LOCUS HSU40623 3324 bp mRNA linear HUM 28-MAR-1996
DEFINITION Human subtilisin-like protease PC8 precursor (PC8) mRNA, complete
cds.
ACCESSION U40623
VERSION U40623.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3324)
AUTHORS Bruzzaniti,A., Goodge,K., Jay,P., Taviaux,S.A., Lam,M.H., Berta,P.,
Martin,T.J., Moseley,J.M. and Gillespie,M.T.
TITLE PC8 [corrected], a new member of the convertase family
JOURNAL Biochem. J. 314 (Pt 3), 727-731 (1996)
PUBMED 8615762
REFERENCE 2 (bases 1 to 3324)
AUTHORS Gillespie,M.T., Bruzzaniti,A., Goodge,K., Jay,P., Taviaux,S.A.,
Lam,M.H.C., Berta,P., Martin,T.J. and Moseley,J.M.
TITLE Direct Submission
JOURNAL Submitted (14-NOV-1995) Matthew T. Gillespie, St Vincent's
Institute of Medical Research, 41 Victoria Parade, Fitzroy,
Victoria 3065, Australia
FEATURES Location/Qualifiers
source 1..3324
/db_xref="H-InvDB:HIT000219733"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q23-q24"
/cell_line="BEN cell line, Moseley, J.M. et al. (1987),
Proc. Natl. Acad. Sci. USA 84: 5048-5052"
gene 1..3324
/gene="PC8"
CDS 22..2379
/gene="PC8"
/note="Prohormone converting enzyme, subtilisin-like
protease, convertase"
/codon_start=1
/product="PC8 precursor"
/protein_id="AAC50417.1"
/translation="MPKGRQKVPHLDAPLGLPTCLWLELAGLFLLVPWVMGLAGTGGP
DGQGTGGASWAVHLESLEGDGEEETLEQQADALAQAAGLVNAGRIGELQGHYLFVQPA
GHRPALEVEPIRQQVEAVLAGHEAVRWHSEQRLLRRAKRSVHFNDPKYPQQWHLNNRR
SPGRDINVTGVWERNVTGRGVTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMP
HPDVENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNK
HYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHN
DNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVTTDWDL
QKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRRAEWV
TNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKENKAIPQSPRSLEV
LWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSDP
NGFNDWTFSTVRCWGERARGTYRLVIRDVGDESFQVGILRQWQLTLYGSVWSAVDIRD
RQRLLESAMSGKYLHDDFALPCPPGLKIPEEDGYTITPNTLKTLVLVGCFTVFWTVYY
MLEVYLSQRNVASNQVCRSGPCHWPHRSRKAKEEGTELESVPLCSSKDPDEVETESRG
PPTTSDLLAPDLLEQGDWSLSQNKSALDCPHQHLDVPHGKEEQIC"
sig_peptide 22..444
/gene="PC8"
mat_peptide 445..2376
/gene="PC8"
/product="PC8"
/note="Prohormone converting enzyme, subtilisin-like
protease, convertase"
BASE COUNT 755 a 930 c 976 g 663 t
ORIGIN
1 agaatccagt ccactgctct gatgccgaag gggaggcaga aagtgccaca cttggatgcc
61 cccctgggcc tgcccacctg cctctggctg gaattagccg ggctcttctt actggttccc
121 tgggtcatgg gcctggcagg gacaggtggg cctgatggcc agggcacagg gggggcgagc
181 tgggctgtgc acctggaaag cctggaaggt gacggggagg aagagactct tgagcagcag
241 gcggatgcct tggcccaggc agcagggctg gtgaatgctg gacgcatcgg agagcttcag
301 gggcactacc tctttgtcca gcctgctggg cacaggccgg ccctggaggt ggagcccatc
361 cgccagcagg tggaggctgt gttggctggg catgaagctg tgcgctggca ctcagagcag
421 aggctgctaa ggcgggccaa gcgcagcgtc cacttcaacg accccaagta cccgcagcaa
481 tggcacctga ataaccgacg gagcccgggc agggacatca acgtgacggg tgtgtgggaa
541 cgcaatgtga ctgggcgagg ggtgacggtg gtggtagtgg atgacggagt ggaacacacc
601 atccaggaca ttgcacccaa ctatagccct gagggtagct atgacctcaa ctctaatgac
661 cctgacccca tgccccaccc ggatgtggag aatggcaacc accatggcac gcgatgtgca
721 ggagagatcg cggctgtgcc caacaacagc ttctgtgccg tgggcgtggc ctacgggagc
781 cgcatcgcag gtatccgggt actggatgga cctctcacag acagcatgga ggcagtggcg
841 ttcaacaagc actatcagat caatgacatc tacagctgca gctggggacc agatgacgat
901 gggaagacag tggatggccc ccatcagctt ggaaaggctg ccttacaaca tggggtgatt
961 gctggtcgcc agggctttgg gagcatcttt gtggtagcca gtggcaacgg aggccaacac
1021 aacgacaact gcaactacga tggctacgcc aactccatct acaccgtcac cataggagct
1081 gtggatgagg agggacgcat gcctttctat gcagaagaat gtgcctccat gctggcagtc
1141 accttcagtg gtggggacaa gatgcttcgg agcattgtga ccactgactg ggaccttcag
1201 aagggcactg gctgcactga gggccacaca gggacctcag ctgcagcgcc tctggcagct
1261 ggcatgatag ccttaatgct gcaggtgcgg ccctgcctca cgtggcgtga cgtccagcac
1321 atcattgtct tcacagccac ccggtatgag gatcgccgtg cagagtgggt caccaacgag
1381 gcaggcttca gccatagcca ccagcacggt ttcggcctcc tcaacgcctg gaggctcgtg
1441 aatgcagcca agatctggac atctgtccct tacttagcat cctacgtcag tcccgtgtta
1501 aaagaaaaca aggcgattcc gcagtccccc cgttccctgg aggtcctgtg gaatgtcagc
1561 aggatggacc tggagatgtc agggctgaag accctggagc atgtggcagt gacagtctcc
1621 atcactcacc cacggcgcgg cagcttggag ctgaagctgt tctgccccag tggcatgatg
1681 tccctcatcg gcgccccccg cagcatggac tcggatccca acggcttcaa tgactggacc
1741 ttctccactg tgcgatgctg gggggagaga gcccgaggga cctacaggct tgtcatcagg
1801 gatgtcgggg atgagtcatt ccaggtcggc atcctccggc aatggcagct gaccctatat
1861 ggctctgtgt ggagtgcagt agacatcagg gacagacaaa ggctgttaga gagtgccatg
1921 agtggaaaat acctgcacga tgacttcgcc ctgccctgcc caccggggct gaaaattcct
1981 gaggaagatg gttacaccat cacccccaac accctcaaga ccctggtgct ggtaggctgt
2041 ttcaccgtct tctggactgt ttactacatg ctggaagtat atttgagcca gaggaatgtg
2101 gcttccaatc aagtttgtag gagtggaccc tgccactggc cccatcggag ccggaaagcc
2161 aaggaggaag ggacagagct agaatcagtg ccactttgca gcagcaagga tccagacgaa
2221 gtggaaacag agagcagggg ccctcccacc acctctgacc tccttgcccc agacctgctg
2281 gagcaagggg actggagcct gtcccagaac aagagcgccc tggactgccc tcatcagcac
2341 ctagacgtac cgcacgggaa ggaggagcag atctgctgac ctcagggcct gacagtgtgg
2401 gacaggctct tctttcccaa aattagggag ctcttgacag aaagcagttc tgatgcttac
2461 atctggaatc tgaggcatcc tctgactcca ctcaaagagg gtgagggcct tcttaagata
2521 caaatggtgg aggattgctg ccagagaagt ctggtcagag ccacagggtc tgcctccagc
2581 caaacgggag cttttggtga gaaggtgttg gacaggggat tggcgccccc ctttggtttg
2641 gcctccatcc tcatctctct tgggccaagc cagctgccta ggtcccccaa gcatggggga
2701 ccccttccca catataagtt gagaaggtgc ctgccatagc caggagcgca tctcaatgga
2761 aacatcactg gggtcacttg ggaagaggac ttcggggtag aggctgggag gagcccctgg
2821 acatgcctgt cctgaaagcg gctgcctcca ttatccattc ccaagatgcc tgatcagaaa
2881 ccaaccatga atgaacccct ggctccttca ccacccccac gattggtatg atgctgccgg
2941 cacagctggg atacacacgg ctcccccagg cctgagctgc ttcactaggg aatcctgcgg
3001 caggactgca gagcagatgg cagatgcaca tgttggagga gagagccttg ggagccactg
3061 ccactccagt cctgccacca ccctgtcttc ctctgcaagt gctcagggaa atggccttcc
3121 cgccggaggc cagctatctg cctgacaggc tgtgactctt ctctcaacct tggccttctc
3181 ccctcttctg agctagttgg ttgaattttt tttaatgctt aagatttgtt tttctctttt
3241 cacagcaaca ttttcttgaa tttttttctg cacagctttt ccaaaataaa aaccttccaa
3301 acaaaaaaaa aaaaaaaaaa aaaa
//