072
/gene="NKG2-A"
/number=2
CDS join(886..1072,1463..1558,2079..2132,2815..2966,
3545..3645,4361..4472)
/gene="NKG2-A"
/note="putative; expressed in NK cells"
/codon_start=1
/product="C-lectin type II protein"
/protein_id="AAB17133.1"
/translation="MDNQGVIYSDLNLPPNPKRQQRKPKGNKSSILATEQEITYAELN
LQKASQDFQGNDKTYHCKDLPSAPEKLIVGILGIICLILMASVVTIVVIPSTLIQRHN
NSSLNTRTQKARHCGHCPEEWITYSNSCYYIGKERRTWEESLLACTSKNSSLLSIDNE
EEMKFLSIISPSSWIGVFRNSSHHPWVTMNGLAFKHEIKDSDNAELNCAVLQVNRLKS
AQCGSSIIYHCKHKL"
intron 1073..1462
/gene="NKG2-A"
/number=2
exon 1463..1558
/gene="NKG2-A"
/number=3
intron 1559..2078
/gene="NKG2-A"
/number=3
exon 2079..2132
/gene="NKG2-A"
/number=4
intron 2133..>2188
/gene="NKG2-A"
/number=4
gap 2189..2288
/estimated_length=unknown
intron <2289..2814
/gene="NKG2-A"
/number=4
exon 2815..2966
/gene="NKG2-A"
/number=5
intron 2967..>3382
/gene="NKG2-A"
/number=5
gap 3383..3482
/estimated_length=unknown
intron <3483..3544
/gene="NKG2-A"
/number=5
exon 3545..3645
/gene="NKG2-A"
/number=6
intron 3646..>3889
/gene="NKG2-A"
/number=6
gap 3890..3989
/estimated_length=unknown
intron <3990..4360
/gene="NKG2-A"
/number=7
exon 4361..4982
/gene="NKG2-A"
/number=7
regulatory 4968..4973
/regulatory_class="polyA_signal_sequence"
/gene="NKG2-A"
BASE COUNT 1576 a 827 c 882 g 1810 t
ORIGIN
1 gcaggcattg tttgttcttg tcttggattt atgcctttaa atttcacctt ttattacaca
61 gctatagcag gcctttttat gagactaacc tggcctctcc actaaaggat gtgtgacttt
121 ctggggacag aaggtatgta ttgctactct ccannnnnnn nnnnnnnnnn nnnnnnnnnn
181 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
241 nnnnnnnnnn nnngctatga ccatgattac gaattcgagc tcggtacctt attcctgaac
301 ttctttattc cttagtaatt tattgcttct cattgcccca gcaataatat tttgtcaaat
361 gcagaaaatt tatctttttt tttttgagtc ggagtctcac tctktysccc aggctggagt
421 gcagtggcac aatctccgct cactgcaacc tctgccgccc atgttcaaga gattctcctg
481 cctcagcctc ccgagtagct aggactacag gcgcctgaca tcatgcccga ctactttttg
541 tatttttagt agagacggag tttccaccgw gttagccagg atggtctcga tctcctgacc
601 tcgtgatcgg catgcctcgg cctcccaaag tgctgggatt acaggcgtga gccaccgcgc
661 ccggcctaaa aatctttttt taaaacaaat attcataaga aacgtgttta ggcttgaaga
721 aaatcagaga aagaacttta gattatttaa tgcaaaatga gctccaatac tcgttctcca
781 cctcaccctt ttaattgcac tagggaatcc tgtatataaa ccatttatta acttcttaac
841 tactgttatt atagagtaca gtccctgaca tcacacactg cagagatgga taaccaagga
901 gtaatctact cagacctgaa tctgccccca aacccaaaga ggcagcaacg aaaacctaaa
961 ggcaataaaa gctccatttt agcaactgaa caggaaataa cctatgcgga attaaacctt
1021 caaaaagctt ctcaggattt tcaagggaat gacaaaacct atcactgcaa aggtaaagca
1081 tttaaaagat cctcaatata acagtctagg atgtgcagct tggggtacag gaatgtgggg
1141 aaagagaagg gagtgctcat atatctncta tttgcaaaga tcagaattcc aagttgagat
1201 atgctatttc awtgtaaagt atgaagactg attgaactca ttgttgaagt ttgtagtctt
1261 tgtcaaataa ttcatggagc attatttttc ctgaaaattc aatggtatat tattctgaga
1321 aaaagattac aatgggagat gagggtttgg ggtccaagtt tctctgtatg attcctgtgc
1381 attcaggttc tcttgtctgt gaatctycta aacgactgta tccacctctc ctttcgcact
1441 gttcccattt ctctccctgc agatttacca tcagctccag agaagctcat tgttgggatc
1501 ctgggaatta tctgtcttat cttaatggcc tctgtggtaa cgatagttgt tattccctgt
1561 aagtctattt tcgaagatta caaggggaat tttcacgtta atgattgaat gtgcctctaa
1621 acatttcata ttttcaggga atagagttct cattgtratg tatatatttg ggactaaatg
1681 tgggaatgat tattctggaa tttgtcaaag gaataaatga aagaataatt gttggaagta
1741 ttcgcttctg atgcaatcgt atgtatatat ttggatttca taactcaaaa atatgttcta
1801 ggagtctgaa aaaccttact gagaaataga aattaatttt tgaaagtagt taaatcaaga
1861 attataagaa ctatatgaga tggtgaaatt tggttcttta gatctatgaa atacttttcc
1921 aaaaaaccac cattacttta tcaaattttt cttaaaatca attttattcc atattattct
1981 aactctaaat aatacaaaaa aattcaaaca aaaacttaaa attattatga ttgatttaga
2041 tgctaatttt tttacaaaga ttactttaat ttttctagct acattaatac agaggcacaa
2101 caattcttcc ctgaatacaa gaactcagaa aggtatataa taatttttaa agttttaata
2161 tngtacngtt tattttttct tgatcttann nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
2221 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
2281 nnnnnnnngt atataataat ttttaaagtt ttaatattgt acagtttatn ttttcttgat
2341 cttaggctgt acaaaaataa aattttgggt gaaaaattat aaaatttggc aataagtgtt
2401 cataaataaa attagagtaa ggcattcact tgtcatcaac tataagtaaa atcactatgc
2461 tttcttttta tctgttgtgt tcaaattctt actgctataa tatgataaga tacaagttat
2521 ttattgttcc ttaaaaatca gattagttca ttgatttttc aagacatgta tagagtggat
2581 ttttgtttgc tggtttgctt tatatgggaa cacaattagg agatgaaagg ctgacccttt
2641 attgcgcatg tgtgtataag tgactgggta ttttgacact atatatttac cagcccatga
2701 agatgtatag atatgttgca tacatatagg tttatatgtt tgcaaatatg tgaactaatt
2761 ttcattttta aaaattcata ttggtctaag atagtaattc atatctttat ttagcacgtc
2821 attgtggcca ttgtcctgag gagtggatta catattccaa cagttgttac tacattggta
2881 aggaaagaag aacttgggaa gagagtttgc tggcctgtac ttcgaagaac tccagtctgc
2941 tttctataga taatgaagaa gaaatggtaa gatgtaaatg ttttaaacac tttatgaaaa
3001 gcttctttcg gtcgataata tatttgtaga aatcatccat atgtgtgggt atatacattt
3061 agcttatatg ttttcaagtt tatgtagtat ttaattgatt gacttaataa tgttttaaaa
3121 ttcatatact gctaatgtac ttttgattat tttcagtttt tgcttttcgt ggaaaaccat
3181 gcttctagaa atgctttcaa tccacaatac attttgctat ctaattttat cgggcatgat
3241 gtgatctggt catgcagatt gatcacaaag tgaatgaact cctgtgatac aagtcagatc
3301 atgaaataaa agtttccagc tctagtagtt ccacccctgt gtatgccctc atcacttatc
3361 ctgactcctc tccaaaacac tgnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
3421 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
3481 nngactctag aggatcccct tttcataatt attatttaag tgaaaattct ttcttttctt
3541 ttagaaattt ctgtccatca tttcaccatc ctcatggatt ggtgtgtttc gtaacagcag
3601 tcatcatcca tgggtgacaa tgaatggttt ggctttcaaa catgagtaag ttgttttgta
3661 tggcgctata taacaatata tatataaagg ataaattcag aagaataata tgaataaatc
3721 tatgtggaat catagagatg aagaaagatg tggaaagtta gtgaaatgct gacataaata
3781 ttttacaata gaccatagta gtccatatat ttcaaccgct cattggtcag ctagtaacct
3841 tcttgattat cagatggacc aggggtgtcc aatctttggc ttctgtgggn nnnnnnnnnn
3901 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
3961 nnnnnnnnnn nnnnnnnnnn nnnnnnnnng gcacaagagt agtgctgttg gcatattgct
4021 ataattttgt tattagtagt tattgttgtc aatctcttat tgtgcctaat ttataaatta
4081 aattttatca cagttatgaa tgtgtagaga aaacataatc tctctatagg ttctgcacta
4141 tctgccgttt caggcatcca ctggaatctt gaaacatatc cctcgtggat gaagggggac
4201 tactctgttg agtgttcaga ataatgactc ttactaatat tatgaaaaat ttaattaccc
4261 ttttccatga aattcttttc ttacagtaca tggaaaatgc tttcgtctca tgaatcattt
4321 gcttaaaatg taacagaata tggatttttc tccattacag gataaaagac tcagataatg
4381 ctgaacttaa ctgtgcagtg ctacaagtaa atcgacttaa atcagcccag tgtggatctt
4441 caataatata tcattgtaag cataagcttt agaggtaaag cgtttgcatt tgcagtgcat
4501 cagataaatt gtatatttct taaaatagaa atatattatg attgcataaa tcttaaaatg
4561 aattatgtta tttgctctaa taagaaaatt ctaaatcaat tattgaaaca ggatacacac
4621 aattactaaa gtacagacat cctagcattt gtgtcgggct cattttgctc aacatggtat
4681 ttgtggtttt cagcctttct aaaagttgca tgttatgtga gtcagcttat aggaagtacc
4741 aagaacagtc aaacccatgg agacagaaag tagaatagtg gttgccaatg tctgagggag
4801 gttgaaatag gagatgacct ctaactgata gaacgttact ttgtgtcgtg atgaaaactt
4861 tctamatttc agtagtggtg atggttgtaa ctctgcgaat atactaaaca tcattgattt
4921 ttaatcattt taagtgcatg aaatgtatgc tttgtacayg acacttcaat aaagctatcc
4981 agaaaaaaaa aagcctctga tgggattgtt tatgactgca tttattctct aaagtaattt
5041 ttaaagatta gcttctttat aatattgact tttctaatca gtataaagtg tttccttcaa
5101 tgtactgtgt tatctttaat ttctctctct tgtattttgt attttggggg attgaagtca
5161 tacagaaatg taggtatttt acatttatgc ttttgtaaat ggcatcctga ttctaaaaty
5221 ccctttagta atttttgttg ttataaatag aaatacaact gatgtctgca ttttgatttt
5281 atatctactt attccactga ttttatatat ttaaatctat tatgtcaact attgatttat
5341 ttctgggtgt tctatataac gagcaatttt atctgcaaat gatcacactt ttattttttt
5401 taatccatgt gctataactt agttttattt tcatttattt tcactggcta aggttttata
5461 cccatagttg aatagaaggc acaatcaaag ttctttgtgg atcatatgc
//