LOCUS HSU52852 8672 bp DNA linear HUM 13-MAR-2001
DEFINITION Homo sapiens TS PST1 (STP1) gene, complete cds.
ACCESSION U52852
VERSION U52852.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 8672)
AUTHORS Raftogianis,R.B., Her,C. and Weinshilboum,R.M.
TITLE Human phenol sulfotransferase pharmacogenetics: STP1 gene cloning
and structural characterization
JOURNAL Pharmacogenetics 6 (6), 473-487 (1996)
PUBMED 9014197
REFERENCE 2 (bases 1 to 8672)
AUTHORS Carlini,E.J., Raftogianis,R.B., Wood,T.C., Jin,F., Zheng,W.,
Rebbeck,T.R. and Weinshilboum,R.M.
TITLE Sulfation pharmacogenetics: SULT1A1 and SULT1A2 allele frequencies
in Caucasian, Chinese and African-American subjects
JOURNAL Pharmacogenetics 11 (1), 57-68 (2001)
PUBMED 11207031
REFERENCE 3 (bases 1 to 8672)
AUTHORS Raftogianis,R.B., Her,C. and Weinshilboum,R.M.
TITLE Direct Submission
JOURNAL Submitted (26-MAR-1996) R.B. Raftogianis, Pharmacology, Mayo
Foundation, 200 First St. SW, Rochester, MN 55905, USA
REFERENCE 4 (bases 1 to 8672)
AUTHORS Raftogianis,R.B., Her,C. and Weinshilboum,R.M.
TITLE Direct Submission
JOURNAL Submitted (08-JUN-2000) R.B. Raftogianis, Pharmacology, Mayo
Foundation, 200 First St. SW, Rochester, MN 55905, USA
REMARK Sequence update by submitter
COMMENT On Jun 8, 2000 this sequence version replaced U52852.1.
FEATURES Location/Qualifiers
source 1..8672
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/chromosome="16"
/map="16p12.1"
/note="cloned from NIGMS Hybrid Somatic cell line Mapping
Panel 2, cell line #GM/NA10479"
gene 1..7065
/gene="STP1"
misc_feature 1..2628
/gene="STP1"
/note="5' flanking region"
mRNA join(2629..2734,3806..3957,4062..4187,4277..4374,
5584..5710,5806..5900,6426..6606,6729..7065)
/gene="STP1"
5'UTR 2629..2734
/gene="STP1"
/note="5' UTR alternative exon IB"
mRNA join(3337..3957,4062..4187,4277..4374,5584..5710,
5806..5900,6426..6606,6729..7065)
/gene="STP1"
5'UTR 3337..3606
/gene="STP1"
/note="5' UTR alternative exon IA"
exon 3806..3957
/gene="STP1"
/note="exon II"
CDS join(3810..3957,4062..4187,4277..4374,5584..5710,
5806..5900,6426..6606,6729..6841)
/gene="STP1"
/note="thermostable (monamine) phenol sulfotransferase"
/codon_start=1
/product="TS PST1"
/protein_id="AAC51816.1"
/translation="MELIQDTSRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLIS
TYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKAPGIPSGMETLKDTPAP
RLLKTHLPLALLPQTLLDQKVKVVYVARNAKDVAVSYYHFYHMAKVHPEPGTWDSFLE
KFMVGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREIQKILEFVGHSLPEE
TVDFMVQHTSFKEMKKNPMTNYTTVPQEFMDHSISPFMRKGMAGDWKTTFTVAQNERF
DADYAEKMAGCSLSFRSEL"
exon 4062..4187
/gene="STP1"
/note="exon III"
exon 4277..4374
/gene="STP1"
/note="exon IV"
exon 5584..5710
/gene="STP1"
/note="exon V"
exon 5806..5900
/gene="STP1"
/note="exon VI"
exon 6426..6606
/gene="STP1"
/note="exon VII"
exon 6729..7065
/gene="STP1"
/note="exon VIII"
3'UTR 6842..7065
/gene="STP1"
misc_feature 7066..8672
/note="3' flanking region"
BASE COUNT 1985 a 2355 c 2374 g 1958 t
ORIGIN
1 ttgctgccag ctgcctctcc ctccttgtct cttacctgcc tgctgcctgg gacaggatga
61 agcggggccc ttgtgttgcc ccaaccctgg ctgttggcta agagcccacg tgatctgcct
121 gtgagaggag ttccttccgg aagaaccagg gcagcttctg cccctagagg gccaatgccc
181 tagctgagtg cagtcccccg gccccagcct ggtccagctt tgggaagagg gtgcccagtt
241 gtgcaatcca ggccggggca gccgtgtcct gatcttggta ttcagggctg agcctggagg
301 gggcttgtga tgcctgactc tgtctctctc tctggcccca tgccttggta gctgtgaggc
361 gtcactgctt tgggtgacct gatctggctg tgatggatga gcacggggga aatagtggaa
421 gactcggaat tagaagacgt gagtgggctt tggccccagc ctccctaccc cactccctgt
481 cctgggctgc ctgtgaccaa ccttgtttct gcaggcacac tggatagccc tgctggagct
541 cagtgtccct aatcccctcc agatactggt ggcctagggg aggtcatcaa agaccggtgg
601 gacatcgacc tcagcccgtt tccacgcttt tttttgtttt tttttttttt ttgagaccga
661 gtttcactct tgttgcccag gctggagtgc aatggcgtga tcttggctca ccgcaacctc
721 cgcctcctgg gttcaagcga ttctcctgcc tcagcctccc aagtagctgg gattacaggc
781 gtgtgccacc aggcttgact aattttctat ttttagtaga gacaaggttt ctccatgttg
841 gtcaggctgg tctcaaactc ccgacttcag gtgatctgcc tgcctcggcc tcccaaagtg
901 ctgggattac aggagtgagc caccgtgcca ggccttctcc aggctcttgg caccttagcc
961 agaaacaatt taaggacaag tgcaaaagtc atgaatgtag gcagatttcc tgcagagtaa
1021 agggactcac tcaagaagag gaacgtgggg gtcctcaaga gagtgtctca tgccctacaa
1081 ggtgtggggc tgacctttat gggcttcttc aactaaagag gggtatattc atgaagagtc
1141 caggaaaagg taaagatttc tcaagaccgt ggtgccacaa tttacaccca aatacaggtg
1201 ttcctggagc cgtcttggca ctggtgggtg tacggtttca tatgttactg atcatacaat
1261 gagatcctag gtgaaaccta catcaaatac agcgccatgt tgtgtctggt tggtcgtagc
1321 cagcttggtc ctcatcctat ttttcaggga cttattggcc cttagcgcat gcagctattt
1381 caagtttcct tcttctcctc atgtgaaact gctgcctggg attttgtatt cacttgctac
1441 cactctatta atctcacatt ctcgcctctt ttctgtgtca ccccgtgtgg gtccgacagg
1501 ttgttactag agtgcaatac aaagtcttag tcaagggaac ctcctgaggg ttgctgaggg
1561 caggggtgga gctagtagcc tgaggacctg ccagtcacgg ggattcctca tgggcacaga
1621 ggagggagga ggggtccatg gccctagcat atgagaagcc tctcctctgc ctggaattcc
1681 catgcctcag cttcccccac actcccacct gtccgcttgc ctctgaactc acgcatttct
1741 tggaagtctt gggagattca cctttactca gatggttgtt tacctgtctc gtgcacagct
1801 tgaccttgga ctttaaagtg aggataaaga acgaggagga tggggggatg ccccccttcc
1861 acggggccct gtggcttcca aacctcggcc tcctctggtc tcttgtctgt ggagcctcct
1921 tcaaacccag ggaaataaaa ccacctgcca cgggttgtgg ttcttctagg atcttctatc
1981 aatgttctct gaggtcccca ggagccatga agctggggct gactcccagg gcaatgggac
2041 tgcagtgtcc ttgttctttc ttgttctatg catccatgct ctgctccacc cctgcccctt
2101 cactctgccc acacacatcc ctctagactg gccttgtggt cagagcctgg agtgcatggg
2161 ctgctggggg cctgtgggct gcactgggcc agaacccctg gcaccttcaa gactggcctg
2221 gagccagcag gtaggtgacc tttccagggc ctgcctatcc cagctttctc ctccaatccc
2281 tcccctctct tgcctgggtc aattagagag agcttgtctg ttggctgcct ggcagggtgg
2341 agttcagggg caggtcagga gcccagtgac agctcggaaa aaaaaaaaaa aaaaaaaaaa
2401 acagaaaaaa aaacctacaa aaacaaaccc accattgggc ctttcccctt tcattcttct
2461 gttttctaca cagcaaactc agtcgtggct ttggagatca ctttaagctt gtctccagct
2521 ggcacactaa ggagggtaat ggagaagctc ccccaccccc aaccccaccc cttccttccg
2581 gaagcaaatc taagtccagc cccggctcca gatccctccc acagtggacc taggaaaccc
2641 tcagctcaga gaacaaccct gcattcccca cacagcaccc acaatcagcc actgcgggcg
2701 aggagggcac gaggccaggt tcccaagagc tcaggtgagt gacacagtgg aacggcccag
2761 ggcgccctca ccctgctcag cttgtggctc taacattcca gaagctgagg cctctggcat
2821 ccctgccctt tccccatgga tatcccattt cagacaaccc tggcctgcgt gaatccccct
2881 cccttccctt gtttgtttgt ttttttcccc ggggaggcca ggtcttgctg tcacccaggc
2941 tggagtgctg tgggatcctg gccactgcag ccttgaattc ctgggctcaa gtgattctct
3001 tgcctcagcc tctggagtag ctaggactac aggccctcat catcctgcct ggttaatgtt
3061 taagaatttt tttaaagatt tttagagatg gggtcttgca atgctgcacc aggttggtct
3121 ccaactcctg gcctcagcct ccctagggtc tgggattata ggtgggagcc accctgccta
3181 ggcctgtgct tttgctgagt catcagagtt ttgttcattc ccacagcagc tctggcccct
3241 agtagcagct cagttcctca atgggccgtg tttgtcctgg agcccagatg gactgtggcc
3301 aggcaagtgg atcacaggcc tggctggcct gggcggtttc cacatgtgag gggctgaggg
3361 gctcaaggag gggagcatct ccactgggtg gaggctgggg gtcccagcag gaaatggtga
3421 gacaaagggc gctggctggc agggagacag cacaggaagg tcctagagct tcctcagtgc
3481 agctggactc tcctggagac cttcacacac cctgatatct gggccttgcc cgacgagggt
3541 gctttcactg gtctgcacca tggcccaggc cctgggattt tgaacagctc cgcaggtgaa
3601 tgaaaggtga ggccaggctg gggaaccacc gcattagagc ccgacctggt tttcagcccc
3661 agccccgcca ctgactggct ttgtgagtgc gggcaagtca ctcagcctcc ctaggcctca
3721 gtgacttccc tgaaagcaag aattccactt tcttgctgtt gtgatggtgg taagggaacg
3781 ggcctggctc tggcccctga cgcaggaaca tggagctgat ccaggacacc tcccgcccgc
3841 cactggagta cgtgaagggg gtcccgctca tcaagtactt tgcagaggca ctggggcccc
3901 tgcagagctt ccaggcccgg cctgatgacc tgctcatcag cacctacccc aagtccggta
3961 agtgaggagg gccacccacc ctctcccagg tggcagtccc caccttggcc agcgaggtcg
4021 tgccctcagc ctgctcaccc cccatctccc tccctctcca ggcaccacct gggtgagcca
4081 gattctggac atgatctacc agggtggtga cctggagaag tgtcaccgag ctcccatctt
4141 catgcgggtg cccttccttg agttcaaagc cccagggatt ccctcaggtg tgtgagtgtg
4201 tcctgggtgc aaggggagtg gaggaagaca gggctggggc ttcagctcac cagaccttcc
4261 ctgacccact gctcagggat ggagactctg aaagacacac cggccccacg actcctgaag
4321 acacacctgc ccctggctct gctcccccag actctgttgg atcagaaggt caaggtgagg
4381 cagggcacag tgtttcacat ccataatccc agcactttgg gaggctgagg caggcagatc
4441 acctgaggtt gggagtttga gagcaccctg agcaacatag aagaaccttg tctctactaa
4501 aaatacagaa ttagccgggt gtggtggcgg gtgcctgtaa tcccagctac tccgaagcct
4561 gagacaggag aatcacttga acccgggaga aggaggttgt ggtgagccag agatcccacc
4621 attgcattcc agcctgagca acaagagcaa aactcacaaa aataaataaa taaatagata
4681 tataaataaa aataaaactg tggcacctgt ggtggctcac tgctgtaatg ccagcacttt
4741 gggaggccaa attgggtgga tcacttgagc tcaggagtta cagaccagcc cgggaaacat
4801 ggggaacttc catctctata aaaatgcaaa atatcagcag ggcatggtgg catggcgctg
4861 tagttccagc tactggaaag tctgaggttg gaggattgct tgagcctggg aggtcaaggt
4921 tgcagtgagt tattatcact ccagtgcact ccaacctggg cgacagaaaa aaagaaagac
4981 caaggtcttt tttctttttt gagattgtct caataaataa ataaatgaat aaataaaaat
5041 aaaataaagt aaaataaatc ccacaattaa aagaaaaagc aaaggtccag gtgtggggca
5101 tgtgaatcca gggaaggagg ccctggctca gcccagcttt ggtcctgttc ttctgggaaa
5161 gtcgcctcac ttcctccagc cttgtctcat cttctgcggc ggggactgtc tgcctcttgc
5221 tctgatgacc aagaacgtaa ggctcttcag tgtagaccta agaaagctag agggtgggtc
5281 ctcacaggcc cacaaaattt ggtggcggtg ggatcacggc tggtggagcg tgccttgctc
5341 cagatcgggg tgtgacgcat tgatgcagat tatattgcta tagaatatga tggtctcagg
5401 gaccaggcag gactttggct tctgagcagg gttcagatcc tgacttggcc ctaccggtgc
5461 cgtgagatct caaacaagtc agcctctaag cctcaggttc ctcctttgcc aatccaagag
5521 atgagctggc ctggggcagg ctgtgtggtg atggtgctgg ggttgagtct tctgcccctg
5581 caggtggtct atgttgcccg caacgcaaag gatgtggcag tttcctacta ccacttctac
5641 cacatggcca aggtgcaccc tgagcctggg acctgggaca gcttcctgga gaagttcatg
5701 gtcggagaag gtgggtttga tgggaggaag gaaagtgtgg agccgagggg tggtggctac
5761 aacgcacagc aaccctgtgt tggcacccct tgcctgcttc tccagtgtcc tacggatcct
5821 ggtaccagca cgtgcaggag tggtgggagc tgagccgcac ccaccctgtt ctctacctct
5881 tctatgaaga catgaaggag gtgagaccac ctgtgaagct tccctccatg tgacacctgg
5941 gggccggcac ctcacaggga cccaccaggg tcacccagcc ccctcccttg gcagccccca
6001 cagcaggccc ggattcccca tcctgccttc ttggcccagg cctccccgct acaggcccca
6061 cctggcagcg ggccccacac ggctctcatc acccacatct gagtcagctg catggggggc
6121 cacggatcag aaacttagtc ctattgctac tccctgccaa agggtgtgcc acccagggcc
6181 acagtcatgg aagaagacca tcacggtcct cacccatagg agccaagccc agctcatgat
6241 gggatcacag ggcagacagc aattcttttt acccccggga ctggggccct gggggttgag
6301 gagttggctc tgcagggtct ctaggagagg tggccagatc gcctctgagg ttagagaagg
6361 ggaccccttt tacttttcct gaatcagcaa tccgagcctc cactgaggag ccctctgctg
6421 ctcagaaccc caaaagggag attcaaaaga tcctggagtt tgtggggcac tccctgccag
6481 aggagaccgt ggacttcatg gttcagcaca cgtcgttcaa ggagatgaag aagaacccta
6541 tgaccaacta caccaccgtc ccccaggagt tcatggacca cagcatctcc cccttcatga
6601 ggaaaggtgg gtgctggcca gtacgggggt ttggggcggg tgggagcagc agctgcagcc
6661 tccccatagg cactcggggc ctcccctggg atgagactcc agccttgctc cctgccttcc
6721 ccccccaggc atggctgggg actggaagac caccttcacc gtggcgcaga atgagcgctt
6781 cgatgcggac tatgcggaga agatggcagg ctgcagcctc agcttccgct ctgagctgtg
6841 agaggggctc ctggggtcac tgcagaggga gtgtgcgaat caaacctgac caagcggctc
6901 aagaataaaa tatgaattga gggcctggga cggtaggtca tgtctgtaat cccagcaatt
6961 tggaggctga ggtgggagga tcatttgagc ccaggagttc gagaccaacc tgggcaacat
7021 agtgagattc tgttaaaaaa ataaaataaa ataaaaccaa tttttaaaaa gagaataaaa
7081 tatgattgtg ggccaggcat agtggctcat gcctgtaatc ccagcaattt gagaagttga
7141 ggctagagga tcactggagg acaggagttt gggaccagcc tgttcaacat tacaagacat
7201 catccctaca aaaatttgag aaaattatct gtacgtgatg gtgggcacct gtagtcccag
7261 ctacttgaca agtgaaggca gtaggatcgc ctgagccagg gaggttatgg ctgcagtggg
7321 ctgactgggc taatccactc aagcctgagg gacagagcaa atcttgcttg agaaataaat
7381 aaaatacaat ttacttaaca taaattatga ttcaggacca gtctggccaa catggtgaaa
7441 ccccgtctct actaaaaaaa aaaaaagata caaaaattag ccgggcatgg tggcagacac
7501 ctgtaacctc agctactctg gaggctgagg caggagaatt gctcgaaccc agggacggat
7561 gatgcagtga gccaagatca tgccacttca ctccagcctg ggcataagag caaaactctg
7621 gcttgaaaat aaataaataa ttaaattaaa ttaaggtatt atttgacctg ggctcggtgg
7681 cttatgcctg gaatctcagc acttcagcct ggcagatcac ttgaggtcag gagttcaaga
7741 ccaggctggc cagcatggga aaaccccatc tctactaaaa atacaaaaat tagctgggca
7801 tgatgatggg cgcctgtaat cccagctact ccagaggctg aggtgggaga atcgattgaa
7861 tccatgaggt ggaggtttca ttgaaccggg atcacaccac tgcactccag tctgggcgac
7921 agagcaagac tcagtcttaa aacaacaaca acaacaacaa caacaacaca actatgattt
7981 gtgttcaatg cagagtctct attccaagcc aagagaaacc ctgagctgaa agagtgatcg
8041 cccactgggg ccaaatacgg ccacctctcc gctccagctc ctcaacttga cctgtttgga
8101 gaggggagag ggtctggaga agtaaaaccc aggagacgag tggaggggga atgtgtttaa
8161 tcccagcaca tcctttgctg tcctgccctg tgtcgttggt ggatggcgaa gtccgccagg
8221 cagcgtcact ttttcttggg ctccttacaa gccaccacct acctctgggc cacgctgagg
8281 ggaggggaat gcttgaagac actcaagcat aggagtgtct tcaaacagga ccaagtagtc
8341 atcctggggc tgtggggcag gcagacagga ggggctgctc agagatcccc aggccatgac
8401 aggcaccccc ttcccccagc ctagaccaca ggaggctctg ggccgtggac tttcagccac
8461 tcctgccatt gttcactctg gggtcaagaa gtcttggccc agtccctgct gctatggagc
8521 tcttttctca gtggctggag gcccagagca gtgaaaaagg tggagggagg aagaggtgct
8581 gactccttcc ccagtggggc catagctaga gggtctgctg cctttcaggg actctgtgtt
8641 cagaggaccg agggcagccc agatggtggc aa
//