LOCUS HSU49356 6858 bp mRNA linear HUM 27-FEB-1996
DEFINITION Human DNA polymerase epsilon catalytic subunit mRNA, complete cds.
ACCESSION U49356
VERSION U49356.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6858)
AUTHORS Asahara,H., Goldsmith,J.S., Lee,E. and Linn,S.
TITLE Direct Submission
JOURNAL Submitted (15-FEB-1996) Stuart M. Linn, Department of Molecular and
Cell Biology, University of California, Berkeley, 401 Barker Hall,
Berkeley, CA 94720-3202, USA
FEATURES Location/Qualifiers
source 1..6858
/db_xref="H-InvDB:HIT000220094"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_type="fetal skin fibroblast and cervical carcinoma
cells"
/clone_lib="fibroblast CRL 1262 cDNA in lambda ZAP and
HeLa S3 cDNA in lambda gt10"
CDS 1..6858
/codon_start=1
/product="DNA polymerase epsilon catalytic subunit"
/protein_id="AAA90924.1"
/translation="MSLRSGGRRRADPGADGEASRDDGATSSVSALKRLERSQWTDKM
DLRFGFERLKEPGEKTGWLINMHPTEILDEDKRLGSAVDYYFIQDDGSRFKVALPYKP
YFYIATRKGCEREVSSFLSKKFQGKIAKVETVPKEDLDLPNHLVGLKRNYIRLSFHTV
EDLVKVRKEISPAVKKNREQDHASDAYTALLSSVLQRGGVITDEEETSKKIADQLDNI
VDMREYDVPYHIRLSIDLKIHVAHWYNVRYRGNAFPVEITRRDDLVERPDPVVLAFDI
ETTKLPLKFPDAETDQIMMISYMIDGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCV
FNEPDEAHLIQRWFEHVQETKPTIMVTYNGDFFDWPFVEARAAVHGLSMQQEIGFQKD
SQGEYKAPQCIHMDCLRWVKRDSYLPVGSHNLKAAASKLGYDPVELDPEDMCRMATEQ
PQTLATYSVSDAVATYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQA
FHANIIFPNKQEQEFNKLTDDGHVLDSETYVGGHVEALESGVFRSDIPCRFRMNPAAF
DFLLQRVEKTLRHALEEEEKVPVEQVTNFEEVCDEIKSKLASLKDVPSRIECPLIYHL
DVGAMYPNIILTNRLQPSAMVDEATCAACDFNKPGANCQRKMAWQWRGEFMPASRSEY
HRIQHQLESEKFPPLFPEGPARAFHELSREEQAKYEKRRLADYCRKAYKKIHITKVEE
RLTTICQRENSFYVDTVRAFRDRRYEFKGLHKVWKKKLSAAVEVGDAAEVKRCKNMEV
LYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCFTGANIITQARELIEQIGRPL
ELDTDGIWCVLPNSFPENFVFKTTNVKKPKVTISYPGAMLNIMVKEGFTNDQYQELAE
PSSLTYVTRSENSIFFEVDGPYLAMILPASKEEGKKLKKRYAVFNEDGSLAELKGFEV
KRRGELQLIKIFQSSVFEAFLKGSTLEEVYGSVAKVADYWLDVLYSKAANMPDSELFE
LISENRSMSRKLEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRYIISRKPEGSPV
TERAIPLAIFQAEPTVRKHFLRKWLKSSSLQDFDIRAILDWDYYIERLGSAIQKIITI
PAALQQVKNPVPRVKHPDWLHKKLLEKNDVYKQKKISELFTLEGRRQVTMAEASEDSP
RPSAPDMEDFGLVKLPHPAAPVTVKRKRVLWESQEESQDLTPTVPWQEILGQPPALGT
SQEEWLVWLRFHKKKWQLQARQRLARRKRQRLESADGVLRPGAIRDGPATGLGSFLRR
TARSILDLPWQIVQISETSQAGLFRLWALVGSDLHCIRLSIPRVFYVNQRVAKAEEGA
SYRKVNRVLPRSNMVYNLYEYSVPEDMYQEHINEINAELSAPDIEGVYETQVPLLFRA
LVHLGCVCVVNKQLVRHLSGWEAETFALEHLEMRSLAQFSYLEPGSIRHIYLYHHAQA
HKALFGIFIPSQRRASVFVLDTVRSNQMPSLGALYSAEHGLLLEKVGPELLPPPKHTF
EVRAETDLKTICRAIQRFLLAYKEERRGPTLIAVQSSWELKRLASEIPVLEEFPLVPI
CVADKINYGVLDWQRHGARRMIRHYLNLDTCLSQAFEMSRYFHIPIGNLPEDISTFGS
DLFFARHLQRHNHLLWLSPTARPDLGGKEADDNCLVMEFDDQATVEINSSGCYSTVCV
ELDLQNLAVNTILQSHHVNDMEGADSMGISFDVIQQASLEDMITGGQAASAPASYDET
ALCSNTFRILKSMVVGWVKEITQYHNIYADNQVMHFYRWLRSPSSLLHDPALHRTLHN
MMKKLFLQLIAEFKRLGSSVIYANFNRIILCTKKRRVEDAIAYVEYITSSIHSKETFH
SLTISFSRCWEFLLWMDPSNYGGIKGKVSSRIHCGLQDSQKAGGAEDEQENEDDEEER
DGEEEEEAEESNVEDLLENNWNILQFLPQAASCQNYFLMIVSAYIVAVYHCMKDGLRR
SAPGSTPVRRRGASQLSQEAEGAVGALPGMITFSQDYVANELTQSFFTITQKIQKKVT
GSRNSTELSEMFPVLPGSHLLLNNPALEFIKYVCKVLSLDTNITNQVNKLNRDLLRLV
DVGEFSEEAQFRDPCRSYVLPEVICRSCNFCRDLDLCKDSSFSEDGAVLPQWLCSNCQ
APYDSSAIEMTLVEVLQKKLMAFTLQDLVCLKCRGVKETSMPVYCSCAGDFALTIHTQ
VFMEQIGIFRNIAQHYGMSYLLETLEWLLQKNPQLGH"
BASE COUNT 1591 a 1917 c 1928 g 1422 t
ORIGIN
1 atgtctctga ggagcggcgg gcggcggcgc gcggacccag gcgcggatgg cgaggccagc
61 agggatgatg gcgccacttc ctcagtttcg gcactcaagc gcctggaacg gagtcagtgg
121 acggataaga tggatttgcg gtttggtttt gagcggctga aggagcctgg tgagaagaca
181 ggctggctca ttaacatgca tcctaccgag attttagatg aagataagcg cttaggcagt
241 gcagtggatt actactttat tcaagatgac ggaagcagat ttaaggtggc tttgccctat
301 aaaccgtatt tctacattgc gaccagaaag ggttgtgagc gagaagtttc atcttttctc
361 tccaagaagt ttcagggcaa aattgcaaaa gtggagactg tccccaaaga ggatctggac
421 ttgccaaatc acttggtggg tttgaagcga aattacatca ggctgtcctt ccacactgtg
481 gaggatcttg tcaaagtgag gaaggagatc tcccctgccg tgaagaagaa cagggagcag
541 gatcacgcca gcgacgcgta cacagctctg ctttccagtg ttctgcagag gggcggtgtc
601 attactgatg aagaggaaac ctctaagaag atagctgacc agttggacaa cattgtggac
661 atgcgcgagt acgatgttcc ctaccacatc cgcctctcca ttgacctgaa gatccacgtg
721 gctcattggt acaatgtcag ataccgagga aatgcttttc cggtagaaat cacccgccga
781 gatgaccttg ttgaacgacc tgaccctgtg gttttggcat ttgacattga gacgaccaaa
841 ctgcccctca agtttcctga tgctgagaca gaccagatta tgatgatttc ctacatgatc
901 gatggccagg gctacctcat caccaacagg gagattgttt cagaagatat tgaagatttt
961 gagttcaccc ccaagccaga atatgaaggc cccttttgtg tcttcaatga acccgatgag
1021 gctcatctga tccaaaggtg gtttgaacac gtccaggaga ccaaacccac catcatggtc
1081 acctacaacg gggacttttt tgactggcca tttgtggagg cccgggcagc agtccacggt
1141 ctgagcatgc agcaggagat aggcttccag aaggacagcc agggggagta caaggcgccc
1201 cagtgcatcc acatggactg cctcaggtgg gtgaagaggg acagttacct tcctgtgggc
1261 agtcataatc tcaaggcggc cgcaagcaag ctaggctatg atcccgtgga gctagacccg
1321 gaggacatgt gccggatggc cacggagcag ccccagactc tggccacgta ttctgtgtca
1381 gatgctgtcg ccacttacta cctgtacatg aagtacgtcc acccattcat ctttgctctg
1441 tgcaccatta ttcccatgga gcccgacgag gtgctgcgga agggctctgg cactctgtgt
1501 gaggccttgc tgatggtgca ggccttccac gccaacatca tcttccccaa caagcaagag
1561 caggagttca ataagctgac ggacgacgga cacgtgctgg actctgagac ctacgtcggg
1621 ggccacgtgg aggccctcga gtctggggtt ttccgcagcg atatcccttg ccggtttagg
1681 atgaatcctg ccgcctttga cttcctgctg cagcgggttg agaagacctt gcgccacgcc
1741 cttgaggaag aggagaaagt gcctgtggag caagtcacca actttgaaga ggtgtgtgat
1801 gagattaaga gcaagcttgc ctccctgaag gacgttccca gccgcatcga gtgtccactc
1861 atctaccacc tggacgtggg ggccatgtac cccaacatca tcctgaccaa ccgcctgcag
1921 ccctctgcca tggtggacga agccacctgt gctgcctgtg acttcaataa gcctggagca
1981 aactgccagc ggaagatggc ctggcagtgg aggggcgagt tcatgccagc cagtcgcagc
2041 gaataccatc ggatccagca ccagctggag tcagagaagt tccccccctt gttcccagag
2101 gggccagctc gggcctttca tgaactgtcc cgcgaggaac aggcgaaata cgagaagaga
2161 aggctggcgg attactgccg gaaagcctac aagaagatcc acatcaccaa ggtggaagag
2221 cgtctcacca ccatctgcca gcgggaaaac tccttctacg tggacaccgt gcgtgccttc
2281 cgggacaggc gttacgagtt caaagggctc cacaaggtgt ggaaaaagaa gctctcggcg
2341 gccgtggagg tgggcgacgc ggctgaggtg aagcgctgca agaacatgga ggtgctgtat
2401 gactcgctgc agctggccca caagtgcatc ctgaactcct tctatggcta tgtcatgcgc
2461 aagggggctc gctggtactc catggagatg gctggcatcg tctgcttcac aggggccaac
2521 atcatcaccc aggcacggga gctgatcgag cagattggga ggcccttaga gctggacaca
2581 gatggtatat ggtgcgtcct gcccaacagc ttcccagaaa attttgtctt caagacgacc
2641 aatgtgaaga agcccaaagt gaccatctcc tacccaggcg ccatgttgaa catcatggtc
2701 aaggaaggct tcaccaatga ccagtaccag gagctggctg agccgtcctc actcacctac
2761 gtcacccgct cagagaacag catctttttt gaggttgatg ggccctacct tgccatgatt
2821 cttccagcct ccaaggaaga aggcaagaaa ttgaagaaga ggtatgctgt gttcaatgaa
2881 gacggttctc tggctgagct caagggcttt gaggtcaaac gccgcgggga actgcagctg
2941 attaagatct tccaatcctc ggtgtttgag gccttcctca agggcagcac gctggaagag
3001 gtgtatggct ctgtagccaa ggtggctgac tactggctgg acgtgctgta cagcaaggca
3061 gccaacatgc ctgactctga gctattcgag ctcatctctg agaaccgttc catgtctcgg
3121 aaactggaag attacgggga gcagaagtct acatccatca gcacagcaaa gcgcctggcc
3181 gagttcctgg gagaccagat ggtcaaggat gcagggctga gttgccgcta catcatctcc
3241 cgcaagcccg agggctcccc tgtcacggag agggccatcc cacttgccat tttccaagca
3301 gagcccacgg tgaggaagca ctttctccgg aaatggctca agagctcttc ccttcaagac
3361 tttgatattc gagcaattct ggattgggac tactacattg agcggctggg aagcgccatc
3421 cagaagatca tcaccatccc tgcggccctg cagcaggtaa agaacccagt gccacgtgtc
3481 aaacaccccg actggctgca caaaaaactg ctggagaaga atgatgtcta caagcagaag
3541 aagatcagtg agctcttcac cctggagggc aggagacagg tcacgatggc cgaggcctca
3601 gaagacagtc cgaggccaag tgctcctgac atggaggact tcggcctcgt aaagctgcct
3661 cacccagcag cccctgtcac tgtgaagagg aagcgagttc tttgggagag ccaggaggag
3721 tcccaggacc tcacgccgac tgtgccctgg caggaaatct tggggcagcc tcccgccctg
3781 ggaaccagcc aggaggaatg gcttgtctgg ctccggttcc acaagaagaa gtggcagctg
3841 caggcccggc agcgcctcgc ccgcaggaag aggcagcgtc tggagtcggc agatggtgtg
3901 ctcaggcccg gggccatccg ggatggtcct gccacggggc tggggagctt cttgcgaaga
3961 actgcccgca gcatcctgga ccttccgtgg cagattgtgc agatcagcga gaccagccag
4021 gccggcctgt tcaggctgtg ggcgctcgtt ggcagtgact tgcactgcat caggctgagc
4081 atcccccgtg tgttctacgt gaaccagcga gtcgctaaag cggaggaggg tgcttcgtat
4141 cgcaaggtaa atcgggtcct tcctcgctcc aacatggtct acaatctcta tgagtattca
4201 gtgccagagg acatgtacca ggaacacatc aacgagatca acgctgagct gtcagcgcca
4261 gacatcgagg gcgtatatga gactcaggtt ccgttactgt tccgggccct ggtgcacctg
4321 ggctgtgtgt gtgtggtcaa taaacagctg gtgaggcacc tttcaggctg ggaagcagag
4381 acctttgctc ttgagcacct ggagatgcgc tctctggccc agttcagcta cctggaacca
4441 gggagtatcc gccatatcta cctgtaccac cacgcacagg cccacaaagc gctcttcggg
4501 atcttcatcc cctcacagcg cagggcatcc gtctttgtgc tggacactgt gcgcagcaac
4561 cagatgccca gccttggcgc cctgtactca gcagagcacg gcctcctcct ggagaaggtg
4621 ggccctgagc tcctgccacc ccccaaacac accttcgaag ttcgggcaga aactgacctg
4681 aagaccatct gcagagccat ccagcgattc ctgctcgcct acaaggagga gcgccggggg
4741 cccacactca tcgctgttca gtccagctgg gagctgaaga ggctggccag tgaaattcct
4801 gtcttggagg aattcccact ggtgcctatc tgtgtggctg acaagatcaa ctatggggtc
4861 ctggactggc agcgccatgg agcccggcgc atgatccgtc actacctcaa cctggacacc
4921 tgcctgtcgc aggccttcga gatgagcagg tactttcaca ttcccattgg gaacctacca
4981 gaggacatct ccacattcgg ctccgacctc ttctttgccc gccacctcca gcgtcacaac
5041 cacctgctct ggctgtcccc tacagcccgc cctgacctgg gtggaaagga ggctgatgac
5101 aactgtcttg tcatggagtt cgatgaccaa gccactgttg agatcaacag ttcaggctgt
5161 tactccacag tgtgtgtgga gctggacctt cagaacctgg ccgtcaacac cattctccag
5221 tctcaccatg tcaacgacat ggagggggcc gacagcatgg ggatcagctt cgacgtgatc
5281 cagcaggcct ccctggagga catgatcacg ggtggtcagg ctgccagtgc cccggccagc
5341 tacgatgaga cagccctgtg ctctaacacc ttcaggatcc tgaagagcat ggtcgtgggc
5401 tgggtgaagg agatcaccca gtaccacaac atctatgcag acaaccaggt gatgcacttc
5461 taccgctggc ttcggtcgcc atcctctctg cttcatgacc ctgccctgca ccgcacactc
5521 cacaacatga tgaagaagct cttcctgcag ctcatcgctg agttcaagcg cctggggtca
5581 tcagtcatct acgccaactt caaccgcatc atcctctgta caaagaagcg ccgtgtggaa
5641 gatgccatcg cttacgtgga gtacatcacc agcagcatcc attcaaagga gaccttccat
5701 tctctgacaa tttctttctc tcgatgctgg gaatttcttc tctggatgga tccatctaac
5761 tatggcggaa tcaaaggaaa agtttcatct cgtattcact gtggactgca agactcccag
5821 aaagcagggg gagcagagga tgagcaggaa aatgaggacg atgaggagga aagagatggg
5881 gaggaggagg aagaggcgga ggaatccaac gtggaggatt tactggaaaa caactggaac
5941 attttgcagt ttttgccaca ggcagcctcc tgccagaact acttcctcat gattgtttca
6001 gcgtacatcg tggccgtgta ccactgcatg aaggacgggc tgaggcgcag tgctccaggg
6061 agcacccccg tgaggaggag gggggccagc cagctctccc aggaggccga gggggcggtc
6121 ggagcccttc ccggaatgat caccttctct caggattatg tcgcaaatga gctcactcag
6181 agcttcttca ccatcactca gaagattcag aagaaagtca caggctctcg gaactccact
6241 gagctctcgg agatgtttcc tgtcctcccc ggttcccact tgctgctcaa taaccctgcc
6301 ctggagttca tcaaatacgt gtgcaaggtg ctgtccctgg acaccaacat cacaaaccag
6361 gtgaataagc tgaaccgaga cctgcttcgc ctggtggatg tcggcgagtt ctccgaggag
6421 gcccagttcc gagacccctg ccgctcctac gtgcttcctg aggtcatctg ccgcagctgt
6481 aacttctgcc gcgacctgga cctgtgtaaa gactcttcct tctcagagga tggggcggtc
6541 ctgcctcagt ggctctgctc caactgtcag gcgccctacg actcctctgc catcgagatg
6601 acgctggtgg aagttctaca gaagaagctg atggccttca ccctgcagga cctggtctgc
6661 ctgaagtgcc gcggggtgaa ggagaccagc atgcctgtgt actgcagctg cgcgggagac
6721 ttcgccctca ccatccacac ccaggtcttc atggaacaga tcggaatatt ccggaacatt
6781 gcccagcact acggcatgtc gtacctcctg gagaccctgg agtggctgct gcagaagaac
6841 ccacagctgg gccattag
//