LOCUS HSU41766 3865 bp mRNA linear HUM 21-MAR-1996
DEFINITION Human metalloprotease/disintegrin/cysteine-rich protein precursor
(MDC9) mRNA, complete cds.
ACCESSION U41766
VERSION U41766.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3865)
AUTHORS Weskamp,G., Kratzschmar,J., Reid,M.S. and Blobel,C.P.
TITLE MDC9, a widely expressed cellular disintegrin containing
cytoplasmic SH3 ligand domains
JOURNAL J. Cell Biol. 132 (4), 717-726 (1996)
PUBMED 8647900
REFERENCE 2 (bases 1 to 3865)
AUTHORS Blobel,C.P.
TITLE Direct Submission
JOURNAL Submitted (04-DEC-1995) Carl P. Blobel, Cellular Biochemistry and
Biophysics Program, Memorial Sloan-Kettering Cancer Center, 1275
York Avenue, New York, NY 10021, USA
FEATURES Location/Qualifiers
source 1..3865
/db_xref="H-InvDB:HIT000219784"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="MDA-MB-468 mammary epithelial carcinoma"
gene 1..3865
/gene="MDC9"
CDS 79..2538
/gene="MDC9"
/note="Method: conceptual translation supplied by author"
/codon_start=1
/product="metalloprotease/disintegrin/cysteine-rich
protein precursor"
/protein_id="AAC50403.1"
/translation="MGSGARFPSGTLRVRWLLLLGLVGPVLGAARPGFQQTSHLSSYE
IITPWRLTRERREAPRPYSKQVSYVIQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGT
LITDHPNIQNHCHYRGYVEGVHNSSIALSDCFGLRGLLHLENASYGIEPLQNSSHFEH
IIYRMDDVYKEPLKCGVSNKDIEKETAKDEEEEPPSMTQLLRRRRAVLPQTRYVELFI
VVDKERYDMMGRNQTAVREEMILLANYLDSMYIMLNIRIVLVGLEIWTNGNLINIVGG
AGDVLGNFVQWREKFLITRRRHDSAQLVLKKGFGGTAGMAFVGTVCSRSHAGGINVFG
QITVETFASIVAHELGHNLGMNHDDGRDCSCGAKSCIMNSGASGSRNFSSCSAEDFEK
LTLNKGGNCLLNIPKPDEAYSAPSCGNKLVDAGEECDCGTPKECELDPCCEGSTCKLK
SFAECAYGDCCKDCRFLPGGTLCRGKTSECDVPEYCNGSSQFCQPDVFIQNGYPCQNN
KAYCYNGMCQYYDAQCQVIFGSKAKAAPKDCFIEVNSKGDRFGNCGFSGNEYKKCATG
NALCGKLQCENVQEIPVFGIVPAIIQTPSRGTKCWGVDFQLGSDVPDPGMVNEGTKCG
AGKICRNFQCVDASVLNYDCDVQKKCHGHGVCNSNKNCHCENGWAPPNCETKGYGGSV
DSGPTYNEMNTALRDGLLVFFFLIVPLIVCAIFIFIKRDQLWRSYFRKKRSQTYESDG
KNQANPSRQPGSVPRHVSPVTPPREVPIYANRFAVPTYAAKQPQQFPSRPPPPQPKVS
SQGNLIPARPAPAPPLYSSLT"
sig_peptide 79..168
/gene="MDC9"
mat_peptide 166..2535
/gene="MDC9"
/product="metalloprotease/disintegrin/cysteine-rich
protein"
misc_feature 167..694
/gene="MDC9"
/note="encodes the pro-domain"
misc_feature 695..1315
/gene="MDC9"
/note="encodes the metalloproteinase domain"
misc_feature 1316..1588
/gene="MDC9"
/note="encodes the disintegrin domain"
misc_feature 1589..2008
/gene="MDC9"
/note="encodes the cysteine-rich domain"
misc_feature 2009..2098
/gene="MDC9"
/note="encodes the EGF-like domain"
misc_feature 2174..2233
/gene="MDC9"
/note="encodes the transmembrane domain"
misc_feature 2234..2535
/gene="MDC9"
/note="encodes the cytoplasmic domain"
BASE COUNT 1201 a 670 c 842 g 1152 t
ORIGIN
1 cggcagggtt ggaaaatgat ggaagaggcg gaggtggagg cgaccgagtg ctgagaggaa
61 cctgcggaat cggccgagat ggggtctggc gcgcgctttc cctcggggac ccttcgtgtc
121 cggtggttgc tgttgcttgg cctggtgggc ccagtcctcg gtgcggcgcg gccaggcttt
181 caacagacct cacatctttc ttcttatgaa attataactc cttggagatt aactagagaa
241 agaagagaag cccctaggcc ctattcaaaa caagtatctt atgttattca ggctgaagga
301 aaagagcata ttattcactt ggaaaggaac aaagaccttt tgcctgaaga ttttgtggtt
361 tatacttaca acaaggaagg gactttaatc actgaccatc ccaatataca gaatcattgt
421 cattatcggg gctatgtgga gggagttcat aattcatcca ttgctcttag cgactgtttt
481 ggactcagag gattgctgca tttagagaat gcgagttatg ggattgaacc cctgcagaac
541 agctctcatt ttgagcacat catttatcga atggatgatg tctacaaaga gcctctgaaa
601 tgtggagttt ccaacaagga tatagagaaa gaaactgcaa aggatgaaga ggaagagcct
661 cccagcatga ctcagctact tcgaagaaga agagctgtct tgccacagac ccggtatgtg
721 gagctgttca ttgtcgtaga caaggaaagg tatgacatga tgggaagaaa tcagactgct
781 gtgagagaag agatgattct cctggcaaac tacttggata gtatgtatat tatgttaaat
841 attcgaattg tgctagttgg actggagatt tggaccaatg gaaacctgat caacatagtt
901 gggggtgctg gtgatgtgct ggggaacttc gtgcagtggc gggaaaagtt tcttatcaca
961 cgtcggagac atgacagtgc acagctagtt ctaaagaaag gttttggtgg aactgcagga
1021 atggcatttg tgggaacagt gtgttcaagg agccacgcag gcgggattaa tgtgtttgga
1081 caaatcactg tggagacatt tgcttccatt gttgctcatg aattgggtca taatcttgga
1141 atgaatcacg atgatgggag agattgttcc tgtggagcaa agagctgcat catgaattca
1201 ggagcatcgg gttccagaaa ctttagcagt tgcagtgcag aggactttga gaagttaact
1261 ttaaataaag gaggaaactg ccttcttaat attccaaagc ctgatgaagc ctatagtgct
1321 ccctcctgtg gtaataagtt ggtggacgct ggggaagagt gtgactgtgg tactccaaag
1381 gaatgtgaat tggacccttg ctgcgaagga agtacctgta agcttaaatc atttgctgag
1441 tgtgcatatg gtgactgttg taaagactgt cggttccttc caggaggtac tttatgccga
1501 ggaaaaacca gtgagtgtga tgttccagag tactgcaatg gttcttctca gttctgtcag
1561 ccagatgttt ttattcagaa tggatatcct tgccagaata acaaagccta ttgctacaac
1621 ggcatgtgcc agtattatga tgctcaatgt caagtcatct ttggctcaaa agccaaggct
1681 gcccccaaag attgtttcat tgaagtgaat tctaaaggtg acagatttgg caattgtggt
1741 ttctctggca atgaatacaa gaagtgtgcc actgggaatg ctttgtgtgg aaagcttcag
1801 tgtgagaatg tacaagagat acctgtattt ggaattgtgc ctgctattat tcaaacgcct
1861 agtcgaggca ccaaatgttg gggtgtggat ttccagctag gatcagatgt tccagatcct
1921 gggatggtta acgaaggcac aaaatgtggt gctggaaaga tctgtagaaa cttccagtgt
1981 gtagatgctt ctgttctgaa ttatgactgt gatgttcaga aaaagtgtca tggacatggg
2041 gtatgtaata gcaataagaa ttgtcactgt gaaaatggct gggctccccc aaattgtgag
2101 actaaaggat acggaggaag tgtggacagt ggacctacat acaatgaaat gaatactgca
2161 ttgagggacg gacttctggt cttcttcttc ctaattgttc cccttattgt ctgtgctatt
2221 tttatcttca tcaagaggga tcaactgtgg agaagctact tcagaaagaa gagatcacaa
2281 acatatgagt cagatggcaa aaatcaagca aacccttcta gacagccggg gagtgttcct
2341 cgacatgttt ctccagtgac acctcccaga gaagttccta tatatgcaaa cagatttgca
2401 gtaccaacct atgcagccaa gcaacctcag cagttcccat caaggccacc tccaccacaa
2461 ccgaaagtat catctcaggg aaacttaatt cctgcccgtc ctgctcctgc acctccttta
2521 tatagttccc tcacttgatt tttttaacct tctttttgca aatgtcttca gggaactgag
2581 ctaatacttt ttttttttct tgatgttttc ttgaaaagcc tttctgttgc aactatgaat
2641 gaaaacaaaa caccacaaaa cagacttcac taacacagaa aaacagaaac tgagtgtgag
2701 agttgtgaaa tacaaggaaa tgcagtaaag ccagggaatt tacaataaca tttccgtttc
2761 catcattgaa taagtcttat tcagtcatcg gtgaggttaa tgcactaatc atggattttt
2821 tgaacatgtt attgcagtga ttctcaaatt aactgtattg gtgtaagatt tttgtcatta
2881 agtgtttaag tgttattctg aattttctac cttagttatc attaatgtag ttcctcattg
2941 aacatgtgat aatctaatac ctgtgaaaac tgactaatca gctgccaata atatctaata
3001 tttttcatca tgcacgaatt aataatcatc atactctaga atcttgtctg tcactcacta
3061 catgaataag caaatattgt cttcaaaaga atgcacaaga accacaatta agatgtcata
3121 ttattttgaa agtacaaaat atactaaaag agtgtgtgtg tattcacgca gttactcgct
3181 tccattttta tgacctttca actataggta ataactctta gagaaattaa tttaatatta
3241 gaatttctat tatgaatcat gtgaaagcat gacattcgtt cacaatagca ctattttaaa
3301 taaattataa gctttaaggt acgaagtatt taatagatct aatcaaatat gttgattcat
3361 ggctataata aagcaggagc aattataaaa tcttcaatca attgaacttt tacaaaacca
3421 cttgagaatt tcatgagcac tttaaaatct gaactttcaa agcttgctat taaatcattt
3481 agaatgttta catttactaa ggtgtgctgg gtcatgtaaa atattagaca ctaatatttt
3541 catagaaatt aggctggaga aagaaggaag aaatggtttt cttaaatacc tacaaaaaag
3601 ttactgtggt atctatgagt tatcatctta gctgtgttaa aaatgaattt ttactatggc
3661 agatatggta tggatcgtaa aattttaagc actaaaaatt ttttcataac ctttcataat
3721 aaagtttaat aataggttta ttaactgaat ttcattagtt ttttaaaagt gtttttggtt
3781 tgtgtatata tacatataca aatacaacat ttacaataaa taaaatactt gaaattctca
3841 aaaaaaaaaa aaaaaaaaaa aaaaa
//