LOCUS HSU48734 3474 bp mRNA linear HUM 22-NOV-2000
DEFINITION Human non-muscle alpha-actinin mRNA, complete cds.
ACCESSION U48734
VERSION U48734.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3474)
AUTHORS Nikolopoulos,S.N., Spengler,B.A., Kisselbach,K., Evans,A.E.,
Biedler,J.L. and Ross,R.A.
TITLE The human non-muscle alpha-actinin protein encoded by the ACTN4
gene suppresses tumorigenicity of human neuroblastoma cells
JOURNAL Oncogene 19 (3), 380-386 (2000)
PUBMED 10656685
REFERENCE 2 (bases 1 to 3474)
AUTHORS Nikolopoulos,S.N.
TITLE Direct Submission
JOURNAL Submitted (07-FEB-1996) Sotiris N. Nikolopoulos, Biological
Sciences, Fordham University, Rose Hill Campus, Bronx, NY 10458,
USA
FEATURES Location/Qualifiers
source 1..3474
/db_xref="H-InvDB:HIT000220066"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="4"
/cell_line="SH-EP1 neuroblastoma cell line"
CDS 78..2816
/codon_start=1
/product="alpha actinin"
/protein_id="AAC17470.1"
/translation="MVDYHAANQSYQYGPSSAAMAWRRGSMGDYMAQEDDWDRDLLLD
PAWEKQQRKTFTAWSNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGK
MRVHKINNVNKALDFIASKGIKLDFHRAEEIVDGNAKMTLGMIWTIILRFAIQDISVE
ETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDD
PVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETE
TAANRICKVLAVNQENCSTSMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKL
EDFRDYRRVHKPPKVQEKCQLEINFNSVQTKLRLSNRPAFMPSEGKMVSDINNGWQHL
EQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSD
IKALIRKHEAFESDLAAHQDRVEQIAASAQELNELDYYDSHNVNTRCQKICDQWDALG
SLTHSRREALEKTEKQLEAIIDQLHLEYAKPAAPFNNWMESAMEDLQDMFIVHTIEEI
EGLISAHDQFKSTLPDADREREAILHPQGGQRIAESNHIKLSGSNPYTTVTPQIINSK
WEKVQQLVPKRDHALLEEQSKQQQSNEHLRRQFASQANVVGPWIQTKMEEIAISIEMN
GTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQ
LLTTIARTINEVENQILTRDAKGISQEQMQEFRASFNHFDKDHGGALGRGVQGLPHQP
GLRRGERPAGEAEFNRIMSLVDPNHSGLVTFQAFIDFMSRETTDTDTADQVITSFKVL
AGDKNFITAEELRRELPPDQAEYCIARMAPYQGPDGVRGALDYKSFSTALYGESDL"
BASE COUNT 820 a 1077 c 1022 g 555 t
ORIGIN
1 gcgcgccggc ggctcgggca gaggggcggg agctgaggcg ggagcggaca ggctggtggg
61 cgagcgagag gcgcggaatg gtggactacc acgcggcgaa ccagtcgtac cagtacggcc
121 ccagcagcgc ggcaatggct tggcggcggg ggagcatggg cgactacatg gcccaggagg
181 acgactggga ccgggacctg ctgctggacc cggcctggga gaagcagcag cgcaagacct
241 tcacggcatg gagcaactcc cacctgcgga aggcaggcac acagatcgag aacattgatg
301 aggacttccg agacgggctc aagctcatgc tgctcctgga ggtcatatca ggggagcggt
361 tacctaagcc ggagcggggg aagatgagag tgcacaaaat caacaatgtg aacaaagcgc
421 tggactttat tgccagcaaa gggatcaagc tggacttcca tcgggcagaa gagattgtgg
481 acggcaacgc aaagatgacc ctgggaatga tctggaccat catccttagg ttcgccatcc
541 aggacatctc cgtggaagag acctcggcca aggaagggct ccttctctgg tgccagagaa
601 agacagcccc atataagaac gtcaatgtgc agaacttcca catcagctgg aaggatggtc
661 ttgccttcaa tgccctgatc caccggcaca gaccagagct gattgagtat gacaagctga
721 ggaaggacga ccctgtcacc aacctgaaca atgccttcga agtggctgag aaatacctcg
781 acatccccaa gatgctggat gcagaggaca tcgtgaacac ggcccggccc gacgagaagg
841 ccataatgac ctatgtgtcc agcttctacc atgccttttc aggagcgcag aaggctgaaa
901 ctgaaactgc cgccaaccgg atctgtaagg tgctggctgt caaccaagag aactgcagca
961 cctcgatgga ggactacgag aagctggcca gcgacctcct ggagtggatc cggcgcacca
1021 tcccctggct ggaggaccgt gtgccccaaa agactatcca ggagatgcag cagaagctgg
1081 aggacttccg cgactaccgg cgtgtgcaca agccgcccaa ggtgcaggag aagtgccagc
1141 tggagatcaa cttcaacagc gtgcagacca agctgcgcct cagcaaccgg cccgccttca
1201 tgccctccga gggcaagatg gtctcggaca tcaacaatgg ctggcagcac ttggagcagg
1261 ctgagaaggg ctacgaggag tggctgctga atgagattcg caggctggag cggctcgacc
1321 acctggcaga gaagttccgg cagaaagcct ccatccacga ggcctggact gacgggaagg
1381 aagccatgct gaagcaccgg gactacgaga cggccacact atcggacatc aaagccctca
1441 ttcgcaagca cgaggccttc gagagcgacc tggctgcgca ccaggaccgc gtggagcaga
1501 tcgccgcctc cgcccaggag ctcaacgagc tggattacta cgactcccac aatgtcaaca
1561 cccggtgcca gaagatctgt gaccagtggg acgccctcgg ctctctgaca catagtcgca
1621 gggaagccct ggagaaaaca gagaagcagc tggaggccat catcgaccag ctgcacctgg
1681 aatacgccaa gcccgcggcc cccttcaaca actggatgga gagcgccatg gaggacctcc
1741 aggacatgtt catcgtccat accatcgagg agattgaggg cctgatctca gcccatgacc
1801 agttcaagtc caccctgccg gacgccgata gggagcgcga ggccatcctg catccacaag
1861 gaggccagag gatcgctgag agcaaccaca tcaagctgtc gggcagcaac ccctacacca
1921 ccgtcacccc gcaaatcatc aactccaagt gggagaaggt gcagcagctg gtgccaaaac
1981 gggaccatgc cctcctggag gagcagagca agcagcagca gtccaacgag cacctgcgcc
2041 gccagttcgc cagccaggcc aatgttgtgg ggccctggat ccagaccaag atggaggaga
2101 tcgcgatctc cattgagatg aacgggaccc tggaggacca gctgagccac ctgaagcagt
2161 atgaacgcag catcgtggac tacaagccca acctggacct gctggagcag cagcaccagc
2221 tcatccagga ggccctcatc ttcgacaaca agcacaccaa ctataccatg gagcacatcc
2281 gcgtgggctg ggagcagctg ctcaccacca ttgcccgcac catcaacgag gtggagaacc
2341 agatccttac ccgcgacgcc aagggcatca gccaggagca gatgcaggag ttccgggcgt
2401 ccttcaacca cttcgacaag gatcatggcg gggcgctggg gcgaggagtt caaggcctgc
2461 ctcatcagcc tgggctacga cgtggagaac gaccggcagg tgaggccgag ttcaaccgca
2521 tcatgagcct ggtcgacccc aaccatagcg gccttgttac cttccaagcc ttcatcgact
2581 tcatgtcgcg ggagaccacc gacaccgaca cggctgacca ggtaatcact tccttcaagg
2641 tcctagcagg ggacaagaac ttcatcacag ctgaggagct gcggagagag ctgccccccg
2701 accaggccga gtactgcatc gcccgcatgg cgccatacca gggccctgac ggcgtgcgcg
2761 gtgccctcga ctacaagtcc ttctccacgg ccttgtatgg cgagagcgac ctgtgaggcc
2821 ccagagacct gacccaacac ccccgacgcc tccaggagcc tggcagcccc acagtcccat
2881 tcctccactc tgtatctatg caaagcactc tctctgcagt ctccggggtg ggtgggtggg
2941 cagggagggg ctggggcagg ctctctcctc tctctctttg tgggttggcc aggaggttcc
3001 cccgaccagg ttggggagac ttggggccag cgcttctggt ctggtaaata tgtatgatgt
3061 gttgtgcttt tttaaccaag gaggggccag tggattccca cagcacaacc ggtcccttcc
3121 atgccctggg atgcctcacc acacccaggt ctcttccttt gctctgaggt cccttcaagg
3181 cctccccaat ccaggccaaa gccccatgtg ccttgtccag ggaactgcct gggccatgcg
3241 aggggccagc agagggcgcc accacctgac ggctgggacc cacccagccc ctctcccctc
3301 tctgctccag actcacttgc cattgccagg agatggcccc aacaagcacc ccgcttttgc
3361 agcagaggag ctgagttggc agaccgggcc cccctgaacc gcaccccatc ccaccagccc
3421 cggccttgct ttgtctggcc tcacgtgtct cagattttct aagaaccaaa aaaa
//