LOCUS HSU49248 5300 bp mRNA linear HUM 01-OCT-1996 DEFINITION Human canalicular multispecific organic anion transporter (cMOAT), gene, complete cds. ACCESSION U49248 VERSION U49248.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 5300) AUTHORS Kool,M., de Haas,M., Ponne,N.J., Paulusma,C.C., Oude-Elferink,R.P.J., Baas,F. and Borst,P. TITLE Direct Submission JOURNAL Submitted (14-FEB-1996) Molecular Biology, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam 1066 CX, The Netherlands FEATURES Location/Qualifiers source 1..5300 /db_xref="H-InvDB:HIT000220086" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /tissue_type="liver and spleen" /clone_lib="Clontech No. HL3006b; library 1NFLS made by Bento Soares and M. Fatima Bonaldo." /dev_stage="fetus" source 1..140 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /clone="124379" /note="obtained from the WashU-Merck EST project" gene 1..5300 /gene="cMOAT" CDS 102..4739 /gene="cMOAT" /note="similar to human multidrug resistance-associated protein (MRP), Swiss-Prot Accession Number P33527" /codon_start=1 /product="canalicular multispecific organic anion transporter" /protein_id="AAB09422.1" /translation="MLEKFCNSTFWNSSFLDSPEADLPLCFEQTVLVWIPLGFLWLLA PWQLLHVYKSRTKRSSTTKLYLAKQVFVGFLLILAAIELALVLTEDSGQATVPAVRYT NPSLYLGTWLLVLLIQYSRQWCVQKNSWFLSLFWILSILCGTFQFQTLIRTLLQGDNS NLAYSCLFFISYGFQILILIFSAFSENNESSNNPSSIASFLSSITYSWYDSIILKGYK RPLTLEDVWEVDEEMKTKTLVSKFETHMKRELQKARRALQRRQEKSSQQNSGARLPGL NKNQSQSQDALVLEDVEKKKKKSGTKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDI FTFVSPQLLKLLISFASDRDTYLWIGYLCAILLFTAALIQSFCLQCYFQLCFKLGVKV RTAIMASVYKKALTLSNLARKEYTVGETVNLMSVDAQKLMDVTNFMHMLWSSVLQIVL SIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVKNMKNKDKRLKIMNEILSG IKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFVFQLTPVLVSVVTFSVYV LVDSNNILDAQKAFTSITLFNILRFPLSMLPMMISSMLQASVSTERLEKYLGGDDLDT SAIRHDCNFDKAMQFSEASFTWEHDSEATVRDVNLDIMAGQLVAVIGPVGSGKSSLIS AMLGEMENVHGHITIKGTTAYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALL PDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKH IFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFA KNLKTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAASITMRRENSFRRTLS RSSRSNGRHLKSLRNSLKTRNVNSLKEDEELVKGQKLIKKEFIETGKVKFSIYLEYLQ AIGLFSIFFIILAFVMNSVAFIGSNLWLSAWTSDSKIFNSTDYPASQRDMRVGVYGAL GLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFAGDI STVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTSR QLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEERIDTNQKCVFSWITSN RWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVRMTSEI ETNIVAVERITEYTKVENEAPWVTDKRPPPDWPSKGKIQFNNYQVRYRPELDLVLRGI TCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLT IIPQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGN LSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHR LHTIMDSDKVMVLDNGKIIEYGSPEELLQIPGPFYFMAKEAGIENVNSTKF" BASE COUNT 1451 a 1233 c 1190 g 1426 t ORIGIN 1 aggataattc ctgttccact ttctttgatg aaacaagtaa agaagaaaca acacaatcat 61 attaatagaa gagtcttcgt tccagacgca gtccaggaat catgctggag aagttctgca 121 actctacttt ttggaattcc tcattcctgg acagtccgga ggcagacctg ccactttgtt 181 ttgagcaaac tgttctggtg tggattccct tgggcttcct atggctcctg gccccctggc 241 agcttctcca cgtgtataaa tccaggacca agagatcctc taccaccaaa ctctatcttg 301 ctaagcaggt attcgttggt tttcttctta ttctagcagc catagagctg gcccttgtac 361 tcacagaaga ctctggacaa gccacagtcc ctgctgttcg atataccaat ccaagcctct 421 acctaggcac atggctcctg gttttgctga tccaatacag cagacaatgg tgtgtacaga 481 aaaactcctg gttcctgtcc ctattctgga ttctctcgat actctgtggc actttccaat 541 ttcagactct gatccggaca ctcttacagg gtgacaattc taatctagcc tactcctgcc 601 tgttcttcat ctcctacgga ttccagatcc tgatcctgat cttttcagca ttttcagaaa 661 ataatgagtc atcaaataat ccatcatcca tagcttcatt cctgagtagc attacctaca 721 gctggtatga cagcatcatt ctgaaaggct acaagcgtcc tctgacactc gaggatgtct 781 gggaagttga tgaagagatg aaaaccaaga cattagtgag caagtttgaa acgcacatga 841 agagagagct gcagaaagcc aggcgggcac tccagagacg gcaggagaag agctcccagc 901 agaactctgg agccaggctg cctggcttga acaagaatca gagtcaaagc caagatgccc 961 ttgtcctgga agatgttgaa aagaaaaaaa agaagtctgg gaccaaaaaa gatgttccaa 1021 aatcctggtt gatgaaggct ctgttcaaaa ctttctacat ggtgctcctg aaatcattcc 1081 tactgaagct agtgaatgac atcttcacgt ttgtgagtcc tcagctgctg aaattgctga 1141 tctcctttgc aagtgaccgt gacacatatt tgtggattgg atatctctgt gcaatcctct 1201 tattcactgc ggctctcatt cagtctttct gccttcagtg ttatttccaa ctgtgcttca 1261 agctgggtgt aaaagtacgg acagctatca tggcttctgt atataagaag gcattgaccc 1321 tatccaactt ggccaggaag gagtacaccg ttggagaaac agtgaacctg atgtctgtgg 1381 atgcccagaa gctcatggat gtgaccaact tcatgcacat gctgtggtca agtgttctac 1441 agattgtctt atctatcttc ttcctatgga gagagttggg accctcagtc ttagcaggtg 1501 ttggggtgat ggtgcttgta atcccaatta atgcgatact gtccaccaag agtaagacca 1561 ttcaggtcaa aaatatgaag aataaagaca aacgtttaaa gatcatgaat gagattctta 1621 gtggaatcaa gatcctgaaa tattttgcct gggaaccttc attcagagac caagtacaaa 1681 acctccggaa gaaagagctc aagaacctgc tggcctttag tcaactacag tgtgtagtaa 1741 tattcgtctt ccagttaact ccagtcctgg tatctgtggt cacattttct gtttatgtcc 1801 tggtggatag caacaatatt ttggatgcac aaaaggcctt cacctccatt accctcttca 1861 atatcctgcg ctttcccctg agcatgcttc ccatgatgat ctcctccatg ctccaggcca 1921 gtgtttccac agagcggcta gagaagtact tgggagggga tgacttggac acatctgcca 1981 ttcgacatga ctgcaatttt gacaaagcca tgcagttttc tgaggcctcc tttacctggg 2041 aacatgattc ggaagccaca gtccgagatg tgaacctgga cattatggca ggccaacttg 2101 tggctgtgat aggccctgtc ggctctggga aatcctcctt gatatcagcc atgctgggag 2161 aaatggaaaa tgtccacggg cacatcacca tcaagggcac cactgcctat gtcccacagc 2221 agtcctggat tcagaatggc accataaagg acaacatcct ttttggaaca gagtttaatg 2281 aaaagaggta ccagcaagta ctggaggcct gtgctctcct cccagacttg gaaatgctgc 2341 ctggaggaga tttggctgag attggagaga agggtataaa tcttagtggg ggtcagaagc 2401 agcggatcag cctggccaga gctacctacc aaaatttaga catctatctt ctagatgacc 2461 ccctgtctgc agtggatgct catgtaggaa aacatatttt taataaggtc ttgggcccca 2521 atggcctgtt gaaaggcaag actcgactct tggttacaca tagcatgcac tttcttcctc 2581 aagtggatga gattgtagtt ctggggaatg gaacaattgt agagaaagga tcctacagtg 2641 ctctcctggc caaaaaagga gagtttgcta agaatctgaa gacatttcta agacatacag 2701 gccctgaaga ggaagccaca gtccatgatg gcagtgaaga agaagacgat gactatgggc 2761 tgatatccag tgtggaagag atccccgaag atgcagcctc cataaccatg agaagagaga 2821 acagctttcg tcgaacactt agccgcagtt ctaggtccaa tggcaggcat ctgaagtccc 2881 tgagaaactc cttgaaaact cggaatgtga atagcctgaa ggaagacgaa gaactagtga 2941 aaggacaaaa actaattaag aaggaattca tagaaactgg aaaggtgaag ttctccatct 3001 acctggagta cctacaagca ataggattgt tttcgatatt cttcatcatc cttgcgtttg 3061 tgatgaattc tgtggctttt attggatcca acctctggct cagtgcttgg accagtgact 3121 ctaaaatctt caatagcacc gactatccag catctcagag ggacatgaga gttggagtct 3181 acggagctct gggattagcc caaggtatat ttgtgttcat agcacatttc tggagtgcct 3241 ttggtttcgt ccatgcatca aatatcttgc acaagcaact gctgaacaat atccttcgag 3301 cacctatgag attttttgac acaacaccca caggccggat tgtgaacagg tttgccggcg 3361 atatttccac agtggatgac accctgcctc agtccttgcg cagctggatt acatgcttcc 3421 tggggataat cagcaccctt gtcatgatct gcatggccac tcctgtcttc accatcatcg 3481 tcattcctct tggcattatt tatgtatctg ttcagatgtt ttatgtgtct acctcccgcc 3541 agctgaggcg tctggactct gtcaccaggt ccccaatcta ctctcacttc agcgagaccg 3601 tatcaggttt gccagttatc cgtgcctttg agcaccagca gcgatttctg aaacacaatg 3661 aggagaggat tgacaccaac cagaaatgtg tcttttcctg gatcacctcc aacaggtggc 3721 ttgcaattcg cctggagctg gttgggaacc tgactgtctt cttttcagcc ttgatgatgg 3781 ttatttatag agatacccta agtggggaca ctgttggctt tgttctgtcc aatgcactca 3841 atatcacaca aaccctgaac tggctggtga ggatgacatc agaaatagag accaacattg 3901 tggctgttga gcgaataact gagtacacaa aagtggaaaa tgaggcaccc tgggtgactg 3961 ataagaggcc tccgccagat tggcccagca aaggcaagat ccagtttaac aactaccaag 4021 tgcggtaccg acctgagctg gatctggtcc tcagagggat cacttgtgac atcggtagca 4081 tggagaagat tggtgtggtg ggcaggacag gagctggaaa gtcatccctc acaaactgcc 4141 tcttcagaat cttagaggct gccggtggtc agattatcat tgatggagta gatattgctt 4201 ccattgggct ccacgacctc cgagagaagc tgaccatcat cccccaggac cccatcctgt 4261 tctctggaag cctgaggatg aatctcgacc ctttcaacaa ctactcagat gaggagattt 4321 ggaaggcctt ggagctggct cacctcaagt cttttgtggc cagcctgcaa cttgggttat 4381 cccacgaagt tacagaggct ggtggcaacc tgagcatagg ccagaggcag ctgctgtgcc 4441 tgggcagggc tctgcttcgg aaatccaaga tcctggtcct ggatgaggcc actgctgcgg 4501 tggatctaga gacagacaac ctcattcaga cgaccatcca aaacgagttc gcccactgca 4561 cagtgatcac catcgcccac aggctgcata ccatcatgga cagtgacaag gtaatggtcc 4621 tagacaacgg gaagattata gagtacggca gccctgaaga actgctacaa atccctggac 4681 ccttttactt tatggctaag gaagctggca ttgagaatgt gaacagcaca aaattctagc 4741 agaaggcccc atgggttaga aaaggactat aagaataatt tcttatttaa ttttattttt 4801 tataaaatac agaatacata caaaagtgtg tataaaatgt acgttttaaa aaaggataag 4861 tgaacaccca tgaacctact acccaggtta agaaaataaa tgtcaccagg tacttgagaa 4921 acccctcgat tgtctacctc gatcgtactt ccttgctacc cacccctccc agggacaacc 4981 actgtcctga atttcacgat aattattcct ttgcctttca tttctgtttt atcacctttg 5041 tatgtatctt taaacaacat ataccctttt ttacttatgt aaatggactg actcatactg 5101 catacatctt ctatgacttg attcttttgt tcaatattat atctgagatt catccatggt 5161 gatgcaaata ggtgcattat tttttttcac tgctctgtag tctggcattg tatgaataca 5221 gcacaatgta tcagttttaa tattggggat cattagcatt attctcaggt ttttaaaaat 5281 tataagcagt actactatgg //