LOCUS HSU52373 2422 bp mRNA linear HUM 08-NOV-1996
DEFINITION Human serine/threonine kinase MNB (mnb) mRNA, complete cds.
ACCESSION U52373
VERSION U52373.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2422)
AUTHORS Guimera,J., Casas,C., Pucharcos,C., Solans,A., Domenech,A.,
Planas,A.M., Ashley,J., Lovett,M., Estivill,X. and Pritchard,M.A.
TITLE A human homologue of Drosophila minibrain (MNB) is expressed in the
neuronal regions affected in Down syndrome and maps to the critical
region
JOURNAL Hum. Mol. Genet. 5 (9), 1305-1310 (1996)
PUBMED 8872470
REFERENCE 2 (bases 1 to 2422)
AUTHORS Guimera,J., Prichard,M., Casas,C., Pucharcos,C. and Estivill,X.
TITLE Direct Submission
JOURNAL Submitted (25-MAR-1996) Molecular Genetics, IRO Hosp. Duran i
Reynals, Autovia de Castelldefels, km 2,7, L'Hospitalet, Barcelona
08907, Spain
FEATURES Location/Qualifiers
source 1..2422
/db_xref="H-InvDB:HIT000220256"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="21"
/map="21q22.2"
gene 1..2422
/gene="mnb"
CDS 76..2367
/gene="mnb"
/note="serine/threonine kinase; similar to mnb mRNA in
Drosophila melanogaster, encoded by Genbank Accession
Number X70794"
/codon_start=1
/product="MNB"
/protein_id="AAB18639.1"
/translation="MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRR
QPNISDQQVSALSYSDQIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIK
TYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYE
IDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK
YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFL
ATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLL
GMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKAR
KFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYL
KFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVSTSPAMEQSQSSGTT
SSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTAAVQAMDCETHSPQVRQQFPAPL
GWSGTEAPTQVTVETHPVQETTFHVAPQQNALHHHHGNSSHHHHHHHHHHHHHGQQAL
GNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSSSTTSSSTSSSSTGNQGNQAYHN
RPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTYQFSANTGPAHYMTEGHLTMR
QGADREESPMTGVCVQQSPVASS"
BASE COUNT 691 a 588 c 532 g 611 t
ORIGIN
1 gttatagttt tgccgctgga ctcttccctc ccttccccca ccccatcagg atgatatgag
61 acttgaaaga agacgatgca tacaggagga gagacttcag catgcaaacc ttcatctgtt
121 cggcttgcac cgtcattttc attccatgct gctggccttc agatggctgg acagatgccc
181 cattcacatc agtacagtga ccgtcgccag ccaaacataa gtgaccaaca ggtttctgcc
241 ttatcatatt ctgaccagat tcagcaacct ctaactaacc aggtgatgcc tgatattgtc
301 atgttacaga ggcggatgcc ccaaaccttc cgtgacccag caactgctcc cctgagaaaa
361 ctttctgttg acttgatcaa aacatacaag catattaatg aggtttacta tgcaaaaaag
421 aagcgaagac accaacaggg ccagggagac gattctagtc ataagaagga acggaaggtt
481 tacaatgatg gttatgatga tgataactat gattatattg taaaaaacgg agaaaagtgg
541 atggatcgtt acgaaattga ctccttgata ggcaaaggtt cctttggaca ggttgtaaag
601 gcatatgatc gtgtggagca agaatgggtt gccattaaaa taataaagaa caagaaggct
661 tttctgaatc aagcacagat agaagtgcga cttcttgagc tcatgaacaa acatgacact
721 gaaatgaaat actacatagt gcatttgaaa cgccacttta tgtttcgaaa ccatctctgt
781 ttagtttttg aaatgctgtc ctacaacctc tatgacttgc tgagaaacac caatttccga
841 ggggtctctt tgaacctaac acgaaagttt gcgcaacaga tgtgcactgc actgcttttc
901 cttgcgactc cagaacttag tatcattcac tgtgatctaa aacctgaaaa tatccttctt
961 tgtaacccca aacgcagtgc aatcaagata gttgactttg gcagttcttg tcagttgggg
1021 cagaggatat accagtatat tcagagtcgc ttttatcggt ctccagaggt gctactggga
1081 atgccttatg accttgccat tgatatgtgg tccctcgggt gtattttggt tgaaatgcac
1141 actggagaac ctctgttcag tggtgccaat gaggtagatc agatgaataa aatagtggaa
1201 gttctgggta ttccacctgc tcatattctt gaccaagcac caaaagcaag aaagttcttt
1261 gagaagttgc cagatggcac ttggaactta aagaagacca aagatggaaa acgggagtac
1321 aaaccaccag gaacccgtaa acttcataac attcttggag tggaaacagg aggacctggt
1381 gggcgacgtg ctggggagtc aggtcatacg gtcgctgact acttgaagtt caaagacctc
1441 attttaagga tgcttgatta tgaccccaaa actcgaattc aaccttatta tgctctgcag
1501 cacagtttct tcaagaaaac agctgatgaa ggtacaaata caagtaatag tgtatctaca
1561 agccccgcca tggagcagtc tcagtcttcg ggcaccacct ccagtacatc gtcaagctca
1621 ggtggctcat cggggacaag caacagtggg agagcccggt cggatccgac gcaccagcat
1681 cggcacagtg gtgggcactt cacagctgcc gtgcaggcca tggactgcga gacacacagt
1741 ccccaggtgc gtcagcaatt tcctgctcct cttggttggt caggcactga agctcctaca
1801 caggtcactg ttgaaactca tcctgttcaa gaaacaacct ttcatgtagc ccctcaacag
1861 aatgcattgc atcatcacca tggtaacagt tcccatcatc accaccacca ccaccaccat
1921 caccaccacc atggacaaca agccttgggt aaccggacca ggccaagggt ctacaattct
1981 ccaacgaata gctcctctac ccaagattct atggaggttg gccacagtca ccactccatg
2041 acatccctgt cttcctcaac gacttcttcc tcgacatctt cctcctctac tggtaaccaa
2101 ggcaatcagg cctaccacaa tcgcccagtg gctgctaata ccttggactt tggacagaat
2161 ggagctatgg acgttaattt gaccgtctac tccaatcccc gccaagagac tggcatagct
2221 ggacatccaa cataccaatt ttctgctaat acaggtcctg cacattacat gactgaagga
2281 catctgacga tgaggcaagg ggctgataga gaagagtccc ccatgacagg agtttgtgtg
2341 caacagagtc ctgtagctag ctcgtgacta cattgaaact tgagtttgtt tcttgtgtgt
2401 ttttatagaa gtggtgtttt tt
//