LOCUS HSU54777 4244 bp mRNA linear HUM 19-OCT-1999
DEFINITION Homo sapiens hMSH6 protein (MSH6) mRNA, complete cds.
ACCESSION U54777
VERSION U54777.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4244)
AUTHORS Acharya,S., Wilson,T., Gradia,S., Kane,M.F., Guerrette,S.,
Marsischky,G.T., Kolodner,R. and Fishel,R.
TITLE hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 93 (24), 13629-13634 (1996)
PUBMED 8942985
REFERENCE 2 (bases 1 to 4244)
AUTHORS Gradia,S. and Fishel,R.
TITLE Direct Submission
JOURNAL Submitted (11-APR-1996) Scott Gradia, Kimmel Cancer Institute,
Thomas Jefferson University, 233 South 10th Street, Philadelphia,
PA 19107, USA
REFERENCE 3 (bases 1 to 4244)
AUTHORS Gradia,S. and Fishel,R.
TITLE Direct Submission
JOURNAL Submitted (23-DEC-1996) Scott Gradia, Kimmel Cancer Institute,
Thomas Jefferson University, 233 South 10th Street, Philadelphia,
PA 19107, USA
REMARK Sequence update by submitter
REFERENCE 4 (bases 1 to 4244)
AUTHORS Gradia,S. and Fishel,R.
TITLE Direct Submission
JOURNAL Submitted (19-OCT-1999) Scott Gradia, Kimmel Cancer Institute,
Thomas Jefferson University, 233 South 10th Street, Philadelphia,
PA 19107, USA
REMARK Sequence update by submitter
COMMENT On Oct 19, 1999 this sequence version replaced U54777.1.
FEATURES Location/Qualifiers
source 1..4244
/db_xref="H-InvDB:HIT000220324"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2p16-15"
/cell_type="fibroblasts"
/dev_stage="embryo"
gene 1..4244
/gene="MSH6"
CDS 71..4153
/gene="MSH6"
/function="putative mismatch binding/repair protein"
/note="GTBP/p160; homolog of E. coli MutS and S.
cerevisiae MSH6"
/codon_start=1
/product="hMSH6 protein"
/protein_id="AAB39212.2"
/translation="MSRQSTLYSFFPKSPALSDANKASARASREGGRAAAAPGASPSP
GGDAAWSEAGPGPRPLARSASPPKAKNLNGGLRRSVAPAAPTSCDFSPGDLVWAKMEG
YPWWPCLVYNHPFDGTFIREKGKSVRVHVQFFDDSPTRGWVSKRLLKPYTGSKSKEAQ
KGGHFYSAKPEILRAMQRADEALNKDKIKRLELAVCDEPSEPEEEEEMEVGTTYVTDK
SEEDNEIESEEEVQPKTQGSRRSSRQIKKRRVISDSESDIGGSDVEFKPDTKEEGSSD
EISSGVGDSESEGLNSPVKVARKRKRMVTGNGSLKRKSSRKETPSATKQATSISSETK
NTLRAFSAPQNSESQAHVSGGGDDSSRPTVWYHETLEWLKEEKRRDEHRRRPDHPDFD
ASTLYVPEDFLNSCTPGMRKWWQIKSQNFDLVICYKVGKFYELYHMDALIGVSELGLV
FMKGNWAHSGFPEIAFGRYSDSLVQKGYKVARVEQTETPEMMEARCRKMAHISKYDRV
VRREICRIITKGTQTYSVLEGDPSENYSKYLLSLKEKEEDSSGHTRAYGVCFVDTSLG
KFFIGQFSDDRHCSRFRTLVAHYPPVQVLFEKGNLSKETKTILKSSLSCSLQEGLIPG
SQFWDASKTLRTLLEEEYFREKLSDGIGVMLPQVLKGMTSESDSIGLTPGEKSELALS
ALGGCVFYLKKCLIDQELLSMANFEEYIPLDSDTVSTTRSGAIFTKAYQRMVLDAVTL
NNLEIFLNGTNGSTEGTLLERVDTCHTPFGKRLLKQWLCAPLCNHYAINDRLDAIEDL
MVVPDKISEVVELLKKLPDLERLLSKIHNVGSPLKSQNHPDSRAIMYEETTYSKKKII
DFLSALEGFKVMCKIIGIMEEVADGFKSKILKQVISLQTKNPEGRFPDLTVELNRWDT
AFDHEKARKTGLITPKAGFDSDYDQALADIRENEQSLLEYLEKQRNRIGCRTIVYWGI
GRNRYQLEIPENFTTRNLPEEYELKSTKKGCKRYWTKTIEKKLANLINAEERRDVSLK
DCMRRLFYNFDKNYKDWQSAVECIAVLDVLLCLANYSRGGDGPMCRPVILLPEDTPPF
LELKGSRHPCITKTFFGDDFIPNDILIGCEEEEQENGKAYCVLVTGPNMGGKSTLMRQ
AGLLAVMAQMGCYVPAEVCRLTPIDRVFTRLGASDRIMSGESTFFVELSETASILMHA
TAHSLVLVDELGRGTATFDGTAIANAVVKELAETIKCRTLFSTHYHSLVEDYSQNVAV
RLGHMACMVENECEDPSQETITFLYKFIKGACPKSYGFNAARLANLPEEVIQKGHRKA
REFEKMNQSLRLFREVCLASERSTVDAEAVHKLLTLIKEL"
BASE COUNT 1243 a 834 c 1071 g 1096 t
ORIGIN
1 gccgcgcggt agatgcggtg cttttaggag ctccgtccga cagaacggtt gggccttgcc
61 ggctgtcggt atgtcgcgac agagcaccct gtacagcttc ttccccaagt ctccggcgct
121 gagtgatgcc aacaaggcct cggccagggc ctcacgcgaa ggcggccgtg ccgccgctgc
181 ccccggggcc tctccttccc caggcgggga tgcggcctgg agcgaggctg ggcctgggcc
241 caggcccttg gcgcgctccg cgtcaccgcc caaggcgaag aacctcaacg gagggctgcg
301 gagatcggta gcgcctgctg cccccaccag ttgtgacttc tcaccaggag atttggtttg
361 ggccaagatg gagggttacc cctggtggcc ttgtctggtt tacaaccacc cctttgatgg
421 aacattcatc cgcgagaaag ggaaatcagt ccgtgttcat gtacagtttt ttgatgacag
481 cccaacaagg ggctgggtta gcaaaaggct tttaaagcca tatacaggtt caaaatcaaa
541 ggaagcccag aagggaggtc atttttacag tgcaaagcct gaaatactga gagcaatgca
601 acgtgcagat gaagccttaa ataaagacaa gattaagagg cttgaattgg cagtttgtga
661 tgagccctca gagccagaag aggaagaaga gatggaggta ggcacaactt acgtaacaga
721 taagagtgaa gaagataatg aaattgagag tgaagaggaa gtacagccta agacacaagg
781 atctaggcga agtagccgcc aaataaaaaa acgaagggtc atatcagatt ctgagagtga
841 cattggtggc tctgatgtgg aatttaagcc agacactaag gaggaaggaa gcagtgatga
901 aataagcagt ggagtggggg atagtgagag tgaaggcctg aacagccctg tcaaagttgc
961 tcgaaagcgg aagagaatgg tgactggaaa tggctctctt aaaaggaaaa gctctaggaa
1021 ggaaacgccc tcagccacca aacaagcaac tagcatttca tcagaaacca agaatacttt
1081 gagagctttc tctgcccctc aaaattctga atcccaagcc cacgttagtg gaggtggtga
1141 tgacagtagt cgccctactg tttggtatca tgaaacttta gaatggctta aggaggaaaa
1201 gagaagagat gagcacagga ggaggcctga tcaccccgat tttgatgcat ctacactcta
1261 tgtgcctgag gatttcctca attcttgtac tcctgggatg aggaagtggt ggcagattaa
1321 gtctcagaac tttgatcttg tcatctgtta caaggtgggg aaattttatg agctgtacca
1381 catggatgct cttattggag tcagtgaact ggggctggta ttcatgaaag gcaactgggc
1441 ccattctggc tttcctgaaa ttgcatttgg ccgttattca gattccctgg tgcagaaggg
1501 ctataaagta gcacgagtgg aacagactga gactccagaa atgatggagg cacgatgtag
1561 aaagatggca catatatcca agtatgatag agtggtgagg agggagatct gtaggatcat
1621 taccaagggt acacagactt acagtgtgct ggaaggtgat ccctctgaga actacagtaa
1681 gtatcttctt agcctcaaag aaaaagagga agattcttct ggccatactc gtgcatatgg
1741 tgtgtgcttt gttgatactt cactgggaaa gtttttcata ggtcagtttt cagatgatcg
1801 ccattgttcg agatttagga ctctagtggc acactatccc ccagtacaag ttttatttga
1861 aaaaggaaat ctctcaaagg aaactaaaac aattctaaag agttcattgt cctgttctct
1921 tcaggaaggt ctgatacccg gctcccagtt ttgggatgca tccaaaactt tgagaactct
1981 ccttgaggaa gaatatttta gggaaaagct aagtgatggc attggggtga tgttacccca
2041 ggtgcttaaa ggtatgactt cagagtctga ttccattggg ttgacaccag gagagaaaag
2101 tgaattggcc ctctctgctc taggtggttg tgtcttctac ctcaaaaaat gccttattga
2161 tcaggagctt ttatcaatgg ctaattttga agaatatatt cccttggatt ctgacacagt
2221 cagcactaca agatctggtg ctatcttcac caaagcctat caacgaatgg tgctagatgc
2281 agtgacatta aacaacttgg agatttttct gaatggaaca aatggttcta ctgaaggaac
2341 cctactagag agggttgata cttgccatac tccttttggt aagcggctcc taaagcaatg
2401 gctttgtgcc ccactctgta accattatgc tattaatgat cgtctagatg ccatagaaga
2461 cctcatggtt gtgcctgaca aaatctccga agttgtagag cttctaaaga agcttccaga
2521 tcttgagagg ctactcagta aaattcataa tgttgggtct cccctgaaga gtcagaacca
2581 cccagacagc agggctataa tgtatgaaga aactacatac agcaagaaga agattattga
2641 ttttctttct gctctggaag gattcaaagt aatgtgtaaa attataggga tcatggaaga
2701 agttgctgat ggttttaagt ctaaaatcct taagcaggtc atctctctgc agacaaaaaa
2761 tcctgaaggt cgttttcctg atttgactgt agaattgaac cgatgggata cagcctttga
2821 ccatgaaaag gctcgaaaga ctggacttat tactcccaaa gcaggctttg actctgatta
2881 tgaccaagct cttgctgaca taagagaaaa tgaacagagc ctcctggaat acctagagaa
2941 acagcgcaac agaattggct gtaggaccat agtctattgg gggattggta ggaaccgtta
3001 ccagctggaa attcctgaga atttcaccac tcgcaatttg ccagaagaat acgagttgaa
3061 atctaccaag aagggctgta aacgatactg gaccaaaact attgaaaaga agttggctaa
3121 tctcataaat gctgaagaac ggagggatgt atcattgaag gactgcatgc ggcgactgtt
3181 ctataacttt gataaaaatt acaaggactg gcagtctgct gtagagtgta tcgcagtgtt
3241 ggatgtttta ctgtgcctgg ctaactatag tcgagggggt gatggtccta tgtgtcgccc
3301 agtaattctg ttgccggaag ataccccccc cttcttagag cttaaaggat cacgccatcc
3361 ttgcattacg aagacttttt ttggagatga ttttattcct aatgacattc taataggctg
3421 tgaggaagag gagcaggaaa atggcaaagc ctattgtgtg cttgttactg gaccaaatat
3481 ggggggcaag tctacgctta tgagacaggc tggcttatta gctgtaatgg cccagatggg
3541 ttgttacgtc cctgctgaag tgtgcaggct cacaccaatt gatagagtgt ttactagact
3601 tggtgcctca gacagaataa tgtcaggtga aagtacattt tttgttgaat taagtgaaac
3661 tgccagcata ctcatgcatg caacagcaca ttctctggtg cttgtggatg aattaggaag
3721 aggtactgca acatttgatg ggacggcaat agcaaatgca gttgttaaag aacttgctga
3781 gactataaaa tgtcgtacat tattttcaac tcactaccat tcattagtag aagattattc
3841 tcaaaatgtt gctgtgcgcc taggacatat ggcatgcatg gtagaaaatg aatgtgaaga
3901 ccccagccag gagactatta cgttcctcta taaattcatt aagggagctt gtcctaaaag
3961 ctatggcttt aatgcagcaa ggcttgctaa tctcccagag gaagttattc aaaagggaca
4021 tagaaaagca agagaatttg agaagatgaa tcagtcacta cgattatttc gggaagtttg
4081 cctggctagt gaaaggtcaa ctgtagatgc tgaagctgtc cataaattgc tgactttgat
4141 taaggaatta tagactgact acattggaag ctttgagttg acttctgaca aaggtggtaa
4201 attcagacaa cattatgatc taataaactt tattttttaa aaat
//