LOCUS HSU41815 3630 bp mRNA linear HUM 09-FEB-1996
DEFINITION Human nucleoporin 98 (NUP98) mRNA, complete cds.
ACCESSION U41815
VERSION U41815.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3630)
AUTHORS Borrow,J., Shearman,A.M., Stanton,V.P., Becher,R., Collins,T.,
Williams,A.J., Dube,I., Katz,F., Kwong,Y.L., Morris,C.,
Ohyashiki,K., Toyama,K., Rowley,J. and Housman,D.E.
TITLE The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses
the genes for nucleoporin NUP98 and class I homeoprotein HOXA9
JOURNAL Nat. Genet. 12 (2), 159-167 (1996)
PUBMED 8563754
REFERENCE 2 (bases 1 to 3630)
AUTHORS Borrow,J.
TITLE Direct Submission
JOURNAL Submitted (04-DEC-1995) Julian Borrow, Center for Cancer Research,
Massachusetts Institute of Technology, 77 Massachusetts Avenue,
Cambridge, MA 02139, USA
FEATURES Location/Qualifiers
source 1..3630
/db_xref="H-InvDB:HIT000219790"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11p15.5"
/clone_lib="U937"
gene 1..3630
/gene="NUP98"
CDS 145..2907
/gene="NUP98"
/codon_start=1
/product="nucleoporin 98"
/protein_id="AAC50366.1"
/translation="MFNKSFGTPFGGGTGGFGTTSTFGQNTGFGTTSGGAFGTSAFGS
SNNTGGLFGNSQTKPGGLFGTSSFSQPATSTSTGFGFGTSTGTANTLFGTASTGTSLF
SSQNNAFAQNKPTGFGNFGTSTSSGGLFGTTNTTSNPFGSTSGSLFGPSSFTAAPTGT
TIKFNPPTGTDTMVKAGVSTNISTKHQCITAMKEYESKSLEELRLEDYQANRKGPQNQ
VGAGTTTGLFGSSPATSSATGLFSSSTTNSGFAYGQNKTAFGTSTTGFGTNPGGLFGQ
QNQQTTSLFSKPFGQATTTQNTGFSFGNTSTIGQPSTNTMGLFGVTQASQPGGLFGTA
TNTSTGTAFGTGTGLFGQTNTGFGAVGSTLFGNNKLTTFGSSTTSAPSFGTTSGGLFG
FGTNTSGNSIFGSKPAPGTLGTGLGAGFGTALGAGQASLFGNNQPKIGGPLGTGAFGA
PGFNTTTATLGFGAPQAPVALTDPNASAAQQAVLQQHINSLTYSPFGDSPLFRNPMSD
PKKKEERLKPTNPAAQKALTTPTHYKLTPRPATRVRPKALQTTGTAKSHLFDGLDDDE
PSLANGAFMPKKSIKKLVLKNLNNSNLFSPVNRDSENLASPSEYPENGERFSFLSKPV
DENHQQDGDEDSLVSHFYTNPIAKPIPQTPESAGNKHSNSNSVDDTIVALNMRAALRN
GLEGSSEETSFHDESLQDDREEIENNSYHMHPAGIILTKVGYYTIPSMDDLAKITNEK
GECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVVVYLDDNQKPPVGEGL
NRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSW
VFKVSHFSKYGLQDSDEEEEEHPSKTSTKKLKTAPLPPASQTTPLQMALNGKPAPPPQ
VEKKGQ"
misc_feature 160..1735
/gene="NUP98"
/note="encodes FG nucleoporin repeat domain"
misc_feature 1552^1553
/gene="NUP98"
/note="t(7;11)(p15;p15) acute myeloid leukaemia breakpoint
position; fused to HOXA9"
misc_feature 2398..2424
/gene="NUP98"
/note="RNA-binding motif"
BASE COUNT 1030 a 789 c 805 g 1006 t
ORIGIN
1 cggtggcagg ggtggtagcg gcggcggcga cggtttcgtg ggggccgcgc gctgctctgt
61 gagcggcggg tggcagcagg ggactcctga cacttcccct tccccaccga accgcgcttt
121 ctgaaacaaa gactcatttt gaagatgttt aacaaatcat ttggaacacc ctttgggggt
181 ggcacaggtg gctttggcac aacttcaaca tttggacaga atactggctt tggcactact
241 agtggagggg catttggaac atctgcattt ggttctagca acaatactgg aggcctcttt
301 ggaaattcac agactaaacc aggaggattg tttggaacca gttcatttag ccagccagct
361 acctccacaa gcactggctt tgggtttggt acgtcaacag gaacagcaaa taccttgttt
421 ggaactgcaa gcacagggac cagtctcttc tcatcccaaa acaatgcctt tgcacaaaat
481 aaaccaactg gctttggcaa ttttggaacc agtactagca gtggaggact ctttggaacc
541 acaaatacca cctctaatcc ttttggcagc acatctggct ccctctttgg gccaagtagt
601 tttacagctg ctcctactgg gactactatt aaatttaacc ctccaactgg tacagatact
661 atggtcaaag ctggagttag cactaacata agtaccaagc accagtgtat tactgctatg
721 aaagaatatg aaagcaagtc actagaggaa cttcgtttag aggattatca ggctaacagg
781 aagggcccac agaaccaggt gggagcaggt accacaactg gcttgtttgg gtcttctcca
841 gccacttcca gcgcaacagg actcttcagc tcctccacca ctaattcagg ctttgcatat
901 ggtcagaaca aaactgcctt tggaactagt acaactggat ttggaacaaa tccaggtggt
961 ctctttggcc aacagaatca gcagactacc agcctcttca gcaaaccatt tggccaggct
1021 acaaccaccc agaacactgg cttttccttt ggtaatacca gcaccatagg acagccaagc
1081 accaacacca tgggattatt tggagtaacc caagcctcac agcctggagg tctttttggg
1141 acagctacaa acaccagcac tgggacagca tttggaacag gaacaggtct ctttgggcag
1201 accaatactg gatttggtgc tgttggttcg accctgtttg gcaataacaa gcttactaca
1261 tttggaagca gcacaaccag tgcaccttca tttggtacaa ccagtggcgg gctctttggt
1321 tttggcacaa ataccagtgg gaatagtatt tttggaagta aaccagcacc tgggactctt
1381 ggaactgggc ttggtgcagg atttggaaca gctcttggtg ctggacaggc atctttgttt
1441 gggaacaacc aacctaagat tggagggcct cttggtacag gagcctttgg ggcccctgga
1501 tttaatacta cgacagccac tttgggcttt ggagcccccc aggccccagt agctttgaca
1561 gatccaaatg cttctgctgc ccagcaggct gttctccagc agcacatcaa tagtctaaca
1621 tactcacctt ttggagactc tcctctcttc cggaatccga tgtcagaccc taagaagaag
1681 gaagagagat tgaaaccaac aaatccagca gcccagaagg ctcttactac acctactcat
1741 tataaactga caccccgccc tgccactaga gtccggccaa aggctttaca aacaacaggc
1801 acagccaagt cacatctctt tgatgggctg gatgacgatg aaccatccct agccaatgga
1861 gcattcatgc ccaagaagag cattaagaag ttggttttga agaaccttaa taatagcaat
1921 ctcttttctc ctgttaatcg tgattcagaa aatctagctt caccatctga atatccagaa
1981 aatggagaga gatttagttt cctaagcaaa cctgttgatg agaatcacca gcaggatgga
2041 gatgaagatt cccttgtttc acatttttat actaacccta ttgccaaacc tattcctcaa
2101 accccagaaa gtgctggaaa taaacacagc aacagcaaca gtgtggatga taccattgtt
2161 gcattaaaca tgcgtgctgc tttgcgaaat gggctggaag gaagcagtga agaaacgtct
2221 tttcatgatg agtcacttca ggatgaccga gaagaaatag aaaataattc ttaccatatg
2281 cacccagcag gtattattct cactaaggtt ggttactata ctattccatc tatggatgac
2341 cttgctaaaa ttaccaatga aaaaggagag tgcattgtct ctgatttcac tattggtcgg
2401 aaaggttatg gttcaatcta ttttgaagga gatgtgaatt tgacaaatct aaatttggat
2461 gatattgtgc atatccggag gaaagaagta gttgtctact tagatgataa ccaaaaacca
2521 cctgtgggtg aagggctaaa taggaaggct gaagttacat tggatggagt ttggccaaca
2581 gataaaacat ctcgttgttt aataaagagc ccagatcgcc ttgctgatat caactatgaa
2641 ggaagattgg aagcagtttc aaggaaacag ggagctcaat tcaaagaata ccggcctgaa
2701 actggttctt gggtgtttaa ggtctcccat ttttctaagt atggccttca ggattctgat
2761 gaagaggagg aggagcatcc gtctaaaact agtacaaaga agttgaagac tgctcctttg
2821 cctcctgcaa gccagactac gcccttgcag atggctctta atggcaaacc tgcacctcca
2881 cctcaggtag agaaaaaagg acagtgaatt tgaatggaat ccgtgatacc gaagttgaaa
2941 gcaagtcatt cagctaatac aaagctgttt tatgaccctt ggaactttga agagtacaaa
3001 cattggcaat cacgttgaaa caagtgcaag ggagggcgtg aggtcttgca ggcatctgtc
3061 tttttactgg agagatttaa agaattctct tgctgtttgg attattcctc tacagattgt
3121 cattttttaa accctttgtt ctctctcatt tgacttgctg aattctctgc tcagtgatta
3181 acttaagatt tgctcatgtg ggttcatgca cagtaaattc tgcctttatt gactacctga
3241 tgtgcagttt aatctttttc tttacctcca tggtttttta aaagttaaat tagctttctg
3301 aaagggtttt taatctccat ttttttaaag ttgtttgctt atacttcggg taaccttgat
3361 atttgtattt taatagtaca taatctttat gaaaaatagt ttgggaatgt aaatgaatta
3421 ttatttggct tggggagatt agggcctaca ttgtttatcg caattacttg tatcattgat
3481 acgggatttc tttgtaaagc atcctctacc tctcagctgc tgaaagctag acctttggta
3541 ttttccatgc tataattctt atggctgctg aatgtgtggt ttttatgatt tattaaataa
3601 tctcttagga ggcatttctg aaaaaaaaaa
//