LOCUS HSU49844 8210 bp mRNA linear HUM 23-MAR-1996 DEFINITION Human FRAP-related protein (FRP1) mRNA, complete cds. ACCESSION U49844 VERSION U49844.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 8210) AUTHORS Cimprich,K.A., Shin,T.B., Keith,C.T. and Schreiber,S.L. TITLE Direct Submission JOURNAL Submitted (22-FEB-1996) Karlene A. Cimprich, Chemistry, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA REFERENCE 2 (bases 1 to 8210) AUTHORS Cimprich,K.A., Shin,T.B., Keith,C.T. and Schreiber,S.L. TITLE cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein JOURNAL Proc. Natl. Acad. Sci. U.S.A. 93 (7), 2850-2855 (1996) PUBMED 8610130 FEATURES Location/Qualifiers source 1..8210 /db_xref="H-InvDB:HIT000220122" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="3" /map="3q22-q24" /cell_type="Jurkat T-cell" gene 1..8210 /gene="FRP1" CDS 106..8040 /gene="FRP1" /note="similar to FRAP, Mec1p, Tor1p, Tor2p, and ATM" /codon_start=1 /product="FRAP-related protein" /protein_id="AAC50405.1" /translation="MGEHGLELASMIPALRELGSATPEEYNTVVQKPRQILCQFIDRI LTDVNVVAVELVKKTDSQPTSVMLLDFIQHIMKSSPLMFVNVSGSHEAKGSCIEFSNW IITRLLRIAATPSCHLLHKKICEVICSLLFLFKSKSPAIFGVLTKELLQLFEDLVYLH RRNVMGHAVEWPVVMSRFLSQLDEHMGYLQSAPLQLMSMQNLEFIEVTLLMVLTRIIA IVFFRRQELLLWQIGCVLLEYGSPKIKSLAISFLTELFQLGGLPAQPASTFFSSFLEL LKHLVEMDTDQLKLYEEPLSKLIKTLFPFEAEAYRNIEPVYLNMLLEKLCVMFEDGVL MRLKSDLLKAALCHLLQYFLKFVPAGYESALQVRKVYVRNICKALLDVLGIEVDAEYL LGPLYAALKMESMEIIEEIQCQTQQENLSSNSDGISPKRRRLSSSLNPSKRAPKQTEE IKHVDMNQKSILWSALKQKAESLQISLEYSGLKNPVIEMLEGIAVVLQLTALCTVHCS HQNMNCRTFKDCQHKSKKKPSVVITWMSLDFYTKVLKSCRSLLESVQKLDLEATIDKV VKIYDALIYMQVNSSFEDHILEDLCGMLSLPWIYSHSDDGCLKLTTFAANLLTLSCRI SDSYSPQAQSRCVFLLTLFPRRIFLEWRTAVYNWALQSSHEVIRASCVSGFFILLQQQ NSCNRVPKILIDKVKDDSDIVKKEFASILGQLVCTLHGMFYLTSSLTEPFSEHGHVDL FCRNLKATSQHECSSSQLKASVCKPFLFLLKKKIPSPVKLAFIDNLHHLCKHLDFRED ETDVKAVLGTLLNLMEDPDKDVRVAFSGNIKHILESLDSEDGFIKELFVLRMKEAYTH AQISRNNELKDTLILTTGDIGRAAKGDLVPFALLHLLHCLLSKSASVSGAAYTEIRAL VAAKSVKLQSFFSQYKKPICQFLVESLHSSQMTALPNTPCQNADVRKQDVAHQREMAL NTLSEIANVFDFPDLNRFLTRTLQVLLPDLAAKASPAASALIRTLGKQLNVNRREILI NNFKYIFSHLVCSCSKDELERALHYLKNETEIELGSLLRQDFQGLHNELLLRIGEHYQ QVFNGLSILASFASSDDPYQGPRDIISPELMADYLQPKLLGILAFFNMQLLSSSVGIE DKKMALNSLMSLMKLMGPKHVSSVRVKMMTTLRTGLRFKDDFPELCCRAWDCFVRCLD HACLGSLLSHVIVALLPLIHIQPKETAAIFHYLIIENRDAVQDFLHEIYFLPDHPELK KIKAVLQEYRKETSESTDLQTTLQLSMKAIQHENVDVRIHALTSLKETLYKNQEKLIK YATDSETVEPIISQLVTVLLKGCQDANSQARLLCGECLGELGAIDPGRLDFSTTETQG KDFTFVTGVEDSSFAYGLLMELTRAYLAYADNSRAQDSAAYAIQELLSIYDCREMETN GPGHQLWRRFPEHVREILEPHLNTRYKSSQKSTDWSGVKKPIYLSKLGSNFAEWSASW AGYLITKVRHDLASKIFTCCSIMMKHDFKVTIYLLPHILVYVLLGCNQEDQQEVYAEI MAVLKHDDQHTINTQDIASDLCQLSTQTVFSMLDHLTQWARHKFQALKAEKCPHSKSN RNKVDSMVSTVDYEDYQSVTRFLDLIPQDTLAVASFRSKAYTRAVMHFESFITEKKQN IQEHLGFLQKLYAAMHEPDGVAGVSAIRKAEPSLKEQILEHESLGLLRDATACYDRAI QLEPDQIIHYHGVVKSMLGLGQLSTVITQVNGVHANRSEWTDELNTYRVEAAWKLSQW DLVENYLAADGKSTTWSVRLGQLLLSAKKRDITAFYDSLKLVRAEQIVPLSAASFERG SYQRGYEYIVRLHMLCELEHSIKPLFQHSPGDSSQEDSLNWVARLEMTQNSYRAKEPI LALRRALLSLNKRPDYNEMVGECWLQSARVARKAGHHQTAYNALLNAGESRLAELYVE RAKWLWSKGDVHQALIVLQKGVELCFPENETPPEGKNMLIHGRAMLLVGRFMEETANF ESNAIMKKYKDVTACLPEWEDGHFYLAKYYDKLMPMVTDNKMEKQGDLIRYIVLHFGR SLQYGNQFIYQSMPRMLTLWLDYGTKAYEWEKAGRSDRVQMRNDLGKINKVITEHTNY LAPYQFLTAFSQLISRICHSHDEVFVVLMEIIAKVFLAYPQQAMWMMTAVSKSSYPMR VNRCKEILNKAIHMKKSLEKFVGDATRLTDKLLELCNKPVDGSSSTLSMSTHFKMLKK LVEEATFSEILIPLQSVMIPTLPSILGTHANHASHEPFPGHWAYIAGFDDMVEILASL QKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRT YAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLK VFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGEN ILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEV TMRLMRDQREPLMSVLKTFLHDPLVEWSKPVKGHSKAPLNETGEVVNEKAKTHVLDIE QRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLLCQMYLGWTPYM" BASE COUNT 2511 a 1555 c 1738 g 2406 t ORIGIN 1 gcctccacac ggctccgtcg ggcgccgcgc tcttccggca gcggtagctt tggagacgcc 61 gggaacccgc gttggcgtgg ttgactagtg cctcgcagcc tcagcatggg ggaacatggc 121 ctggagctgg cttccatgat ccccgccctg cgggagctgg gcagtgccac accagaggaa 181 tataatacag ttgtacagaa gccaagacaa attctgtgtc aattcattga ccggatactt 241 acagatgtaa atgttgttgc tgtagaactt gtaaagaaaa ctgactctca gccaacctcc 301 gtgatgttgc ttgatttcat ccagcatatc atgaaatcct ccccacttat gtttgtaaat 361 gtgagtggaa gccatgaggc caaaggcagt tgtattgaat tcagtaattg gatcataacg 421 agacttctgc ggattgcagc aactccctcc tgtcatttgt tacacaagaa aatctgtgaa 481 gtcatctgtt cattattatt tctttttaaa agcaagagtc ctgctatttt tggggtactc 541 acaaaagaat tattacaact ttttgaagac ttggtttacc tccatagaag aaatgtgatg 601 ggtcatgctg tggaatggcc agtggtcatg agccgatttt taagtcaatt agatgaacac 661 atgggatatt tacaatcagc tcctttgcag ttgatgagta tgcaaaattt agaatttatt 721 gaagtcactt tattaatggt tcttactcgt attattgcaa ttgtgttttt tagaaggcaa 781 gaactcttac tttggcagat aggttgtgtt ctgctagagt atggtagtcc aaaaattaaa 841 tccctagcaa ttagcttttt aacagaactt tttcagcttg gaggactacc agcacaacca 901 gctagcactt ttttcagctc atttttggaa ttattaaaac accttgtaga aatggatact 961 gaccaattga aactctatga agagccatta tcaaagctga taaagacact atttcccttt 1021 gaagcagaag cttatagaaa tattgaacct gtctatttaa atatgctgct ggaaaaactc 1081 tgtgtcatgt ttgaagacgg tgtgctcatg cggcttaagt ctgatttgct aaaagcagct 1141 ttgtgccatt tactgcagta tttccttaaa tttgtgccag ctgggtatga atctgcttta 1201 caagtcagga aggtctatgt gagaaatatt tgtaaagctc ttttggatgt gcttggaatt 1261 gaggtagatg cagagtactt gttgggccca ctttatgcag ctttgaaaat ggaaagtatg 1321 gaaatcattg aggagattca atgccaaact caacaggaaa acctcagcag taatagtgat 1381 ggaatatcac ccaaaaggcg tcgtctcagc tcgtctctaa acccttctaa aagagcacca 1441 aaacagactg aggaaattaa acatgtggac atgaaccaaa agagcatatt atggagtgca 1501 ctgaaacaga aagctgaatc ccttcagatt tcccttgaat acagtggcct aaagaatcct 1561 gttattgaga tgttagaagg aattgctgtt gtcttacaac tgactgctct gtgtactgtt 1621 cattgttctc atcaaaacat gaactgccgt actttcaagg actgtcaaca taaatccaag 1681 aagaaacctt ctgtagtgat aacttggatg tcattggatt tttacacaaa agtgcttaag 1741 agctgtagaa gtttgttaga atctgttcag aaactggacc tggaggcaac cattgataag 1801 gtggtgaaaa tttatgatgc tttgatttat atgcaagtaa acagttcatt tgaagatcat 1861 atcctggaag atttatgtgg tatgctctca cttccatgga tttattccca ttctgatgat 1921 ggctgtttaa agttgaccac atttgccgct aatcttctaa cattaagctg taggatttca 1981 gatagctatt caccacaggc acaatcacga tgtgtgtttc ttctgactct gtttccaaga 2041 agaatattcc ttgagtggag aacagcagtt tacaactggg ccctgcagag ctcccatgaa 2101 gtaatccggg ctagttgtgt tagtggattt tttatcttat tgcagcagca gaattcttgt 2161 aacagagttc ccaagattct tatagataaa gtcaaagatg attctgacat tgtcaagaaa 2221 gaatttgctt ctatacttgg tcaacttgtc tgtactcttc acggcatgtt ttatctgaca 2281 agttctttaa cagaaccttt ctctgaacac ggacatgtgg acctcttctg taggaacttg 2341 aaagccactt ctcaacatga atgttcatct tctcaactaa aagcttctgt ctgcaagcca 2401 ttccttttcc tactgaaaaa aaaaatacct agtccagtaa aacttgcttt catagataat 2461 ctacatcatc tttgtaagca tcttgatttt agagaagatg aaacagatgt aaaagcagtt 2521 cttggaactt tattaaattt aatggaagat ccagacaaag atgttagagt ggcttttagt 2581 ggaaatatca agcacatatt ggaatccttg gactctgaag atggatttat aaaggagctt 2641 tttgtcttaa gaatgaagga agcatataca catgcccaaa tatcaagaaa taatgagctg 2701 aaggatacct tgattcttac aacaggggat attggaaggg ccgcaaaagg agatttggta 2761 ccatttgcac tcttacactt attgcattgt ttgttatcca agtcagcatc tgtctctgga 2821 gcagcataca cagaaattag agctctggtt gcagctaaaa gtgttaaact gcaaagtttt 2881 ttcagccagt ataagaaacc catctgtcag tttttggtag aatcccttca ctctagtcag 2941 atgacagcac ttccgaatac tccatgccag aatgctgacg tgcgaaaaca agatgtggct 3001 caccagagag aaatggcttt aaatacgttg tctgaaattg ccaacgtttt cgactttcct 3061 gatcttaatc gttttcttac taggacatta caagttctac tacctgatct tgctgccaaa 3121 gcaagccctg cagcttctgc tctcattcga actttaggaa aacaattaaa tgtcaatcgt 3181 agagagattt taataaacaa cttcaaatat attttttctc atttggtctg ttcttgttcc 3241 aaagatgaat tagaacgtgc ccttcattat ctgaagaatg aaacagaaat tgaactgggg 3301 agcctgttga gacaagattt ccaaggattg cataatgaat tattgctgcg tattggagaa 3361 cactatcaac aggtttttaa tggtttgtca atacttgcct catttgcatc cagtgatgat 3421 ccatatcagg gcccgagaga tatcatatca cctgaactga tggctgatta tttacaaccc 3481 aaattgttgg gcattttggc tttttttaac atgcagttac tgagctctag tgttggcatt 3541 gaagataaga aaatggcctt gaacagtttg atgtctttga tgaagttaat gggacccaaa 3601 catgtcagtt ctgtgagggt gaagatgatg accacactga gaactggcct tcgattcaag 3661 gatgattttc ctgaattgtg ttgcagagct tgggactgct ttgttcgctg cctggatcat 3721 gcttgtctgg gctcccttct cagtcatgta atagtagctt tgttacctct tatacacatc 3781 cagcctaaag aaactgcagc tatcttccac tacctcataa ttgaaaacag ggatgctgtg 3841 caagattttc ttcatgaaat atatttttta cctgatcatc cagaattaaa aaagataaaa 3901 gccgttctcc aggaatacag aaaggagacc tctgagagca ctgatcttca gacaactctt 3961 cagctctcta tgaaggccat tcaacatgaa aatgtcgatg ttcgtattca tgctcttaca 4021 agcttgaagg aaaccttgta taaaaatcag gaaaaactga taaagtatgc aacagacagt 4081 gaaacagtag aacctattat ctcacagttg gtgacagtgc ttttgaaagg ttgccaagat 4141 gcaaactctc aagctcggtt gctctgtggg gaatgtttag gggaattggg ggcgatagat 4201 ccaggtcgat tagatttctc aacaactgaa actcaaggaa aagattttac atttgtgact 4261 ggagtagaag attcaagctt tgcctatgga ttattgatgg agctaacaag agcttacctt 4321 gcgtacgctg ataatagccg agctcaagat tcagctgcct atgccattca ggagttgctt 4381 tctatttatg actgtagaga gatggagacc aacggcccag gtcaccaatt gtggaggaga 4441 tttcctgagc atgttcggga aatactagaa cctcatctaa ataccagata caagagttct 4501 cagaagtcaa ccgattggtc tggagtaaag aagccaattt acttaagtaa attgggtagt 4561 aactttgcag aatggtcagc atcttgggca ggttatctta ttacaaaggt tcgacatgat 4621 cttgccagta aaattttcac ctgctgtagc attatgatga agcatgattt caaagtgacc 4681 atctatcttc ttccacatat tctggtgtat gtcttactgg gttgtaatca agaagatcag 4741 caggaggttt atgcagaaat tatggcagtt ctaaagcatg acgatcagca taccataaat 4801 acccaagaca ttgcatctga tctgtgtcaa ctcagtacac agactgtgtt ctccatgctt 4861 gaccatctca cacagtgggc aaggcacaaa tttcaggcac tgaaagctga gaaatgtcca 4921 cacagcaaat caaacagaaa taaggtagac tcaatggtat ctactgtgga ttatgaagac 4981 tatcagagtg taacccgttt tctagacctc ataccccagg atactctggc agtagcttcc 5041 tttcgctcca aagcatacac acgagctgta atgcactttg aatcatttat tacagaaaag 5101 aagcaaaata ttcaggaaca tcttggattt ttacagaaat tgtatgctgc tatgcatgaa 5161 cctgatggag tggccggagt cagtgcaatt agaaaggcag aaccatctct aaaagaacag 5221 atccttgaac atgaaagcct tggcttgctg agggatgcca ctgcttgtta tgacagggct 5281 attcagctag aaccagacca gatcattcat tatcatggtg tagtaaagtc catgttaggt 5341 cttggtcagc tgtctactgt tatcactcag gtgaatggag tgcatgctaa caggtccgag 5401 tggacagatg aattaaacac gtacagagtg gaagcagctt ggaaattgtc acagtgggat 5461 ttggtggaaa actatttggc agcagatgga aaatctacaa catggagtgt cagactggga 5521 cagctattat tatcagccaa aaaaagagat atcacagctt tttatgactc actgaaacta 5581 gtgagagcag aacaaattgt acctctttca gctgcaagct ttgaaagagg ctcctaccaa 5641 cgaggatatg aatatattgt gagattgcac atgttatgtg agttggagca tagcatcaaa 5701 ccacttttcc agcattctcc aggtgacagt tctcaagaag attctctaaa ctgggtagct 5761 cgactagaaa tgacccagaa ttcctacaga gccaaggagc ctatcctggc tctccggagg 5821 gctttactaa gcctcaacaa aagaccagat tacaatgaaa tggttggaga atgctggctg 5881 cagagtgcca gggtagctag aaaggctggt caccaccaga cagcctacaa tgctctcctt 5941 aatgcagggg aatcacgact cgctgaactg tacgtggaaa gggcaaagtg gctctggtcc 6001 aagggtgatg ttcaccaggc actaattgtt cttcaaaaag gtgttgaatt atgttttcct 6061 gaaaatgaaa ccccacctga gggtaagaac atgttaatcc atggtcgagc tatgctacta 6121 gtgggccgat ttatggaaga aacagctaac tttgaaagca atgcaattat gaaaaaatat 6181 aaggatgtga ccgcgtgcct gccagaatgg gaggatgggc atttttacct tgccaagtac 6241 tatgacaaat tgatgcccat ggtcacagac aacaaaatgg aaaagcaagg tgatctcatc 6301 cggtatatag ttcttcattt tggcagatct ctacaatatg gaaatcagtt catatatcag 6361 tcaatgccac gaatgttaac tctatggctt gattatggta caaaggcata tgaatgggaa 6421 aaagctggcc gctccgatcg tgtacaaatg aggaatgatt tgggtaaaat aaacaaggtt 6481 atcacagagc atacaaacta tttagctcca tatcaatttt tgactgcttt ttcacaattg 6541 atctctcgaa tttgtcattc tcacgatgaa gtttttgttg tcttgatgga aataatagcc 6601 aaagtatttc tagcctatcc tcaacaagca atgtggatga tgacagctgt gtcaaagtca 6661 tcttatccca tgcgtgtgaa cagatgcaag gaaatcctca ataaagctat tcatatgaaa 6721 aaatccttag agaagtttgt tggagatgca actcgcctaa cagataagct tctagaattg 6781 tgcaataaac cggttgatgg aagtagttcc acattaagca tgagcactca ttttaaaatg 6841 cttaaaaagc tggtagaaga agcaacattt agtgaaatcc tcattcctct acaatcagtc 6901 atgataccta cacttccatc aattctgggt acccatgcta accatgctag ccatgaacca 6961 tttcctggac attgggccta tattgcaggg tttgatgata tggtggaaat tcttgcttct 7021 cttcagaaac caaagaagat ttctttaaaa ggctcagatg gaaagttcta catcatgatg 7081 tgtaagccaa aagatgacct gagaaaggat tgtagactaa tggaattcaa ttccttgatt 7141 aataagtgct taagaaaaga tgcagagtct cgtagaagag aacttcatat tcgaacatat 7201 gcagttattc cactaaatga tgaatgtggg attattgaat gggtgaacaa cactgctggt 7261 ttgagaccta ttctgaccaa actatataaa gaaaagggag tgtatatgac aggaaaagaa 7321 cttcgccagt gtatgctacc aaagtcagca gctttatctg aaaaactcaa agtattccga 7381 gaatttctcc tgcccaggca tcctcctatt tttcatgagt ggtttctgag aacattccct 7441 gatcctacat catggtacag tagtagatca gcttactgcc gttccactgc agtaatgtca 7501 atggttggtt atattctggg gcttggagac cgtcatggtg aaaatattct ctttgattct 7561 ttgactggtg aatgcgtaca tgtagatttc aattgtcttt tcaataaggg agaaaccttt 7621 gaagttccag aaattgtgcc atttcgcctg actcataata tggttaatgg aatgggtcct 7681 atgggaacag agggtctttt tcgaagagca tgtgaagtta caatgaggct gatgcgtgat 7741 cagcgagagc ctttaatgag tgtcttaaag acttttctac atgatcctct tgtggaatgg 7801 agtaaaccag tgaaagggca ttccaaagcg ccactgaatg aaactggaga agttgtcaat 7861 gaaaaggcca agacccatgt tcttgacatt gagcagcgac tacaaggtgt aatcaagact 7921 cgaaatagag tgacaggact gccgttatct attgaaggac atgtgcatta ccttatacag 7981 gaagctactg atgaaaactt actatgccag atgtatcttg gttggactcc atatatgtga 8041 aatgaaatta tgtaaaagaa tatgttaata atctaaaagt aatgcatttg gtatgaatct 8101 gtggttgtat ctgttcaatt ctaaagtaca acataaattt acgttctcag caactgttat 8161 ttctctctga tcattaatta tatgtaaaat aatatacatt cactcgtgcc //