LOCUS HSU53204 14800 bp mRNA linear HUM 13-DEC-2001
DEFINITION Human plectin (PLEC1) mRNA, complete cds.
ACCESSION U53204
VERSION U53204.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 14800)
AUTHORS McLean,W.H., Pulkkinen,L., Smith,F.J., Rugg,E.L., Lane,E.B.,
Bullrich,F., Burgeson,R.E., Amano,S., Hudson,D.L., Owaribe,K.,
McGrath,J.A., McMillan,J.R., Eady,R.A., Leigh,I.M., Christiano,A.M.
and Uitto,J.
TITLE Loss of plectin causes epidermolysis bullosa with muscular
dystrophy: cDNA cloning and genomic organization
JOURNAL Genes Dev. 10 (14), 1724-1735 (1996)
PUBMED 8698233
REFERENCE 2 (bases 1 to 14800)
AUTHORS McLean,W.H.I. and Smith,F.J.D.
TITLE Direct Submission
JOURNAL Submitted (30-MAR-1996) W.H.I. McLean, Anatomy and Physiology,
University of Dundee, Medical Sciences Institute, Dundee DD1 4HN,
UK
FEATURES Location/Qualifiers
source 1..14800
/db_xref="H-InvDB:HIT000220292"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="8"
/map="8q24"
/cell_line="normal human primary keratinocyte culture"
gene 1..14800
/gene="PLEC1"
5'UTR 1..51
/gene="PLEC1"
CDS 52..13776
/gene="PLEC1"
/function="high molecular weight cytoskeletal-associated
protein which is a component of hemidesmosomes in basal
keratinocytes and also a component of the sarcolemma in
muscle"
/note="previously known as HD1; Loss of plectin expression
causes the autosomal recessive disorder epidermolysis
bullosa with muscular dystrophy, a disease characterised
by hereditary skin blistering (at the level of the
hemidesmosome) and late-onset progressive muscular
dystrophy; Cytoskeleton-associated protein"
/codon_start=1
/product="plectin"
/protein_id="AAB05427.1"
/translation="MSGEDAEVRAVSEDVSNGSSGSPSPGDTLPWNLGKTQRSRRSGG
GAGSNGSVLDPAERAVIRIADERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHN
LISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRDDDIADGNPKLT
LGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGR
LFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEK
SIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRF
PSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLD
VEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDV
RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERL
VAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRV
DGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRL
DLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKK
ESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCC
IEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEK
EQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQ
LVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLH
VDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGG
FGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT
VHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAP
TLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVP
ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDLEVERW
RERVAQVLERWQAVLAQTDLRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA
MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL
EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLA
EQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV
DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ
RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAET
EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA
SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEA
LRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ
LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL
AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR
QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE
AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK
ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER
VQKSLAAEEEAARQRKAALEEVERLKANVEEARRLRERAEQESARQLQLAQEAAQKRL
QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA
QARRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA
DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR
QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE
AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE
LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA
QARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA
ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ
EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK
QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP
NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR
EDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPV
RNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREH
GIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTH
ENLTYLQLLERCVEDPETGLCLLPLTDKAAEGGELVYTDSEARDVFEKATVSAPFGKF
QGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFE
GLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEE
AGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEF
HEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKS
HRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGL
SLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAE
QRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVL
SRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLR
ATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDP
YSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEE
MNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETT
QVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRV
TKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLREGTR
SLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAA
TGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMK
KELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRS
YVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEELVRSQVM
DEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPG
TAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYS
GKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMN
EILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSS
VRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSM
IIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVG
SSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQ
RLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTK
MSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKL
RDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGS
GSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGG
PESAVA"
3'UTR 13777..14800
/gene="PLEC1"
regulatory 14780..14785
/regulatory_class="polyA_signal_sequence"
/gene="PLEC1"
BASE COUNT 2890 a 4567 c 5319 g 2024 t
ORIGIN
1 cgcccgggca ggtggcggca gagctgaagt gagcggagcc accaggaggc catgtcgggt
61 gaggacgctg aggtccgggc agtctctgaa gatgtctcca atggaagcag tggctcgccc
121 agccctgggg acacactgcc ctggaacctt gggaaaacgc agcggagccg gcgcagcggg
181 ggtggcgctg ggagcaacgg gagtgtcctg gacccagctg agcgggcggt cattcgcatc
241 gcagatgagc gggatcgtgt gcagaagaaa accttcacca agtgggtcaa caagcacctc
301 atcaaggccc agaggcacat cagtgacctg tatgaagacc tccgcgatgg ccacaacctc
361 atctccctgc tggaggtcct ctcgggggac agcctgcccc gggagaaggg gaggatgcgt
421 ttccacaagc tgcagaatgt ccagattgcc ctggactacc tccggcaccg ccaggtgaag
481 ctggtgaaca tcagggatga tgacatcgct gacggcaacc ccaagctgac ccttggcctc
541 atctggacaa tcattctgca cttccagatc tcagatatcc aggtgagtgg gcagtcggag
601 gacatgacgg ccaaggagaa gctgctgctg tggtcgcagc gaatggtgga ggggtaccag
661 ggcctgcgat gcgacaactt cacctccagc tggagagacg gccgcctctt caatgccatc
721 atccaccggc acaagcccct gctcatcgac atgaacaagg tgtaccggca gaccaacctg
781 gagaacctgg accaggcctt ctctgtggcg gagcgggacc tgggagtgac gcggctcctg
841 gaccctgagg acgtggatgt ccctcagccc gacgagaagt ccatcatcac ctacgtctcg
901 tcgctgtatg acgccatgcc ccgcgtgccg gacgtgcagg atggggtgag ggccaacgag
961 ctgcagctgc gctggcagga gtaccgggag ctggtgctgc tgctgcttca gtggatgcga
1021 caccacacgg ccgcctttga ggaacgcagg ttcccctcca gcttcgagga gattgagatc
1081 ctgtggtctc agttcctgaa gtttaaggag atggagctac cagccaagga ggccgacaag
1141 aacaggtcca agggcatcta ccaatccctg gagggagcgg tgcaagcagg ccagctcaag
1201 gtgccccctg gctaccaccc gctggatgtg gagaaggagt ggggcaagct gcacgtggcc
1261 atcctggagc gggagaagca gctccgcagc gagtttgaga ggctggagtg tcttcagcgc
1321 atcgtgacca agctgcagat ggaggcgggg ctgtgtgagg agcagctgaa ccaggccgac
1381 gccctgctgc agtcggatgt ccggctgctg gctgcaggca aagtgccaca gcgggcgggg
1441 gaggtggaac gggacttgga caaggcggat agcatgatcc ggctgctctt caacgacgtg
1501 cagaccctca aggatggacg gcacccgcag ggcgagcaga tgtaccgcag ggtgtaccgt
1561 ctgcacgagc gcctggtagc catccgcacc gagtacaacc tacggctgaa ggcaggcgtg
1621 gcggcccctg caacccaggt ggcccaggtg actctgcaga gtgtgcagag gcgccccgag
1681 ctggaggact ccactctgcg ctacctgcag gacctgctgg cctgggtgga ggagaaccag
1741 caccgtgtgg atggcgctga gtggggtgtg gacctgccca gcgtggaggc gcagctgggc
1801 agccaccgag gcctgcacca gtccatcgaa gaattccggg ccaagatcga gcgggcacgg
1861 agtgacgagg gccagctctc ccccgccacc cggggtgcct accgtgactg cctgggtcgg
1921 ctggacctgc agtacgccaa gctgctgaac tcctccaagg cccgcctcag gtccctggag
1981 agcttgcaca gctttgtggc agccgccact aaggagctaa tgtggctgaa tgagaaggag
2041 gaggaggagg tgggcttcga ctggagcgac cgcaacacca acatgaccgc caagaaggag
2101 agctactcgg cgctgatgcg ggagctggag ctgaaggaga agaagatcaa ggagctccaa
2161 aatgctgggg accggctgct gcgggaggac cacccggccc ggcccacggt ggagtccttc
2221 caggcggccc tgcagacgca gtggagctgg atgctacagc tgtgctgctg tatcgaggca
2281 cacctgaagg agaacgctgc ctactttcag ttcttctcag atgtgcggga ggccgagggg
2341 cagttgcaga agctgcagga ggcactgcgt aggaaataca gttgtgatcg ctccgccacc
2401 gtcacccggc tggaggacct gctgcaggat gcccaggacg agaaggaaca gctgaacgag
2461 tacaagggcc acctctcagg cctggccaag cgggccaagg ccgtcgtgca gctgaagccc
2521 cgccacccag cccaccccat gcggggccgc ctgcccctgc tggccgtgtg cgactataag
2581 caggtggagg tgactgtgca caagggtgac gagtgccagc tggtgggccc tgcacagccg
2641 tcccactgga aggtgctcag cagctccggc agcgaggccg ccgtgccctc cgtgtgcttc
2701 ctggtgcccc cgcccaacca ggaggcccag gaggccgtca ccaggctgga ggcccagcac
2761 caggccctgg tcacgctgtg gcaccagttg cacgtggaca tgaagagcct tctggcctgg
2821 cagagccttc gccgcgacgt gcagctcatc cgctcgtggt ccctggccac gttccgcacc
2881 ctgaagccag aggagcagcg ccaagccctg cacagcctgg agctgcacta ccaggccttc
2941 ctgcgggaca gccaggacgc gggcggcttc ggacccgagg accggctgat ggctgagcgc
3001 gagtacggct cctgcagcca ccactaccag cagctgctgc agagcctgga acagggtgca
3061 caggaagagt ctcgctgcca gcgctgcatc tccgagctca aagacatccg gctgcagctg
3121 gaggcctgtg agacgcgcac cgtgcaccgc ctgcggctgc cgctggacaa agagccggca
3181 cgggagtgtg cccagcgcat cgccgagcag cagaaggcac aggcagaggt ggaggggctg
3241 ggcaaggggg tcgcccggct ctctgccgag gccgagaagg tcttggccct accagagcca
3301 tcgcctgcgg cccccacgct gcgctcggag ctggagctga cgctgggcaa gctggagcag
3361 gtccgcagcc tgtctgccat ctacctggag aagctcaaga ccatcagcct ggtgatccgc
3421 ggcacgcagg gggccgagga ggtgctcagg gcccacgagg agcagctcaa ggaggcccag
3481 gccgtgccgg ccaccctccc ggagctcgag gccaccaagg cctctctgaa gaagctgcgg
3541 gcccaggccg aggcacagca gcccacgttc gacgccctgc gggatgagct gcggggggca
3601 caggaggtgg gggagcgact gcagcagcgg cacggggagc gggacttgga ggtggagcgc
3661 tggcgggagc gggtcgccca ggtgcttgag cgctggcagg ctgtgctggc ccagaccgac
3721 ttgcggcagc gcgagctcga gcaactgggc cgccagctgc gttactaccg cgagagtgca
3781 gaccccttgg gcgcctggct gcaggacgcc aggcggcggc aggagcagat ccaggccatg
3841 ccgctggccg acagccaggc tgtgcgggag cagctgcggc aggagcaggc cctgctggag
3901 gagatcgagc gccacggcga gaaggtcgag gagtgccaga ggtttgcgaa acagtacatc
3961 aacgccatca aggactatga actccagctg gtgacgtaca aggcgcagct tgagccggtg
4021 gcctccccgg ccaagaagcc caaggtccag tcgggatcag agagtgtcat ccaggagtac
4081 gtggacctgc gtacgcacta cagcgagctg accacactga cgagccagta catcaagttc
4141 atcagcgaga ctctgcggcg catggaggag gaggagaggc tggctgagca gcagcgggca
4201 gaggagcgcg agcggctggc cgaggtggag gccgcgctgg agaagcagcg gcagctggcc
4261 gaggcgcacg cccaggcaaa ggcacaggcg gagcgggagg cgaaggagct gcagcagcgc
4321 atgcaggagg aggtggtgcg gcgggaggag gcggcggtgg acgcgcagca gcagaagcgc
4381 agcattcagg aggagctgca gcagctgcgg cagagctcgg aggcggagat ccaggccaag
4441 gcccggcagg cagaggcggc tgagcgcagc cggctgcgca tcgaggagga gatccgcgtg
4501 gtgcgcctgc agttggaggc caccgagcgc cagcgtggcg gggctgaggg ggagctgcag
4561 gcactgcgtg cacgggcgga ggaggctgag gcacaaaagc gacaggcgca ggaggaggcc
4621 gagcgcttgc ggaggcaggt gcaggacgag agccagcgta agcggcaggc ggaggtggag
4681 ctggcctcgc gcgtgaaggc cgagaccgag gcggcgcgcg agaagcagcg ggccctgcag
4741 gccctggagg agctgcggct gcaggcggag gaggcggagc ggcgcctgcg gcaggccgag
4801 gtggagcgag cgcggcaggt acaggtggcc ctggagacgg cgcagcgcag tgcagaggcg
4861 gagctgcaga gcaaacgcgc ctccttcgcc gagaagacgg cacagctgga gcgctccctg
4921 caggaggaac acgtggctgt ggcacagctg cgggaggagg ctgagcggcg ggcacagcag
4981 caggccgagg ccgagcgggc gcgcgaggag gcagagcggg agctggagcg ctggcagctc
5041 aaggccaacg aggcgctacg gctgcggctg caggcggagg aggtggcgca gcagaagagc
5101 ctggcgcagg ccgaggctga gaagcagaag gaggaggcgg agcgcgaggc gcggcggcgc
5161 ggcaaggcgg aggagcaggc cgtccggcag cgggagctgg ctgaacaaga gctggagaag
5221 cagcggcagc tggcggaagg caccgcgcag cagcgcctgg ccgcggagca ggagttgatc
5281 cggctgcggg ccgagacgga gcagggggag cagcagcggc agctgctgga ggaggagctg
5341 gcccggctgc agcgtgaggc ggctgcagcc acgcagaaac ggcaggagct ggaagccgag
5401 ctggccaagg tgcgggccga gatggaggtg ctgctggcca gcaaggcgag ggctgaggag
5461 gagtcgcgct ccaccagcga gaagtccaag cagaggctgg aggccgaggc cggccggttc
5521 cgcgagctgg ccgaggaggc cgcccgcctg cgtgccctgg cggaagaggc caagcggcag
5581 cggcagctgg ccgaggaaga cgcggcgcgg cagcgggccg aggcggagcg ggtgcttgcg
5641 gagaagctgg ccgccatcgg cgaggccacg cggctcaaga cggaggcgga gatcgcgctc
5701 aaggagaagg aggcggagaa cgagcgcctg cggcggctgg cggaggacga ggccttccag
5761 cggcggcggc tggaggagca ggccgcgcaa cacaaggctg acatcgagga gcgcctggcc
5821 cagctgcgca aggcatcgga cagcgagctg gagcggcaga aggggctggt ggaggacacg
5881 ctgaggcagc ggcggcaggt ggaggaagag atcctggcgc tgaaggcgag cttcgagaag
5941 gcggccgctg gcaaggcgga gctggagctg gagctgggac gcatccgcag caacgcggag
6001 gacacgctgc gcagcaagga gcaggccgag ctggaggccg cgaggcagcg gcagctggcg
6061 gcggaggagg agcggcggcg ccgtgaggct gaggagcgcg tgcagaagag cctggcggcc
6121 gaggaggagg ccgcacggca gcggaaggcg gcgctggagg aagtcgagcg gctgaaagcc
6181 aacgtggagg aggcgcggcg cctgcgggag cgagcggagc aggagtcggc gcggcagctg
6241 cagctggccc aggaggccgc ccagaagcgg ctgcaggcgg aagagaaggc acacgccttc
6301 gcggtgcagc agaaggagca ggagctacag cagacgctgc agcaggagca gagcgtgctg
6361 gaccagctgc gcggcgaggc ggaggcggcc cggcgggcgg ctgaggaggc ggaggaggcc
6421 cgggtgcagg cggagcgtga ggcggcgcag gcccggcggc aggtggaaga ggccgagcgg
6481 ctgaagcagt cggcagagga gcaggcacag gcccgggctc aggcacaggc ggctgcagag
6541 aagctgcgca aggaggccga gcaagaggcg gcgcggcggg cacaggcgga gcaggcggcc
6601 ctgcggcaga agcaggcagc tgacgcggag atggagaagc ataagaaatt cgccgagcag
6661 acgctgcggc agaaggcgca ggtggagcag gagctgacaa cactgcggct gcagctggag
6721 gagaccgacc accagaagaa cctgctggac gaggagctgc agcggctgaa ggcggaggcc
6781 acggaggccg cacgccagcg cagccaggtg gaggaggagc tcttctcggt gcgcgtgcag
6841 atggaggagc tgagcaagct caaggcacgc atcgaggctg agaaccgcgc actcatcttg
6901 cgtgacaagg acaatacgca gcgcttcctg caggaggagg ctgagaagat gaagcaggtg
6961 gcggaggagg ccgcgcggct gagtgtggcg gcccaagagg ctgcgcgact gcggcagctg
7021 gcagaggagg acctggcaca gcagcgggcc ttggcagaga agatgctcaa ggagaagatg
7081 caggcggtgc aggaggccac gcgactcaag gctgaggcgg aactgctgca gcagcagaag
7141 gagcttgcgc aggagcaggc gcggcggctg caggaggaca aggagcagat ggcgcagcag
7201 ctggcggagg agacgcaggg cttccagcgg acgctggagg ccgagcggca gcggcagctg
7261 gagatgagcg ctgaggctga gcgcctcaag ctgcgtgtgg ccgagatgag ccgagcccag
7321 gcccgcgctg aggaggacgc ccagcgcttc cggaagcagg cggaggagat cggtgagaag
7381 ctgcaccgca cggagctcgc cacccaggag aaggtgaccc tggtgcagac actggagatc
7441 cagcgacagc agagtgacca tgatgccgag cgcctgcggg aggccatcgc tgagctggag
7501 cgtgagaagg agaagctcca acaggaggcc aaactgctgc agctcaagtc tgaggagatg
7561 cagacggtgc agcaggagca gctgctgcag gagacgcagg ccctgcagca aagcttcctc
7621 tctgaaaagg acagcctgct acagcgggag cgcttcatcg agcaggagaa ggccaagctg
7681 gagcagctct tccaggacga ggtggccaag gcacagcagc tgcgtgagga gcagcagcgg
7741 cagcagcagc agatggagca ggaacggcag cggctggtgg ccagcatgga ggaggcgcgg
7801 cggcggcagc atgaggccga ggagggcgtg cggcgcaagc aggaggagct gcagcagctg
7861 gagcagcagc ggcggcagca ggaggagctg ctggctgagg agaaccagag gctgcgtgag
7921 cagctgcagc tcctggagga gcagcaccgg gccgcgctgg cgcactcaga ggaggtcact
7981 gcctcgcagg tggctgccac aaagaccctg cccaatggcc gggatgcact tgatggcccc
8041 gcggcagagg cagagccgga gcacagcttc gatggcctgc ggcggaaggt gtcagctcag
8101 aggctgcagg aggccggcat cctgagtgcg gaggagctgc agcggttggc gcagggccac
8161 accacggtgg acgagctcgc acggcgggaa gacgtgcgcc actacctgca gggccgcagc
8221 agtatcgcag ggctgttgct gaaggccacc aatgagaagc tgagtgttta cgccgccctg
8281 cagaggcagc tgctgagtcc cggcacggcc ctcatcctgc tggaggcgca ggcggcctca
8341 ggcttcctgc tggaccctgt gcggaaccgg cggctgaccg tcaacgaggc tgtgaaggag
8401 ggtgtggtgg gccccgagct gcaccacaag ctgctgtcgg ccgagcgcgc cgtcactggc
8461 tacaaggacc cctacactgg ccagcagatc tctctcttcc aagccatgca gaagggcctc
8521 atcgtccggg agcacggcat ccgcctgctg gaggcccaga tcgccacggg cggcgttatc
8581 gaccccgtgc acagccaccg cgtgcccgtg gacgtggcct accggcgcgg ctacttcgac
8641 gaggagatga accgcgtcct ggcggacccc agcgacgaca ccaagggctt ctttgacccc
8701 aacacgcacg agaacctcac gtacctgcag ctactggagc gctgcgtgga ggaccccgag
8761 acgggcctgt gccttctgcc actcacggat aaggctgccg agggcgggga gctggtctac
8821 actgactccg aggcccggga cgtctttgag aaggccaccg tgtctgcgcc gttcggcaag
8881 ttccagggca agacggtgac catttgggag atcatcaact cggaatactt cacggcagag
8941 cagcggcggg acctgctgcg gcagttccgc acgggccgga tcacagtgga gaagatcatc
9001 aagatcatca tcacggtggt ggaggagcag gagcagaagg gccggctttg ctttgagggc
9061 ctgcgcagcc tggtgccagc cgccgagctg ctggagagca gggtcatcga ccgcgagctc
9121 taccagcagc tgcagcgagg tgagcgctct gtgcgagacg tagccgaggt ggacactgtg
9181 cggcgggctc tccggggtgc caacgtcatc gcgggtgtat ggctggagga ggcggggcag
9241 aagctgagta tctacaatgc cctgaagaaa gacctgctgc catccgacat ggccgtggcc
9301 ctgttggaag cccaggccgg caccgggcac atcatcgacc ccgccaccag cgcccggctg
9361 accgtggacg aggcagtgcg tgctggcctg gtgggccccg agtttcatga gaagctgcta
9421 tcagccgaga aggctgtgac agggtacagg gacccctaca cagggcagag cgtctccctg
9481 ttccaggccc tgaagaaggg cctcattccc cgggagcagg gcctgcgcct gttggacgcc
9541 cagctgtcca cgggcggcat cgtggacccc agcaagagcc accgcgtgcc cctggatgtc
9601 gcctgcgccc gaggctgcct ggatgaggag accagcaggg ccctgtcggc accaagggcc
9661 gacgccaagg cctacagtga ccccagcaca ggggagccgg ccacctacgg cgagctccag
9721 cagcggtgcc ggcccgacca gctgaccggg ctgagcctgc tgccgctctc agaaaaggct
9781 gctcgggccc ggcaggagga gctctactca gagctgcagg cccgtgagac ctttgaaaag
9841 accccggttg aggtccccgt gggtggcttc aagggcagga cggtgacggt gtgggagctc
9901 atcagctctg agtacttcac tgcggagcag cggcaggagc tgttgcgtca gttccgcacg
9961 ggcaaggtca ccgtggagaa ggtcatcaag attctcatta ccatcgtgga ggaggtggag
10021 accctgcggc aggagaggct gtccttcagc ggcctccgtg cccctgtgcc agccagcgag
10081 ctcctggctt ccggggtcct cagcagagcc cagtttgagc agctcaagga cggcaagacg
10141 acggtcaagg acctttcgga gctgggctcc gtgcggacgc tgctgcaggg cagtggctgc
10201 ctcgccggca tctacctgga ggacaccaag gagaaggtgt ccatctacga ggccatgcgc
10261 cggggcctgc tgagagccac aacggctgcg ctcctgctgg aggcgcaggc ggccactggc
10321 ttcctggtgg accccgtgcg gaaccagcgc ctgtatgtcc acgaggccgt gaaggcgggc
10381 gtggtgggcc ccgagcttca cgagcagctg ctgtctgccg agaaggccgt caccggctac
10441 agagacccct actcgggcag caccatctcc ctcttccagg ccatgcagaa gggcctggtt
10501 ctccggcagc acggcatccg cctgctggag gcccagatcg ccacgggcgg catcatcgac
10561 cccgtgcaca gccaccgcgt gcctgtggac gtggcctacc agcgcggcta cttcagtgag
10621 gagatgaacc gcgtcctggc ggaccccagc gacgacacca agggcttctt tgaccccaac
10681 acgcatgaga acctcacgta caggcagctg ctggagcggt gcgtggagga ccccgagacg
10741 ggcttgcgcc ttctgccact gaaaggggcg gagaaggctg aggtggtgga gaccacgcag
10801 gtgtacactg aggaggagac aagaagggca tttgaagaga cacagatcga cattcccggc
10861 ggcggcagcc acggcggctc caccatgtcc ctgtgggagg tgatgcagtc ggacctgatc
10921 cccgaggagc agcgggccca gctgatggct gacttccagg ccggccgggt gaccaaggaa
10981 cgcatgatca tcatcatcat cgagatcatt gagaagacag agatcatccg ccagcagggt
11041 ctggcctcct atgactacgt gcgccgccgc ctcacggctg aggacctgtt cgaggctcgg
11101 atcatctctc tcgagaccta caacctgctc cgggagggca ccaggagcct ccgtgaggct
11161 ctcgaggcgg agtccgcctg gtgctacctc tatggcacgg gctccgtggc tggtgtctac
11221 ctgcccggtt ccaggcagac actgagcatc taccaggctc tcaagaaagg gctgctgagt
11281 gccgaggtgg cccgcctgct gctggaggca caggcagcca caggcttcct gctggacccg
11341 gtgaaggggg agcggctgac tgtggatgag gctgtgcgga agggcctcgt ggggcccgag
11401 ctgcacgacc gcctgctctc ggctgagcgg gcggtcaccg gctaccgtga cccctacacc
11461 gagcagacca tctcgctctt ccaggccatg aagaaggagc tgatccctac tgaggaggcc
11521 ctgcggctgc tggatgccca gctggccacc ggcggcatcg tggacccccg cctgggcttc
11581 caccttcccc tggaggtggc ttaccagcgt ggctacctca acaaggacac gcacgaccag
11641 ctgtcagagc ccagcgaggt gcgcagctac gtggacccgt ccaccgacga gcgcctcagc
11701 tacacgcagc tgctcaggcg gtgccgtcgt gacgacggca ccggccagct gctcctgcca
11761 ctgtcggacg cccgcaagct gaccttccgt ggcctgcgga agcagatcac catggaggag
11821 ctggtgcgct cgcaggtcat ggacgaggcc acggcgctgc agctgcggga gggcctgacc
11881 tccatcgagg aggtcaccaa gaacttgcag aagttcctgg aaggcaccag ctgcatcgct
11941 ggtgtcttcg tggacgccac caaggaacgg ctctcggtgt accaggccat gaagaaaggc
12001 atcatccgcc ccggcacagc ctttgagctc ctggaggcgc aggcggccac cggttacgtc
12061 atcgacccca tcaagggact gaagctgacg gtggaggagg ctgtgcgtat gggcattgtg
12121 ggccccgagt tcaaggacaa gctgctgtcg gccgagcgcg ccgtcactgg gtacaaggac
12181 ccctactctg ggaagctcat ctccctcttc caggccatga agaagggcct gatcctgaag
12241 gaccatggca tccgcctgct ggaggcccag atcgccacgg gcggcatcat cgaccctgag
12301 gagagccacc ggctgcccgt ggaggtggcc tacaagcgcg gcctcttcga tgaggagatg
12361 aacgagatcc tgaccgaccc ctcggacgac accaagggct tctttgaccc taacacggag
12421 gagaacctca cctacctgca gctgatggag cgttgtatca ctgaccccca gacgggcctg
12481 tgtctcttgc cgctgaagga gaagaagcgg gagcggaaga cgtcctccaa gtcctccgtg
12541 cgcaagcgcc gagtggtcat cgtggacccc gagacgggca aggagatgtc agtgtacgag
12601 gcctaccgca agggcctgat tgaccaccag acgtacctgg agctgtccga gcaggagtgc
12661 gagtgggagg agatcaccat ctcctcctcg gacggcgtgg tcaagtccat gatcatcgac
12721 cgccgctccg ggcgccagta cgacatcgat gatgccatcg ccaagaacct catcgaccgc
12781 tcggcactgg accagtaccg cgccggcacg ctctccatca ccgagttcgc cgacatgctc
12841 tcgggcaacg ccggtggttt ccgctcccgt tcctcctcgg tgggatcctc ctcctcctac
12901 cccatcagcc ccgccgtctc caggacccag ctggcctcct ggtcagaccc cactgaggag
12961 acgggccccg tggctggcat cctggacacg gagacgctgg agaaggtgtc catcaccgag
13021 gccatgcacc ggaacctggt ggataacatc acggggcagc ggctgctgga ggcgcaggcc
13081 tgcaccgggg gcatcatcga ccccagcacc ggtgagcgct tccctgtcac cgacgccgtc
13141 aacaagggcc tggtggacaa gatcatggtg gaccgcatca acctggccca gaaggccttt
13201 tgcggcttcg aggacccacg caccaagacc aagatgtcgg ccgcccaggc cctgaagaag
13261 ggctggctct actacgaggc cggccagcgc ttcctggagg tgcagtacct gaccggcggc
13321 ttgatcgagc ccgacacgcc gggccgcgtg cccctggacg aggccctgca gcgcggcacg
13381 gtggacgccc gcaccgcaca gaagctgcgt gacgtgggcg cctactccaa gtacctcacc
13441 tgccctaaga ccaagctcaa gatctcctat aaggacgcgc tggaccgcag catggtggag
13501 gagggcacgg ggctgcggct gctggaggct gccgcgcagt ccaccaaggg ctactacagc
13561 ccctacagcg tcagcggctc cggctctacc gctggctccc gcaccggctc gcgcaccggc
13621 tcccgggccg gctcccgccg cggcagcttt gacgccaccg gctccggctt ctccatgacc
13681 ttctcttcat cctcctactc ctcctcgggc tacggccgcc gctacgcctc ggggtcctcg
13741 gcctccctgg ggggccctga gtctgccgtg gcctgaggct gcctgcgccc accccgctct
13801 gcatgcggcc cagcccggct cccaccgagg cgcgggggcc gttttcaacg cttaaaggtg
13861 tcttcctccc aagtggtgcc taaagtttaa ccaaaaagac cagactaata tattaatata
13921 tatctgctgt ccagacagcc tgtatcttgg gggacagggc tggcccagcc ctgctggccg
13981 cctcaccccc tcgggtctcc tcactccctt ctacctgcca ctcacacagc caggtgcctt
14041 ggagggtccc aagctgggcc ccagcccacc ctcctgtctt cccagggtag cccgcctgcc
14101 agtcctagct gcacagggca gctgggccca accctgtctg tagagggccc tggtgtttct
14161 agcactggcc tgcacggtgg gccttgctgg ggacgggggg ccccagtcag cctctctccc
14221 agtctaccca gagaagcccc ttccccatgg gaagacgagg ccctcgggcc cagcccccac
14281 agtgctgtct gatctgtgct ttccagctca ccccccacac tcactcctga gacccctggc
14341 ctccggcgtc agcctccagc ctctgttccc ctagtaagtg ccttccatgt cggcctctaa
14401 ccccaggccc cgaggaccca gacccagtgg ggaggcggac gttccagccg gcatggctgg
14461 gaactgcaga cctgtcctcc tggtgggtcc aggggcccct ccagcttgtg gagccccaca
14521 ctggggtgcc gcctgcccgt ctctctccca tggagcccca gccccctttg ggcccaggga
14581 caccagccag gctctgtgct gaccctcctg ttgcgcccag ccctggtctc agcagcgacc
14641 acccctgcct ccaccctctg agctttgcat gttccactaa ccccgggcgg gtggcaggtg
14701 gaggtgtcag gctgctggcg cctctgcaag ggcagaacac taacctgacc gtgggcgggg
14761 ccttgcggta tccgccccca ataaaagcaa ttccaacctt
//