LOCUS       HSU49248                5300 bp    mRNA    linear   HUM 01-OCT-1996
DEFINITION  Human canalicular multispecific organic anion transporter (cMOAT),
            gene, complete cds.
ACCESSION   U49248
VERSION     U49248.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5300)
  AUTHORS   Kool,M., de Haas,M., Ponne,N.J., Paulusma,C.C.,
            Oude-Elferink,R.P.J., Baas,F. and Borst,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-FEB-1996) Molecular Biology, The Netherlands Cancer
            Institute, Plesmanlaan 121, Amsterdam 1066 CX, The Netherlands
FEATURES             Location/Qualifiers
     source          1..5300
                     /db_xref="H-InvDB:HIT000220086"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /tissue_type="liver and spleen"
                     /clone_lib="Clontech No. HL3006b; library 1NFLS made by
                     Bento Soares and M. Fatima Bonaldo."
                     /dev_stage="fetus"
     source          1..140
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="124379"
                     /note="obtained from the WashU-Merck EST project"
     gene            1..5300
                     /gene="cMOAT"
     CDS             102..4739
                     /gene="cMOAT"
                     /note="similar to human multidrug resistance-associated
                     protein (MRP), Swiss-Prot Accession Number P33527"
                     /codon_start=1
                     /product="canalicular multispecific organic anion
                     transporter"
                     /protein_id="AAB09422.1"
                     /translation="MLEKFCNSTFWNSSFLDSPEADLPLCFEQTVLVWIPLGFLWLLA
                     PWQLLHVYKSRTKRSSTTKLYLAKQVFVGFLLILAAIELALVLTEDSGQATVPAVRYT
                     NPSLYLGTWLLVLLIQYSRQWCVQKNSWFLSLFWILSILCGTFQFQTLIRTLLQGDNS
                     NLAYSCLFFISYGFQILILIFSAFSENNESSNNPSSIASFLSSITYSWYDSIILKGYK
                     RPLTLEDVWEVDEEMKTKTLVSKFETHMKRELQKARRALQRRQEKSSQQNSGARLPGL
                     NKNQSQSQDALVLEDVEKKKKKSGTKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDI
                     FTFVSPQLLKLLISFASDRDTYLWIGYLCAILLFTAALIQSFCLQCYFQLCFKLGVKV
                     RTAIMASVYKKALTLSNLARKEYTVGETVNLMSVDAQKLMDVTNFMHMLWSSVLQIVL
                     SIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVKNMKNKDKRLKIMNEILSG
                     IKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFVFQLTPVLVSVVTFSVYV
                     LVDSNNILDAQKAFTSITLFNILRFPLSMLPMMISSMLQASVSTERLEKYLGGDDLDT
                     SAIRHDCNFDKAMQFSEASFTWEHDSEATVRDVNLDIMAGQLVAVIGPVGSGKSSLIS
                     AMLGEMENVHGHITIKGTTAYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALL
                     PDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKH
                     IFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFA
                     KNLKTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAASITMRRENSFRRTLS
                     RSSRSNGRHLKSLRNSLKTRNVNSLKEDEELVKGQKLIKKEFIETGKVKFSIYLEYLQ
                     AIGLFSIFFIILAFVMNSVAFIGSNLWLSAWTSDSKIFNSTDYPASQRDMRVGVYGAL
                     GLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFAGDI
                     STVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTSR
                     QLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEERIDTNQKCVFSWITSN
                     RWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVRMTSEI
                     ETNIVAVERITEYTKVENEAPWVTDKRPPPDWPSKGKIQFNNYQVRYRPELDLVLRGI
                     TCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLT
                     IIPQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGN
                     LSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHR
                     LHTIMDSDKVMVLDNGKIIEYGSPEELLQIPGPFYFMAKEAGIENVNSTKF"
BASE COUNT         1451 a         1233 c         1190 g         1426 t
ORIGIN      
        1 aggataattc ctgttccact ttctttgatg aaacaagtaa agaagaaaca acacaatcat
       61 attaatagaa gagtcttcgt tccagacgca gtccaggaat catgctggag aagttctgca
      121 actctacttt ttggaattcc tcattcctgg acagtccgga ggcagacctg ccactttgtt
      181 ttgagcaaac tgttctggtg tggattccct tgggcttcct atggctcctg gccccctggc
      241 agcttctcca cgtgtataaa tccaggacca agagatcctc taccaccaaa ctctatcttg
      301 ctaagcaggt attcgttggt tttcttctta ttctagcagc catagagctg gcccttgtac
      361 tcacagaaga ctctggacaa gccacagtcc ctgctgttcg atataccaat ccaagcctct
      421 acctaggcac atggctcctg gttttgctga tccaatacag cagacaatgg tgtgtacaga
      481 aaaactcctg gttcctgtcc ctattctgga ttctctcgat actctgtggc actttccaat
      541 ttcagactct gatccggaca ctcttacagg gtgacaattc taatctagcc tactcctgcc
      601 tgttcttcat ctcctacgga ttccagatcc tgatcctgat cttttcagca ttttcagaaa
      661 ataatgagtc atcaaataat ccatcatcca tagcttcatt cctgagtagc attacctaca
      721 gctggtatga cagcatcatt ctgaaaggct acaagcgtcc tctgacactc gaggatgtct
      781 gggaagttga tgaagagatg aaaaccaaga cattagtgag caagtttgaa acgcacatga
      841 agagagagct gcagaaagcc aggcgggcac tccagagacg gcaggagaag agctcccagc
      901 agaactctgg agccaggctg cctggcttga acaagaatca gagtcaaagc caagatgccc
      961 ttgtcctgga agatgttgaa aagaaaaaaa agaagtctgg gaccaaaaaa gatgttccaa
     1021 aatcctggtt gatgaaggct ctgttcaaaa ctttctacat ggtgctcctg aaatcattcc
     1081 tactgaagct agtgaatgac atcttcacgt ttgtgagtcc tcagctgctg aaattgctga
     1141 tctcctttgc aagtgaccgt gacacatatt tgtggattgg atatctctgt gcaatcctct
     1201 tattcactgc ggctctcatt cagtctttct gccttcagtg ttatttccaa ctgtgcttca
     1261 agctgggtgt aaaagtacgg acagctatca tggcttctgt atataagaag gcattgaccc
     1321 tatccaactt ggccaggaag gagtacaccg ttggagaaac agtgaacctg atgtctgtgg
     1381 atgcccagaa gctcatggat gtgaccaact tcatgcacat gctgtggtca agtgttctac
     1441 agattgtctt atctatcttc ttcctatgga gagagttggg accctcagtc ttagcaggtg
     1501 ttggggtgat ggtgcttgta atcccaatta atgcgatact gtccaccaag agtaagacca
     1561 ttcaggtcaa aaatatgaag aataaagaca aacgtttaaa gatcatgaat gagattctta
     1621 gtggaatcaa gatcctgaaa tattttgcct gggaaccttc attcagagac caagtacaaa
     1681 acctccggaa gaaagagctc aagaacctgc tggcctttag tcaactacag tgtgtagtaa
     1741 tattcgtctt ccagttaact ccagtcctgg tatctgtggt cacattttct gtttatgtcc
     1801 tggtggatag caacaatatt ttggatgcac aaaaggcctt cacctccatt accctcttca
     1861 atatcctgcg ctttcccctg agcatgcttc ccatgatgat ctcctccatg ctccaggcca
     1921 gtgtttccac agagcggcta gagaagtact tgggagggga tgacttggac acatctgcca
     1981 ttcgacatga ctgcaatttt gacaaagcca tgcagttttc tgaggcctcc tttacctggg
     2041 aacatgattc ggaagccaca gtccgagatg tgaacctgga cattatggca ggccaacttg
     2101 tggctgtgat aggccctgtc ggctctggga aatcctcctt gatatcagcc atgctgggag
     2161 aaatggaaaa tgtccacggg cacatcacca tcaagggcac cactgcctat gtcccacagc
     2221 agtcctggat tcagaatggc accataaagg acaacatcct ttttggaaca gagtttaatg
     2281 aaaagaggta ccagcaagta ctggaggcct gtgctctcct cccagacttg gaaatgctgc
     2341 ctggaggaga tttggctgag attggagaga agggtataaa tcttagtggg ggtcagaagc
     2401 agcggatcag cctggccaga gctacctacc aaaatttaga catctatctt ctagatgacc
     2461 ccctgtctgc agtggatgct catgtaggaa aacatatttt taataaggtc ttgggcccca
     2521 atggcctgtt gaaaggcaag actcgactct tggttacaca tagcatgcac tttcttcctc
     2581 aagtggatga gattgtagtt ctggggaatg gaacaattgt agagaaagga tcctacagtg
     2641 ctctcctggc caaaaaagga gagtttgcta agaatctgaa gacatttcta agacatacag
     2701 gccctgaaga ggaagccaca gtccatgatg gcagtgaaga agaagacgat gactatgggc
     2761 tgatatccag tgtggaagag atccccgaag atgcagcctc cataaccatg agaagagaga
     2821 acagctttcg tcgaacactt agccgcagtt ctaggtccaa tggcaggcat ctgaagtccc
     2881 tgagaaactc cttgaaaact cggaatgtga atagcctgaa ggaagacgaa gaactagtga
     2941 aaggacaaaa actaattaag aaggaattca tagaaactgg aaaggtgaag ttctccatct
     3001 acctggagta cctacaagca ataggattgt tttcgatatt cttcatcatc cttgcgtttg
     3061 tgatgaattc tgtggctttt attggatcca acctctggct cagtgcttgg accagtgact
     3121 ctaaaatctt caatagcacc gactatccag catctcagag ggacatgaga gttggagtct
     3181 acggagctct gggattagcc caaggtatat ttgtgttcat agcacatttc tggagtgcct
     3241 ttggtttcgt ccatgcatca aatatcttgc acaagcaact gctgaacaat atccttcgag
     3301 cacctatgag attttttgac acaacaccca caggccggat tgtgaacagg tttgccggcg
     3361 atatttccac agtggatgac accctgcctc agtccttgcg cagctggatt acatgcttcc
     3421 tggggataat cagcaccctt gtcatgatct gcatggccac tcctgtcttc accatcatcg
     3481 tcattcctct tggcattatt tatgtatctg ttcagatgtt ttatgtgtct acctcccgcc
     3541 agctgaggcg tctggactct gtcaccaggt ccccaatcta ctctcacttc agcgagaccg
     3601 tatcaggttt gccagttatc cgtgcctttg agcaccagca gcgatttctg aaacacaatg
     3661 aggagaggat tgacaccaac cagaaatgtg tcttttcctg gatcacctcc aacaggtggc
     3721 ttgcaattcg cctggagctg gttgggaacc tgactgtctt cttttcagcc ttgatgatgg
     3781 ttatttatag agatacccta agtggggaca ctgttggctt tgttctgtcc aatgcactca
     3841 atatcacaca aaccctgaac tggctggtga ggatgacatc agaaatagag accaacattg
     3901 tggctgttga gcgaataact gagtacacaa aagtggaaaa tgaggcaccc tgggtgactg
     3961 ataagaggcc tccgccagat tggcccagca aaggcaagat ccagtttaac aactaccaag
     4021 tgcggtaccg acctgagctg gatctggtcc tcagagggat cacttgtgac atcggtagca
     4081 tggagaagat tggtgtggtg ggcaggacag gagctggaaa gtcatccctc acaaactgcc
     4141 tcttcagaat cttagaggct gccggtggtc agattatcat tgatggagta gatattgctt
     4201 ccattgggct ccacgacctc cgagagaagc tgaccatcat cccccaggac cccatcctgt
     4261 tctctggaag cctgaggatg aatctcgacc ctttcaacaa ctactcagat gaggagattt
     4321 ggaaggcctt ggagctggct cacctcaagt cttttgtggc cagcctgcaa cttgggttat
     4381 cccacgaagt tacagaggct ggtggcaacc tgagcatagg ccagaggcag ctgctgtgcc
     4441 tgggcagggc tctgcttcgg aaatccaaga tcctggtcct ggatgaggcc actgctgcgg
     4501 tggatctaga gacagacaac ctcattcaga cgaccatcca aaacgagttc gcccactgca
     4561 cagtgatcac catcgcccac aggctgcata ccatcatgga cagtgacaag gtaatggtcc
     4621 tagacaacgg gaagattata gagtacggca gccctgaaga actgctacaa atccctggac
     4681 ccttttactt tatggctaag gaagctggca ttgagaatgt gaacagcaca aaattctagc
     4741 agaaggcccc atgggttaga aaaggactat aagaataatt tcttatttaa ttttattttt
     4801 tataaaatac agaatacata caaaagtgtg tataaaatgt acgttttaaa aaaggataag
     4861 tgaacaccca tgaacctact acccaggtta agaaaataaa tgtcaccagg tacttgagaa
     4921 acccctcgat tgtctacctc gatcgtactt ccttgctacc cacccctccc agggacaacc
     4981 actgtcctga atttcacgat aattattcct ttgcctttca tttctgtttt atcacctttg
     5041 tatgtatctt taaacaacat ataccctttt ttacttatgt aaatggactg actcatactg
     5101 catacatctt ctatgacttg attcttttgt tcaatattat atctgagatt catccatggt
     5161 gatgcaaata ggtgcattat tttttttcac tgctctgtag tctggcattg tatgaataca
     5221 gcacaatgta tcagttttaa tattggggat cattagcatt attctcaggt ttttaaaaat
     5281 tataagcagt actactatgg
//