LOCUS HSU51120 1740 bp mRNA linear HUM 18-JUL-1996
DEFINITION Human protein kinase PAK1 mRNA, complete cds.
ACCESSION U51120
VERSION U51120.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1740)
AUTHORS Brown,J.L., Stowers,L., Baer,M., Trejo,J., Coughlin,S. and Chant,J.
TITLE Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase
pathway
JOURNAL Curr. Biol. 6 (5), 598-605 (1996)
PUBMED 8805275
REFERENCE 2 (bases 1 to 1740)
AUTHORS Brown,J.L.
TITLE Direct Submission
JOURNAL Submitted (11-MAR-1996) Jeffrey L. Brown, Molecular & Cellular
Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA
02138, USA
FEATURES Location/Qualifiers
source 1..1740
/db_xref="H-InvDB:HIT000220197"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 55..1692
/note="Mutation L107F renders the kinase constitutively
active; protein kinase"
/codon_start=1
/product="PAK1"
/protein_id="AAC50590.1"
/translation="MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPN
PEEKKKKDRFYRSILPGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQ
WARLLQTSNITKSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSSNALN
VKAVSETPAVPPVSEDEDDDDDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVA
TSPISPTENNTTPPDALTLNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKI
GQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSY
LVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALESLHSNQVIHRDIKS
DNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSL
GIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEK
RGSAKELLQHQFLKIAKPLSSLTPLIAAAKEATKNNH"
BASE COUNT 524 a 408 c 431 g 377 t
ORIGIN
1 ggagagccga gaggagctga gcgagcgcgg aagtagctgc tgctggtggt gacaatgtca
61 aataacggcc tagacattca agacaaaccc ccagcccctc cgatgagaaa taccagcact
121 atgattggag ccggcagcaa agatgctgga accctaaacc atggttctaa acctctgcct
181 ccaaacccag aggagaagaa aaagaaggac cgattttacc gatccatttt acctggagat
241 aaaacaaata aaaagaaaga gaaagagcgg ccagagattt ctctcccttc agattttgaa
301 cacacaattc atgtcggttt tgatgctgtc acaggggagt ttaccggaat gccagagcag
361 tgggcccgct tgcttcagac atcaaatatc actaagtcgg agcagaagaa aaacccgcag
421 gctgttctgg atgtgttgga gttttacaac tcgaagaaga catccaacag ccagaaatac
481 atgagcttta cagataagtc agctgaggat tacaattctt ctaatgcctt gaatgtgaag
541 gctgtgtctg agactcctgc agtgccacca gtttcagaag atgaggatga tgatgatgat
601 gatgctaccc caccaccagt gattgctcca cgcccagagc acacaaaatc tgtatacaca
661 cggtctgtga ttgaaccact tcctgtcact ccaactcggg acgtggctac atctcccatt
721 tcacctactg aaaataacac cactccacca gatgctttga cccttaatac tgagaagcag
781 aagaagaagc ctaaaatgtc tgatgaggag atcttggaga aattacgaag catagtgagt
841 gtgggcgatc ctaagaagaa atatacacgg tttgagaaga ttggacaagg tgcttcaggc
901 accgtgtaca cagcaatgga tgtggccaca ggacaggagg tggccattaa gcagatgaat
961 cttcagcagc agcccaagaa agagctgatt attaatgaga tcctggtcat gagggaaaac
1021 aagaacccaa acattgtgaa ttacttggac agttacctcg tgggagatga gctgtgggtt
1081 gttatggaat acttggctgg aggctccttg acagatgtgg tgacagaaac ttgcatggat
1141 gaaggccaaa ttgcagctgt gtgccgtgag tgtctgcagg ctctggagtc tttgcattcg
1201 aaccaggtca ttcacagaga catcaagagt gacaatattc tgttgggaat ggatggctct
1261 gtcaagctaa ctgactttgg attctgtgca cagataaccc cagagcagag caaacggagc
1321 accatggtag gaaccccata ctggatggca ccagaggttg tgacacgaaa ggcctatggg
1381 cccaaggttg acatctggtc cctgggcatc atggccatcg aaatgattga aggggagcct
1441 ccatacctca atgaaaaccc tctgagagcc ttgtacctca ttgccaccaa tgggacccca
1501 gaacttcaga acccagagaa gctgtcagct atcttccggg actttctgaa ccgctgtctc
1561 gagatggatg tggagaagag aggttcagct aaagagctgc tacagcatca attcctgaag
1621 attgccaagc ccctctccag cctcactcca ctgattgctg cagctaagga ggcaacaaag
1681 aacaatcact aaaaccacac tcaccccagc ctcattgtgc caagccttct gtgagataaa
//