LOCUS HSU38545 3609 bp mRNA linear HUM 10-MAR-1997 DEFINITION Human ARF-activated phosphatidylcholine-specific phospholipase D1a (hPLD1) mRNA, complete cds. ACCESSION U38545 VERSION U38545.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3609) AUTHORS Hammond,S.M., Altshuller,Y.M., Sung,T.C., Rudge,S.A., Rose,K., Engebrecht,J., Morris,A.J. and Frohman,M.A. TITLE Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family JOURNAL J. Biol. Chem. 270 (50), 29640-29643 (1995) PUBMED 8530346 REFERENCE 2 (bases 1 to 3609) AUTHORS Hammond,S.M. and Frohman,M.A. TITLE Direct Submission JOURNAL Submitted (13-OCT-1995) Michael A. Frohman, Pharmacology, SUNY Stony Brook, BST, T7-172, Stony Brook, NY 11794-8651, USA COMMENT On Feb 16, 1996 this sequence version replaced gi:1125738. FEATURES Location/Qualifiers source 1..3609 /db_xref="H-InvDB:HIT000219594" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="3" /map="3q21.1-28" /note="Cloned from HeLa cell library." gene 1..3609 /gene="hPLD1" CDS 96..3320 /gene="hPLD1" /function="Cleaves phosphatidylcholine to phosphatidic acid and choline" /note="PLD1a; phosphatidylcholine-specific; activated by PIP2, ARF; inhibited by oleate; membrane associated" /codon_start=1 /product="phospholipase D1a" /protein_id="AAB49031.1" /translation="MSLKNEPRVNTSALQKIAADMSNIIENLDTRELHFEGEEVDYDV SPSDPKIQEVYIPFSAIYNTQGFKEPNIQTYLSGCPIKAQVLEVERFTSTTRVPSINL YTIELTHGEFKWQVKRKFKHFQEFHRELLKYKAFIRIPIPTRRHTFRRQNVREEPREM PSLPRSSENMIREEQFLGRRKQLEDYLTKILKMPMYRNYHATTEFLDISQLSFIHDLG PKGIEGMIMKRSGGHRIPGLNCCGQGRACYRWSKRWLIVKDSFLLYMKPDSGAIAFVL LVDKEFKIKVGKKETETKYGIRIDNLSRTLILKCNSYRHARWWGGAIEEFIQKHGTNF LKDHRFGSYAAIQENALAKWYVNAKGYFEDVANAMEEANEEIFITDWWLSPEIFLKRP VVEGNRWRLDCILKRKAQQGVRIFIMLYKEVELALGINSEYTKRTLMRLHPNIKVMRH PDHVSSTVYLWAHHEKLVIIDQSVAFVGGIDLAYGRWDDNEHRLTDVGSVKRVTSGPS LGSLPPAAMESMESLRLKDKNEPVQNLPIQKSIDDVDSKLKGIGKPRKFSKFSLYKQL HRHHLHDADSISSIDSTSSYFNHYRSHHNLIHGLKPHFKLFHPSSESEQGLTRPHADT GSIRSLQTGVGELHGETRFWHGKDYCNFVFKDWVQLDKPFADFIDRYSTPRMPWHDIA SAVHGKAARDVARHFIQRWNFTKIMKSKYRSLSYPFLLPKSQTTAHELRYQVPGSVHA NVQLLRSAADWSAGIKYHEESIHAAYVHVIENSRHYIYIENQFFISCADDKVVFNKIG DAIAQRILKAHRENQKYRVYVVIPLLPGFEGDISTGGGNALQAIMHFNYRTMCRGENS ILGQLKAELGNQWINYISFCGLRTHAELEGNLVTELIYVHSKLLIADDNTVIIGSANI NDRSMLGKRDSEMAVIVQDTETVPSVMDGKEYQAGRFARGLRLQCFRVVLGYLDDPSE DIQDPVSDKFFKEVWVSTAARNATIYDKVFRCLPNDEVHNLIQLRDFINKPVLAKEDP IRAEEELKKIRGFLVQFPFYFLSEESLLPSVGTKEAIVPMEVWT" BASE COUNT 1085 a 791 c 837 g 896 t ORIGIN 1 ggcacgagga gccctgagag tccgccgcca acgcgcaggt gctagcggcc ccttcgccct 61 gcagcccctt tgcttttact ctgtccaaag ttaacatgtc actgaaaaac gagccacggg 121 taaatacctc tgcactgcag aaaattgctg ctgacatgag taatatcata gaaaatctgg 181 acacgcggga actccacttt gagggagagg aggtagacta cgacgtgtct cccagcgatc 241 ccaagataca agaagtgtat atccctttct ctgctattta taacactcaa ggatttaagg 301 agcctaatat acagacgtat ctctccggct gtccaataaa agcacaagtt ctggaagtgg 361 aacgcttcac atctacaaca agggtaccaa gtattaatct ttacactatt gaattaacac 421 atggggaatt taaatggcaa gttaagagga aattcaagca ttttcaagaa tttcacagag 481 agctgctcaa gtacaaagcc tttatccgca tccccattcc cactagaaga cacacgttta 541 ggaggcaaaa cgtcagagag gagcctcgag agatgcccag tttgccccgt tcatctgaaa 601 acatgataag agaagaacaa ttccttggta gaagaaaaca actggaagat tacttgacaa 661 agatactaaa aatgcccatg tatagaaact atcatgccac aacagagttt cttgatataa 721 gccagctgtc tttcatccat gatttgggac caaagggcat agaaggtatg ataatgaaaa 781 gatctggagg acacagaata ccaggcttga attgctgtgg tcagggaaga gcctgctaca 841 gatggtcaaa aagatggtta atagtgaaag attccttttt attgtatatg aaaccagaca 901 gcggtgccat tgccttcgtc ctgctggtag acaaagaatt caaaattaag gtggggaaga 961 aggagacaga aacgaaatat ggaatccgaa ttgataatct ttcaaggaca cttattttaa 1021 aatgcaacag ctatagacat gctcggtggt ggggaggggc tatagaagaa ttcatccaga 1081 aacatggcac caactttctc aaagatcatc gatttgggtc atatgctgct atccaagaga 1141 atgctttagc taaatggtat gttaatgcca aaggatattt tgaagatgtg gcaaatgcaa 1201 tggaagaggc aaatgaagag atttttatca cagactggtg gctgagtcca gaaatcttcc 1261 tgaaacgccc agtggttgag ggaaatcgtt ggaggttgga ctgcattctt aaacgaaaag 1321 cacaacaagg agtgaggatc ttcataatgc tctacaaaga ggtggaactc gctcttggca 1381 tcaatagtga atacaccaag aggactttga tgcgtctaca tcccaacata aaggtgatga 1441 gacacccgga tcatgtgtca tccaccgtct atttgtgggc tcaccatgag aagcttgtca 1501 tcattgacca atcggtggcc tttgtgggag ggattgacct ggcctatgga aggtgggacg 1561 acaatgagca cagactcaca gacgtgggca gtgtgaagcg ggtcacttca ggaccgtctc 1621 tgggttccct cccacctgcc gcaatggagt ctatggaatc cttaagactc aaagataaaa 1681 atgagcctgt tcaaaaccta cccatccaga agagtattga tgatgtggat tcaaaactga 1741 aaggaatagg aaagccaaga aagttctcca aatttagtct ctacaagcag ctccacaggc 1801 accacctgca cgacgcagat agcatcagca gcattgacag cacctccagt tattttaatc 1861 actatagaag tcatcacaat ttaatccatg gtttaaaacc ccacttcaaa ctctttcacc 1921 cgtccagtga gtctgagcaa ggactcacta gacctcatgc tgataccggg tccatccgta 1981 gtttacagac aggtgtggga gagctgcatg gggaaaccag attctggcat ggaaaggact 2041 actgcaattt cgtcttcaaa gactgggttc aacttgataa accttttgct gatttcattg 2101 acaggtactc cacgccccgg atgccctggc atgacattgc ctctgcagtc cacgggaagg 2161 cggctcgtga tgtggcacgt cacttcatcc agcgctggaa cttcacaaaa attatgaaat 2221 caaaatatcg gtccctttct tatccttttc tgcttccaaa gtctcaaaca acagcccatg 2281 agttgagata tcaagtgcct gggtctgtcc atgctaacgt acagttgctc cgctctgctg 2341 ctgattggtc tgctggtata aagtaccatg aagagtccat ccacgccgct tacgtccatg 2401 tgatagagaa cagcaggcac tatatctata tcgaaaacca gtttttcata agctgtgctg 2461 atgacaaagt tgtgttcaac aagataggcg atgccattgc ccagaggatc ctgaaagctc 2521 acagggaaaa ccagaaatac cgggtatatg tcgtgatacc acttctgcca gggttcgaag 2581 gagacatttc aaccggcgga ggaaatgctc tacaggcaat catgcacttc aactacagaa 2641 ccatgtgcag aggagaaaat tccatccttg gacagttaaa agcagagctt ggtaatcagt 2701 ggataaatta catatcattc tgtggtctta gaacacatgc agagctcgaa ggaaacctag 2761 taactgagct tatctatgtc cacagcaagt tgttaattgc tgatgataac actgttatta 2821 ttggctctgc caacataaat gaccgcagca tgctgggaaa gcgtgacagt gaaatggctg 2881 tcattgtgca agatacagag actgttcctt cagtaatgga tggaaaagag taccaagctg 2941 gccggtttgc ccgaggactt cggctacagt gctttagggt tgtccttggc tatcttgatg 3001 acccaagtga ggacattcag gatccagtga gtgacaaatt cttcaaggag gtgtgggttt 3061 caacagcagc tcgaaatgct acaatttatg acaaggtttt ccggtgcctt cccaatgatg 3121 aagtacacaa tttaattcag ctgagagact ttataaacaa gcccgtatta gctaaggaag 3181 atcccattcg agctgaggag gaactgaaga agatccgtgg atttttggtg caattcccct 3241 tttatttctt gtctgaagaa agcctactgc cttctgttgg gaccaaagag gccatagtgc 3301 ccatggaggt ttggacttaa gagatattca ttggcagctc aaagacttcc accctggaga 3361 ccacactgca cacagtgact tcctggggat gtcatagcca aagccaggcc tgacgcattc 3421 tcgtatccaa cccaaggacc ttttggaatg actggggagg gctgcagtca cattgatgta 3481 aggactgtaa acatcagcaa gactttataa ttccttctgc ctaacttgta aaaagggggc 3541 tgcattcttg ttggtagcat gtactctgtt gagtaaaaca catattcaaa ttccgctcgt 3601 gccgaattc //