LOCUS HSU39817 4437 bp mRNA linear HUM 16-FEB-1996
DEFINITION Human Bloom's syndrome protein (BLM) mRNA, complete cds.
ACCESSION U39817
VERSION U39817.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4437)
AUTHORS Ellis,N.A., Groden,J., Ye,T.Z., Straughen,J., Lennon,D.J.,
Ciocci,S., Proytcheva,M. and German,J.
TITLE The Bloom's syndrome gene product is homologous to RecQ helicases
JOURNAL Cell 83 (4), 655-666 (1995)
PUBMED 7585968
REFERENCE 2 (bases 1 to 4437)
AUTHORS Ellis,N.
TITLE Direct Submission
JOURNAL Submitted (01-NOV-1995) Nathan A. Ellis, Human Genetics, New York
Blood Center, 310 E 67th St., New York, NY 10021, USA
FEATURES Location/Qualifiers
source 1..4437
/db_xref="H-InvDB:HIT000219697"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="15"
/map="15q26.1"
/cell_line="lymphoblastoid; normal diploid fibroblast"
/cell_type="HeLa"
gene 1..4437
/gene="BLM"
CDS 75..4328
/gene="BLM"
/note="putative DNA helicase; contain motifs similar to
the seven helicase motifs in RecQ helicases"
/codon_start=1
/product="Bloom's syndrome protein"
/protein_id="AAA87850.1"
/translation="MAAVPQNNLQEQLERHSARTLNNKLSLSKPKFSGFTFKKKTSSD
NNVSVTNVSVAKTPVLRNKDVNVTEDFSFSEPLPNTTNQQRVKDFFKNAPAGQETQRG
GSKSLLPDFLQTPKEVVCTTQNTPTVKKSRDTALKKLEFSSSPDSLSTINDWDDMDDF
DTSETSKSFVTPPQSHFVRVSTAQKSKKGKRNFFKAQLYTTNTVKTDLPPPSSESEQI
DLTEEQKDDSEWLSSDVICIDDGPIAEVHINEDAQESDSLKTHLEDERDNSEKKKNLE
EAELHSTEKVPCIEFDDDDYDTDFVPPSPEEIISASSSSSKCLSTLKDLDTSDRKEDV
LSTSKDLLSKPEKMSMQELNPETSTDCDARQISLQQQLIHVMEHICKLIDTIPDDKLK
LLDCGNELLQQRNIRRKLLTEVDFNKSDASLLGSLWRYRPDSLDGPMEGDSCPTGNSM
KELNFSHLPSNSVSPGDCLLTTTLGKTGFSATRKNLFERPLFNTHLQKSFVSSNWAET
PRLGKKNESSYFPGNVLTSTAVKDQNKHTASINDLERETQPSYDIDNFDIDDFDDDDD
WEDIMHNLAASKSSTAAYQPIKEGRPIKSVSERLSSAKTDCLPVSSTAQNINFSESIQ
NYTDKSAQNLASRNLKHERFQSLSFPHTKEMMKIFHKKFGLHNFRTNQLEAINAALLG
EDCFILMPTGGGKSLCYQLPACVSPGVTVVISPLRSLIVDQVQKLTSLDIPATYLTGD
KTDSEATNIYLQLSKKDPIIKLLYVTPEKICASNRLISTLENLYERKLLARFVIDEAH
CVSQWGHDFRQDYKRMNMLRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMS
FNRHNLKYYVLPKKPKKVAFDCLEWIRKHHPYDSGIIYCLSRRECDTMADTLQRDGLA
ALAYHAGLSDSARDEVQQKWINQDGCQVICATIAFGMGIDKPDVRFVIHASLPKSVEG
YYQESGRAGRDGEISHCLLFYTYHDVTRLKRLIMMEKDGNHHTRETHFNNLYSMVHYC
ENITECRRIQLLAYFGENGFNPDFCKKHPDVSCDNCCKTKDYKTRDVTDDVKSIVRFV
QEHSSSQGMRNIKHVGPSGRFTMNMLVDIFLGSKSAKIQSGIFGKGSAYSRHNAERLF
KKLILDKILDEDLYINANDQAIAYVMLGNKAQTVLNGNLKVDFMETENSSSVKKQKAL
VAKVSQREEMVKKCLGELTEVCKSLGKVFGVHYFNIFNTVTLKKLAESLSSDPEVLLQ
IDGVTEDKLEKYGAEVISVLQKYSEWTSPAEDSSPGISLSSSRGPGRSAAEELDEEIP
VSSHYFASKTRNERKRKKMPASQRSKRRKTASSGSKAKGGSATCRKISSKTKSSSIIG
SSSASHTSQATSGANSKLGIMAPPKPINRPFLKPSYAFS"
BASE COUNT 1465 a 865 c 913 g 1194 t
ORIGIN
1 gcgcggcggc cgtggttgcg gcgcgggaag tttggatcct ggttccgtcc gctaggagtc
61 tgcgtgcgag gattatggct gctgttcctc aaaataatct acaggagcaa ctagaacgtc
121 actcagccag aacacttaat aataaattaa gtctttcaaa accaaaattt tcaggtttca
181 cttttaaaaa gaaaacatct tcagataaca atgtatctgt aactaatgtg tcagtagcaa
241 aaacacctgt attaagaaat aaagatgtta atgttaccga agacttttcc ttcagtgaac
301 ctctacccaa caccacaaat cagcaaaggg tcaaggactt ctttaaaaat gctccagcag
361 gacaggaaac acagagaggt ggatcaaaat cattattgcc agatttcttg cagactccga
421 aggaagttgt atgcactacc caaaacacac caactgtaaa gaaatcccgg gatactgctc
481 tcaagaaatt agaatttagt tcttcaccag attctttaag taccatcaat gattgggatg
541 atatggatga ctttgatact tctgagactt caaaatcatt tgttacacca ccccaaagtc
601 actttgtaag agtaagcact gctcagaaat caaaaaaggg taagagaaac ttttttaaag
661 cacagcttta tacaacaaac acagtaaaga ctgatttgcc tccaccctcc tctgaaagcg
721 agcaaataga tttgactgag gaacagaagg atgactcaga atggttaagc agcgatgtga
781 tttgcatcga tgatggcccc attgctgaag tgcatataaa tgaagatgct caggaaagtg
841 actctctgaa aactcatttg gaagatgaaa gagataatag cgaaaagaag aagaatttgg
901 aagaagctga attacattca actgagaaag ttccatgtat tgaatttgat gatgatgatt
961 atgatacgga ttttgttcca ccttctccag aagaaattat ttctgcttct tcttcctctt
1021 caaaatgcct tagtacgtta aaggaccttg acacatctga cagaaaagag gatgttctta
1081 gcacatcaaa agatcttttg tcaaaacctg agaaaatgag tatgcaggag ctgaatccag
1141 aaaccagcac agactgtgac gctagacaga taagtttaca gcagcagctt attcatgtga
1201 tggagcacat ctgtaaatta attgatacta ttcctgatga taaactgaaa cttttggatt
1261 gtgggaacga actgcttcag cagcggaaca taagaaggaa acttctaacg gaagtagatt
1321 ttaataaaag tgatgccagt cttcttggct cattgtggag atacaggcct gattcacttg
1381 atggccctat ggagggtgat tcctgcccta cagggaattc tatgaaggag ttaaattttt
1441 cacaccttcc ctcaaattct gtttctcctg gggactgttt actgactacc accctaggaa
1501 agacaggatt ctctgccacc aggaagaatc tttttgaaag gcctttattc aatacccatt
1561 tacagaagtc ctttgtaagt agcaactggg ctgaaacacc aagactagga aaaaaaaatg
1621 aaagctctta tttcccagga aatgttctca caagcactgc tgtgaaagat cagaataaac
1681 atactgcttc aataaatgac ttagaaagag aaacccaacc ttcctatgat attgataatt
1741 ttgacataga tgactttgat gatgatgatg actgggaaga cataatgcat aatttagcag
1801 ccagcaaatc ttccacagct gcctatcaac ccatcaagga aggtcggcca attaaatcag
1861 tatcagaaag actttcctca gccaagacag actgtcttcc agtgtcatct actgctcaaa
1921 atataaactt ctcagagtca attcagaatt atactgacaa gtcagcacaa aatttagcat
1981 ccagaaatct gaaacatgag cgtttccaaa gtcttagttt tcctcataca aaggaaatga
2041 tgaagatttt tcataaaaaa tttggcctgc ataattttag aactaatcag ctagaggcga
2101 tcaatgctgc actgcttggt gaagactgtt ttatcctgat gccgactgga ggtggtaaga
2161 gtttgtgtta ccagctccct gcctgtgttt ctcctggggt cactgttgtc atttctccct
2221 tgagatcact tatcgtagat caagtccaaa agctgacttc cttggatatt ccagctacat
2281 atctgacagg tgataagact gactcagaag ctacaaatat ttacctccag ttatcaaaaa
2341 aagacccaat cataaaactt ctatatgtca ctccagaaaa gatctgtgca agtaacagac
2401 tcatttctac tctggagaat ctctatgaga ggaagctctt ggcacgtttt gttattgatg
2461 aagcacattg tgtcagtcag tggggacatg attttcgtca agattacaaa agaatgaata
2521 tgcttcgcca gaagtttcct tctgttccgg tgatggctct tacggccaca gctaatccca
2581 gggtacagaa ggacatcctg actcagctga agattctcag acctcaggtg tttagcatga
2641 gctttaacag acataatctg aaatactatg tattaccgaa aaagcctaaa aaggtggcat
2701 ttgattgcct agaatggatc agaaagcacc acccatatga ttcagggata atttactgcc
2761 tctccaggcg agaatgtgac accatggctg acacgttaca gagagatggg ctcgctgctc
2821 ttgcttacca tgctggcctc agtgattctg ccagagatga agtgcagcag aagtggatta
2881 atcaggatgg ctgtcaggtt atctgtgcta caattgcatt tggaatgggg attgacaaac
2941 cggacgtgcg atttgtgatt catgcatctc tccctaaatc tgtggagggt tactaccaag
3001 aatctggcag agctggaaga gatggggaaa tatctcactg cctgcttttc tatacctatc
3061 atgatgtgac cagactgaaa agacttataa tgatggaaaa agatggaaac catcatacaa
3121 gagaaactca cttcaataat ttgtatagca tggtacatta ctgtgaaaat ataacggaat
3181 gcaggagaat acagcttttg gcctactttg gtgaaaatgg atttaatcct gatttttgta
3241 agaaacaccc agatgtttct tgtgataatt gctgtaaaac aaaggattat aaaacaagag
3301 atgtgactga cgatgtgaaa agtattgtaa gatttgttca agaacatagt tcatcacaag
3361 gaatgagaaa tataaaacat gtaggtcctt ctggaagatt tactatgaat atgctggtcg
3421 acattttctt ggggagtaag agtgcaaaaa tccagtcagg tatatttgga aaaggatctg
3481 cttattcacg acacaatgcc gaaagacttt ttaaaaagct gatacttgac aagattttgg
3541 atgaagactt atatatcaat gccaatgacc aggcgatcgc ttatgtgatg ctcggaaata
3601 aagcccaaac tgtactaaat ggcaatttaa aggtagactt tatggaaaca gaaaattcca
3661 gcagtgtgaa aaaacaaaaa gcgttagtag caaaagtgtc tcagagggaa gagatggtta
3721 aaaaatgtct tggagaactt acagaagtct gcaaatctct ggggaaagtt tttggtgtcc
3781 attacttcaa tatttttaat accgtcactc tcaagaagct tgcagaatct ttatcttctg
3841 atcctgaggt tttgcttcaa attgatggtg ttactgaaga caaactggaa aaatatggtg
3901 cggaagtgat ttcagtatta cagaaatact ctgaatggac atcgccagct gaagacagtt
3961 ccccagggat aagcctgtcc agcagcagag gccccggaag aagtgccgct gaggagcttg
4021 acgaggaaat acccgtatct tcccactact ttgcaagtaa aaccagaaat gaaaggaaga
4081 ggaaaaagat gccagcctcc caaaggtcta agaggagaaa aactgcttcc agtggttcca
4141 aggcaaaggg ggggtctgcc acatgtagaa agatatcttc caaaacgaaa tcctccagca
4201 tcattggatc cagttcagcc tcacatactt ctcaagcgac atcaggagcc aatagcaaat
4261 tggggattat ggctccaccg aagcctataa atagaccgtt tcttaagcct tcatatgcat
4321 tctcataaca accgaatctc aatgtacata gaccctcttt cttgtttgtc agcatctgac
4381 catctgtgac tataaagctg ttattcttgt tataccaaaa aaaaaaaaaa aaaaaaa
//