LOCUS HSIRF4 5320 bp mRNA linear HUM 29-OCT-1996
DEFINITION Human lymphocyte specific interferon regulatory factor/interferon
regulatory factor 4 (LSIRF/IRF4) mRNA, complete cds.
ACCESSION U52682
VERSION U52682.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5320)
AUTHORS Grossman,A., Mittrucker,H.W., Nicholl,J., Suzuki,A., Chung,S.,
Antonio,L., Suggs,S., Sutherland,G.R., Siderovski,D.P. and Mak,T.W.
TITLE Cloning of human lymphocyte-specific interferon regulatory factor
(hLSIRF/hIRF4) and mapping of the gene to 6p23-p25
JOURNAL Genomics 37 (2), 229-233 (1996)
PUBMED 8921401
REFERENCE 2 (bases 1 to 5320)
AUTHORS Grossman,A., Mittrucker,H.-W., Nicholl,J., Baker,E., Suzuki,A.,
Chung,S., Antonio,L., Suggs,S., Sutherland,G.R., Siderovski,D.P.
and Mak,T.W.
TITLE Direct Submission
JOURNAL Submitted (26-MAR-1996) A. Grossman, Medical Biophysics, Ontario
Cancer Institute, 610 University Ave, Toronto, ON M5G 2C1, Canada
COMMENT On Jun 18, 1996 this sequence version replaced gi:1272476.
FEATURES Location/Qualifiers
source 1..5320
/db_xref="H-InvDB:HIT000220264"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="6"
/map="6p23-25"
/cell_type="PHA stimulated T lymphocyte, peripheral blood
lymphocyte"
/tissue_type="spleen"
gene 1..5320
/gene="IRF4"
5'UTR 1..125
/gene="IRF4"
exon 1..71
/gene="IRF4"
/number=1
exon 72..341
/gene="IRF4"
/number=2
CDS 126..1478
/gene="IRF4"
/note="Induced by T-cell/ B-cell receptor crosslinking;
Not induced by interferon; Binds the interferon stimulated
response element (ISRE) in vitro; Binds the immunoglobulin
lambda light chain enhancer, together with PU.1; Also
known as PIP/NF-EM5; LSIRF/IRF4; Intron4-Exon
5A=tagcagGTTCACAACTAC..; Intron4-Exon
5B=tagCAGGTTCACAACTAC..; Two forms of the protein exist
(450/451 aa), one with an additional glutamine at aa 164
(Q/QQ); transcription factor"
/codon_start=1
/product="lymphocyte specific interferon regulatory
factor/interferon regulatory factor 4"
/protein_id="AAC50779.1"
/translation="MNLEGGGRGGEFGMSAVSCGNGKLRQWLIDQIDSGKYPGLVWEN
EEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALN
KSNDFEELVERSQLDISDPYKVYRIVPEGAKKGAKQLTLEDPQMSMSHPYTMTTPYPS
LPAQVHNYMMPPLDRSWRDYVPDQPHPEIPYQCPMTFGPRGHHWQGPACENGCQVTGT
FYACAPPESQAPGVPTEPSIRSAEALAFSDCRLHICLYYREILVKELTTSSPEGCRIS
HGHTYDASNLDQVLFPYPEDNGQRKNIEKLLSHLERGVVLWMAPDGLYAKRLCQSRIY
WDGPLALCNDRPNKLERDQTCKLFDTQQFLSELQAFAHHGRSLPRFQVTLCFGEEFPD
PQRQRKLITAHVEPLLARQLYYFAQQNSGHFLRGYDLPEHISNPEDYHRSIRHSSIQE
"
misc_feature 183..537
/gene="IRF4"
/note="encodes tryptophan pentad repeat DNA binding
domain"
exon 342..538
/gene="IRF4"
/number=3
exon 539..617
/gene="IRF4"
/number=4
exon 618..759
/gene="IRF4"
/note="exon 5A/5B"
exon 760..867
/gene="IRF4"
/number=6
exon 868..1221
/gene="IRF4"
/number=7
exon 1222..1334
/gene="IRF4"
/number=8
exon 1335..(1489.5320)
/gene="IRF4"
/number=9
3'UTR 1479..5320
/gene="IRF4"
repeat_region 1519..1684
/gene="IRF4"
/rpt_family="Alu"
regulatory 5297..5302
/regulatory_class="polyA_signal_sequence"
/gene="IRF4"
BASE COUNT 1373 a 1256 c 1250 g 1441 t
ORIGIN
1 acctcgcact ctcagtttca ccgctcgatc ttgggaccca ccgctgccct cagctccgag
61 tccagggcga gtgcagagca gagcgggcgg aggaccccgg gcgcgggcgc ggacggcacg
121 cgggcatgaa cctggagggc ggcggccgag gcggagagtt cggcatgagc gcggtgagct
181 gcggcaacgg gaagctccgc cagtggctga tcgaccagat cgacagcggc aagtaccccg
241 ggctggtgtg ggagaacgag gagaagagca tcttccgcat cccctggaag cacgcgggca
301 agcaggacta caaccgcgag gaggacgccg cgctcttcaa ggcttgggca ctgtttaaag
361 gaaagttccg agaaggcatc gacaagccgg accctcccac ctggaagacg cgcctgcggt
421 gcgctttgaa caagagcaat gactttgagg aactggttga gcggagccag ctggacatct
481 cagacccgta caaagtgtac aggattgttc ctgagggagc caaaaaagga gccaagcagc
541 tcaccctgga ggacccgcag atgtccatga gccaccccta caccatgaca acgccttacc
601 cttcgctccc agcccaggtt cacaactaca tgatgccacc cctcgaccga agctggaggg
661 actacgtccc ggatcagcca cacccggaaa tcccgtacca atgtcccatg acgtttggac
721 cccgcggcca ccactggcaa ggcccagctt gtgaaaatgg ttgccaggtg acaggaacct
781 tttatgcttg tgccccacct gagtcccagg ctcccggagt ccccacagag ccaagcataa
841 ggtctgccga agccttggcg ttctcagact gccggctgca catctgcctg tactaccggg
901 aaatcctcgt gaaggagctg accacgtcca gccccgaggg ctgccggatc tcccatggac
961 atacgtatga cgccagcaac ctggaccagg tcctgttccc ctacccagag gacaatggcc
1021 agaggaaaaa cattgagaag ctgctgagcc acctggagag gggcgtggtc ctctggatgg
1081 cccccgacgg gctctatgcg aaaagactgt gccagagcag gatctactgg gacgggcccc
1141 tggcgctgtg caacgaccgg cccaacaaac tggagagaga ccagacctgc aagctctttg
1201 acacacagca gttcttgtca gagctgcaag cgtttgctca ccacggccgc tccctgccaa
1261 gattccaggt gactctatgc tttggagagg agtttccaga ccctcagagg caaagaaagc
1321 tcatcacagc tcacgtagaa cctctgctag ccagacaact atattatttt gctcaacaaa
1381 acagtggaca tttcctgagg ggctacgatt taccagaaca catcagcaat ccagaagatt
1441 accacagatc tatccgccat tcctctattc aagaatgaaa aatgtcaaga tgagtggttt
1501 tctttttcct tttttttttt tttttttgat acggggatac ggggtcttgc tctgtctccc
1561 aggctggagt gcagtgacac aatctcagct cactgtgacc tccgcctcct gggttcaaga
1621 gactctcctg cctcagcctc cctggtagct gggattacag gtgtgagcca ctgcacccac
1681 ccaagacaag tgattttcat tgtaaatatt tgactttagt gaaagcgtcc aattgactgc
1741 cctcttactg ttttgaggaa ctcagaagtg gagatttcag ttcagcggtt gaggagaatt
1801 gcggcgagac aagcatggaa aatcagtgac atctgattgg cagatgagct tatttcaaaa
1861 ggaagggtgg ctttgcattt cttgtgttct atagactgcc atcattgatg atcactgtga
1921 aaattgacca agtgatgtgt ttacatttac tgaaatgtgc tctttaattt gttgtagatt
1981 aggtcttgct ggaagacaga gaaaacttgc ctttcagtat tgacactgac tagagtgatg
2041 actgcttgta ggtatgtctg tgccatttct cagggaagta agatgtaaat tgaagaagcc
2101 tcacacgtaa aagaaatgta ttaatgtatg taggagctgc agttcttgtg gaagacactt
2161 gctgagtgaa ggaaatgaat ctttgactga agccgtgcct gtagccttgg ggaggcccat
2221 cccccacctg ccagcggttt cctggtgtgg gtccctctgc cccaccctcc ttcccattgg
2281 ctttctctcc ttggcctttc ctggaagcca gttagtaaac ttcctatttt cttgagtcaa
2341 aaaacatgag cgctactctt ggatgggaca tttttgtctg tcctacaatc tagtaatgtc
2401 taagtaatgg ttaagttttc ttgtttctgc atctttttga ccctcattct ttagagatgc
2461 taaaattctt cgcataaaga agaagaaatt aaggaacata aatcttaata cttgaactgt
2521 tgcccttctg tccaagtact taactatctg ttcccttcct ctgtgccacg ctcctctgtt
2581 tgcttggctg tccagcgatc agccatggcg acactaaagg aggaggagcc ggggactccc
2641 aggctggaga gcactgccag gacccaccac tggaagcagg atggagctga ctacggaact
2701 gcacactcag tgggctgttt ctgcttattt catctgttct atgcttcctc gtgccaatta
2761 tagtttgaca gggccttaaa attacttggc tttttccaaa tgcttctatt tatagaatcc
2821 caaagacctc cacttgctta agtataccta tcacttacat ttttgtggtt ttgagaaagt
2881 acagcagtag actggggcgt cacctccagg ccgtttctca tactacagga tatttactat
2941 tactcccagg atcagcagaa gattgcgtag ctctcaaatg tgtgttcctg cttttctaat
3001 ggatatttta aattcattca acaagcacct agtaagtgcc tgctgtatcc ctacattaca
3061 cagttcagcc tttatcaagc ttagtgagca gtgagcactg aaacattatt ttttaatgtt
3121 taaaaagttt ctaatattaa agtcagaata ttaatacaat taatattaat attaactaca
3181 gaaaagacaa acagtagaga acagcaaaaa aataaaaagg atctcctttt ttcccagccc
3241 aaattctcct ctctaaaagt gtccacaaga aggggtgttt attcttccaa cacatttcac
3301 ttttctgtaa atatacataa acttaaaaag aaaacctcat ggagtcatct tgcacacact
3361 ttcatgcagt gctctttgta gctaacagtg aagatttacc tcgttctgct cagaggcctt
3421 gctgtggagc tccactgcca tgtacccagt agggtttgac atttcattag ccatgcaaca
3481 tggatatgta ttgggcagca gactgtgttt cgtgaactgc agtgatgtat acatcttata
3541 gatgcaaagt attttggggt atattatcct aagggaagat aaagatgata ttaagaactg
3601 ctgtttcacg gggcccttac ctgtgaccct ctttgctgaa gaatatttaa ccccacacag
3661 cacttcaaag aagctgtctt ggaagtctgt ctcaggagca ccctgtcttc ttaattctcc
3721 aagcggatgc tccatttcaa ttgctttgtg acttcttctt ctttgttttt ttaaatatta
3781 tgctgcttta acagtggagc tgaattttct ggaaaatgct tcttggctgg ggccactacc
3841 tcctttccta tctttacatc tatgtgtatg ttgacttttt aaaattctga gtgatccagg
3901 gtatgaccta gggaatgaac tagctatgaa atactcaggg ttaggaatcc tagcacttgt
3961 ctcaggactc tgaaaaggaa cggcttcctc attccttgtc ttgataaagt ggaattggca
4021 aactagaatt tagtttgtac tcagtggaca gtgctgttga agatttgagg acttgttaaa
4081 gagcactggg tcatatggaa aaaatgtatg tgtctcccag gtgcatttct tggtttatgt
4141 cttgttcttg agattttgta tatttaggaa aacctcaagc agtaattaat atctcctgga
4201 acactataga gaaccaagtg accgactcat ttacaactga aacctaggaa gcccctgagt
4261 cctgagcgaa aacaggagag ttagtcgccc tacaggaaac ccagctagac tattgggtat
4321 gaactaaaaa gagactgtgc catggtgaga aaaatgtaaa atcctacagt ggaatgagca
4381 gcccttacag tgttgttacc accaagggca ggtaggtatt agtgtttgaa aaagctggtc
4441 tttgagcgag ggcataaata cagctagccc caggggtgga acaactgtgg gagtcttggg
4501 tactcgcacc tcttggcttt gttgatgctc cgccaggaag gccacttgtg tgtgcgtgtc
4561 agttactttt ttagtaacaa ttcagatcca gtgtaaactt ccgttcattg ctctccagtc
4621 acatgccccc acttccccac aggtgaaagt ttttctgaaa gtgttgggat tggttaaggt
4681 ctttatttgt attacgtatc tccccaagtc ctctgtggcc agctgcatct gtctgaatgg
4741 tgcgtgaagg ctctcagacc ttacacacca ttttgtaagt tatgttttac atgccccgtt
4801 tttgagactg atctcgatgc aggtggatct ccttgagatc ctgatagcct gttacaggaa
4861 tgaagtaaag gtcagttttt tttgtattga ttttcacagc tttgaggaac atgcataaga
4921 aatgtagctg aagtagaggg gacgtgagag aagggccagg ccggcaggcc aaccctcctc
4981 caatggaaat tcccgtgttg cttcaaactg agacagatgg gacttaacag gcaatggggt
5041 ccacttcccc ctcttcagca tcccccgtac cccacttttt gctgaaagaa ctgccagcag
5101 gtaggacccc agaggccccc aaatgaaagc ttgaatttcc cctactggct ctgcgttttg
5161 ctgagatctg taggaaagga tgcttcacaa actgaggtag ataatgctat gctgtcgttg
5221 gtatacatca tgaattttta tgtaaattgc tctgcaaagc aaattgatat gtttgataaa
5281 tttatgtttt taggtaaata aaaactttta aaaagttgtt
//