LOCUS HSU39226 7465 bp mRNA linear HUM 11-JUL-1996
DEFINITION Human myosin VIIA (USH1B) mRNA, complete cds.
ACCESSION U39226 U17180
VERSION U39226.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 558 to 1962)
AUTHORS Weil,D., Blanchard,S., Kaplan,J., Guilford,P., Gibson,F., Walsh,J.,
Mburu,P., Valera,A., Levilliers,J., Weston,M.D., Kelley,P.M.,
Kimberling,W.J., Wagenaar,M., Levi-Acobas,F., Larget-Piet,D.,
Munnich,A., Steel,K.P., Brown,S.D.M. and Petit,C.
TITLE Defective myosin VIIA gene responsible for Usher syndrome type 1B
JOURNAL Nature 374 (6517), 60-61 (1995)
PUBMED 7870171
REFERENCE 2 (bases 1 to 7465)
AUTHORS Weil,D., Levy,G., Sahly,I., Levi-Acobas,F., Blanchard,S.,
El-Amraoui,A., Crozet,F., Philippe,H., Abitbol,M. and Petit,C.
TITLE Human myosin VIIA responsible for the Usher 1B syndrome: a
predicted membrane-associated motor protein expressed in developing
sensory epithelia
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 93 (8), 3232-3237 (1996)
PUBMED 8622919
REFERENCE 3 (bases 1 to 7465)
AUTHORS Weil,D., Levy,G., Sahly,I., Levi-Acobas,F., Blanchard,S.,
El-Amraoui,A., Crozet,F., Philippe,H., Abitbol,M. and Petit,C.
TITLE The Usher 1B protein, myosin VIIA: a predicted membrane-associated
motor protein expressed in developing sensory epithelia
JOURNAL Unpublished
REFERENCE 4 (bases 1 to 7465)
AUTHORS Weil,D.
TITLE Direct Submission
JOURNAL Submitted (24-OCT-1995) Dominique Weil, Genetique Moleculaire
Humaine, CNRS URA 1968, Institut Pasteur, 25 rue du Docteur Roux,
75724 Paris, Cedex 15, France
COMMENT On Mar 22, 1996 this sequence version replaced gi:699391.
FEATURES Location/Qualifiers
source 1..7465
/db_xref="H-InvDB:HIT000219678"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q13.5"
gene 1..7465
/gene="USH1B"
5'UTR 1..272
/gene="USH1B"
CDS 273..6920
/gene="USH1B"
/function="binds to ATP and actin"
/note="an unconventional myosin, probably a member of the
myosin I family"
/codon_start=1
/product="myosin VIIA"
/protein_id="AAB03679.1"
/translation="MVILQQGDHVWMDLRLGQEFDVPIGAVVKLCDSGQVQVVDDEDN
EHWISPQNATHIKPMHPTSVHGVEDMIRLGDLNEAGILRNLLIRYRDHLIYTYTGSIL
VAVNPYQLLSIYSPEHIRQYTNKKIGEMPPHIFAIADNCYFNMKRNSRDQCCIISGES
GAGKTESTKLILQFLAAISGQHSWIEQQVLEATPILEAFGNAKTIRNDNSSRFGKYID
IHFNKRGAIEGAKIEQYLLEKSRVCRQALDERNYHVFYCMLEGMSEDQKKKLGLGQAS
DYNYLAMGNCITCEGRVDSQEYANIRSAMKVLMFTDTENWEISKLLAAILHLGNLQYE
ARTFENLDACEVLFSPSLATAASLLEVNPPDLMSCLTSRTLITRGETVSTPLSREQAL
DVRDAFVKGIYGRLFVWIVDKINAAIYKPPSQDVKNSRRSIGLLDIFGFENFAVNSFE
QLCINFANEHLQQFFVRHVFKLEQEEYDLESIDWLHIEFTDNQDALDMIANKPMNIIS
LIDEESKFPKGTDTTMLHKLNSQHKLNANYIPPKNNHETQFGINHFAGIVYYETQGFL
EKNRDTLHGDIIQLVHSSRNKFIKQIFQADVAMGAETRKRSPTLSSQFKRSLELLMRT
LGACQPFFVRCIKPNEFKKPMLFDRHLCVRQLRYSGMMETIRIRRAGYPIRYSFVEFV
ERYRVLLPGVKPAYKQGDLRGTCQRMAEAVLGTHDDWQIGKTKIFLKDHHDMLLEVER
DKAITDRVILLQKVIRGFKDRSNFLKLKNAATLIQRHWRGHNCRKNYGLMRLGFLRLQ
ALHRSRKLHQQYRLARQRIIQFQARCRAYLVRKAFRHRLWAVLTVQAYARGMIARRLH
QRLRAEYLWRLEAEKMRLAEEEKLRKEMSAKKAKEEAERKHQERLAQLAREDAERELK
EKEAARRKKELLEQMERARHEPVNHSDMVDKMFGFLGTSGGLPGQEGQAPSGFEDLER
GRREMVEEDLDAALPLPDEDEEDLSEYKFAKFAATYFQGTTTHSYTRRPLKQPLLYHD
DEGDQLAALAVWITILRFMGDLPEPKYHTAMSDGSEKIPVMTKIYETLGKKTYKRELQ
ALQGEGEAQLPEGQKKSSVRHKLVHLTLKKKSKLTEEVTKRLHDGESTVQGNSMLEDR
PTSNLEKLHFIIGNGILRPALRDEIYCQISKQLTHNPSKSSYARGWILVSLCVGCFAP
SEKFVKYLRNFIHGGPPGYAPYCEERLRRTFVNGTRTQPPSWLELQATKSKKPIMLPV
TFMDGTTKTLLTDSATTAKELCNALADKISLKDRFGFSLYIALFDKVSSLGSGSDHVM
DAISQCEQYAKEQGAQERNAPWRLFFRKEVFTPWHSPSEDNVATNLIYQQVVRGVKFG
EYRCEKEDDLAELASQQYFVDYGSEMILERLLNLVPTYIPDREITPLKTLEKWAQLAI
AAHKKGIYAQRRTDAQKVKEDVVSYARFKWPLLFSRFYEAYKFSGPSLPKNDVIVAVN
WTGVYFVDEQEQVLLELSFPEIMAVSSSRECRVWLSLGCSDLGCAAPHSGWAGLTPAG
PCSPCWSCRGAKTTAPSFTLATIKGDEYTFTSSNAEDIRDLVVTFLEGLRKRSKYVVA
LQDNPNPAGEESGFLSFAKGDLIILDHDTGEQVMNSGWANGINERTKQRGDFPTDCVY
VMPTVTMPPREIVALVTMTPDQRQDVVRLLQLRTAEPEVRAKPYTLEEFSYDYFRPPP
KHTLSRVMVSKARGKDRLWSHTREPLKQALLKKLLGSEELSQEACLAFIAVLKYMGDY
PSKRTRSVNELTDQIFEGPLKAEPLKDEAYVQILKQLTDNHIRYSEERGWELLWLCTG
LFPPSNILLPHVQRFLQSRKHCPLAIDCLQRLQKALRNGSRKYPPHLVEVEAIQHKTT
QIFHKVYFPDDTDEAFEVESSTKAKDFCQNIATRLLLKSSEGFSLFVKIADKVISVPE
NDFFFDFVRHLTDWIKKARPIKDGIVPSLTYQVFFMKKLWTTTVPGKDPMADSIFHYY
QELPKYLRGYHKCTREEVLQLGALIYRVKFEEDKSYFPSIPKLLRELVPQDLIRQVSP
DDWKRSIVAYFNKHAGKSKEEAKLAFLKLIFKWPTFGSAFFEVKQTTEPNFPEILLIA
INKYGVSLIDPKTKDILTTHPFTKISNWSSGNTYFHITIGNLVRGSKLLCETSLGYKM
DDLLTSYISQMLTAMSKQRGSRSGK"
3'UTR 6921..7465
/gene="USH1B"
BASE COUNT 1695 a 2226 c 2155 g 1389 t
ORIGIN
1 gctctgggca ggagagagag tgagagacaa gagacacaca cagagagacg gcgaggaagg
61 gaaagaccca gagggacgcc tagaacgaga cttggagcca gacagaggaa gaggggacgt
121 gtgtttgcag actggctggg cccgtgaccc agcttcctga gtcctccgtg caggtggcag
181 ctgtaccagg ctggcaggtc actgagagtg ggcagctggg ccccagaact gtgcctggcc
241 cagtgggcag caggagctcc tgacttggga ccatggtgat tcttcagcag ggggaccatg
301 tgtggatgga cctgagattg gggcaggagt tcgacgtgcc catcggggcg gtggtgaagc
361 tctgcgactc tgggcaggtc caggtggtgg atgatgaaga caatgaacac tggatctctc
421 cgcagaacgc aacgcacatc aagcctatgc accccacgtc ggtccacggc gtggaggaca
481 tgatccgcct gggggacctc aacgaggcgg gcatcttgcg caacctgctt atccgctacc
541 gggaccacct catctacacg tatacgggct ccatcctggt ggctgtgaac ccctaccagc
601 tgctctccat ctactcgcca gagcacatcc gccagtatac caacaagaag attggggaga
661 tgccccccca catctttgcc attgctgaca actgctactt caacatgaaa cgcaacagcc
721 gagaccagtg ctgcatcatc agtggggaat ctggggccgg gaagacggag agcacaaagc
781 tgatcctgca gttcctggca gccatcagtg ggcagcactc gtggattgag cagcaggtct
841 tggaggccac ccccattctg gaagcatttg ggaatgccaa gaccatccgc aatgacaact
901 caagccgttt cggaaagtac atcgacatcc acttcaacaa gcggggcgcc atcgagggcg
961 cgaagattga gcagtacctg ctggaaaagt cacgtgtctg tcgccaggcc ctggatgaaa
1021 ggaactacca cgtgttctac tgcatgctgg agggtatgag tgaggatcag aagaagaagc
1081 tgggcttggg ccaggcctct gactacaact acttggccat gggtaactgc ataacctgtg
1141 agggccgggt ggacagccag gagtacgcca acatccgctc cgccatgaag gtgctcatgt
1201 tcactgacac cgagaactgg gagatctcga agctcctggc tgccatcctg cacctgggca
1261 acctgcagta tgaggcacgc acatttgaaa acctggatgc ctgtgaggtt ctcttctccc
1321 catcgctggc cacagctgca tccctgcttg aggtgaaccc cccagacctg atgagctgcc
1381 tgactagccg caccctcatc acccgcgggg agacggtgtc caccccactg agcagggaac
1441 aggcactgga cgtgcgcgac gccttcgtaa aggggatcta cgggcggctg ttcgtgtgga
1501 ttgtggacaa gatcaacgca gcaatttaca agcctccctc ccaggatgtg aagaactctc
1561 gcaggtccat cggcctcctg gacatctttg ggtttgagaa ctttgctgtg aacagctttg
1621 agcagctctg catcaacttc gccaatgagc acctgcagca gttctttgtg cggcacgtgt
1681 tcaagctgga gcaggaggaa tatgacctgg agagcattga ctggctgcac atcgagttca
1741 ctgacaacca ggatgccctg gacatgattg ccaacaagcc catgaacatc atctccctca
1801 tcgatgagga gagcaagttc cccaagggca cagacaccac catgttacac aagctgaact
1861 cccagcacaa gctcaacgcc aactacatcc cccccaagaa caaccatgag acccagtttg
1921 gcatcaacca ttttgcaggc atcgtctact atgagaccca aggcttcctg gagaagaacc
1981 gagacaccct gcatggggac attatccagc tggtccactc ctccaggaac aagttcatca
2041 agcagatctt ccaggccgat gtcgccatgg gcgccgagac caggaagcgc tcgcccacac
2101 ttagcagcca gttcaagcgg tcactggagc tgctgatgcg cacgctgggt gcctgccagc
2161 ccttctttgt gcgatgcatc aagcccaatg agttcaagaa gcccatgctg ttcgaccggc
2221 acctgtgcgt gcgccagctg cggtactcag gaatgatgga gaccatccga atccgccgag
2281 ctggctaccc catccgctac agcttcgtag agtttgtgga gcggtaccgt gtgctgctgc
2341 caggtgtgaa gccggcctac aagcagggcg acctccgcgg gacttgccag cgcatggctg
2401 aggctgtgct gggcacccac gatgactggc agataggcaa aaccaagatc tttctgaagg
2461 accaccatga catgctgctg gaagtggagc gggacaaagc catcaccgac agagtcatcc
2521 tccttcagaa agtcatccgg ggattcaaag acaggtctaa ctttctgaag ctgaagaacg
2581 ctgccacact gatccagagg cactggcggg gtcacaactg taggaagaac tacgggctga
2641 tgcgtctggg cttcctgcgg ctgcaggccc tgcaccgctc ccggaagctg caccagcagt
2701 accgcctggc ccgccagcgc atcatccagt tccaggcccg ctgccgcgcc tatctggtgc
2761 gcaaggcctt ccgccaccgc ctctgggctg tgctcaccgt gcaggcctat gcccggggca
2821 tgatcgcccg caggctgcac caacgcctca gggctgagta tctgtggcgc ctcgaggctg
2881 agaaaatgcg gctggcggag gaagagaagc ttcggaagga gatgagcgcc aagaaggcca
2941 aggaggaggc cgagcgcaag catcaggagc gcctggccca gctggctcgt gaggacgctg
3001 agcgggagct gaaggagaag gaggccgctc ggcggaagaa ggagctcctg gagcagatgg
3061 aaagggcccg ccatgagcct gtcaatcact cagacatggt ggacaagatg tttggcttcc
3121 tggggacttc aggtggcctg ccaggccagg agggccaggc acctagtggc tttgaggacc
3181 tggagcgagg gcggagggag atggtggagg aggacctgga tgcagccctg cccctgcctg
3241 acgaggatga ggaggacctc tctgagtata aatttgccaa gttcgcggcc acctacttcc
3301 aggggacaac cacgcactcc tacacccggc ggccactcaa acagccactg ctctaccatg
3361 acgacgaggg tgaccagctg gcagccctgg cggtctggat caccatcctc cgcttcatgg
3421 gggacctccc tgagcccaag taccacacag ccatgagtga tggcagtgag aagatccctg
3481 tgatgaccaa gatttatgag accctgggca agaagacgta caagagggag ctgcaggccc
3541 tgcagggcga gggcgaggcc cagctccccg agggccagaa gaagagcagt gtgaggcaca
3601 agctggtgca tttgactctg aaaaagaagt ccaagctcac agaggaggtg accaagaggc
3661 tgcatgacgg ggagtccaca gtgcagggca acagcatgct ggaggaccgg cccacctcca
3721 acctggagaa gctgcacttc atcatcggca atggcatcct gcggccagca ctccgggacg
3781 agatctactg ccagatcagc aagcagctga cccacaaccc ctccaagagc agctatgccc
3841 ggggctggat tctcgtgtct ctctgcgtgg gctgtttcgc cccctccgag aagtttgtca
3901 agtacctgcg gaacttcatc cacgggggcc cgcccggcta cgccccgtac tgtgaggagc
3961 gcctgagaag gacctttgtc aatgggacac ggacacagcc gcccagctgg ctggagctgc
4021 aggccaccaa gtccaagaag ccaatcatgt tgcccgtgac attcatggat gggaccacca
4081 agaccctgct gacggactcg gcaaccacgg ccaaggagct ctgcaacgcg ctggccgaca
4141 agatctctct caaggaccgg ttcgggttct ccctctacat tgccctgttt gacaaggtgt
4201 cctccctggg cagcggcagt gaccacgtca tggacgccat ctcccagtgc gagcagtacg
4261 ccaaggagca gggcgcccag gagcgcaacg ccccctggag gctcttcttc cgcaaagagg
4321 tcttcacgcc ctggcacagc ccctccgagg acaacgtggc caccaacctc atctaccagc
4381 aggtggtgcg aggagtcaag tttggggagt acaggtgtga gaaggaggac gacctggctg
4441 agctggcctc ccagcagtac tttgtagact atggctctga gatgatcctg gagcgcctcc
4501 tgaacctcgt gcccacctac atccccgacc gcgagatcac gcccctgaag acgctggaga
4561 agtgggccca gctggccatc gccgcccaca agaaggggat ttatgcccag aggagaactg
4621 atgcccagaa ggtcaaagag gatgtggtca gttatgcccg cttcaagtgg cccttgctct
4681 tctccaggtt ttatgaagcc tacaaattct caggccccag tctccccaag aacgacgtca
4741 tcgtggccgt caactggacg ggtgtgtact ttgtggatga gcaggagcag gtacttctgg
4801 agctgtcctt cccagagatc atggccgtgt ccagcagcag ggagtgccgt gtctggctct
4861 cactgggctg ctctgatctt ggctgtgctg cgcctcactc aggctgggca ggactgaccc
4921 cggcggggcc ctgttctccg tgttggtcct gcaggggagc gaaaacgacg gcccccagct
4981 tcacgctggc caccatcaag ggggacgaat acaccttcac ctccagtaat gctgaggaca
5041 ttcgtgacct ggtggtcacc ttcctagagg ggctccggaa gagatctaag tatgttgtgg
5101 ccctgcagga taaccccaac cccgcaggcg aggagtcagg cttcctcagc tttgccaagg
5161 gagacctcat catcctggac catgacacgg gcgagcaggt catgaactcg ggctgggcca
5221 acggcatcaa tgagaggacc aagcagcgtg gggacttccc caccgactgt gtgtacgtca
5281 tgcccactgt caccatgcca ccgcgggaga ttgtggccct ggtcaccatg actcccgatc
5341 agaggcagga cgttgtccgg ctcttgcagc tgcgaacggc ggagcccgag gtgcgtgcca
5401 agccctacac gctggaggag ttttcctatg actacttcag gcccccaccc aagcacacgc
5461 tgagccgtgt catggtgtcc aaggcccgag gcaaggaccg gctgtggagc cacacgcggg
5521 aaccgctcaa gcaggcgctg ctcaagaagc tcctgggcag tgaggagctc tcgcaggagg
5581 cctgcctggc cttcattgct gtgctcaagt acatgggcga ctacccgtcc aagaggacac
5641 gctccgtcaa cgagctcacc gaccagatct ttgagggtcc cctgaaagcc gagcccctga
5701 aggacgaggc atatgtgcag atcctgaagc agctgaccga caaccacatc aggtacagcg
5761 aggagcgggg ttgggagctg ctctggctgt gcacgggcct tttcccaccc agcaacatcc
5821 tcctgcccca cgtgcagcgc ttcctgcagt cccgaaagca ctgcccactc gccatcgact
5881 gcctgcaacg gctccagaaa gccctgagaa acgggtcccg gaagtaccct ccgcacctgg
5941 tggaggtgga ggccatccag cacaagacca cccagatttt ccacaaggtc tacttccctg
6001 atgacactga cgaggccttc gaagtggagt ccagcaccaa ggccaaggac ttctgccaga
6061 acatcgccac caggctgctc ctcaagtcct cagagggatt cagcctcttt gtcaaaattg
6121 cagacaaggt catcagcgtt cctgagaatg acttcttctt tgactttgtt cgacacttga
6181 cagactggat aaagaaagct cggcccatca aggacggaat tgtgccctca ctcacctacc
6241 aggtgttctt catgaagaag ctgtggacca ccacggtgcc agggaaggat cccatggccg
6301 attccatctt ccactattac caggagttgc ccaagtatct ccgaggctac cacaagtgca
6361 cgcgggagga ggtgctgcag ctgggggcgc tgatctacag ggtcaagttc gaggaggaca
6421 agtcctactt ccccagcatc cccaagctgc tgcgggagct ggtgccccag gaccttatcc
6481 ggcaggtctc acctgatgac tggaagcggt ccatcgtcgc ctacttcaac aagcacgcag
6541 ggaagtccaa ggaggaggcc aagctggcct tcctgaagct catcttcaag tggcccacct
6601 ttggctcagc cttcttcgag gtgaagcaaa ctacggagcc aaacttccct gagatcctcc
6661 taattgccat caacaagtat ggggtcagcc tcatcgatcc caaaacgaag gatatcctca
6721 ccactcatcc cttcaccaag atctccaact ggagcagcgg caacacctac ttccacatca
6781 ccattgggaa cttggtgcgc gggagcaaac tgctctgcga gacgtcactg ggctacaaga
6841 tggatgacct cctgacttcc tacattagcc agatgctcac agccatgagc aaacagcggg
6901 gctccaggag cggcaagtga acagtcacgg ggaggtgctg gttccatgcc tgctctcgag
6961 gcagcagtgg gttcaggccc atcagctacc cctgcagctg gggaagactt atgccatccc
7021 ggcagcgagg ctgggctggc cagccaccac tgactatacc aactgggcct ctgatgttct
7081 tccagtgagg catctctctg ggatgcagaa cttccctcca tccacccctc tggcacctgg
7141 gttggtctaa tcctagtttg ctgtggcctt cccggttgtg agagcctgtg atccttagat
7201 gtgtctcctg tttcagacca gccccaccat gcaacttcct ttgactttct gtgtaccact
7261 gggatagagg aatcaagagg acaatctagc tctccatact ttgaacaacc aaatgtgcat
7321 tgaatactct gaaaccgaag ggactggatc tgcaggtggg atgagggaga cagaccactt
7381 ttctatattg cagtgtgaat gctgggcccc tgctcaagtc taccctgatc acctcagggc
7441 ataaagcatg tttcattctc tgaaa
//