LOCUS HSU37673 3443 bp mRNA linear HUM 14-OCT-1995
DEFINITION Human neuron-specific vesicle coat protein and cerebellar
degeneration antigen (beta-NAP) mRNA, complete cds.
ACCESSION U37673
VERSION U37673.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (sites)
AUTHORS Darnell,R.B., Furneaux,H.M. and Posner,J.B.
TITLE Antiserum from a patient with cerebellar degeneration identifies a
novel protein in Purkinje cells, cortical neurons, and
neuroectodermal tumors
JOURNAL J. Neurosci. 11 (5), 1224-1230 (1991)
PUBMED 1851215
REFERENCE 1 (bases 1 to 3443)
AUTHORS Newman,L.S., McKeever,M.O., Okano,H.J. and Darnell,R.B.
TITLE Beta-NAP, a cerebellar degeneration antigen, is a neuron-specific
vesicle coat protein
JOURNAL Cell 82 (5), 773-783 (1995)
PUBMED 7671305
REFERENCE 2 (bases 1 to 3443)
AUTHORS Darnell,R.B.
TITLE Direct Submission
JOURNAL Submitted (04-OCT-1995) Robert B. Darnell, Head, Laboratory of
Molecular Neuro-Oncology, Rockefeller University, 1230 York Avenue,
New York, NY 10021, USA
FEATURES Location/Qualifiers
source 1..3443
/db_xref="H-InvDB:HIT000219529"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="cerebellum; hippocampus"
/note="initial clone: human cerebellar cDNA library
(ATCC);Overlapping clones obtained from human cerebellar,
hippocampal libraries (Stratagene)"
CDS 62..3307
/note="similar to beta-adaptin and beta-COP proteins;
phosphoprotein, with membrane (including vesicular) and
cytoplasmic pools; protein and mRNA expression is entirely
neuron-specific; human autoimmune cerebellar degeneration
antigen; neuron-specific vesicle coat protein"
/codon_start=1
/product="beta-NAP"
/protein_id="AAC50219.1"
/translation="MSAAPAYSEDKGGSAGPGEPEYGHDPASGGIFSSDYKRHDDLKE
MLDTNKDSLKLEAMKRIVAMIARGKNASDLFPAVVKNVACKNIEVKKLVYVYLVRYAE
EQQDLALLSISTFQRGLKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAASDMSPY
VRKTAAHAIPKLYSLDSDQKDQLIEVIEKLLADKTTLVAGSVVMAFEEVCPERIDLIH
KNYRKLCNLLIDVEEWGQVVIISMLTRYARTQFLSPTQNESLLEENAEKAFYGSEEDE
AKGAGSEETAAAAAPSRKPYVMDPDHRLLLRNTKPLLQSRSAAVVMAVAQLYFHLGPR
RKWRHRQGAGALLRSHSEVQYVVLQNVATMSIKRRGMFEPYLKSFYIRSTDPTQIKIL
KLEVLTNLANETNIPTVLREFQTYIRSMDKDFVAATIQAIGRCATNIGRVRDTCLNGL
VQLLSNRDELVVAESVVVIKKLLQMQPAQHGEIIKHLAKLTDNIQVPMARASILWLIG
EYCEHVPRIAPDVLRKMAKSFTAEEDIVKLQVINLAAKLYLTNSKQTKLLTQYVLSLA
KYDQNYDIRDRARFTRQLIVPSEQGGALSRHAKKLFLAPKPAPVLESSFKDRDHFQLG
SLSHLLNAKATGYQELPDWPEEAPDPSVRNVEVPEWTKCSNREKRKEKEKPFYSDSEG
ESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQSEED
GKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLEPASWSRKTPPSSKS
APATKEISLLDLEDFTPPSVQPVSPPAIVSTSLAADLEGLTLTDSTLVPSLLSPVSGV
GRQELLHRVAGEGLAVDYTFSRQPFSGDPHMVSVHIHFSNSSDTPIKGLHVGTPKLPA
GISIQEFPEIESLAPGESATAVMGINFCDSTQAANFQLCTQTRQFYVSIQPPVGELMA
PVFMSENEFKKEQGKLMGMNEITEKLMLPDTCRSDHIVVQKVTATANLGRVPCGTSDE
YRFAGRTLTGGSLVLLTLDARPAGAAQLTVNSEKMVIGTMLVKDVIQALTQ"
misc_feature 1574..1591
/note="encodes WLIGEY; adaptin & COP coat protein
consensus sequence"
misc_feature 2000..2452
/note="encodes autoimmune epitope (hydrophilic domain)"
3'UTR 3308..3443
BASE COUNT 811 a 1016 c 953 g 663 t
ORIGIN
1 cgggctccag cggcctcccg cgccgcaacc tcctcctcgg cgaagtctcc ctggccgccc
61 catgtcggcc gcccccgcct acagcgaaga caagggcggc tccgctggcc ccggggagcc
121 cgagtacggc cacgaccccg cgagcggcgg catcttctcc tccgactaca agcggcatga
181 tgacctgaag gagatgctgg acaccaacaa ggattctctc aagctggagg ccatgaagag
241 gattgtggcg atgattgccc gaggaaagaa tgcttcagac ctgtttcccg cggtggtgaa
301 gaacgtggcc tgtaagaaca tagaggtgaa gaagcttgtc tatgtgtacc tggtacgcta
361 cgctgaggag cagcaagacc tggccctgct gtccatctcc accttccaac gtggcctaaa
421 ggatcccaac cagctgattc gtgccagtgc cctccgtgtc ctctctagca tccgtgtgcc
481 catcatagtg cccatcatga tgctagctat caaggaagcc gcctcggaca tgtcacccta
541 tgtgcggaaa acagctgccc acgccatccc taaactctac agtttggact ctgaccagaa
601 ggatcagctg atagaagtca ttgagaagct tctggctgac aagaccacgc tggtggcggg
661 cagtgtggtg atggcctttg aggaggtctg cccggagcgc atcgacctga ttcacaaaaa
721 ctaccggaaa ctctgtaacc tgctgatcga cgtggaggag tggggccagg tggtcatcat
781 cagcatgctc acccgctacg cccgcacgca gttcctgagc cccacccaga acgaatccct
841 actagaggag aacgcggaaa aagccttcta cggctcagag gaggacgagg ccaagggcgc
901 ggggtctgag gagacggccg ccgcggccgc cccctcccga aagccctatg tcatggaccc
961 cgaccaccgg ctgctgctgc gcaacaccaa acccctgctg cagagccgca gcgccgcggt
1021 ggtgatggcg gtggcgcagc tctacttcca cctgggccca aggcggaagt ggcgtcatcg
1081 ccaaggcgct ggtgcgctgc tgcgcagcca cagtgaggtg cagtacgttg tgctccagaa
1141 cgtggccacc atgtccatca agcgccgggg tatgtttgag ccctacctga agagcttcta
1201 catcaggtcc accgacccca cccagattaa gatcctgaag ctggaagtgc tgaccaacct
1261 ggccaatgag accaacattc ctactgtcct acgggaattc cagacctata ttcgcagcat
1321 ggacaaggac tttgtggcag ccacaatcca ggccattgga cgctgtgcaa ctaacatcgg
1381 ccgagtccgt gacacctgcc tcaatggcct ggtgcagctg ctgtccaacc gtgatgagct
1441 tgtggttgca gagtcagtgg tcgtcattaa gaaattgcta cagatgcagc cagcacaaca
1501 tggagagatc atcaaacact tggcaaagct tacagacaac atccaggtgc ccatggcccg
1561 agccagcatc ctgtggctca tcggagagta ctgtgagcat gtccccagga ttgcacctga
1621 tgtcttaaga aaaatggcca agtcattcac agcagaggag gatattgtca agctgcaggt
1681 catcaacctg gcagccaagc tctacctgac caactctaaa cagaccaagc tgctgaccca
1741 gtatgtgctg agtctggcca aatatgacca gaactatgat attcgcgacc gggcgcgctt
1801 cacccggcag ctcatcgtcc cttccgagca gggtggggcc ctcagccgcc atgccaagaa
1861 gctcttcctg gcacccaaac cagctccagt cttggagtca tccttcaaag accgggacca
1921 cttccagctg ggctcactgt cccacctgct taatgccaag gccacaggct accaggagct
1981 cccagactgg ccggaggaag ccccagaccc atctgtgcgc aacgtggagg tacctgaatg
2041 gaccaagtgc tcaaatcggg agaagagaaa ggagaaggaa aaacccttct actcggactc
2101 tgagggggag tcaggcccca cggagtccgc agacagtgac cctgagtctg agagtgaatc
2161 ggacagtaag agcagcagtg agagcggctc tggggagtcc agcagtgagt ccgacaatga
2221 agaccaggat gaggatgagg agaaagggag aggcagtgag agtgaacaga gtgaggagga
2281 tggtaagagg aagacaaaga agaaggtgcc agagagaaaa ggagaagcgt catcctctga
2341 tgagggcagc gattccagca gtagctcatc agagtccgag atgacatcgg agtccgagga
2401 ggagcagtta gaacctgcct cctggagcag gaaaacacct cccagcagca aaagtgctcc
2461 tgcaaccaag gagatctccc tgcttgatct agaggatttc acccctccca gtgtccagcc
2521 tgtgtctccc ccagcaattg tgtctaccag tctggctgct gacctggagg gcctgacact
2581 cacagactcc accctggtac cgtcgcttct gagtccagta tcgggtgttg ggcggcagga
2641 gctgctgcac cgggtagctg gcgaggggct ggctgtggac tacaccttca gccgccaacc
2701 tttctccggg gatccccaca tggtgtccgt gcacatccac ttctccaaca gctctgatac
2761 ccccatcaag ggcctgcatg tgggcactcc caaactgcct gctggcatca gcatccaaga
2821 atttcccgaa attgagtccc tggcacctgg agaatctgcc actgctgtaa tgggcattaa
2881 tttctgtgac tcaacccagg cagccaactt ccagctgtgc acccagaccc gacagttcta
2941 cgtctccatt cagccacctg ttggggagct gatggcccct gtgttcatga gtgaaaatga
3001 gtttaagaag gaacagggaa agctgatggg catgaatgag atcacagaga aactcatgct
3061 gccagacacc tgtcggagtg accacattgt ggtgcagaaa gtgactgcca ctgccaacct
3121 gggtcgtgtt ccttgtggga catctgatga gtacaggttt gcagggagga cactgactgg
3181 tggaagcctc gttctgctga ccctggatgc ccggccagct ggagctgccc agctgactgt
3241 caacagcgag aaaatggtga ttggcaccat gctggtaaag gatgtgatac aggctctgac
3301 ccagtgactt ccaaatgctg tgacctgttt ggctcccatc tatacctccc catgacacct
3361 aggctgtcag tctctctcat ctttctctct ctctctcatc atcctcctca tgccagatag
3421 cattcagggt gtcctctctc ccc
//