LOCUS HSU43185 4279 bp mRNA linear HUM 26-AUG-1996
DEFINITION Human signal transducer and activator of transcription Stat5A mRNA,
complete cds.
ACCESSION U43185
VERSION U43185.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4279)
AUTHORS Lin,J.X., Mietz,J., Modi,W.S., John,S. and Leonard,W.J.
TITLE Cloning of human Stat5B. Reconstitution of interleukin-2-induced
Stat5A and Stat5B DNA binding activity in COS-7 cells
JOURNAL J. Biol. Chem. 271 (18), 10738-10744 (1996)
PUBMED 8631883
REFERENCE 2 (bases 1 to 4279)
AUTHORS Lin,J.-X., Mietz,J., Modi,W.S., John,S. and Leonard,W.J.
TITLE Direct Submission
JOURNAL Submitted (12-DEC-1995) Jian-Xin Lin, Laboratory of Molecular
Immunology, NHLBI, NIH, 9000 Rockville Pike, Bldg. 10, Rm. 7N244,
Bethesda, MD 20892, USA
FEATURES Location/Qualifiers
source 1..4279
/db_xref="H-InvDB:HIT000219834"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17q11.2"
CDS 641..3025
/note="signal transducer and activator of transcription;
Stat5A is activated by IL-2, IL-7, IL-15, IL-3, GM-CSF,
growth hormone, prolactin, erythropoietin and
thrombopoietin; activation and dimerization of Stat5A
requires phosphorylation of tyrosine 694"
/codon_start=1
/product="Stat5A"
/protein_id="AAB06589.1"
/translation="MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWD
AIDLDNPQDRAQATQLLEGLVQELQKKAEHQVGEDGFLLKIKLRHYATQLQKTYDRCP
LELVRCIRHILYNEQRLVREANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTEN
ELKKLQQTQEYFIIQYQESLRIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQRE
AQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQ
SWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFII
EKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNEC
SGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRADRRGAESVTEEKFTVLFESQFSV
GSNELVFQVKTLSLPVVVIVHGSQDHNATATVLWDNAFAEPGRVPFAVPDKVLWPQLC
EALNMKFKAEVQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGW
NYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEI
GGITIAWKFDSPERNLWNLKPFTTRDFSIRSLADRLGDLSYLIYVFPDRPKDEVFSKY
YTPVLAKAVDGYVKPQIKQVVPEFVNASADAGGSSATYMDQAPSPAVCPQAPYNMYPQ
NPDHVLDQDGEFDLDETMDVARHVEELLRRPMDSLDSRLSPPAGLFTSARGSLS"
BASE COUNT 920 a 1194 c 1291 g 874 t
ORIGIN
1 cagacaggat attcactgct gtggcaaggc ctgtagagag tttcgaagtt aggaggactc
61 aagacggtcc ctccctggac ttttctgaag gggctcaaaa gatgacacgc gccagagctg
121 gaaggcgtcg ccaattggtc caacttttcc ctcctccctt tttgcggatg agaaaaactg
181 aggcccaggt ttgggatttc cagagcccgg gatttcccgg caacgccgac aaccacattc
241 ccccggctat tctgacccgc cccggttccg ggacgctccc tgggagccgc cgccgagggc
301 ctgctgggac tcccggggac cccgccgtcg gggcagcccc cacgcccggc gccgcccgcc
361 ggaacggcgc cgctgttgcg cacttgcagg ggagccggcg actgagggcg aggcagggag
421 ggagcaagcg gggctgggag ggctgctggc gcgggctcgc cggctgtgta tggtctatcg
481 caggcagctg acctttgagg aggaaatcgc tgctctccgc tccttcctgt agtaacagcc
541 gccgctgccg ccgccgccag gaacccggcc gggagcgaga gccgcggggc gcagagccgg
601 cccggctgcc ggacggtgcg gccccaccag gtgaacggcc atggcgggct ggatccaggc
661 ccagcagctg cagggagacg cgctgcgcca gatgcaggtg ctgtacggcc agcacttccc
721 catcgaggtc cggcactact tggcccagtg gattgagagc cagccatggg atgccattga
781 cttggacaat ccccaggaca gagcccaagc cacccagctc ctggagggcc tggtgcagga
841 gctgcagaag aaggcggagc accaggtggg ggaagatggg tttttactga agatcaagct
901 gaggcactac gccacgcagc tccagaaaac atatgaccgc tgccccctgg agctggtccg
961 ctgcatccgg cacattctgt acaatgaaca gaggctggtc cgagaagcca acaattgcag
1021 ctctccggct gggatcctgg ttgacgccat gtcccagaag caccttcaga tcaaccagac
1081 atttgaggag ctgcgactgg tcacgcagga cacagagaat gagctgaaga aactgcagca
1141 gactcaggag tacttcatca tccagtacca ggagagcctg aggatccaag ctcagtttgc
1201 ccagctggcc cagctgagcc cccaggagcg tctgagccgg gagacggccc tccagcagaa
1261 gcaggtgtct ctggaggcct ggttgcagcg tgaggcacag acactgcagc agtaccgcgt
1321 ggagctggcc gagaagcacc agaagaccct gcagctgctg cggaagcagc agaccatcat
1381 cctggatgac gagctgatcc agtggaagcg gcggcagcag ctggccggga acggcgggcc
1441 ccccgagggc agcctggacg tgctacagtc ctggtgtgag aagttggccg agatcatctg
1501 gcagaaccgg cagcagatcc gcagggctga gcacctctgc cagcagctgc ccatccccgg
1561 cccagtggag gagatgctgg ccgaggtcaa cgccaccatc acggacatta tctcagccct
1621 ggtgaccagc acattcatca ttgagaagca gcctcctcag gtcctgaaga cccagaccaa
1681 gtttgcagcc accgtacgcc tgctggtggg cgggaagctg aacgtgcaca tgaatccccc
1741 ccaggtgaag gccaccatca tcagtgagca gcaggccaag tctctgctta aaaatgagaa
1801 cacccgcaac gagtgcagtg gtgagatcct gaacaactgc tgcgtgatgg agtaccacca
1861 agccacgggc accctcagtg cccacttcag gaacatgtca ctgaagagga tcaagcgtgc
1921 tgaccggcgg ggtgcagagt ccgtgacaga ggagaagttc acagtcctgt ttgagtctca
1981 gttcagtgtt ggcagcaatg agcttgtgtt ccaggtgaag actctgtccc tacctgtggt
2041 tgtcatcgtc cacggcagcc aggaccacaa tgccacggct actgtgctgt gggacaatgc
2101 ctttgctgag ccgggcaggg tgccatttgc cgtgcctgac aaagtgctgt ggccgcagct
2161 gtgtgaggcg ctcaacatga aattcaaggc cgaagtgcag agcaaccggg gcctgaccaa
2221 ggagaacctc gtgttcctgg cgcagaaact gttcaacaac agcagcagcc acctggagga
2281 ctacagtggc ctgtccgtgt cctggtccca gttcaacagg gagaacttgc cgggctggaa
2341 ctacaccttc tggcagtggt ttgacggggt gatggaggtg ttgaagaagc accacaagcc
2401 ccactggaat gatggggcca tcctaggttt tgtgaataag caacaggccc acgacctgct
2461 catcaacaag cccgacggga ccttcttgtt gcgctttagt gactcagaaa tcgggggcat
2521 caccatcgcc tggaagtttg attccccgga acgcaacctg tggaacctga aaccattcac
2581 cacgcgggat ttctccatca ggtccctggc tgaccggctg ggggacctga gctatctcat
2641 ctatgtgttt cctgaccgcc ccaaggatga ggtcttctcc aagtactaca ctcctgtgct
2701 ggctaaagct gttgatggat atgtgaaacc acagatcaag caagtggtcc ctgagtttgt
2761 gaatgcatct gcagatgctg ggggcagcag cgccacgtac atggaccagg ccccctcccc
2821 agctgtgtgc ccccaggctc cctataacat gtacccacag aaccctgacc atgtactcga
2881 tcaggatgga gaattcgacc tggatgagac catggatgtg gccaggcacg tggaggaact
2941 cttacgccga ccaatggaca gtcttgactc ccgcctctcg ccccctgccg gtcttttcac
3001 ctctgccaga ggctccctct catgaatgtt tgaatcccac gcttctcttt ggaaacaata
3061 tgcaatgtga agcggtcgtg ttgtgagttt agtaaggctg tgtacactga cacctttgca
3121 ggcatgcatg tgcttgtgtg tgtgtgtgtg tgtccttgcg catgagctac gcctgcctcc
3181 cctgtgccag tcctgggatg tggctgcagc agcggtggcc ggcctctttt cagatcatgg
3241 catccaagag tgcgccgagt ctgtctctgt catggtagag accgagcctc tgtcactgca
3301 ggcactcaat gcagccagac ctattcctcc tgtgcccctc atctgctcag cagctatttg
3361 aatgagatga ttcagaaggg gaggggagac aggtaacgtc tgtaagctga agtttcactc
3421 cggagtgaga agctttgccc tcctaagaga gagagacaga gagacagaga gagagaaaga
3481 gagagtgtgt gggtctatgt aaatgcatct gtcctcatgt gttgatgtaa ccgattcatc
3541 tctcagaagg gaggctgggg ttcattttcg agtagtattt tatactttag tgaacgtgga
3601 ctccagactc tctgtgaacc ctatgagagc gcgtctgggc ccggccatgt ccttagcaca
3661 ggggggccgc cggtttgagt gagggtttct gagctgctct gaattagtcc ttgcttggct
3721 gcttggcctt gggttcattc aagctcacga tgctgttccc acgtttcccg ggatatatat
3781 tctctcccct ccgttgggcc ccagccttct ttgcttgcct ctctgtttgt aaccttgtcg
3841 acaaagaggt agaaaagatt gggtctagga tatggtgggt ggacaggggc cccgggactt
3901 ggagggttgg tcctcttgcc tcctggaaaa aacaaaaaca aaaaactgca gtgaaagaca
3961 agctgcaaat cagccatgtg ctgcgtgcct gtggaatctg gagtgagggg taaaagctga
4021 tctggtttga ctccgctgga ggtggggcct ggagcaggcc ttgcgctgtt gcgtaactgg
4081 ctgtgttctg gtgaggcctt gctcccaacc ccacacgctc ctccctctga ggcgtgagga
4141 ctcgcagtca ggggcagctg accatggaag attgagagcc caaggtttaa acttcttctc
4201 tgaagggagg tggggatgag aagaggggtt tttttgtact ttgtacaaag accacacatt
4261 tgtgtaaaca gtgttttgg
//