LOCUS HSU47077 13509 bp mRNA linear HUM 27-AUG-2001
DEFINITION Homo sapiens DNA-dependent protein kinase catalytic subunit
(DNA-PKcs) mRNA, complete cds.
ACCESSION U47077
VERSION U47077.5
KEYWORDS DNAPKcs; serine/threonine protein kinase; double-strand break
repair; V(D)J recombination; mouse SCID product.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 13509)
AUTHORS Hartley,K.O., Gell,D., Smith,G.C., Zhang,H., Divecha,N.,
Connelly,M.A., Admon,A., Lees-Miller,S.P., Anderson,C.W. and
Jackson,S.P.
TITLE DNA-dependent protein kinase catalytic subunit: a relative of
phosphatidylinositol 3-kinase and the ataxia telangiectasia gene
product
JOURNAL Cell 82 (5), 849-856 (1995)
PUBMED 7671312
REFERENCE 2 (bases 1 to 13509)
AUTHORS Connelly,M.A., Zhang,H., Kieleczawa,J. and Anderson,C.W.
TITLE Alternate splice-site utilization in the gene for the catalytic
subunit of the DNA-activated protein kinase, DNA-PKcs
JOURNAL Gene 175 (1-2), 271-273 (1996)
PUBMED 8917110
REFERENCE 3 (bases 1 to 13509)
AUTHORS Anderson,C.W., Dunn,J.J., Freimuth,P.I., Galloway,A.M. and
Allalunis-Turner,M.J.
TITLE Frameshift mutation in PRKDC, the gene for DNA-PKcs, in the DNA
repair-defective, human, glioma-derived cell line M059J
JOURNAL Radiat. Res. 156 (1), 2-9 (2001)
PUBMED 11418067
REFERENCE 4 (bases 1 to 13509)
AUTHORS Anderson,C.W.
TITLE Direct Submission
JOURNAL Submitted (25-JAN-1996) Biology, Brookhaven National Laboratory, 50
Bell Avenue, Upton, NY 11973-5000, USA
REFERENCE 5 (bases 1 to 13509)
AUTHORS Anderson,C.W.
TITLE Direct Submission
JOURNAL Submitted (06-DEC-1999) Biology, Brookhaven National Laboratory, 50
Bell Avenue, Upton, NY 11973-5000, USA
REMARK Sequence update by submitter
REFERENCE 6 (bases 1 to 13509)
AUTHORS Anderson,C.W.
TITLE Direct Submission
JOURNAL Submitted (11-JUL-2000) Biology, Brookhaven National Laboratory, 50
Bell Avenue, Upton, NY 11973-5000, USA
REMARK Sequence update by submitter
REFERENCE 7 (bases 1 to 13509)
AUTHORS Anderson,C.W.
TITLE Direct Submission
JOURNAL Submitted (23-MAR-2001) Biology, Brookhaven National Laboratory, 50
Bell Avenue, Upton, NY 11973-5000, USA
REMARK Sequence update by submitter
REFERENCE 8 (bases 1 to 13509)
AUTHORS Anderson,C.W.
TITLE Direct Submission
JOURNAL Submitted (10-APR-2001) Biology, Brookhaven National Laboratory, 50
Bell Avenue, Upton, NY 11973-5000, USA
REMARK Sequence update by submitter
COMMENT On Apr 10, 2001 this sequence version replaced U47077.4.
FEATURES Location/Qualifiers
source 1..13509
/db_xref="H-InvDB:HIT000220021"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="8"
/map="8q11"
/cell_line="Daudi and CCRF-CEM"
/clone_lib="Clontech HL-1117a and HL-10638"
gene 1..13509
/gene="DNA-PKcs"
CDS 58..12444
/gene="DNA-PKcs"
/codon_start=1
/product="DNA-dependent protein kinase catalytic subunit"
/protein_id="AAB39925.5"
/translation="MAGSGAGVRCSLLRLQETLSAADRCGAALAGHQLIRGLGQECVL
SSSPAVLALQTSLVFSRDFGLLVFVRKSLNSIEFRECREEILKFLCIFLEKMGQKIAP
YSVEIKNTCTSVYTKDRAAKCKIPALDLLIKLLQTFRSSRLMDEFKIGELFSKFYGEL
ALKKKIPDTVLEKVYELLGLLGEVHPSEMINNAENLFRAFLGELKTQMTSAVREPKLP
VLAGCLKGLSSLLCNFTKSMEEDPQTSREIFNFVLKAIRPQIDLKRYAVPSAGLRLFA
LHASQFSTCLLDNYVSLFEVLLKWCAHTNVELKKAALSALESFLKQVSNMVAKNAEMH
KNKLQYFMEQFYGIIRNVDSNNKELSIAIRGYGLFAGPCKVINAKDVDFMYVELIQRC
KQMFLTQTDTGDDRVYQMPSFLQSVASVLLYLDTVPEVYTPVLEHLVVMQIDSFPQYS
PKMQLVCCRAIVKVFLALAAKGPVLRNCISTVVHQGLIRICSKPVVLPKGPESESEDH
RASGEVRTGKWKVPTYKDYVDLFRHLLSSDQMMDSILADEAFFSVNSSSESLNHLLYD
EFVKSVLKIVEKLDLTLEIQTVGEQENGDEAPGVWMIPTSDPAANLHPAKPKDFSAFI
NLVEFCREILPEKQAEFFEPWVYSFSYELILQSTRLPLISGFYKLLSITVRNAKKIKY
FEGVSPKSLKHSPEDPEKYSCFALFVKFGKEVAVKMKQYKDELLASCLTFLLSLPHNI
IELDVRAYVPALQMAFKLGLSYTPLAEVGLNALEEWSIYIDRHVMQPYYKDILPCLDG
YLKTSALSDETKNNWEVSALSRAAQKGFNKVVLKHLKKTKNLSSNEAISLEEIRIRVV
QMLGSLGGQINKNLLTVTSSDEMMKSYVAWDREKRLSFAVPFREMKPVIFLDVFLPRV
TELALTASDRQTKVAACELLHSMVMFMLGKATQMPEGGQGAPPMYQLYKRTFPVLLRL
ACDVDQVTRQLYEPLVMQLIHWFTNNKKFESQDTVALLEAILDGIVDPVDSTLRDFCG
RCIREFLKWSIKQITPQQQEKSPVNTKSLFKRLYSLALHPNAFKRLGASLAFNNIYRE
FREEESLVEQFVFEALVIYMESLALAHADEKSLGTIQQCCDAIDHLCRIIEKKHVSLN
KAKKRRLPRGFPPSASLCLLDLVKWLLAHCGRPQTECRHKSIELFYKFVPLLPGNRSP
NLWLKDVLKEEGVSFLINTFEGGGCGQPSGILAQPTLLYLRGPFSLQATLCWLDLLLA
ALECYNTFIGERTVGALQVLGTEAQSSLLKAVAFFLESIAMHDIIAAEKCFGTGAAGN
RTSPQEGERYNYSKCTVVVRIMEFTTTLLNTSPEGWKLLKKDLCNTHLMRVLVQTLCE
PASIGFNIGDVQVMAHLPDVCVNLMKALKMSPYKDILETHLREKITAQSIEELCAVNL
YGPDAQVDRSRLAAVVSACKQLHRAGLLHNILPSQSTDLHHSVGTELLSLVYKGIAPG
DERQCLPSLDLSCKQLASGLLELAFAFGGLCERLVSLLLNPAVLSTASLGSSQGSVIH
FSHGEYFYSLFSETINTELLKNLDLAVLELMQSSVDNTKMVSAVLNGMLDQSFRERAN
QKHQGLKLATTILQHWKKCDSWWAKDSPLETKMAVLALLAKILQIDSSVSFNTSHGSF
PEVFTTYISLLADTKLDLHLKGQAVTLLPFFTSLTGGSLEELRRVLEQLIVAHFPMQS
REFPPGTPRFNNYVDCMKKFLDALELSQSPMLLELMTEVLCREQQHVMEELFQSSFRR
IARRGSCVTQVGLLESVYEMFRKDDPRLSFTRQSFVDRSLLTLLWHCSLDALREFFST
IVVDAIDVLKSRFTKLNESTFDTQITKKMGYYKILDVMYSRLPKDDVHAKESKINQVF
HGSCITEGNELTKTLIKLCYDAFTENMAGENQLLERRRLYHCAAYNCAISVICCVFNE
LKFYQGFLFSEKPEKNLLIFENLIDLKRRYNFPVEVEVPMERKKKYIEIRKEAREAAN
GDSDGPSYMSSLSYLADSTLSEEMSQFDFSTGVQSYSYSSQDPRPATGRFRRREQRDP
TVHDDVLELEMDELNRHECMAPLTALVKHMHRSLGPPQGEEDSVPRDLPSWMKFLHGK
LGNPIVPLNIRLFLAKLVINTEEVFRPYAKHWLSPLLQLAASENNGGEGIHYMVVEIV
ATILSWTGLATPTGVPKDEVLANRLLNFLMKHVFHPKRAVFRHNLEIIKTLVECWKDC
LSIPYRLIFEKFSGKDPNSKDNSVGIQLLGIVMANDLPPYDPQCGIQSSEYFQALVNN
MSFVRYKEVYAAAAEVLGLILRYVMERKNILEESLCELVAKQLKQHQNTMEDKFIVCL
NKVTKSFPPLADRFMNAVFFLLPKFHGVLKTLCLEVVLCRVEGMTELYFQLKSKDFVQ
VMRHRDDERQKVCLDIIYKMMPKLKPVELRELLNPVVEFVSHPSTTCREQMYNILMWI
HDNYRDPESETDNDSQEIFKLAKDVLIQGLIDENPGLQLIIRNFWSHETRLPSNTLDR
LLALNSLYSPKIEVHFLSLATNFLLEMTSMSPDYPNPMFEHPLSECEFQEYTIDSDWR
FRSTVLTPMFVETQASQGTLQTRTQEGSLSARWPVAGQIRATQQQHDFTLTQTADGRS
SFDWLTGSSTDPLVDHTSPSSDSLLFAHKRSERLQRAPLKSVGPDFGKKRLGLPGDEV
DNKVKGAAGRTDLLRLRRRFMRDQEKLSLMYARKGVAEQKREKEIKSELKMKQDAQVV
LYRSYRHGDLPDIQIKHSSLITPLQAVAQRDPIIAKQLFSSLFSGILKEMDKFKTLSE
KNNITQKLLQDFNRFLNTTFSFFPPFVSCIQDISCQHAALLSLDPAAVSAGCLASLQQ
PVGIRLLEEALLRLLPAELPAKRVRGKARLPPDVLRWVELAKLYRSIGEYDVLRGIFT
SEIGTKQITQSALLAEARSDYSEAAKQYDEALNKQDWVDGEPTEAEKDFWELASLDCY
NHLAEWKSLEYCSTASIDSENPPDLNKIWSEPFYQETYLPYMIRSKLKLLLQGEADQS
LLTFIDKAMHGELQKAILELHYSQELSLLYLLQDDVDRAKYYIQNGIQSFMQNYSSID
VLLHQSRLTKLQSVQALTEIQEFISFISKQGNLSSQVPLKRLLNTWTNRYPDAKMDPM
NIWDDIITNRCFFLSKIEEKLTPLPEDNSMNVDQDGDPSDRMEVQEQEEDISSLIRSC
KFSMKMKMIDSARKQNNFSLAMKLLKELHKESKTRDDWLVSWVQSYCRLSHCRSRSQG
CSEQVLTVLKTVSLLDENNVSSYLSKNILAFRDQNILLGTTYRIIANALSSEPACLAE
IEEDKARRILELSGSSSEDSEKVIAGLYQRAFQHLSEAVQAAEEEAQPPSWSCGPAAG
VIDAYMTLADFCDQQLRKEEENASVIDSAELQAYPALVVEKMLKALKLNSNEARLKFP
RLLQIIERYPEETLSLMTKEISSVPCWQFISWISHMVALLDKDQAVAVQHSVEEITDN
YPQAIVYPFIISSESYSFKDTSTGHKNKEFVARIKSKLDQGGVIQDFINALDQLSNPE
LLFKDWSNDVRAELAKTPVNKKNIEKMYERMYAALGDPKAPGLGAFRRKFIQTFGKEF
DKHFGKGGSKLLRMKLSDFNDITNMLLLKMNKDSKPPGNLKECSPWMSDFKVEFLRNE
LEIPGQYDGRGKPLPEYHVRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGE
DLRQDQRVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKD
LLLNTMSQEEKAAYLSDPRAPPCEYKDWLTKMSGKHDVGAYMLMYKGANRTETVTSFR
KRESKVPADLLKRAFVRMSTSPEAFLALRSHFASSHALICISHWILGIGDRHLNNFMV
AMETGGVIGIDFGHAFGSATQFLPVPELMPFRLTRQFINLMLPMKETGLMYSIMVHAL
RAFRSDPGLLTNTMDVFVKEPSFDWKNFEQKMLKKGGSWIQEINVAEKNWYPRQKICY
AKRKLAGANPAVITCDELLLGHEKAPAFRDYVAVARGSKDHNIRAQEPESGLSEETQV
KCLMDQATDPNILGRTWEGWEPWM"
misc_difference 3079
/gene="DNA-PKcs"
/note="compared with GenBank Accessions U34994"
/replace="t"
exon 11454..11547
/gene="DNA-PKcs"
/note="exon occasionally removed by improper splicing;
alternatively spliced transcript without this exon
deposited in GenBank Accession Number U34994"
BASE COUNT 3824 a 2888 c 3226 g 3571 t
ORIGIN
1 ggggcatttc cgggtccggg ccgagcgggc gcacgcgcgg gagcgggact cggcggcatg
61 gcgggctccg gagccggtgt gcgttgctcc ctgctgcggc tgcaggagac cttgtccgct
121 gcggaccgct gcggtgctgc cctggccggt catcaactga tccgcggcct ggggcaggaa
181 tgcgtcctga gcagcagccc cgcggtgctg gcattacaga catctttagt tttttccaga
241 gatttcggtt tgcttgtatt tgtccggaag tcactcaaca gtattgaatt tcgtgaatgt
301 agagaagaaa tcctaaagtt tttatgtatt ttcttagaaa aaatgggcca gaagatcgca
361 ccttactctg ttgaaattaa gaacacttgt accagtgttt atacaaaaga tagagctgct
421 aaatgtaaaa ttccagccct ggaccttctt attaagttac ttcagacttt tagaagttct
481 agactcatgg atgaatttaa aattggagaa ttatttagta aattctatgg agaacttgca
541 ttgaaaaaaa aaataccaga tacagtttta gaaaaagtat atgagctcct aggattattg
601 ggtgaagttc atcctagtga gatgataaat aatgcagaaa acctgttccg cgcttttctg
661 ggtgaactta agacccagat gacatcagca gtaagagagc ccaaactacc tgttctggca
721 ggatgtctga aggggttgtc ctcacttctg tgcaacttca ctaagtccat ggaagaagat
781 ccccagactt caagggagat ttttaatttt gtactaaagg caattcgtcc tcagattgat
841 ctgaagagat atgctgtgcc ctcagctggc ttgcgcctat ttgccctgca tgcatctcag
901 tttagcacct gccttctgga caactacgtg tctctatttg aagtcttgtt aaagtggtgt
961 gcccacacaa atgtagaatt gaaaaaagct gcactttcag ccctggaatc ctttctgaaa
1021 caggtttcta atatggtggc gaaaaatgca gaaatgcata aaaataaact gcagtacttt
1081 atggagcagt tttatggaat catcagaaat gtggattcga acaacaagga gttatctatt
1141 gctatccgtg gatatggact ttttgcagga ccgtgcaagg ttataaacgc aaaagatgtt
1201 gacttcatgt acgttgagct cattcagcgc tgcaagcaga tgttcctcac ccagacagac
1261 actggtgacg accgtgttta tcagatgcca agcttcctcc agtctgttgc aagcgtcttg
1321 ctgtaccttg acacagttcc tgaggtgtat actccagttc tggagcacct cgtggtgatg
1381 cagatagaca gtttcccaca gtacagtcca aaaatgcagc tggtgtgttg cagagccata
1441 gtgaaggtgt tcctagcttt ggcagcaaaa gggccagttc tcaggaattg cattagtact
1501 gtggtgcatc agggtttaat cagaatatgt tctaaaccag tggtccttcc aaagggccct
1561 gagtctgaat ctgaagacca ccgtgcttca ggggaagtca gaactggcaa atggaaggtg
1621 cccacataca aagactacgt ggatctcttc agacatctcc tgagctctga ccagatgatg
1681 gattctattt tagcagatga agcatttttc tctgtgaatt cctccagtga aagtctgaat
1741 catttacttt atgatgaatt tgtaaaatcc gttttgaaga ttgttgagaa attggatctt
1801 acacttgaaa tacagactgt tggggaacaa gagaatggag atgaggcgcc tggtgtttgg
1861 atgatcccaa cttcagatcc agcggctaac ttgcatccag ctaaacctaa agatttttcg
1921 gctttcatta acctggtgga attttgcaga gagattctcc ctgagaaaca agcagaattt
1981 tttgaaccat gggtgtactc attttcatat gaattaattt tgcaatctac aaggttgccc
2041 ctcatcagtg gtttctacaa attgctttct attacagtaa gaaatgccaa gaaaataaaa
2101 tatttcgagg gagttagtcc aaagagtctg aaacactctc ctgaagaccc agaaaagtat
2161 tcttgctttg ctttatttgt gaaatttggc aaagaggtgg cagttaaaat gaagcagtac
2221 aaagatgaac ttttggcctc ttgtttgacc tttcttctgt ccttgccaca caacatcatt
2281 gaactcgatg ttagagccta cgttcctgca ctgcagatgg ctttcaaact gggcctgagc
2341 tataccccct tggcagaagt aggcctgaat gctctagaag aatggtcaat ttatattgac
2401 agacatgtaa tgcagcctta ttacaaagac attctcccct gcctggatgg atacctgaag
2461 acttcagcct tgtcagatga gaccaagaat aactgggaag tgtcagctct ttctcgggct
2521 gcccagaaag gatttaataa agtggtgtta aagcatctga agaagacaaa gaacctttca
2581 tcaaacgaag caatatcctt agaagaaata agaattagag tagtacaaat gcttggatct
2641 ctaggaggac aaataaacaa aaatcttctg acagtcacgt cctcagatga gatgatgaag
2701 agctatgtgg cctgggacag agagaagcgg ctgagctttg cagtgccctt tagagagatg
2761 aaacctgtca ttttcctgga tgtgttcctg cctcgagtca cagaattagc gctcacagcc
2821 agtgacagac aaactaaagt tgcagcctgt gaacttttac atagcatggt tatgtttatg
2881 ttgggcaaag ccacgcagat gccagaaggg ggacagggag ccccacccat gtaccagctc
2941 tataagcgga cgtttcctgt gctgcttcga cttgcgtgtg atgttgatca ggtgacaagg
3001 caactgtatg agccactagt tatgcagctg attcactggt tcactaacaa caagaaattt
3061 gaaagtcagg atactgttgc cttactagaa gctatattgg atggaattgt ggaccctgtt
3121 gacagtactt taagagattt ttgtggtcgg tgtattcgag aattccttaa atggtccatt
3181 aagcaaataa caccacagca gcaggagaag agtccagtaa acaccaaatc gcttttcaag
3241 cgactttata gccttgcgct tcaccccaat gctttcaaga ggctgggagc atcacttgcc
3301 tttaataata tctacaggga attcagggaa gaagagtctc tggtggaaca gtttgtgttt
3361 gaagccttgg tgatatacat ggagagtctg gccttagcac atgcagatga gaagtcctta
3421 ggtacaattc aacagtgttg tgatgccatt gatcacctat gccgcatcat tgaaaagaag
3481 catgtttctt taaataaagc aaagaaacga cgtttgccgc gaggatttcc accttccgca
3541 tcattgtgtt tattggatct ggtcaagtgg cttttagctc attgtgggag gccccagaca
3601 gaatgtcgac acaaatccat tgaactcttt tataaattcg ttcctttatt gccaggcaac
3661 agatccccta atttgtggct gaaagatgtt ctcaaggaag aaggtgtctc ttttctcatc
3721 aacacctttg aggggggtgg ctgtggccag ccctcgggca tcctggccca gcccaccctc
3781 ttgtaccttc gggggccatt cagcctgcag gccacgctat gctggctgga cctgctcctg
3841 gccgcgttgg agtgctacaa cacgttcatt ggcgagagaa ctgtaggagc gctccaggtc
3901 ctaggtactg aagcccagtc ttcacttttg aaagcagtgg ctttcttctt agaaagcatt
3961 gccatgcatg acattatagc agcagaaaag tgctttggca ctggggcagc aggtaacaga
4021 acaagcccac aagagggaga aaggtacaac tacagcaaat gcaccgttgt ggtccggatt
4081 atggagttta ccacgactct gctaaacacc tccccggaag gatggaagct cctgaagaag
4141 gacttgtgta atacacacct gatgagagtc ctggtgcaga cgctgtgtga gcccgcaagc
4201 ataggtttca acatcggaga cgtccaggtt atggctcatc ttcctgatgt ttgtgtgaat
4261 ctgatgaaag ctctaaagat gtccccatac aaagatatcc tagagaccca tctgagagag
4321 aaaataacag cacagagcat tgaggagctt tgtgccgtca acttgtatgg ccctgacgcg
4381 caagtggaca ggagcaggct ggctgctgtt gtgtctgcct gtaaacagct tcacagagct
4441 gggcttctgc ataatatatt accgtctcag tccacagatt tgcatcattc tgttggcaca
4501 gaacttcttt ccctggttta taaaggcatt gcccctggag atgagagaca gtgtctgcct
4561 tctctagacc tcagttgtaa gcagctggcc agcggacttc tggagttagc ctttgctttt
4621 ggaggactgt gtgagcgcct tgtgagtctt ctcctgaacc cagcggtgct gtccacggcg
4681 tccttgggca gctcacaggg cagcgtcatc cacttctccc atggggagta tttctatagc
4741 ttgttctcag aaacgatcaa cacggaatta ttgaaaaatc tggatcttgc tgtattggag
4801 ctcatgcagt cttcagtgga taataccaaa atggtgagtg ccgttttgaa cggcatgtta
4861 gaccagagct tcagggagcg agcaaaccag aaacaccaag gactgaaact tgcgactaca
4921 attctgcaac actggaagaa gtgtgattca tggtgggcca aagattcccc tctcgaaact
4981 aaaatggcag tgctggcctt actggcaaaa attttacaga ttgattcatc tgtatctttt
5041 aatacaagtc atggttcatt ccctgaagtc tttacaacat atattagtct acttgctgac
5101 acaaagctgg atctacattt aaagggccaa gctgtcactc ttcttccatt cttcaccagc
5161 ctcactggag gcagtctgga ggaacttaga cgtgttctgg agcagctcat cgttgctcac
5221 ttccccatgc agtccaggga atttcctcca ggaactccgc ggttcaataa ttatgtggac
5281 tgcatgaaaa agtttctaga tgcattggaa ttatctcaaa gccctatgtt gttggaattg
5341 atgacagaag ttctttgtcg ggaacagcag catgtcatgg aagaattatt tcaatccagt
5401 ttcaggagga ttgccagaag gggttcatgt gtcacacaag taggccttct ggaaagcgtg
5461 tatgaaatgt tcaggaagga tgacccccgc ctaagtttca cacgccagtc ctttgtggac
5521 cgctccctcc tcactctgct gtggcactgt agcctggatg ctttgagaga attcttcagc
5581 acaattgtgg tggatgccat tgatgtgttg aagtccaggt ttacaaagct aaatgaatct
5641 acctttgata ctcaaatcac caagaagatg ggctactata agattctaga cgtgatgtat
5701 tctcgccttc ccaaagatga tgttcatgct aaggaatcaa aaattaatca agttttccat
5761 ggctcgtgta ttacagaagg aaatgaactt acaaagacat tgattaaatt gtgctacgat
5821 gcatttacag agaacatggc aggagagaat cagctgctgg agaggagaag actttaccat
5881 tgtgcagcat acaactgcgc catatctgtc atctgctgtg tcttcaatga gttaaaattt
5941 taccaaggtt ttctgtttag tgaaaaacca gaaaagaact tgcttatttt tgaaaatctg
6001 atcgacctga agcgccgcta taattttcct gtagaagttg aggttcctat ggaaagaaag
6061 aaaaagtaca ttgaaattag gaaagaagcc agagaagcag caaatgggga ttcagatggt
6121 ccttcctata tgtcttccct gtcatatttg gcagacagta ccctgagtga ggaaatgagt
6181 caatttgatt tctcaaccgg agttcagagc tattcataca gctcccaaga ccctagacct
6241 gccactggtc gttttcggag acgggagcag cgggacccca cggtgcatga tgatgtgctg
6301 gagctggaga tggacgagct caatcggcat gagtgcatgg cgcccctgac ggccctggtc
6361 aagcacatgc acagaagcct gggcccgcct caaggagaag aggattcagt gccaagagat
6421 cttccttctt ggatgaaatt cctccatggc aaactgggaa atccaatagt accattaaat
6481 atccgtctct tcttagccaa gcttgttatt aatacagaag aggtctttcg cccttacgcg
6541 aagcactggc ttagcccctt gctgcagctg gctgcttctg aaaacaatgg aggagaagga
6601 attcactaca tggtggttga gatagtggcc actattcttt catggacagg cttggccact
6661 ccaacagggg tccctaaaga tgaagtgtta gcaaatcgat tgcttaattt cctaatgaaa
6721 catgtctttc atccaaaaag agctgtgttt agacacaacc ttgaaattat aaagaccctt
6781 gtcgagtgct ggaaggattg tttatccatc ccttataggt taatatttga aaagttttcc
6841 ggtaaagatc ctaattctaa agacaactca gtagggattc aattgctagg catcgtgatg
6901 gccaatgacc tgcctcccta tgacccacag tgtggcatcc agagtagcga atacttccag
6961 gctttggtga ataatatgtc ctttgtaaga tataaagaag tgtatgccgc tgcagcagaa
7021 gttctaggac ttatacttcg atatgttatg gagagaaaaa acatactgga ggagtctctg
7081 tgtgaactgg ttgcgaaaca attgaagcaa catcagaata ctatggagga caagtttatt
7141 gtgtgcttga acaaagtgac caagagcttc cctcctcttg cagacaggtt catgaatgct
7201 gtgttctttc tgctgccaaa atttcatgga gtgttgaaaa cactctgtct ggaggtggta
7261 ctttgtcgtg tggagggaat gacagagctg tacttccagt taaagagcaa ggacttcgtt
7321 caagtcatga gacatagaga tgatgaaaga caaaaagtat gtttggacat aatttataag
7381 atgatgccaa agttaaaacc agtagaactc cgagaacttc tgaaccccgt tgtggaattc
7441 gtttcccatc cttctacaac atgtagggaa caaatgtata atattctcat gtggattcat
7501 gataattaca gagatccaga aagtgagaca gataatgact cccaggaaat atttaagttg
7561 gcaaaagatg tgctgattca aggattgatc gatgagaacc ctggacttca attaattatt
7621 cgaaatttct ggagccatga aactaggtta ccttcaaata ccttggaccg gttgctggca
7681 ctaaattcct tatattctcc taagatagaa gtgcactttt taagtttagc aacaaatttt
7741 ctgctcgaaa tgaccagcat gagcccagat tatccaaacc ccatgttcga gcatcctctg
7801 tcagaatgcg aatttcagga atataccatt gattctgatt ggcgtttccg aagtactgtt
7861 ctcactccga tgtttgtgga gacccaggcc tcccagggca ctctccagac ccgtacccag
7921 gaagggtccc tctcagctcg ctggccagtg gcagggcaga taagggccac ccagcagcag
7981 catgacttca cactgacaca gactgcagat ggaagaagct catttgattg gctgaccggg
8041 agcagcactg acccgctggt cgaccacacc agtccctcat ctgactcctt gctgtttgcc
8101 cacaagagga gtgaaaggtt acagagagca cccttgaagt cagtggggcc tgattttggg
8161 aaaaaaaggc tgggccttcc aggggacgag gtggataaca aagtgaaagg tgcggccggc
8221 cggacggacc tactacgact gcgcagacgg tttatgaggg accaggagaa gctcagtttg
8281 atgtatgcca gaaaaggcgt tgctgagcaa aaacgagaga aggaaatcaa gagtgagtta
8341 aaaatgaagc aggatgccca ggtcgttctg tacagaagct accggcacgg agaccttcct
8401 gacattcaga tcaagcacag cagcctcatc accccgttac aggccgtggc ccagagggac
8461 ccaataattg caaaacagct ctttagcagc ttgttttctg gaattttgaa agagatggat
8521 aaatttaaga cactgtctga aaaaaacaac atcactcaaa agttgcttca agacttcaat
8581 cgttttctta ataccacctt ctctttcttt ccaccctttg tctcttgtat tcaggacatt
8641 agctgtcagc acgcagccct gctgagcctc gacccagcgg ctgttagcgc tggttgcctg
8701 gccagcctac agcagcccgt gggcatccgc ctgctagagg aggctctgct ccgcctgctg
8761 cctgctgagc tgcctgccaa gcgagtccgt gggaaggccc gcctccctcc tgatgtcctc
8821 agatgggtgg agcttgctaa gctgtataga tcaattggag aatacgacgt cctccgtggg
8881 atttttacca gtgagatagg aacaaagcaa atcactcaga gtgcattatt agcagaagcc
8941 agaagtgatt attctgaagc tgctaagcag tatgatgagg ctctcaataa acaagactgg
9001 gtagatggtg agcccacaga agccgagaag gatttttggg aacttgcatc ccttgactgt
9061 tacaaccacc ttgctgagtg gaaatcactt gaatactgtt ctacagccag tatagacagt
9121 gagaaccccc cagacctaaa taaaatctgg agtgaaccat tttatcagga aacatatcta
9181 ccttacatga tccgcagcaa gctgaagctg ctgctccagg gagaggctga ccagtccctg
9241 ctgacattta ttgacaaagc tatgcacggg gagctccaga aggcgattct agagcttcat
9301 tacagtcaag agctgagtct gctttacctc ctgcaagatg atgttgacag agccaaatat
9361 tacattcaaa atggcattca gagttttatg cagaattatt ctagtattga tgtcctctta
9421 caccaaagta gactcaccaa attgcagtct gtacaggctt taacagaaat tcaggagttc
9481 atcagcttta taagcaaaca aggcaattta tcatctcaag ttccccttaa gagacttctg
9541 aacacctgga caaacagata tccagatgct aaaatggacc caatgaacat ctgggatgac
9601 atcatcacaa atcgatgttt ctttctcagc aaaatagagg agaagcttac ccctcttcca
9661 gaagataata gtatgaatgt ggatcaagat ggagacccca gtgacaggat ggaagtgcaa
9721 gagcaggaag aagatatcag ctccctgatc aggagttgca agttttccat gaaaatgaag
9781 atgatagaca gtgcccggaa gcagaacaat ttctcacttg ctatgaaact actgaaggag
9841 ctgcataaag agtcaaaaac cagagacgat tggctggtga gctgggtgca gagctactgc
9901 cgcctgagcc actgccggag ccggtcccag ggctgctctg agcaggtgct cactgtgctg
9961 aaaacagtct ctttgttgga tgagaacaac gtgtcaagct acttaagcaa aaatattctg
10021 gctttccgtg accagaacat tctcttgggt acaacttaca ggatcatagc gaatgctctc
10081 agcagtgagc cagcctgcct tgctgaaatc gaggaggaca aggctagaag aatcttagag
10141 ctttctggat ccagttcaga ggattcagag aaggtgatcg cgggtctgta ccagagagca
10201 ttccagcacc tctctgaggc tgtgcaggcg gctgaggagg aggcccagcc tccctcctgg
10261 agctgtgggc ctgcagctgg ggtgattgat gcttacatga cgctggcaga tttctgtgac
10321 caacagctgc gcaaggagga agagaatgca tcagttattg attctgcaga actgcaggcg
10381 tatccagcac ttgtggtgga gaaaatgttg aaagctttaa aattaaattc caatgaagcc
10441 agattgaagt ttcctagatt acttcagatt atagaacggt atccagagga gactttgagc
10501 ctcatgacaa aagagatctc ttccgttccc tgctggcagt tcatcagctg gatcagccac
10561 atggtggcct tactggacaa agaccaagcc gttgctgttc agcactctgt ggaagaaatc
10621 actgataact acccgcaggc tattgtttat cccttcatca taagcagcga aagctattcc
10681 ttcaaggata cttctactgg tcataagaat aaggagtttg tggcaaggat taaaagtaag
10741 ttggatcaag gaggagtgat tcaagatttt attaatgcct tagatcagct ctctaatcct
10801 gaactgctct ttaaggattg gagcaatgat gtaagagctg aactagcaaa aacccctgta
10861 aataaaaaaa acattgaaaa aatgtatgaa agaatgtatg cagccttggg tgacccaaag
10921 gctccaggcc tgggggcctt tagaaggaag tttattcaga cttttggaaa agaatttgat
10981 aaacattttg ggaaaggagg ttctaaacta ctgagaatga agctcagtga cttcaacgac
11041 attaccaaca tgctactttt aaaaatgaac aaagactcaa agccccctgg gaatctgaaa
11101 gaatgttcac cctggatgag cgacttcaaa gtggagttcc tgagaaatga gctggagatt
11161 cccggtcagt atgacggtag gggaaagcca ttgccagagt accacgtgcg aatcgccggg
11221 tttgatgagc gggtgacagt catggcgtct ctgcgaaggc ccaagcgcat catcatccgt
11281 ggccatgacg agagggaaca ccctttcctg gtgaagggtg gcgaggacct gcggcaggac
11341 cagcgcgtgg agcagctctt ccaggtcatg aatgggatcc tggcccaaga ctccgcctgc
11401 agccagaggg ccctgcagct gaggacctat agcgttgtgc ccatgacctc caggttagga
11461 ttaattgagt ggcttgaaaa tactgttacc ttgaaggacc ttcttttgaa caccatgtcc
11521 caagaggaga aggcggctta cctgagtgat cccagggcac cgccgtgtga atataaagat
11581 tggctgacaa aaatgtcagg aaaacatgat gttggagctt acatgctaat gtataagggc
11641 gctaatcgta ctgaaacagt cacgtctttt agaaaacgag aaagtaaagt gcctgctgat
11701 ctcttaaagc gggccttcgt gaggatgagt acaagccctg aggctttcct ggcgctccgc
11761 tcccacttcg ccagctctca cgctctgata tgcatcagcc actggatcct cgggattgga
11821 gacagacatc tgaacaactt tatggtggcc atggagactg gcggcgtgat cgggatcgac
11881 tttgggcatg cgtttggatc cgctacacag tttctgccag tccctgagtt gatgcctttt
11941 cggctaactc gccagtttat caatctgatg ttaccaatga aagaaacggg ccttatgtac
12001 agcatcatgg tacacgcact ccgggccttc cgctcagacc ctggcctgct caccaacacc
12061 atggatgtgt ttgtcaagga gccctccttt gattggaaaa attttgaaca gaaaatgctg
12121 aaaaaaggag ggtcatggat tcaagaaata aatgttgctg aaaaaaattg gtacccccga
12181 cagaaaatat gttacgctaa gagaaagtta gcaggtgcca atccagcagt cattacttgt
12241 gatgagctac tcctgggtca tgagaaggcc cctgccttca gagactatgt ggctgtggca
12301 cgaggaagca aagatcacaa cattcgtgcc caagaaccag agagtgggct ttcagaagag
12361 actcaagtga agtgcctgat ggaccaggca acagacccca acatccttgg cagaacctgg
12421 gaaggatggg agccctggat gtgaggtctg tgggagtctg cagatagaaa gcattacatt
12481 gtttaaagaa tctactatac tttggttggc agcattccat gagctgattt tcctgaaaca
12541 ctaaagagaa atgtcttttg tgctacagtt tcgtagcatg agtttaaatc aagattatga
12601 tgagtaaatg tgtatgggtt aaatcaaaga taaggttata gtaacatcaa agattaggtg
12661 aggtttatag aaagatagat atccaggctt accaaagtat taagtcaaga atataatatg
12721 tgatcagctt tcaaagcatt tacaagtgct gcaagttagt gaaacagctg tctccgtaaa
12781 tggaggaaat gtggggaagc cttggaatgc ccttctggtt ctggcacatt ggaaagcaca
12841 ctcagaaggc ttcatcacca agattttggg agagtaaagc taagtatagt tgatgtaaca
12901 ttgtagaagc agcataggaa caataagaac aataggtaaa gctataatta tggcttatat
12961 ttagaaatga ctgcatttga tattttagga tatttttcta ggttttttcc tttcatttta
13021 ttctcttcta gttttgacat tttatgatag atttgctctc tagaaggaaa cgtctttatt
13081 taggagggca aaaattttgg tcatagcatt cacttttgct attccaatct acaactggaa
13141 gatacataaa agtgctttgc attgaatttg ggataacttc aaaaatccca tggttgttgt
13201 tagggatagt actaagcatt tcagttccag gagaataaaa gaaattccta tttgaaatga
13261 attcctcatt tggaggaaaa aaagcatgca ttctagcaca acaagatgaa attatggaat
13321 acaaaagtgg ctccttccca tgtgcagtcc ctgtcccccc ccgccagtcc tccacaccca
13381 aactgtttct gattggcttt tagctttttg ttgttttttt ttttccttct aacacttgta
13441 tttggaggct cttctgtgat tttgagaagt atactcttga gtgtttaata aagttttttt
13501 ccaaaagta
//