LOCUS       HSU49844                8210 bp    mRNA    linear   HUM 23-MAR-1996
DEFINITION  Human FRAP-related protein (FRP1) mRNA, complete cds.
ACCESSION   U49844
VERSION     U49844.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8210)
  AUTHORS   Cimprich,K.A., Shin,T.B., Keith,C.T. and Schreiber,S.L.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-FEB-1996) Karlene A. Cimprich, Chemistry, Harvard
            University, 12 Oxford Street, Cambridge, MA 02138, USA
REFERENCE   2  (bases 1 to 8210)
  AUTHORS   Cimprich,K.A., Shin,T.B., Keith,C.T. and Schreiber,S.L.
  TITLE     cDNA cloning and gene mapping of a candidate human cell cycle
            checkpoint protein
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 93 (7), 2850-2855 (1996)
   PUBMED   8610130
FEATURES             Location/Qualifiers
     source          1..8210
                     /db_xref="H-InvDB:HIT000220122"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q22-q24"
                     /cell_type="Jurkat T-cell"
     gene            1..8210
                     /gene="FRP1"
     CDS             106..8040
                     /gene="FRP1"
                     /note="similar to FRAP, Mec1p, Tor1p, Tor2p, and ATM"
                     /codon_start=1
                     /product="FRAP-related protein"
                     /protein_id="AAC50405.1"
                     /translation="MGEHGLELASMIPALRELGSATPEEYNTVVQKPRQILCQFIDRI
                     LTDVNVVAVELVKKTDSQPTSVMLLDFIQHIMKSSPLMFVNVSGSHEAKGSCIEFSNW
                     IITRLLRIAATPSCHLLHKKICEVICSLLFLFKSKSPAIFGVLTKELLQLFEDLVYLH
                     RRNVMGHAVEWPVVMSRFLSQLDEHMGYLQSAPLQLMSMQNLEFIEVTLLMVLTRIIA
                     IVFFRRQELLLWQIGCVLLEYGSPKIKSLAISFLTELFQLGGLPAQPASTFFSSFLEL
                     LKHLVEMDTDQLKLYEEPLSKLIKTLFPFEAEAYRNIEPVYLNMLLEKLCVMFEDGVL
                     MRLKSDLLKAALCHLLQYFLKFVPAGYESALQVRKVYVRNICKALLDVLGIEVDAEYL
                     LGPLYAALKMESMEIIEEIQCQTQQENLSSNSDGISPKRRRLSSSLNPSKRAPKQTEE
                     IKHVDMNQKSILWSALKQKAESLQISLEYSGLKNPVIEMLEGIAVVLQLTALCTVHCS
                     HQNMNCRTFKDCQHKSKKKPSVVITWMSLDFYTKVLKSCRSLLESVQKLDLEATIDKV
                     VKIYDALIYMQVNSSFEDHILEDLCGMLSLPWIYSHSDDGCLKLTTFAANLLTLSCRI
                     SDSYSPQAQSRCVFLLTLFPRRIFLEWRTAVYNWALQSSHEVIRASCVSGFFILLQQQ
                     NSCNRVPKILIDKVKDDSDIVKKEFASILGQLVCTLHGMFYLTSSLTEPFSEHGHVDL
                     FCRNLKATSQHECSSSQLKASVCKPFLFLLKKKIPSPVKLAFIDNLHHLCKHLDFRED
                     ETDVKAVLGTLLNLMEDPDKDVRVAFSGNIKHILESLDSEDGFIKELFVLRMKEAYTH
                     AQISRNNELKDTLILTTGDIGRAAKGDLVPFALLHLLHCLLSKSASVSGAAYTEIRAL
                     VAAKSVKLQSFFSQYKKPICQFLVESLHSSQMTALPNTPCQNADVRKQDVAHQREMAL
                     NTLSEIANVFDFPDLNRFLTRTLQVLLPDLAAKASPAASALIRTLGKQLNVNRREILI
                     NNFKYIFSHLVCSCSKDELERALHYLKNETEIELGSLLRQDFQGLHNELLLRIGEHYQ
                     QVFNGLSILASFASSDDPYQGPRDIISPELMADYLQPKLLGILAFFNMQLLSSSVGIE
                     DKKMALNSLMSLMKLMGPKHVSSVRVKMMTTLRTGLRFKDDFPELCCRAWDCFVRCLD
                     HACLGSLLSHVIVALLPLIHIQPKETAAIFHYLIIENRDAVQDFLHEIYFLPDHPELK
                     KIKAVLQEYRKETSESTDLQTTLQLSMKAIQHENVDVRIHALTSLKETLYKNQEKLIK
                     YATDSETVEPIISQLVTVLLKGCQDANSQARLLCGECLGELGAIDPGRLDFSTTETQG
                     KDFTFVTGVEDSSFAYGLLMELTRAYLAYADNSRAQDSAAYAIQELLSIYDCREMETN
                     GPGHQLWRRFPEHVREILEPHLNTRYKSSQKSTDWSGVKKPIYLSKLGSNFAEWSASW
                     AGYLITKVRHDLASKIFTCCSIMMKHDFKVTIYLLPHILVYVLLGCNQEDQQEVYAEI
                     MAVLKHDDQHTINTQDIASDLCQLSTQTVFSMLDHLTQWARHKFQALKAEKCPHSKSN
                     RNKVDSMVSTVDYEDYQSVTRFLDLIPQDTLAVASFRSKAYTRAVMHFESFITEKKQN
                     IQEHLGFLQKLYAAMHEPDGVAGVSAIRKAEPSLKEQILEHESLGLLRDATACYDRAI
                     QLEPDQIIHYHGVVKSMLGLGQLSTVITQVNGVHANRSEWTDELNTYRVEAAWKLSQW
                     DLVENYLAADGKSTTWSVRLGQLLLSAKKRDITAFYDSLKLVRAEQIVPLSAASFERG
                     SYQRGYEYIVRLHMLCELEHSIKPLFQHSPGDSSQEDSLNWVARLEMTQNSYRAKEPI
                     LALRRALLSLNKRPDYNEMVGECWLQSARVARKAGHHQTAYNALLNAGESRLAELYVE
                     RAKWLWSKGDVHQALIVLQKGVELCFPENETPPEGKNMLIHGRAMLLVGRFMEETANF
                     ESNAIMKKYKDVTACLPEWEDGHFYLAKYYDKLMPMVTDNKMEKQGDLIRYIVLHFGR
                     SLQYGNQFIYQSMPRMLTLWLDYGTKAYEWEKAGRSDRVQMRNDLGKINKVITEHTNY
                     LAPYQFLTAFSQLISRICHSHDEVFVVLMEIIAKVFLAYPQQAMWMMTAVSKSSYPMR
                     VNRCKEILNKAIHMKKSLEKFVGDATRLTDKLLELCNKPVDGSSSTLSMSTHFKMLKK
                     LVEEATFSEILIPLQSVMIPTLPSILGTHANHASHEPFPGHWAYIAGFDDMVEILASL
                     QKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRT
                     YAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLK
                     VFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGEN
                     ILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEV
                     TMRLMRDQREPLMSVLKTFLHDPLVEWSKPVKGHSKAPLNETGEVVNEKAKTHVLDIE
                     QRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLLCQMYLGWTPYM"
BASE COUNT         2511 a         1555 c         1738 g         2406 t
ORIGIN      
        1 gcctccacac ggctccgtcg ggcgccgcgc tcttccggca gcggtagctt tggagacgcc
       61 gggaacccgc gttggcgtgg ttgactagtg cctcgcagcc tcagcatggg ggaacatggc
      121 ctggagctgg cttccatgat ccccgccctg cgggagctgg gcagtgccac accagaggaa
      181 tataatacag ttgtacagaa gccaagacaa attctgtgtc aattcattga ccggatactt
      241 acagatgtaa atgttgttgc tgtagaactt gtaaagaaaa ctgactctca gccaacctcc
      301 gtgatgttgc ttgatttcat ccagcatatc atgaaatcct ccccacttat gtttgtaaat
      361 gtgagtggaa gccatgaggc caaaggcagt tgtattgaat tcagtaattg gatcataacg
      421 agacttctgc ggattgcagc aactccctcc tgtcatttgt tacacaagaa aatctgtgaa
      481 gtcatctgtt cattattatt tctttttaaa agcaagagtc ctgctatttt tggggtactc
      541 acaaaagaat tattacaact ttttgaagac ttggtttacc tccatagaag aaatgtgatg
      601 ggtcatgctg tggaatggcc agtggtcatg agccgatttt taagtcaatt agatgaacac
      661 atgggatatt tacaatcagc tcctttgcag ttgatgagta tgcaaaattt agaatttatt
      721 gaagtcactt tattaatggt tcttactcgt attattgcaa ttgtgttttt tagaaggcaa
      781 gaactcttac tttggcagat aggttgtgtt ctgctagagt atggtagtcc aaaaattaaa
      841 tccctagcaa ttagcttttt aacagaactt tttcagcttg gaggactacc agcacaacca
      901 gctagcactt ttttcagctc atttttggaa ttattaaaac accttgtaga aatggatact
      961 gaccaattga aactctatga agagccatta tcaaagctga taaagacact atttcccttt
     1021 gaagcagaag cttatagaaa tattgaacct gtctatttaa atatgctgct ggaaaaactc
     1081 tgtgtcatgt ttgaagacgg tgtgctcatg cggcttaagt ctgatttgct aaaagcagct
     1141 ttgtgccatt tactgcagta tttccttaaa tttgtgccag ctgggtatga atctgcttta
     1201 caagtcagga aggtctatgt gagaaatatt tgtaaagctc ttttggatgt gcttggaatt
     1261 gaggtagatg cagagtactt gttgggccca ctttatgcag ctttgaaaat ggaaagtatg
     1321 gaaatcattg aggagattca atgccaaact caacaggaaa acctcagcag taatagtgat
     1381 ggaatatcac ccaaaaggcg tcgtctcagc tcgtctctaa acccttctaa aagagcacca
     1441 aaacagactg aggaaattaa acatgtggac atgaaccaaa agagcatatt atggagtgca
     1501 ctgaaacaga aagctgaatc ccttcagatt tcccttgaat acagtggcct aaagaatcct
     1561 gttattgaga tgttagaagg aattgctgtt gtcttacaac tgactgctct gtgtactgtt
     1621 cattgttctc atcaaaacat gaactgccgt actttcaagg actgtcaaca taaatccaag
     1681 aagaaacctt ctgtagtgat aacttggatg tcattggatt tttacacaaa agtgcttaag
     1741 agctgtagaa gtttgttaga atctgttcag aaactggacc tggaggcaac cattgataag
     1801 gtggtgaaaa tttatgatgc tttgatttat atgcaagtaa acagttcatt tgaagatcat
     1861 atcctggaag atttatgtgg tatgctctca cttccatgga tttattccca ttctgatgat
     1921 ggctgtttaa agttgaccac atttgccgct aatcttctaa cattaagctg taggatttca
     1981 gatagctatt caccacaggc acaatcacga tgtgtgtttc ttctgactct gtttccaaga
     2041 agaatattcc ttgagtggag aacagcagtt tacaactggg ccctgcagag ctcccatgaa
     2101 gtaatccggg ctagttgtgt tagtggattt tttatcttat tgcagcagca gaattcttgt
     2161 aacagagttc ccaagattct tatagataaa gtcaaagatg attctgacat tgtcaagaaa
     2221 gaatttgctt ctatacttgg tcaacttgtc tgtactcttc acggcatgtt ttatctgaca
     2281 agttctttaa cagaaccttt ctctgaacac ggacatgtgg acctcttctg taggaacttg
     2341 aaagccactt ctcaacatga atgttcatct tctcaactaa aagcttctgt ctgcaagcca
     2401 ttccttttcc tactgaaaaa aaaaatacct agtccagtaa aacttgcttt catagataat
     2461 ctacatcatc tttgtaagca tcttgatttt agagaagatg aaacagatgt aaaagcagtt
     2521 cttggaactt tattaaattt aatggaagat ccagacaaag atgttagagt ggcttttagt
     2581 ggaaatatca agcacatatt ggaatccttg gactctgaag atggatttat aaaggagctt
     2641 tttgtcttaa gaatgaagga agcatataca catgcccaaa tatcaagaaa taatgagctg
     2701 aaggatacct tgattcttac aacaggggat attggaaggg ccgcaaaagg agatttggta
     2761 ccatttgcac tcttacactt attgcattgt ttgttatcca agtcagcatc tgtctctgga
     2821 gcagcataca cagaaattag agctctggtt gcagctaaaa gtgttaaact gcaaagtttt
     2881 ttcagccagt ataagaaacc catctgtcag tttttggtag aatcccttca ctctagtcag
     2941 atgacagcac ttccgaatac tccatgccag aatgctgacg tgcgaaaaca agatgtggct
     3001 caccagagag aaatggcttt aaatacgttg tctgaaattg ccaacgtttt cgactttcct
     3061 gatcttaatc gttttcttac taggacatta caagttctac tacctgatct tgctgccaaa
     3121 gcaagccctg cagcttctgc tctcattcga actttaggaa aacaattaaa tgtcaatcgt
     3181 agagagattt taataaacaa cttcaaatat attttttctc atttggtctg ttcttgttcc
     3241 aaagatgaat tagaacgtgc ccttcattat ctgaagaatg aaacagaaat tgaactgggg
     3301 agcctgttga gacaagattt ccaaggattg cataatgaat tattgctgcg tattggagaa
     3361 cactatcaac aggtttttaa tggtttgtca atacttgcct catttgcatc cagtgatgat
     3421 ccatatcagg gcccgagaga tatcatatca cctgaactga tggctgatta tttacaaccc
     3481 aaattgttgg gcattttggc tttttttaac atgcagttac tgagctctag tgttggcatt
     3541 gaagataaga aaatggcctt gaacagtttg atgtctttga tgaagttaat gggacccaaa
     3601 catgtcagtt ctgtgagggt gaagatgatg accacactga gaactggcct tcgattcaag
     3661 gatgattttc ctgaattgtg ttgcagagct tgggactgct ttgttcgctg cctggatcat
     3721 gcttgtctgg gctcccttct cagtcatgta atagtagctt tgttacctct tatacacatc
     3781 cagcctaaag aaactgcagc tatcttccac tacctcataa ttgaaaacag ggatgctgtg
     3841 caagattttc ttcatgaaat atatttttta cctgatcatc cagaattaaa aaagataaaa
     3901 gccgttctcc aggaatacag aaaggagacc tctgagagca ctgatcttca gacaactctt
     3961 cagctctcta tgaaggccat tcaacatgaa aatgtcgatg ttcgtattca tgctcttaca
     4021 agcttgaagg aaaccttgta taaaaatcag gaaaaactga taaagtatgc aacagacagt
     4081 gaaacagtag aacctattat ctcacagttg gtgacagtgc ttttgaaagg ttgccaagat
     4141 gcaaactctc aagctcggtt gctctgtggg gaatgtttag gggaattggg ggcgatagat
     4201 ccaggtcgat tagatttctc aacaactgaa actcaaggaa aagattttac atttgtgact
     4261 ggagtagaag attcaagctt tgcctatgga ttattgatgg agctaacaag agcttacctt
     4321 gcgtacgctg ataatagccg agctcaagat tcagctgcct atgccattca ggagttgctt
     4381 tctatttatg actgtagaga gatggagacc aacggcccag gtcaccaatt gtggaggaga
     4441 tttcctgagc atgttcggga aatactagaa cctcatctaa ataccagata caagagttct
     4501 cagaagtcaa ccgattggtc tggagtaaag aagccaattt acttaagtaa attgggtagt
     4561 aactttgcag aatggtcagc atcttgggca ggttatctta ttacaaaggt tcgacatgat
     4621 cttgccagta aaattttcac ctgctgtagc attatgatga agcatgattt caaagtgacc
     4681 atctatcttc ttccacatat tctggtgtat gtcttactgg gttgtaatca agaagatcag
     4741 caggaggttt atgcagaaat tatggcagtt ctaaagcatg acgatcagca taccataaat
     4801 acccaagaca ttgcatctga tctgtgtcaa ctcagtacac agactgtgtt ctccatgctt
     4861 gaccatctca cacagtgggc aaggcacaaa tttcaggcac tgaaagctga gaaatgtcca
     4921 cacagcaaat caaacagaaa taaggtagac tcaatggtat ctactgtgga ttatgaagac
     4981 tatcagagtg taacccgttt tctagacctc ataccccagg atactctggc agtagcttcc
     5041 tttcgctcca aagcatacac acgagctgta atgcactttg aatcatttat tacagaaaag
     5101 aagcaaaata ttcaggaaca tcttggattt ttacagaaat tgtatgctgc tatgcatgaa
     5161 cctgatggag tggccggagt cagtgcaatt agaaaggcag aaccatctct aaaagaacag
     5221 atccttgaac atgaaagcct tggcttgctg agggatgcca ctgcttgtta tgacagggct
     5281 attcagctag aaccagacca gatcattcat tatcatggtg tagtaaagtc catgttaggt
     5341 cttggtcagc tgtctactgt tatcactcag gtgaatggag tgcatgctaa caggtccgag
     5401 tggacagatg aattaaacac gtacagagtg gaagcagctt ggaaattgtc acagtgggat
     5461 ttggtggaaa actatttggc agcagatgga aaatctacaa catggagtgt cagactggga
     5521 cagctattat tatcagccaa aaaaagagat atcacagctt tttatgactc actgaaacta
     5581 gtgagagcag aacaaattgt acctctttca gctgcaagct ttgaaagagg ctcctaccaa
     5641 cgaggatatg aatatattgt gagattgcac atgttatgtg agttggagca tagcatcaaa
     5701 ccacttttcc agcattctcc aggtgacagt tctcaagaag attctctaaa ctgggtagct
     5761 cgactagaaa tgacccagaa ttcctacaga gccaaggagc ctatcctggc tctccggagg
     5821 gctttactaa gcctcaacaa aagaccagat tacaatgaaa tggttggaga atgctggctg
     5881 cagagtgcca gggtagctag aaaggctggt caccaccaga cagcctacaa tgctctcctt
     5941 aatgcagggg aatcacgact cgctgaactg tacgtggaaa gggcaaagtg gctctggtcc
     6001 aagggtgatg ttcaccaggc actaattgtt cttcaaaaag gtgttgaatt atgttttcct
     6061 gaaaatgaaa ccccacctga gggtaagaac atgttaatcc atggtcgagc tatgctacta
     6121 gtgggccgat ttatggaaga aacagctaac tttgaaagca atgcaattat gaaaaaatat
     6181 aaggatgtga ccgcgtgcct gccagaatgg gaggatgggc atttttacct tgccaagtac
     6241 tatgacaaat tgatgcccat ggtcacagac aacaaaatgg aaaagcaagg tgatctcatc
     6301 cggtatatag ttcttcattt tggcagatct ctacaatatg gaaatcagtt catatatcag
     6361 tcaatgccac gaatgttaac tctatggctt gattatggta caaaggcata tgaatgggaa
     6421 aaagctggcc gctccgatcg tgtacaaatg aggaatgatt tgggtaaaat aaacaaggtt
     6481 atcacagagc atacaaacta tttagctcca tatcaatttt tgactgcttt ttcacaattg
     6541 atctctcgaa tttgtcattc tcacgatgaa gtttttgttg tcttgatgga aataatagcc
     6601 aaagtatttc tagcctatcc tcaacaagca atgtggatga tgacagctgt gtcaaagtca
     6661 tcttatccca tgcgtgtgaa cagatgcaag gaaatcctca ataaagctat tcatatgaaa
     6721 aaatccttag agaagtttgt tggagatgca actcgcctaa cagataagct tctagaattg
     6781 tgcaataaac cggttgatgg aagtagttcc acattaagca tgagcactca ttttaaaatg
     6841 cttaaaaagc tggtagaaga agcaacattt agtgaaatcc tcattcctct acaatcagtc
     6901 atgataccta cacttccatc aattctgggt acccatgcta accatgctag ccatgaacca
     6961 tttcctggac attgggccta tattgcaggg tttgatgata tggtggaaat tcttgcttct
     7021 cttcagaaac caaagaagat ttctttaaaa ggctcagatg gaaagttcta catcatgatg
     7081 tgtaagccaa aagatgacct gagaaaggat tgtagactaa tggaattcaa ttccttgatt
     7141 aataagtgct taagaaaaga tgcagagtct cgtagaagag aacttcatat tcgaacatat
     7201 gcagttattc cactaaatga tgaatgtggg attattgaat gggtgaacaa cactgctggt
     7261 ttgagaccta ttctgaccaa actatataaa gaaaagggag tgtatatgac aggaaaagaa
     7321 cttcgccagt gtatgctacc aaagtcagca gctttatctg aaaaactcaa agtattccga
     7381 gaatttctcc tgcccaggca tcctcctatt tttcatgagt ggtttctgag aacattccct
     7441 gatcctacat catggtacag tagtagatca gcttactgcc gttccactgc agtaatgtca
     7501 atggttggtt atattctggg gcttggagac cgtcatggtg aaaatattct ctttgattct
     7561 ttgactggtg aatgcgtaca tgtagatttc aattgtcttt tcaataaggg agaaaccttt
     7621 gaagttccag aaattgtgcc atttcgcctg actcataata tggttaatgg aatgggtcct
     7681 atgggaacag agggtctttt tcgaagagca tgtgaagtta caatgaggct gatgcgtgat
     7741 cagcgagagc ctttaatgag tgtcttaaag acttttctac atgatcctct tgtggaatgg
     7801 agtaaaccag tgaaagggca ttccaaagcg ccactgaatg aaactggaga agttgtcaat
     7861 gaaaaggcca agacccatgt tcttgacatt gagcagcgac tacaaggtgt aatcaagact
     7921 cgaaatagag tgacaggact gccgttatct attgaaggac atgtgcatta ccttatacag
     7981 gaagctactg atgaaaactt actatgccag atgtatcttg gttggactcc atatatgtga
     8041 aatgaaatta tgtaaaagaa tatgttaata atctaaaagt aatgcatttg gtatgaatct
     8101 gtggttgtat ctgttcaatt ctaaagtaca acataaattt acgttctcag caactgttat
     8161 ttctctctga tcattaatta tatgtaaaat aatatacatt cactcgtgcc
//