LOCUS HSU51990 1450 bp mRNA linear HUM 28-JAN-1997
DEFINITION Human hPrp18 mRNA, complete cds.
ACCESSION U51990
VERSION U51990.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1450)
AUTHORS Horowitz,D.S. and Krainer,A.R.
TITLE A human protein required for the second step of pre-mRNA splicing
is functionally related to a yeast splicing factor
JOURNAL Genes Dev. 11 (1), 139-151 (1997)
PUBMED 9000057
REFERENCE 2 (bases 1 to 1450)
AUTHORS Horowitz,D.S. and Krainer,A.R.
TITLE Direct Submission
JOURNAL Submitted (21-MAR-1996) David S. Horowitz, Cold Spring Harbor
Laboratory, 1 Bungtown Rd., Cold Spring Harbor, NY 11724, USA
FEATURES Location/Qualifiers
source 1..1450
/db_xref="H-InvDB:HIT000220233"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_type="HeLa cells"
CDS 73..1101
/function="required for the second step of mRNA splicing"
/note="pre-mRNA splicing factor; similar to S. cerevisiae
Prp18 protein encoded by GenBank Accession Number L03536,
to C. elegans EST sequence in dbEST T01256, and to rice
protein encoded by GenBank Accession Number D15798"
/codon_start=1
/product="hPrp18"
/protein_id="AAB41490.1"
/translation="MDILKSEILRKRQLVEDRNLLVENKKYFKRSELAKKEEEAYFER
CGYKIQPKEEDQKPLTSSNPVLELELAEEKLPMTLSRQEVIRRLRERGEPIRLFGETD
YDAFQRLRKIEILTPEVNKGLRNDLKAALDKIDQQYLNEIVGGQEPGEEDTQNDLKVH
EENTTIEELEALGESLGKGDDHKDMDIITKFLKFLLGVWAKELNAREDYVKRSVQGKL
NSATQKQTESYLRPLFRKLRKRNLPADIKESITDIIKFMLQREYVKANDAYLQMAIGN
APWPIGVTMVGIHARTGREKIFSKHVAHVLNDETQRKYIQGLKRLMTICQKHFPTDPS
KCVEYNAL"
BASE COUNT 483 a 248 c 352 g 367 t
ORIGIN
1 cggccgccgg cccagtgagg ctgggttcga ggagctggag cgggaaactg gagcttaaat
61 tctggcggcg agatggacat tctgaaatca gagatccttc ggaagcggca gctggtggag
121 gacaggaacc tgctggtgga aaataaaaaa tatttcaagc gtagtgagct cgccaaaaaa
181 gaagaggaag catattttga aagatgtggc tacaagatac agccaaaaga ggaggaccag
241 aaaccattaa cttcatcgaa tccagtgtta gaacttgaac tggcagagga aaaattacct
301 atgacgcttt ctaggcaaga ggtcatcaga agattgagag aaagaggaga accaatcaga
361 ctatttggag agactgatta tgatgctttt caacgtttaa ggaaaataga gatcctcaca
421 ccagaagtta acaagggatt gaggaatgat ttgaaagcag ccttggataa gattgatcag
481 cagtacctca atgaaatcgt cggcggtcag gagcctggag aggaagacac acagaatgat
541 ctgaaagttc atgaggaaaa caccacaatt gaagagttag aggcgcttgg agagtcctta
601 gggaaaggcg atgatcataa agacatggac atcatcacca aattcctgaa gtttcttctt
661 ggcgtttggg ctaaagaatt gaatgccaga gaagattatg tgaaacgcag tgtgcagggt
721 aaactgaaca gtgcgaccca gaaacagacc gagtcctacc taagaccact ttttagaaag
781 ctacggaaaa ggaatcttcc tgctgatatt aaagaatcaa taacggatat tattaaattc
841 atgttgcaga gagaatacgt gaaggcaaat gatgcttatc ttcagatggc cattggaaat
901 gcgccttggc ccatcggtgt cactatggtt ggtatccatg ccagaactgg cagagaaaag
961 attttttcca agcatgttgc acatgtttta aatgacgaaa ctcagcggaa atatattcag
1021 ggattgaaga ggttaatgac catttgccag aaacactttc ctacagaccc atccaaatgt
1081 gtggagtaca atgcactgtg agatctgtgt atggtgtgtt aataacaata agaaacttag
1141 ggaagcaggc tgtggacttc tggaattacc aacaggaatg aggaaagaag aaaactggag
1201 tttccagtct ctgagttcta cctgatgtaa ctcttgattg gttttaagaa ctttgttggc
1261 cttcatttca tatctgactg caagctgatt tttctttctt gctttcattt taattagtcc
1321 aaaattaagt tttaaagatt tttcctcaca atttaaatcc atagacaaca gaagggggtt
1381 taaaatgacc tttttttcag ttgacccgaa agttgtggtt agatgattaa aaagaaacat
1441 ttgaaaaaaa
//