LOCUS HSU40434 2114 bp mRNA linear HUM 19-JAN-1996 DEFINITION Human mesothelin or CAK1 antigen precursor mRNA, complete cds. ACCESSION U40434 VERSION U40434.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2114) AUTHORS Chang,K. and Pastan,I. TITLE Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers JOURNAL Proc. Natl. Acad. Sci. U.S.A. 93 (1), 136-140 (1996) PUBMED 8552591 REFERENCE 2 (bases 1 to 2114) AUTHORS Chang,K. TITLE Direct Submission JOURNAL Submitted (09-NOV-1995) Kai Chang, Laboratory of Molecular Biology, National Cancer Institute, Building 37, Room 4B19, 37 Convent Drive, MSC4255, Bethesda, MD MD20892-4255, USA FEATURES Location/Qualifiers source 1..2114 /db_xref="H-InvDB:HIT000219720" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="16" /clone="pcD3CAK1-9" /cell_line="KB, HeLa, OVCAR-3" /cell_type="HeLa" /tissue_type="ovarian cancers and squamous cell carcinoma." CDS 100..1986 /codon_start=1 /product="mesothelin or CAK1 antigen precursor" /protein_id="AAC50348.1" /translation="MALQRLDPCWSCGDRPGSLLFLLFSLGWVHPARTLAGETGTESA PLGGVLTTPHNISSLSPRQLLGFPCAEVSGLSTERVRELAVALAQKNVKLSTEQLRCL AHRLSEPPEDLDALPLDLLLFLNPDAFSGPQACTRFFSRITKANVDLLPRGAPERQRL LPAALACWGVRGSLLSEADVRALGGLACDLPGRFVAESAEVLLPRLVSCPGPLDQDQQ EAARAALQGGGPPYGPPSTWSVSTMDALRGLLPVLGQPIIRSIPQGIVAAWRQRSSRD PSWRQPERTILRPRFRREVEKTACPSGKKAREIDESLIFYKKWELEACVDAALLATQM DRVNAIPFTYEQLDVLKHKLDELYPQGYPESVIQHLGYLFLKMSPEDIRKWNVTSLET LKALLEVDKGHEMSPQAPRRPLPQVATLIDRFVKGRGQLDKDTLDTLTAFYPGYLCSL SPEELSSVPPSSIWAVRPQDLDTCDPRQLDVLYPKARLAFQNMNGSEYFVKIQSFLGG APTEDLKALSQQNVSMDLATFMKLRTDAVLPLTVAEVQKLLGPHVEGLKAEERHRPVR DWILRQRQDDLDTLGLGLQGGIPNGYLVLDLSVQETLSGTPCLLGPGPVLTVLALLLA STLA" sig_peptide 100..192 mat_peptide 193..1857 /product="mesothelin" misc_feature 193..978 /note="encodes putative cleaved N-terminal portion of mesothelin" misc_feature 973..978 /note="encodes putative proteolytic site" misc_feature 979..1983 /note="encodes putative membrane bound portion of mesothelin, bearing epitope(s) recognized by MAb K1" misc_feature 1858..1983 /note="encodes putative hydrophobic region for GPI anchorage" regulatory 2087..2093 /regulatory_class="polyA_signal_sequence" /note="putative" polyA_site 2114 BASE COUNT 361 a 722 c 661 g 370 t ORIGIN 1 aggaattccg gtggccggcc actcccgtct gctgtgacgc gcggacagag agctaccggt 61 ggacccacgg tgcctccctc cctgggatct acacagacca tggccttgca acggctcgac 121 ccctgttggt cctgtgggga ccgccctggc agcctcctgt tcctgctctt cagcctcgga 181 tgggtgcatc ccgcgaggac cctggctgga gagacaggga cggagtctgc ccccctgggg 241 ggagtcctga caacccccca taacatttcc agcctctccc ctcgccaact ccttggcttc 301 ccgtgtgcgg aggtgtccgg cctgagcacg gagcgtgtcc gggagctggc tgtggccttg 361 gcacagaaga atgtcaagct ctcaacagag cagctgcgct gtctggctca ccggctctct 421 gagccccccg aggacctgga cgccctccca ttggacctgc tgctattcct caacccagat 481 gcgttctcgg ggccccaggc ctgcacccgt ttcttctccc gcatcacgaa ggccaatgtg 541 gacctgctcc cgaggggggc tcccgagcga cagcggctgc tgcctgcggc tctggcctgc 601 tggggtgtgc gggggtctct gctgagcgag gctgatgtgc gggctctggg aggcctggct 661 tgcgacctgc ctgggcgctt tgtggccgag tcggccgaag tgctgctacc ccggctggtg 721 agctgcccgg gacccctgga ccaggaccag caggaggcag ccagggcggc tctgcagggc 781 gggggacccc cctacggccc cccgtcgaca tggtctgtct ccacgatgga cgctctgcgg 841 ggcctgctgc ccgtgctggg ccagcccatc atccgcagca tcccgcaggg catcgtggcc 901 gcgtggcggc aacgctcctc tcgggaccca tcctggcggc agcctgaacg gaccatcctc 961 cggccgcggt tccggcggga agtggagaag acagcctgtc cttcaggcaa gaaggcccgc 1021 gagatagacg agagcctcat cttctacaag aagtgggagc tggaagcctg cgtggatgcg 1081 gccctgctgg ccacccagat ggaccgcgtg aacgccatcc ccttcaccta cgagcagctg 1141 gacgtcctaa agcataaact ggatgagctc tacccacaag gttaccccga gtctgtgatc 1201 cagcacctgg gctacctctt cctcaagatg agccctgagg acattcgcaa gtggaatgtg 1261 acgtccctgg agaccctgaa ggctttgctt gaagtcgaca aagggcacga aatgagtcct 1321 caggctcctc ggcggcccct cccacaggtg gccaccctga tcgaccgctt tgtgaaggga 1381 aggggccagc tagacaaaga caccctagac accctgaccg ccttctaccc tgggtacctg 1441 tgctccctca gccccgagga gctgagctcc gtgcccccca gcagcatctg ggcggtcagg 1501 ccccaggacc tggacacgtg tgacccaagg cagctggacg tcctctatcc caaggcccgc 1561 cttgctttcc agaacatgaa cgggtccgaa tacttcgtga agatccagtc cttcctgggt 1621 ggggccccca cggaggattt gaaggcgctc agtcagcaga atgtgagcat ggacttggcc 1681 acgttcatga agctgcggac ggatgcggtg ctgccgttga ctgtggctga ggtgcagaaa 1741 cttctgggac cccacgtgga gggcctgaag gcggaggagc ggcaccgccc ggtgcgggac 1801 tggatcctac ggcagcggca ggacgacctg gacacgctgg ggctggggct acagggcggc 1861 atccccaacg gctacctggt cctagacctc agcgtgcaag agaccctctc ggggacgccc 1921 tgcctcctag gacctggacc tgttctcacc gtcctggcac tgctcctagc ctccaccctg 1981 gcctgagggc cccactccct tgctggcccc agccctgctg gggatccccg cctggccagg 2041 agcaggcacg ggtgatcccc gttccacccc aagagaactc gcgctcagta aacgggaaca 2101 tgccccctgc agac //