LOCUS HSU44378 2680 bp mRNA linear HUM 01-MAR-1996
DEFINITION Human homozygous deletion target in pancreatic carcinoma (DPC4)
mRNA, complete cds.
ACCESSION U44378
VERSION U44378.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2680)
AUTHORS Hahn,S.A., Hoque,A.T., Moskaluk,C.A., da Costa,L.T., Schutte,M.,
Rozenblum,E., Seymour,A.B., Weinstein,C.L., Yeo,C.J., Hruban,R.H.
and Kern,S.E.
TITLE Homozygous deletion map at 18q21.1 in pancreatic cancer
JOURNAL Cancer Res. 56 (3), 490-494 (1996)
PUBMED 8564959
REFERENCE 2 (bases 1 to 2680)
AUTHORS Hahn,S.A., Schutte,M., Shamsul Hoque,A.T.M., Moskaluk,C.A., da
Costa,L.T., Rozenblum,E., Weinstein,C.L., Fischer,A., Yeo,C.J.,
Hruban,R.H. and Kern,S.E.
TITLE DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
JOURNAL Science 271 (5247), 350-353 (1996)
PUBMED 8553070
REFERENCE 3 (bases 1 to 2680)
AUTHORS Hahn,S.A., Schutte,M. and Kern,S.E.
TITLE Direct Submission
JOURNAL Submitted (03-JAN-1996) Scott E. Kern, Oncology, Johns Hopkins, 628
Ross Bldg, 720 Rutland Ave., Baltimore, MD 21205-2196, USA
FEATURES Location/Qualifiers
source 1..2680
/db_xref="H-InvDB:HIT000219917"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="18"
/map="18q21.1"
gene 1..2680
/gene="DPC4"
exon 1..377
/gene="DPC4"
/number=1
5'UTR 1..128
/gene="DPC4"
/note="exon structure of untranslated region was not
determined"
CDS 129..1787
/gene="DPC4"
/standard_name="homozygous deletion target in pancreatic
carcinoma"
/note="similar to Drosophila melanogaster Mothers against
dpp (Mad) gene, GenBank Accession Number U10328"
/codon_start=1
/product="Dpc4"
/protein_id="AAA91041.1"
/translation="MDNMSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLV
KKLKEKKDELDSLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWP
DLHKNELKHVKYCQYAFDLKCDSVCVNPYHYERVVSPGIDLSGLTLQSNAPSSMMVKD
EYVHDFEGQPSLSTEGHSIQTIQHPPSNRASTETYSTPALLAPSESNATSTANFPNIP
VASTSQPASILGGSHSEGLLQIASGPQPGQQQNGFTGQPATYHHNSTTTWTGSRTAPY
TPNLPHHQNGHLQHHPPMPPHPGHYWPVHNELAFQPPISNHPAPEYWCSIAYFEMDVQ
VGETFKVPSSCPIVTVDGYVDPSGGDRFCLGQLSNVHRTEAIERARLHIGKGVQLECK
GEGDVWVRCLSDHAVFVQSYYLDREAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQ
AATAQAAAAAQAAAVAGNIPGPGSVGGIAPAISLSAAAGIGVDDLRRLCILRMSFVKG
WGPDYPRQSIKETPCWIEIHLHRALQLLDEVLHTMPIADPQPLD"
exon 378..552
/gene="DPC4"
/number=2
exon 553..582
/gene="DPC4"
/number=3
exon 583..796
/gene="DPC4"
/number=4
exon 797..915
/gene="DPC4"
/number=5
exon 916..1032
/gene="DPC4"
/number=6
exon 1033..1083
/gene="DPC4"
/number=7
exon 1084..1267
/gene="DPC4"
/number=8
exon 1268..1436
/gene="DPC4"
/number=9
exon 1437..1575
/gene="DPC4"
/number=10
exon 1576..>1787
/gene="DPC4"
/number=11
3'UTR 1785..2680
/gene="DPC4"
/note="exon structure of untranslated region was not
determined"
BASE COUNT 775 a 548 c 567 g 790 t
ORIGIN
1 ggttatcctg aatacatgtc taacaatttt ccttgcaacg ttagctgttg tttttcactg
61 tttccaaagg atcaaaattg cttcagaaat tggagacata tttgatttaa aaggaaaaac
121 ttgaacaaat ggacaatatg tctattacga atacaccaac aagtaatgat gcctgtctga
181 gcattgtgca tagtttgatg tgccatagac aaggtggaga gagtgaaaca tttgcaaaaa
241 gagcaattga aagtttggta aagaagctga aggagaaaaa agatgaattg gattctttaa
301 taacagctat aactacaaat ggagctcatc ctagtaaatg tgttaccata cagagaacat
361 tggatgggag gcttcaggtg gctggtcgga aaggatttcc tcatgtgatc tatgcccgtc
421 tctggaggtg gcctgatctt cacaaaaatg aactaaaaca tgttaaatat tgtcagtatg
481 cgtttgactt aaaatgtgat agtgtctgtg tgaatccata tcactacgaa cgagttgtat
541 cacctggaat tgatctctca ggattaacac tgcagagtaa tgctccatca agtatgatgg
601 tgaaggatga atatgtgcat gactttgagg gacagccatc gttgtccact gaaggacatt
661 caattcaaac catccagcat ccaccaagta atcgtgcatc gacagagaca tacagcaccc
721 cagctctgtt agccccatct gagtctaatg ctaccagcac tgccaacttt cccaacattc
781 ctgtggcttc cacaagtcag cctgccagta tactgggggg cagccatagt gaaggactgt
841 tgcagatagc atcagggcct cagccaggac agcagcagaa tggatttact ggtcagccag
901 ctacttacca tcataacagc actaccacct ggactggaag taggactgca ccatacacac
961 ctaatttgcc tcaccaccaa aacggccatc ttcagcacca cccgcctatg ccgccccatc
1021 ccggacatta ctggcctgtt cacaatgagc ttgcattcca gcctcccatt tccaatcatc
1081 ctgctcctga gtattggtgt tccattgctt actttgaaat ggatgttcag gtaggagaga
1141 catttaaggt tccttcaagc tgccctattg ttactgttga tggatacgtg gacccttctg
1201 gaggagatcg cttttgtttg ggtcaactct ccaatgtcca caggacagaa gccattgaga
1261 gagcaaggtt gcacataggc aaaggtgtgc agttggaatg taaaggtgaa ggtgatgttt
1321 gggtcaggtg ccttagtgac cacgcggtct ttgtacagag ttactactta gacagagaag
1381 ctgggcgtgc acctggagat gctgttcata agatctaccc aagtgcatat ataaaggtct
1441 ttgatttgcg tcagtgtcat cgacagatgc agcagcaggc ggctactgca caagctgcag
1501 cagctgccca ggcagcagcc gtggcaggaa acatccctgg cccaggatca gtaggtggaa
1561 tagctccagc tatcagtctg tcagctgctg ctggaattgg tgttgatgac cttcgtcgct
1621 tatgcatact caggatgagt tttgtgaaag gctggggacc ggattaccca agacagagca
1681 tcaaagaaac accttgctgg attgaaattc acttacaccg ggccctccag ctcctagacg
1741 aagtacttca taccatgccg attgcagacc cacaaccttt agactgaggt cttttaccgt
1801 tggggccctt aaccttatca ggatggtgga ctacaaaata caatcctgtt tataatctga
1861 agatatattt cacttttctt ctgctttatc ttttcataaa gggttgaaaa tgtgtttgct
1921 gccttgctcc tagcagacag aaactggatt aaaacaattt ttttttcctc ttcagaactt
1981 gtcaggcatg gctcagagct tgaagattag gagaaacaca ttcttattaa ttcttcacct
2041 gttatgtatg aaggaatcat tccagtgcta gaaaatttag ccctttaaaa cgtcttagag
2101 ccttttatct gcagaacatc gatatgtata tcattctaca gaataatcca gtattgctga
2161 ttttaaaggc agagaagttc tcaaagttaa ttcacctatg ttattttgtg tacaagttgt
2221 tattgttgaa catacttcaa aaataatgtg ccatgtgggt gagttaattt taccaagagt
2281 aactttactc tgtgtttaaa aatgaagtta ataatgtatt gtaatctttc atccaaaata
2341 ttttttgcaa gttatattag tgaagatggt ttcaattcag attgtcttgc aacttcagtt
2401 ttatttttgc caaggcaaaa aactcttaat ctgtgtgtat attgagaatc ccttaaaatt
2461 accagacaaa aaaatttaaa attacgtttg ttattcctag tggatgactg ttgatgaagt
2521 atacttttcc cctgttaaac agtagttgta ttcttctgta tttctaggca caaggttggt
2581 tgctaagaag cctataagag gaatttcttt tccttcattc atagggaaag gttttgtatt
2641 ttttaaaaca ctaaaagcag cgtcactcta cctaatgtct
//