LOCUS HSU43168 3800 bp mRNA linear HUM 28-MAR-1996
DEFINITION Human leptin receptor (Ob-r) mRNA, complete cds.
ACCESSION U43168
VERSION U43168.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3800)
AUTHORS Tartaglia,L.A., Dembski,M., Weng,X., Deng,N., Culpepper,J.,
Devos,R., Richards,G.J., Campfield,L.A., Clark,F.T., Deeds,J.,
Muir,C., Sanker,S., Moriarty,A., Moore,K.J., Smutko,J.S.,
Mays,G.G., Woolf,E.A., Selent-Munro,C. and Tepper,R.I.
TITLE Identification and expression cloning of a leptin receptor, OB-R
JOURNAL Cell 83 (7), 1263-1271 (1995)
PUBMED 8548812
REFERENCE 2 (bases 1 to 3800)
AUTHORS Tartaglia,L.A.
TITLE Direct Submission
JOURNAL Submitted (12-DEC-1995) Louis A. Tartaglia, Millennium
Pharmaceuticals, 640 Memorial Drive, Cambridge, MA 02139
FEATURES Location/Qualifiers
source 1..3800
/db_xref="H-InvDB:HIT000219833"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..3800
/gene="0b-r"
CDS 194..3691
/gene="0b-r"
/note="OB-R"
/codon_start=1
/product="leptin receptor"
/protein_id="AAA93015.1"
/translation="MICQKFCVVLLHWEFIYVITAFNLSYPITPWRFKLSCMPPNSTY
DYFLLPAGLSKNTSNSNGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLC
ADNIEGKTFVSTVNSLVFQQIDANWNIQCWLKGDLKLFICYVESLFKNLFRNYNYKVH
LLYVLPEVLEDSPLVPQKGSFQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSG
GVIFQSPLMSVQPINMVKPDPPLGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSEN
STTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVI
YFPPKILTSVGSNVSFHCIYKKENKIVPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVT
FFNLNETKPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINISCETDGYLTKMTCRWS
TSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIFQPIFLLSG
YTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLKISWEKPVFPEN
NLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDLCAVYAVQVRCKRLDGLGYWSN
WSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYVIN
HHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANFNLTFSWPMSKVNI
VQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNEDGEIKWLRISSSVKKYYIH
DHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDAGLYVIVPVIISSSILL
LGTLLISHQRMKKLFWEDVPNPKNCSWAQGLNFQKPETFEHLFIKHTASVTCGPLLLE
PETISEDISVDTSWKNKDEMMPTTVVSLLSTTDLEKGSVCISDQFNSVNFSEAEGTEV
TYEAESQRQPFVKYATLISNSKPSETGEEQGLINSSVTKCFSSKNSPLKDSFSNSSWE
IEAQAFFILSDQHPNIISPHLTFSEGLDELLKLEGNFPEENNDKKSIYYLGVTSIKKR
ESGVLLTDKSRVSCPFPAPCLFTDIRVLQDSCSHFVENNINLGTSSKKTFASYMPQFQ
TCSTQTHKIMENKMCDLTV"
BASE COUNT 1154 a 715 c 778 g 1153 t
ORIGIN
1 ggcacgagcc ggtctggctt gggcaggctg cccgggccgt ggcaggaagc cggaagcagc
61 cgcggcccca gttcgggaga catggcgggc gttaaagctc tcgtggcatt atccttcagt
121 ggggctattg gactgacttt tcttatgctg ggatgtgcct tagaggatta tgggtgtact
181 tctctgaagt aagatgattt gtcaaaaatt ctgtgtggtt ttgttacatt gggaatttat
241 ttatgtgata actgcgttta acttgtcata tccaattact ccttggagat ttaagttgtc
301 ttgcatgcca ccaaattcaa cctatgacta cttccttttg cctgctggac tctcaaagaa
361 tacttcaaat tcgaatggac attatgagac agctgttgaa cctaagttta attcaagtgg
421 tactcacttt tctaacttat ccaaaacaac tttccactgt tgctttcgga gtgagcaaga
481 tagaaactgc tccttatgtg cagacaacat tgaaggaaag acatttgttt caacagtaaa
541 ttctttagtt tttcaacaaa tagatgcaaa ctggaacata cagtgctggc taaaaggaga
601 cttaaaatta ttcatctgtt atgtggagtc attatttaag aatctattca ggaattataa
661 ctataaggtc catcttttat atgttctgcc tgaagtgtta gaagattcac ctctggttcc
721 ccaaaaaggc agttttcaga tggttcactg caattgcagt gttcatgaat gttgtgaatg
781 tcttgtgcct gtgccaacag ccaaactcaa cgacactctc cttatgtgtt tgaaaatcac
841 atctggtgga gtaattttcc agtcacctct aatgtcagtt cagcccataa atatggtgaa
901 gcctgatcca ccattaggtt tgcatatgga aatcacagat gatggtaatt taaagatttc
961 ttggtccagc ccaccattgg taccatttcc acttcaatat caagtgaaat attcagagaa
1021 ttctacaaca gttatcagag aagctgacaa gattgtctca gctacatccc tgctagtaga
1081 cagtatactt cctgggtctt cgtatgaggt tcaggtgagg ggcaagagac tggatggccc
1141 aggaatctgg agtgactgga gtactcctcg tgtctttacc acacaagatg tcatatactt
1201 tccacctaaa attctgacaa gtgttgggtc taatgtttct tttcactgca tctataagaa
1261 ggaaaacaag attgttccct caaaagagat tgtttggtgg atgaatttag ctgagaaaat
1321 tcctcaaagc cagtatgatg ttgtgagtga tcatgttagc aaagttactt ttttcaatct
1381 gaatgaaacc aaacctcgag gaaagtttac ctatgatgca gtgtactgct gcaatgaaca
1441 tgaatgccat catcgctatg ctgaattata tgtgattgat gtcaatatca atatctcatg
1501 tgaaactgat gggtacttaa ctaaaatgac ttgcagatgg tcaaccagta caatccagtc
1561 acttgcggaa agcactttgc aattgaggta tcataggagc agcctttact gttctgatat
1621 tccatctatt catcccatat ctgagcccaa agattgctat ttgcagagtg atggttttta
1681 tgaatgcatt ttccagccaa tcttcctatt atctggctac acaatgtgga ttaggatcaa
1741 tcactctcta ggttcacttg actctccacc aacatgtgtc cttcctgatt ctgtggtgaa
1801 gccactgcct ccatccagtg tgaaagcaga aattactata aacattggat tattgaaaat
1861 atcttgggaa aagccagtct ttccagagaa taaccttcaa ttccagattc gctatggttt
1921 aagtggaaaa gaagtacaat ggaagatgta tgaggtttat gatgcaaaat caaaatctgt
1981 cagtctccca gttccagact tgtgtgcagt ctatgctgtt caggtgcgct gtaagaggct
2041 agatggactg ggatattgga gtaattggag caatccagcc tacacagttg tcatggatat
2101 aaaagttcct atgagaggac ctgaattttg gagaataatt aatggagata ctatgaaaaa
2161 ggagaaaaat gtcactttac tttggaagcc cctgatgaaa aatgactcat tgtgcagtgt
2221 tcagagatat gtgataaacc atcatacttc ctgcaatgga acatggtcag aagatgtggg
2281 aaatcacacg aaattcactt tcctgtggac agagcaagca catactgtta cggttctggc
2341 catcaattca attggtgctt ctgttgcaaa ttttaattta accttttcat ggcctatgag
2401 caaagtaaat atcgtgcagt cactcagtgc ttatccttta aacagcagtt gtgtgattgt
2461 ttcctggata ctatcaccca gtgattacaa gctaatgtat tttattattg agtggaaaaa
2521 tcttaatgaa gatggtgaaa taaaatggct tagaatctct tcatctgtta agaagtatta
2581 tatccatgat cattttatcc ccattgagaa gtaccagttc agtctttacc caatatttat
2641 ggaaggagtg ggaaaaccaa agataattaa tagtttcact caagatgata ttgaaaaaca
2701 ccagagtgat gcaggtttat atgtaattgt gccagtaatt atttcctctt ccatcttatt
2761 gcttggaaca ttattaatat cacaccaaag aatgaaaaag ctattttggg aagatgttcc
2821 gaaccccaag aattgttcct gggcacaagg acttaatttt cagaagccag aaacgtttga
2881 gcatcttttt atcaagcata cagcatcagt gacatgtggt cctcttcttt tggagcctga
2941 aacaatttca gaagatatca gtgttgatac atcatggaaa aataaagatg agatgatgcc
3001 aacaactgtg gtctctctac tttcaacaac agatcttgaa aagggttctg tttgtattag
3061 tgaccagttc aacagtgtta acttctctga ggctgagggt actgaggtaa cctatgaggc
3121 cgaaagccag agacaaccct ttgttaaata cgccacgctg atcagcaact ctaaaccaag
3181 tgaaactggt gaagaacaag ggcttataaa tagttcagtc accaagtgct tctctagcaa
3241 aaattctccg ttgaaggatt ctttctctaa tagctcatgg gagatagagg cccaggcatt
3301 ttttatatta tcagatcagc atcccaacat aatttcacca cacctcacat tctcagaagg
3361 attggatgaa cttttgaaat tggagggaaa tttccctgaa gaaaataatg ataaaaagtc
3421 tatctattat ttaggggtca cctcaatcaa aaagagagag agtggtgtgc ttttgactga
3481 caagtcaagg gtatcgtgcc cattcccagc cccctgttta ttcacggaca tcagagttct
3541 ccaggacagt tgctcacact ttgtagaaaa taatatcaac ttaggaactt ctagtaagaa
3601 gacttttgca tcttacatgc ctcaattcca aacttgttct actcagactc ataagatcat
3661 ggaaaacaag atgtgtgacc taactgtgta atttcactga agaaaccttc agatttgtgt
3721 tataatgggt aatataaagt gtaatagatt atagttgtgg gtgggagaga gaaaagaaac
3781 cagagtccaa atttgaaaat
//