LOCUS HSU50157 1770 bp mRNA linear HUM 25-SEP-2002
DEFINITION Human cAMP-specific phosphodiesterase HPDE4D1 variant (PDE4D) mRNA,
complete cds.
ACCESSION U50157
VERSION U50157.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1770)
AUTHORS Swinnen,J.V., Joseph,D.R. and Conti,M.
TITLE The mRNA encoding a high-affinity cAMP phosphodiesterase is
regulated by hormones and cAMP
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 86 (21), 8197-8201 (1989)
PUBMED 2554303
REFERENCE 2 (bases 1 to 1770)
AUTHORS Nemoz,G., Zhang,R., Sette,C. and Conti,M.
TITLE Identification of cyclic AMP-phosphodiesterase variants from the
PDE4D gene expressed in human peripheral mononuclear cells
JOURNAL FEBS Lett. 384 (1), 97-102 (1996)
PUBMED 8797812
REFERENCE 3 (bases 1 to 1770)
AUTHORS Conti,M.
TITLE Direct Submission
JOURNAL Submitted (28-FEB-1996) Marco Conti, Gynecology and Obstetrics,
Stanford University, 300 Pasteur Dr, Stanford, CA 94305-5317, USA
FEATURES Location/Qualifiers
source 1..1770
/db_xref="H-InvDB:HIT000220134"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="5"
/map="5q11"
gene 1..1770
/gene="PDE4D"
CDS 4..1761
/gene="PDE4D"
/codon_start=1
/product="cAMP-specific phosphodiesterase HPDE4D1 variant"
/protein_id="AAA97890.1"
/translation="MKEQPSCAGTGHPSMAGYGRMAPFELASGPVKRLRTESPFPCLF
AEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSG
NQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRF
GVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVD
TLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASA
IHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQ
RQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMV
HCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGF
IDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTE
KFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLRTQDSESTEIPLDEQVEEEAVG
EEEESQPEACVIDDRSPDT"
BASE COUNT 527 a 391 c 421 g 431 t
ORIGIN
1 aatatgaagg agcagccctc atgtgccggc accgggcatc cgagcatggc ggggtatggc
61 aggatggccc cctttgaact cgctagcgga cccgtgaagc gcttgagaac tgagtccccc
121 tttccctgtc tcttcgcaga ggaggcctac cagaaactgg ccagcgagac cctggaggag
181 ctggactggt gtctggacca gctagagacc ctacagacca ggcactccgt cagtgagatg
241 gcctccaaca agtttaaaag gatgcttaat cgggagctca cccatctctc tgaaatgagt
301 cggtctggaa atcaagtgtc agagtttata tcaaacacat tcttagataa gcaacatgaa
361 gtggaaattc cttctccaac tcagaaggaa aaggagaaaa agaaaagacc aatgtctcag
421 atcagtggag tcaagaaatt gatgcacagc tctagtctga ctaattcaag tatcccaagg
481 tttggagtta aaactgaaca agaagatgtc cttgccaagg aactagaaga tgtgaacaaa
541 tggggtcttc atgttttcag aatagcagag ttgtctggta accggccctt gactgttatc
601 atgcacacca tttttcagga acgggattta ttaaaaacat ttaaaattcc agtagatact
661 ttaattacat atcttatgac tctcgaagac cattaccatg ctgatgtggc ctatcacaac
721 aatatccatg ctgcagatgt tgtccagtct actcatgtgc tattatctac acctgctttg
781 gaggctgtgt ttacagattt ggagattctt gcagcaattt ttgccagtgc aatacatgat
841 gtagatcatc ctggtgtgtc caatcaattt ctgatcaata caaactctga acttgccttg
901 atgtacaatg attcctcagt cttagagaac catcatttgg ctgtgggctt taaattgctt
961 caggaagaaa actgtgacat tttccagaat ttgaccaaaa aacaaagaca atctttaagg
1021 aaaatggtca ttgacatcgt acttgcaaca gatatgtcaa aacacatgaa tctactggct
1081 gatttgaaga ctatggttga aactaagaaa gtgacaagct ctggagttct tcttcttgat
1141 aattattccg ataggattca ggttcttcag aatatggtgc actgtgcaga tctgagcaac
1201 ccaacaaagc ctctccagct gtaccgccag tggacggacc ggataatgga ggagttcttc
1261 cgccaaggag accgagagag ggaacgtggc atggagataa gccccatgtg tgacaagcac
1321 aatgcttccg tggaaaaatc acaggtgggc ttcatagact atattgttca tcccctctgg
1381 gagacatggg cagacctcgt ccaccctgac gcccaggata ttttggacac tttggaggac
1441 aatcgtgaat ggtaccagag cacaatccct cagagcccct ctcctgcacc tgatgaccca
1501 gaggagggcc ggcagggtca aactgagaaa ttccagtttg aactaacttt agaggaagat
1561 ggtgagtcag acacggaaaa ggacagtggc agtcaagtgg aagaagacac tagctgcagt
1621 gactccaaga ctcttcgtac tcaagactca gagtctactg aaattcccct tgatgaacag
1681 gttgaagagg aggcagtagg ggaagaagag gaaagccaac ctgaagcctg tgtcatagat
1741 gatcgttctc ctgacacgta acagtgcaaa
//