LOCUS       HSU53786                6457 bp    mRNA    linear   HUM 20-OCT-1998
DEFINITION  Homo sapiens envoplakin (EVPL) mRNA, complete cds.
ACCESSION   U53786
VERSION     U53786.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6457)
  AUTHORS   Ruhrberg,C., Hajibagheri,M.A., Simon,M., Dooley,T.P. and Watt,F.M.
  TITLE     Envoplakin, a novel precursor of the cornified envelope that has
            homology to desmoplakin
  JOURNAL   J. Cell Biol. 134 (3), 715-729 (1996)
   PUBMED   8707850
REFERENCE   2  (bases 1 to 6457)
  AUTHORS   Ruhrberg,C. and Watt,F.M.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-APR-1996) Christiana Ruhrberg, Keratinocyte
            Laboratory, ICRF, 44 Lincoln's Inn Fields, London WC2A 3PX, UK
REFERENCE   3  (bases 1 to 6457)
  AUTHORS   Ruhrberg,C. and Watt,F.M.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-SEP-1998) Christiana Ruhrberg, Keratinocyte
            Laboratory, ICRF, 44 Lincoln's Inn Fields, London WC2A 3PX, UK
  REMARK    Sequence update by submitter
COMMENT     On Sep 30, 1998 this sequence version replaced gi:1524400.
FEATURES             Location/Qualifiers
     source          1..6457
                     /db_xref="H-InvDB:HIT000220312"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /cell_type="primary keratinocyte"
     gene            1..6457
                     /gene="EVPL"
     5'UTR           1..98
                     /gene="EVPL"
     CDS             99..6200
                     /gene="EVPL"
                     /note="cornified envelope precursor"
                     /codon_start=1
                     /product="envoplakin"
                     /protein_id="AAC64662.1"
                     /translation="MFKGLSKGSQGKGSPKGSPAKGSPKGSPSRHSRAATQELALLIS
                     RMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLFLDVD
                     KARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVLPPDVGPRVDWARVLEQKQ
                     KQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQLRSLVGPDAATIRSQYRDLLKAA
                     SWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHEL
                     LSQEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKMEWQNFLNLCICQETQLQHVED
                     YRRFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQQLEAEEKRLAVTERAT
                     GDLQRRSRDVAPLPQRRNPPQQPLHVDSICDWDSGEVQLLQGERYKLVDNTEPHAWVV
                     QGPGGETKRAPAACFCIPAPDPDAVARASRLASELQALKQKLATVQSRLKASAVESLR
                     PSQQAPSGSDLANPQAQKLLTQMTRLDGDLGQIERQVLAWARAPLSRPTPLEDLEGRI
                     HSHEGTAQRLQSLGTEKETAQKECEAFLSTRPVGPAALQLPVALNSVKNKFSDVQVLC
                     SLYGEKAKAALDLERQIQDADRVIRGFEATLVQEAPIPAEPGALQERVSELQRQRREL
                     LEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVRALTDRYHAVGDQLDL
                     REKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGPSQIAYKLQAQKRLTQEIQ
                     SRERDRATASHLSQALQAALQDYELQADTYRCSLEPTLAVSAPKRPRVAPLQESIQAQ
                     EKNLAKAYTEVAAAQQQLLQQLEFARKMLEKKELSEDIRRTHDAKQGSESPAQAGRES
                     EALKAQLEEERKRVARVQHELEAQRSQLLQLRTQRPLERLEEKEVVEFYRDPQLEGSL
                     SRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLTKEVTQVERDPGLDS
                     QAAQLRIQIQQLRGEDAVISARLEGLKKELLALEKREVDVKEKVVVKEVVKVEKNLEM
                     VKAAQALRLQMEEDAARRKQAEEAVAKLQARIEDLERAISSVEPKVIVKEVKKVEQDP
                     GLLQESSRLRSLLEEERTKNATLARELSDLHSKYSVVEKQRPKVQLQERVHEIFQVDP
                     ETEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQEVVRHER
                     SPEVLREIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVETKTVSKEVVRH
                     EKDPVLEKEAERLRQEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVVVT
                     QKDPKLREEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVE
                     RELRQLTLRIQELEKRPPTVQEKIIMEEVVKLEKDPDLEKSTEALRWDLDQEKTQVTE
                     LNRECKNLQVQIDVLQKAKSQEKTIYKEVIRVQKDRVLEDERARVWEMLNRERTARQA
                     REEEARRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQQELRALERQKQQQT
                     LQLQEESKLLSQKTESERQKAAQRGQELSRLEAAILREKDQIYEKERTLRDLHAKVSR
                     EELSQETQTRETNLSTKISILEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEEV
                     TTSGPCGEESVLLDRKSGKQYSIEAALRCRRISKEEYHLYKDGHLPISEFALLVAGET
                     KPSSSLSIGSIISKSPLASPAPQSTSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCSIK
                     TAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQ
                     KAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQA
                     LLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLPAALE
                     GYRCYRSASPTVPRSLR"
     3'UTR           6201..6457
                     /gene="EVPL"
     regulatory      6433..6438
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EVPL"
                     /note="polyA signal"
     polyA_site      6457
                     /gene="EVPL"
BASE COUNT         1425 a         1958 c         2234 g          840 t
ORIGIN      
        1 gctgaccagc cagtgaggac gcccgctgcc tcccacctgc cctcctgccg tctttcgcca
       61 gccaagccca gcctgagcca gcacttgcct ttacgaccat gttcaagggg ctgagcaaag
      121 gctcccaggg gaaggggtcc cccaagggct cccccgccaa ggggtccccc aaaggctccc
      181 ccagcaggca cagccgggct gccacccagg agctggccct tctcatctcc cgcatgcaag
      241 ccaacgccga ccaggtggag cgggacatcc tggagacgca gaagaggctg cagcaggacc
      301 ggctgaacag tgagcagagc caggccctgc agcaccagca ggagacgggc cgcagcctga
      361 aggaggctga ggtgctgctc aaggacctct tcctggacgt ggacaaggcc cggcggctca
      421 agcacccgca ggctgaggag attgagaagg acatcaagca gctgcacgag cgggtgaccc
      481 aggagtgtgc ggagtaccgt gccctgtacg agaagatggt gctgcccccc gacgtgggac
      541 ccagggtcga ctgggcacgc gtgctggagc agaaacagaa gcaggtctgc gcaggccagt
      601 acgggccggg catggcggag ctggagcaac agatcgccga gcacaacatc ctgcagaagg
      661 agatcgacgc ctatgggcag cagctgcgga gcctcgtggg gccggatgca gccaccatcc
      721 ggagccaata ccgagaccta ctgaaggcgg cgtcgtggcg cgggcagagc ctgggcagcc
      781 tgtacacgca cctccagggc tgcacgcggc agctgagcgc cctggctgag cagcagcgcc
      841 gcatcctgca gcaggactgg agcgacctca tggccgaccc tgcgggcgtg cggcgggagt
      901 acgagcactt caagcagcac gagctgctga gccaggagca gagcgtgaac cagctggagg
      961 acgacggcga gcgcatggtg gagctgcggc accccgcggt ggggcccatc caggcccacc
     1021 aggaggccct gaagatggag tggcagaact tcctgaacct gtgtatctgc caggagaccc
     1081 agctgcagca cgtggaggac taccgccggt tccaggaaga ggccgactca gtcagccaga
     1141 ccctggcgaa gctcaactcc aacttggatg ccaagtacag ccctgcacct gggggccccc
     1201 ctggcgcccc cacagagctg ctgcaacagc tggaggcaga ggaaaaacgg ctggccgtca
     1261 ccgagagggc cactggggac ctgcagcggc gaagccggga tgtggcccct ctgccacagc
     1321 gaagaaaccc ccctcagcag cccctgcacg tggacagcat ctgcgactgg gactcaggag
     1381 aagtgcagct gctgcagggt gagcggtata agctggtaga taacactgaa ccgcacgcct
     1441 gggtcgtgca gggccctggc ggggagacca agcgtgctcc cgccgcctgc ttctgcatcc
     1501 cagcaccaga ccctgatgct gtggccaggg cctcccggct ggcctcagag ctgcaggccc
     1561 tgaagcagaa attggccaca gtccagagcc gcctgaaggc cagtgctgtg gagtctcttc
     1621 ggcccagcca gcaggctcca tctggctcag acctggccaa cccacaggcc cagaagctcc
     1681 tgacacagat gacccggctg gatggagacc tgggacagat agagaggcag gtgctggcct
     1741 gggcgcgggc cccgctgagc cgccccacac ccttggagga cttggagggc cgcatccaca
     1801 gccatgaggg cacagcccag cgcctgcaga gcctgggaac ggagaaggag acagcccaga
     1861 aggagtgcga ggcgtttctg tccacgcggc ccgtgggccc cgctgccctg cagctgcccg
     1921 tagccctcaa cagcgtgaag aacaagttca gtgacgtgca ggttctgtgc agcctctacg
     1981 gggagaaagc caaggctgcc ctggatctgg agcggcagat ccaggatgcg gacagggtca
     2041 tccgaggctt cgaggccacc ctggtgcagg aggcccccat ccctgctgaa ccgggggctc
     2101 tgcaggagag ggtcagcgag ctgcagcgcc agcggaggga gctgctggaa cagcagacct
     2161 gcgtgctgcg gctacaccgc gcgctgaagg cctcggagca cgcatgcgct gccctgcaga
     2221 acaacttcca ggagttctgc caagacctgc ctcgccagca gcgccaggtg cgagccctca
     2281 ccgaccgcta ccacgccgta ggggaccagc tggacctgcg ggagaaggtg gtgcaggatg
     2341 ccgccctcac ctaccagcag ttcaagaact gcaaggataa cctgagctcc tggctggagc
     2401 acctgccccg cagccaggtg cggcccagcg acggccccag ccagatcgcc tacaagctgc
     2461 aggcgcagaa gaggctgacg caggagatcc agagccgaga gcgggacagg gccacagcat
     2521 cccacctctc ccaggccctg caggcagcgc tccaggacta tgagctccag gcagacacct
     2581 accgctgctc tttggagccc accctggcag tgtcagcccc caagagaccc cgagtggctc
     2641 ccctgcaaga gagcatccaa gcccaggaga agaaccttgc aaaggcctat actgaggttg
     2701 cagcagcaca gcagcagctg ctccagcagc tggagtttgc tagaaaaatg ctggagaaga
     2761 aggagctcag tgaggacatc cgaaggaccc atgatgcaaa gcagggctcc gagagccctg
     2821 cccaagcagg gagagagtca gaggccctga aggcccagct ggaagaggag aggaagcggg
     2881 tggcccgggt gcagcatgag ctggaggcgc agaggagcca actgctgcag ctgaggaccc
     2941 agcggccctt ggagaggctg gaggagaagg aagtggtaga gttctaccgg gacccccagc
     3001 tggagggcag cctgtccagg gtgaaggccc aggtggagga ggagggcaag cggcgggctg
     3061 gcctgcaggc agacctggaa gtggcagccc agaaggtcgt gcagctggaa agcaagagga
     3121 agaccatgca gcctcatctg ctgaccaagg aggtcaccca ggtggagagg gaccccggcc
     3181 tggacagcca ggcggcccag ctcaggatcc agatccagca gctccgcggg gaggatgccg
     3241 tcatctcggc ccggctggaa gggctgaaga aggagctact ggcccttgag aagagggagg
     3301 tggacgtgaa ggagaaggtc gtggtgaaag aggtagtcaa ggtggagaag aatctggaaa
     3361 tggtcaaggc agcccaggct ctgaggctgc agatggagga ggatgctgcg cggaggaagc
     3421 aggcggagga ggctgtggcc aagctacagg ctcgcatcga agacctggag cgggctatca
     3481 gctcggtgga gcccaaggtc atcgtgaagg aggtgaagaa ggtggagcag gacccagggc
     3541 tcctccagga gtcctccagg ctgaggagcc tcctcgagga ggagaggacc aagaacgcga
     3601 cgctggccag ggagctgagc gacctgcaca gcaagtacag cgtggtggag aagcagaggc
     3661 ccaaagtgca gctccaggag cgcgtccacg agatcttcca ggtggatccg gagacagagc
     3721 aggagatcac tcggctcaag gccaagctgc aggagatggc gggcaagagg agcggtgtgg
     3781 agaaggaggt ggagaagctg ctgcccgacc tggaggtcct gcgggcccag aagcccacgg
     3841 tggagtacaa ggaggtgacc caggaggtgg tgaggcatga gaggagcccc gaggtgctgc
     3901 gtgagatcga ccgcctgaag gctcagctca acgagctcgt caacagccac gggcgctccc
     3961 aggagcagct catccgcctg cagggtgagc gcgacgagtg gaggcgcgag cgggccaagg
     4021 tggagaccaa gacggtgagc aaggaggtgg tgcgccacga gaaggacccg gtgctggaga
     4081 aagaagcaga gcggctccgc caggaggtgc gggaggcggc ccagaagagg cgggccgcgg
     4141 aggacgcggt gtacgagctg cagagcaagc gcctgctgct ggagaggagg aagcccgagg
     4201 agaaggtggt ggtgcaggag gtggtggtca cccagaagga cccgaagctg cgcgaggagc
     4261 acagccggct gagcgggagc ctggatgagg aggtgggccg gcggcgccag ctagagcttg
     4321 aggtgcagca gctgcgggcc ggcgtggagg agcaggaggg cctgctcagc ttccaggagg
     4381 accgcagcaa gaagctggcc gtggagaggg agctgcggca gctgaccttg aggatccagg
     4441 agctcgagaa gcggcctccc acggtgcagg agaagatcat catggaggaa gtggtcaagc
     4501 tggagaagga cccggacctg gagaagtcca cggaagccct gcggtgggac ctggaccagg
     4561 agaagaccca ggtaaccgag ctgaatcggg agtgcaagaa cctgcaggtc cagattgacg
     4621 tcctccagaa agccaaatcg caggagaaga ccatctacaa ggaagtgatc cgggtgcaga
     4681 aggaccgcgt cctggaagat gagcgggccc gcgtgtggga gatgctcaac agggagcgca
     4741 cggcccggca ggcccgggag gaggaggcac ggcgcctgcg ggagcgcatt gaccgggccg
     4801 agacgctggg gagaacctgg tcccgggagg agtccgagct gcagagggcc cgggaccagg
     4861 ccgaccagga gtgtgggcgg ctgcagcagg agctgcgggc tctggagagg cagaagcagc
     4921 agcagacact gcagctgcag gaggagtcga agctgctcag ccagaagacg gagagcgagc
     4981 gacagaaggc ggcccagcgg ggccaggagc tctcgcggct ggaggcggcc atcctccgcg
     5041 agaaggacca gatctacgag aaggagcgga cgctccggga cctccacgcc aaggtgagcc
     5101 gggaggagct cagccaggag acccagacgc gagagaccaa cctttccacc aagatctcca
     5161 tcctggaacc cgagacgggg aaggacatgt ccccatacga ggcctacaag aggggcatca
     5221 tcgacagggg ccagtacttg cagctgcagg agctcgagtg tgactgggag gaggtcacca
     5281 cctcggggcc ctgtggggag gagtctgtgc tcctggaccg caagagcggg aagcagtact
     5341 ccatcgaggc cgccctccgc tgccggcgca tctctaagga ggagtaccat ctgtacaagg
     5401 acggccacct gcccatctcc gagtttgcgc tgcttgtagc tggggagacc aagccaagct
     5461 cctcactctc catcggctct atcatctcca agtccccgct cgcctccccg gccccccaga
     5521 gcaccagttt cttctctccc agcttctctc tcgggctcgg tgatgacagc ttccctatcg
     5581 ccgggatcta tgacacaacc acagacaaca agtgcagcat caagacggcc gtggccaaga
     5641 acatgctgga ccccatcact gggcagaagc tactggaggc ccaggcggcc acagggggca
     5701 tcgtggacct gctcagccgt gagcgctact ctgtgcacaa ggcgatggag aggggcctga
     5761 tcgagaacac ctccacacag aggctgctta acgcccagaa ggccttcacc ggcatcgagg
     5821 accccgtcac caagaagagg ctctcggtgg gcgaggccgt ccagaagggc tggatgcccc
     5881 gggagagcgt gctcccacac ctgcaggtgc agcacctgac cggggggctc atcgacccca
     5941 agaggacagg ccgcatcccc atccagcagg ccctcctctc cgggatgatc agtgaagagc
     6001 tggcccagct cctgcaggac gagtccagct acgagaagga tttgacagac cccatctcca
     6061 aggaacggct gagctacaag gaggccatgg gccgctgccg caaagacccc ctgagcggcc
     6121 tgctgctcct gccagcggca ctggaggggt accgctgcta ccgctccgcc tcccccaccg
     6181 tcccgcgctc ccttcgctga cacgggccaa ggagccagtg gggaagtgcg tgtgttgggc
     6241 caggtaggat acgtacacct cttgcctcag agcagcctca tcccaggcag tgggtcttcc
     6301 ctctgtccaa ccactgtttt attattttac taacatggtg atgggctccc tcccctaacc
     6361 ttggtgcctg atccatcccc agaccaggac agcagccact cagttcttcc tccacctcca
     6421 cccagtgatc ccaataaacg aattctgtct ccccgtg
//