LOCUS HSU45880 2540 bp mRNA linear HUM 16-FEB-1996
DEFINITION Human X-linked inhibitor of apotosis protein XIAP mRNA, complete
cds.
ACCESSION U45880
VERSION U45880.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2540)
AUTHORS Liston,P., Roy,N., Tamai,K., Lefebvre,C., Baird,S.,
Cherton-Horvat,G., Farahani,R., McLean,M., Ikeda,J., MacKenzie,A.
and Korneluk,R.G.
TITLE Suppression of apoptosis in mammalian cells by NAIP and a related
family of IAP genes
JOURNAL Nature 379 (6563), 349-353 (1996)
PUBMED 8552191
REFERENCE 2 (bases 1 to 2540)
AUTHORS Baird,S.D.
TITLE Direct Submission
JOURNAL Submitted (16-JAN-1996) Stephen D. Baird, Children's Hospital of
Eastern Ontario, Genetics, 401 Smyth Rd., Ottawa, Ontario, K1H 8L1,
Canada
FEATURES Location/Qualifiers
source 1..2540
/db_xref="H-InvDB:HIT000219972"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="Xq24-25"
/tissue_type="brain"
/clone_lib="Stratagene lambdaZap-II human fetal brain"
/dev_stage="fetal"
CDS 34..1527
/function="inhibition of apoptosis"
/experiment="experimental evidence, no additional details
recorded"
/note="XIAP"
/codon_start=1
/product="X-linked inhibitor of apotosis protein"
/protein_id="AAC50373.1"
/translation="MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSA
STLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSA
TQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAM
YCEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWS
EHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWI
YSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQK
GQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKI
MEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLC
KICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS"
misc_feature 108..309
/note="encodes BIR1 (Baculovirus IAP Repeat)"
misc_feature 520..723
/note="encodes BIR2"
misc_feature 826..1020
/note="encodes BIR3"
misc_feature 1381..1485
/note="encodes Ring Zinc Finger"
BASE COUNT 781 a 415 c 571 g 773 t
ORIGIN
1 gaaaaggtgg acaagtccta ttttcaagag aagatgactt ttaacagttt tgaaggatct
61 aaaacttgtg tacctgcaga catcaataag gaagaagaat ttgtagaaga gtttaataga
121 ttaaaaactt ttgctaattt tccaagtggt agtcctgttt cagcatcaac actggcacga
181 gcagggtttc tttatactgg tgaaggagat accgtgcggt gctttagttg tcatgcagct
241 gtagatagat ggcaatatgg agactcagca gttggaagac acaggaaagt atccccaaat
301 tgcagattta tcaacggctt ttatcttgaa aatagtgcca cgcagtctac aaattctggt
361 atccagaatg gtcagtacaa agttgaaaac tatctgggaa gcagagatca ttttgcctta
421 gacaggccat ctgagacaca tgcagactat cttttgagaa ctgggcaggt tgtagatata
481 tcagacacca tatacccgag gaaccctgcc atgtattgtg aagaagctag attaaagtcc
541 tttcagaact ggccagacta tgctcaccta accccaagag agttagcaag tgctggactc
601 tactacacag gtattggtga ccaagtgcag tgcttttgtt gtggtggaaa actgaaaaat
661 tgggaacctt gtgatcgtgc ctggtcagaa cacaggcgac actttcctaa ttgcttcttt
721 gttttgggcc ggaatcttaa tattcgaagt gaatctgatg ctgtgagttc tgataggaat
781 ttcccaaatt caacaaatct tccaagaaat ccatccatgg cagattatga agcacggatc
841 tttacttttg ggacatggat atactcagtt aacaaggagc agcttgcaag agctggattt
901 tatgctttag gtgaaggtga taaagtaaag tgctttcact gtggaggagg gctaactgat
961 tggaagccca gtgaagaccc ttgggaacaa catgctaaat ggtatccagg gtgcaaatat
1021 ctgttagaac agaagggaca agaatatata aacaatattc atttaactca ttcacttgag
1081 gagtgtctgg taagaactac tgagaaaaca ccatcactaa ctagaagaat tgatgatacc
1141 atcttccaaa atcctatggt acaagaagct atacgaatgg ggttcagttt caaggacatt
1201 aagaaaataa tggaggaaaa aattcagata tctgggagca actataaatc acttgaggtt
1261 ctggttgcag atctagtgaa tgctcagaaa gacagtatgc aagatgagtc aagtcagact
1321 tcattacaga aagagattag tactgaagag cagctaaggc gcctgcaaga ggagaagctt
1381 tgcaaaatct gtatggatag aaatattgct atcgtttttg ttccttgtgg acatctagtc
1441 acttgtaaac aatgtgctga agcagttgac aagtgtccca tgtgctacac agtcattact
1501 ttcaagcaaa aaatttttat gtcttaatct aactctatag taggcatgtt atgttgttct
1561 tattaccctg attgaatgtg tgatgtgaac tgactttaag taatcaggat tgaattccat
1621 tagcatttgc taccaagtag gaaaaaaaat gtacatggca gtgttttagt tggcaatata
1681 atctttgaat ttcttgattt ttcagggtat tagctgtatt atccattttt tttactgtta
1741 tttaattgaa accatagact aagaataaga agcatcatac tataactgaa cacaatgtgt
1801 attcatagta tactgattta atttctaagt gtaagtgaat taatcatctg gattttttat
1861 tcttttcaga taggcttaac aaatggagct ttctgtatat aaatgtggag attagagtta
1921 atctccccaa tcacataatt tgttttgtgt gaaaaaggaa taaattgttc catgctggtg
1981 gaaagataga gattgttttt agaggttggt tgttgtgttt taggattctg tccattttct
2041 tgtaaaggga taaacacgga cgtgtgcgaa atatgtttgt aaagtgattt gccattgttg
2101 aaagcgtatt taatgataga atactatcga gccaacatgt actgacatgg aaagatgtca
2161 gagatatgtt aagtgtaaaa tgcaagtggc gggacactat gtatagtctg agccagatca
2221 aagtatgtat gttgttaata tgcatagaac gagagatttg gaaagatata caccaaactg
2281 ttaaatgtgg tttctcttcg gggagggggg gattggggga ggggccccag aggggtttta
2341 gaggggcctt ttcactttcg acttttttca ttttgttctg ttcggatttt ttataagtat
2401 gtagaccccg aagggtttta tgggaactaa catcagtaac ctaacccccg tgactatcct
2461 gtgctcttcc tagggagctg tgttgtttcc cacccaccac ccttccctct gaacaaatgc
2521 ctgagtgctg gggcactttg
//