LOCUS HSU37183 1560 bp mRNA linear HUM 17-JAN-1997
DEFINITION Human islet cell autoantigen ICAp69 (ICA1) mRNA, partial cds.
ACCESSION U37183
VERSION U37183.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1560)
AUTHORS Gaedigk,R., Karges,W., Hui,M.F., Scherer,S.W. and Dosch,H.M.
TITLE Genomic organization and transcript analysis of ICAp69, a target
antigen in diabetic autoimmunity
JOURNAL Genomics 38 (3), 382-391 (1996)
PUBMED 8975715
REFERENCE 2 (bases 1 to 1560)
AUTHORS Gaedigk,R.
TITLE Direct Submission
JOURNAL Submitted (27-SEP-1995) Roger Gaedigk, Immunology, The Hospital for
Sick Children, 555 University Ave., Toronto, Ontario M5G 1X8,
Canada
FEATURES Location/Qualifiers
source 1..1560
/db_xref="H-InvDB:HIT000219502"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="7"
/map="7p22-23"
/clone="IS5"
gene 1..1560
/gene="ICA1"
CDS <1..1418
/gene="ICA1"
/note="autoantigen in type 1 diabetes"
/codon_start=3
/product="islet cell autoantigen p69"
/protein_id="AAC50935.1"
/translation="QDRYAQDKSVVNKMQQKYWETKQAFIKATGKKEDEHVVASDADL
DAKLELFHSIQRTCLDLSKAIVLYQKRICFLSQEENELGKFLRSQGFQDKTRAGKMMQ
ATGKALCFSSQQRLALRNPLCRFHQEVETFRHRAISDTWLTVNRMEQCRTEYRGALLW
MKDVSQELDPDLYKQMEKFRKVQTQVRLAKKNFDKLKMDVCQKVDLLGASRCNLLSHM
LATYQTTLLHFWEKTSHTMAAIHESFKGYQPYEFTTLKSLQDPMKKLVEKEEKKKINQ
QESTDAAVQEPSQLISLEEENQRKESSSFKTEDGKSILSALDKGSTHTACSGPIDELL
DMKSEEGACLGPVAGTPEPEGADKDDLLLLSEIFNASSLEEGEFSKEWAAVFGDGQVK
EPVPTMALGEPDPKAQTGSGFLPSQLLDQNMKDLQASLQEPAKAASDLTAWFSLFADL
DPLSNPDAVGKTDKEHELLNA"
regulatory 1528..1533
/regulatory_class="polyA_signal_sequence"
/gene="ICA1"
BASE COUNT 492 a 337 c 374 g 356 t
ORIGIN
1 tacaggatcg atatgctcaa gataagtcag ttgtaaataa gatgcaacag aaatattggg
61 agacgaagca ggcctttatt aaagccacag ggaagaagga agatgaacat gttgttgcct
121 ctgacgcgga cctggatgcc aagctagagc tgtttcattc aattcagaga acctgtctgg
181 acttatcgaa agcaattgta ctctatcaaa agaggatatg tttcttgtct caagaagaaa
241 acgaactggg aaaatttctt cgatcccaag gtttccaaga taaaaccaga gcaggaaaga
301 tgatgcaagc gacaggaaag gccctctgct tttcttccca gcaaaggttg gccttacgaa
361 atcctttgtg tcgatttcac caagaagtgg agacttttcg gcatcgggcc atctcagata
421 cttggctgac ggtgaaccgc atggaacagt gcaggacgga atatagagga gcactnttat
481 ggatgaagga cgtgtctcag gagcttgatc cagacctcta caagcaaatg gagaagttca
541 ggaaggtaca aacacaagtg cgccttgcaa aaaaaaactt tgacaaattg aagatggatg
601 tttgtcaaaa agtggatctt cttggagcga gcagatgcaa tctcttgtct cacatgctag
661 caacatacca gaccactctg cttcattttt gggagaaaac ttctcacact atggcagcca
721 tccatgagag tttcaaaggt tatcaaccat atgaatttac tactttaaag agcttacaag
781 accctatgaa aaaattagtt gagaaagaag agaagaagaa aatcaaccag caggaaagta
841 cagatgcagc cgtgcaggag ccgagccaat taatttcatt agaggaagaa aaccagcgca
901 aggaatcctc tagttttaag actgaagatg gaaaaagtat tttatctgcc ttagacaaag
961 gctctacaca tactgcatgc tcaggaccca tagatgaact attagacatg aaatctgagg
1021 aaggtgcttg cctgggacca gtggcaggga ccccggaacc tgaaggtgct gacaaagatg
1081 acctgctgct gttgagtgag atcttcaatg cttcctcctt ggaagagggc gagttcagca
1141 aagagtgggc cgctgtgttt ggagacggcc aagtgaagga gccagtgccc actatggccc
1201 tgggagagcc agaccccaag gcccagacag gctcaggttt ccttccttcg cagcttttag
1261 accaaaatat gaaagactta caggcctcgc tacaagaacc tgctaaggct gcctcagacc
1321 tgactgcctg gttcagcctc ttcgctgacc tcgacccact ctcaaatcct gatgctgttg
1381 ggaaaaccga taaagaacac gaattgctca atgcatgaat ctgtaccctt cgggagggca
1441 ctcacatgcc gcccccagca gctcccctgg gggctagcag aagtataaag tgatcagtat
1501 gctgttttaa taattatgtg ccattttaat aaaatgaaag ggtcaacggc aaaaaaaaaa
//