LOCUS HSU35116 3102 bp mRNA linear HUM 09-JAN-2003
DEFINITION Human ubiquitin isopeptidase T mRNA, complete cds.
ACCESSION U35116
VERSION U35116.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3102)
AUTHORS Wilkinson,K.D., Tashayev,V.L., O'Connor,L.B., Larsen,C.N.,
Kasperek,E. and Pickart,C.M.
TITLE Metabolism of the polyubiquitin degradation signal: structure,
mechanism, and role of isopeptidase T
JOURNAL Biochemistry 34 (44), 14535-14546 (1995)
PUBMED 7578059
REFERENCE 2 (bases 1 to 3102)
AUTHORS Wilkinson,K.
TITLE Direct Submission
JOURNAL Submitted (30-AUG-1995) Keith Wilkinson, Biochemistry, Emory
University, 1510 Clifton Road, 4017 RRC, Atlanta, GA 30322, USA
FEATURES Location/Qualifiers
source 1..3102
/db_xref="H-InvDB:HIT000219413"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="HL60 cells"
CDS 44..2551
/EC_number="3.1.2.15"
/note="ubiquitin carboxyl-terminal hydrolase;
ubiquitinthiolesterase; ubiquitin-specific processing
protease; deubiquinating enzyme"
/codon_start=1
/product="ubiquitin isopeptidase T"
/protein_id="AAA78934.1"
/translation="MAELSEEALLSVLPTIRVPKAGDRVHKDECAFSFDTPESEGGLY
ICMNTFLGFGKQYVERHFNKTGQRVYLHLRRTRRPKEEDPATGTGDPPRKKPTRLAIG
VEGGFDLSEEKFELDEDVKIVILPDYLEIARDGLGGLPDIVRDRVTSAVEALLSADSA
SRKQEVQAWDGEVRQVSKHAFSLKQLDNPARIPPCGWKCSKCDMRENLWLNLTDGSIL
CGRRYFDGSGGNNHAVEHYRETGYPLAVKLGTITPDGADVYSYDEDDMVLDPSLAEHL
SHFGIDMLKMQKTDKTMTELEIDMNQRIGEWELIQESGVPLKPLFGPGYTGIRNLGNS
CYLNSVVQVLFSIPDFQRKYVDKLEKIFQNAPTDPTQDFSTQVAKLGHGLLSGEYSKP
VPESGDGERVPEQKEVQDGIAPRMFKALIGKGHPEFSTNRQQDAQEFFLHLINMVERN
CRSSENPNEVFRFLVEERIKCLATEKVKYTQRVDYIMQLPVPMDAALNKEELLEYEEK
KRQAEEEKMALPELVRAQVPFSSCLEAYGAPEQVDDFWSTALQAKSVAVKTTRFASFP
DYLVIQIKKFTFGLDWVPKKLDVSIEMPEELDISQLRGTGLQPGEEELPDIAPPLVTP
DEPKAPMLDESVIIQLVEMGFPMDACRKAVYYTDNSGAEAAMNWVMSHMDDPDFANPL
ILPGSSGPGSTSAAADPPPEDCVTTIVSMGFSRDQALKALRATNNSLERAVDWIFSHI
DDLDAEAAMDISEGRSAADSISESVPVGPKVRDGPGKYQLFAFISHMGTSTMCGHYVC
HIKKEGRWVIYNDQKVCASEKPPKDLGYIYFYQRVAS"
BASE COUNT 680 a 865 c 933 g 624 t
ORIGIN
1 gcggccgcgg atccgcggcc gcggagaagc tgctgccggt gtcatggcgg agctgagtga
61 ggaggcgctg ctgtcagtat taccgacgat ccgggtccct aaggctggag accgggtcca
121 caaagacgag tgcgccttct ccttcgacac gccggagtct gaggggggcc tctacatctg
181 tatgaacacg tttctgggct ttgggaaaca gtatgtggag agacatttca ataagaccgg
241 ccagcgagtc tacttgcacc tccggcggac ccggcgcccg aaagaggagg accctgctac
301 aggcactgga gacccacccc ggaagaagcc cacgcggctg gctattggtg ttgaaggcgg
361 atttgacctt agcgaggaga agtttgaatt agacgaggat gtgaagattg tcattttgcc
421 agattacctg gagattgccc gggatggact ggggggactg cctgacattg tcagagatcg
481 ggtgaccagt gcagtggagg ccctactgtc ggccgactca gcctcccgca agcaggaggt
541 gcaggcatgg gatggggaag tacggcaggt gtctaagcat gccttcagcc tcaagcagtt
601 ggacaaccct gctcgaatcc ctccctgtgg ctggaagtgc tccaagtgtg acatgagaga
661 gaacctgtgg ctcaacctga ctgatggctc catcctctgt gggcgacgct acttcgatgg
721 cagtgggggc aacaaccacg ctgtggagca ctaccgagag acaggctacc cgttagctgt
781 caagctgggc accatcaccc ctgatggagc tgacgtgtac tcatatgatg aggatgacat
841 ggtcctggac cccagcctgg ctgagcacct gtcccacttc ggcatcgaca tgctgaagat
901 gcagaagaca gacaagacga tgactgagtt ggagatagac atgaaccagc ggattggtga
961 atgggagctg atccaggagt caggtgtgcc actcaagccc ctgtttgggc ctggctacac
1021 aggcatccgg aacctgggta acagctgcta cctcaactct gtggtccagg tgctcttcag
1081 catccctgac ttccagagga agtatgtgga taagctggag aagatcttcc agaatgcccc
1141 gacagaccct acccaggatt tcagcaccca ggtggccaag ctgggccatg gccttctctc
1201 cggggagtat tccaagccag taccggagtc gggcgatggg gagcgggtgc cagaacagaa
1261 ggaagttcaa gatggcattg cccctcggat gttcaaggcc ctcatcggca agggccaccc
1321 tgaattctcc accaaccggc agcaggatgc ccaggagttc ttccttcacc ttatcaacat
1381 ggtggagagg aattgccgga gctctgaaaa tcctaatgaa gtgttccgct tcttggtgga
1441 ggaaaggatc aagtgcctgg ccacagagaa ggtgaagtac acccagcgag ttgactacat
1501 catgcagctg cctgtgccca tggatgcagc ccttaacaaa gaggagcttc tggagtacga
1561 ggagaagaag cggcaagccg aagaggagaa gatggcactg ccagaactgg ttcgggccca
1621 ggtgcccttc agctcttgcc tggaggccta cggggcccct gagcaggtcg atgacttctg
1681 gagcacggcc ctgcaggcca agtcagtagc tgtcaagacc acacgatttg cctcattccc
1741 tgactacctg gtcatccaga tcaagaagtt caccttcggc ttagactggg tgcccaagaa
1801 actggatgtg tccatcgaga tgccagagga gctcgacatc tcccagttga ggggcacagg
1861 gctgcagccc ggagaggagg agctgccaga cattgcccca cccctggtca ctccggatga
1921 gcccaaagcg cccatgctgg atgaatcagt catcatccag ctggtggaga tgggattccc
1981 tatggacgcc tgccgcaaag ctgtctacta cacggacaac agcggggctg aggccgccat
2041 gaactgggtc atgtcacaca tggatgatcc agattttgca aaccccctca tcctgcctgg
2101 ctctagtggg ccgggctcca caagcgcagc agccgacccc cctcctgagg actgtgtgac
2161 caccattgtc tccatgggct tctcccggga ccaggccttg aaagcgctgc gggccacgaa
2221 caatagttta gaacgggctg tggactggat cttcagtcac attgacgacc tggatgctga
2281 agctgccatg gacatctcag agggccgctc agctgccgac tccatctctg agtctgtgcc
2341 agtgggacct aaagtccggg atggtcctgg aaagtatcag ctctttgcct tcattagtca
2401 catgggcacc tctaccatgt gtggtcacta cgtctgccac atcaagaaag aaggcagatg
2461 ggtgatctac aatgaccaga aagtgtgtgc ctccgagaag ccgcccaagg acctgggcta
2521 catctacttc taccagagag tggccagcta agagcctgcc tcacccctta ccaatgaggg
2581 caggggaaga ccacctggca tgagggagag gggctgaggg atggacttca gcccctctgc
2641 tctgtaccct ttttcctttt gtccccggca gcagggaaga agctggaggc cgtgggagaa
2701 tggctgggca gagcagaggg gcagcgatag actctgggga tggagcagga cggggacggg
2761 aggggccggc cacctgtctg taaggagact ttgttgcttc ccctcccccc ggaatccaca
2821 gtgctctgct tctctgtgtc gccccgccca gccccctggt gtggagggag gggtctcgtt
2881 tgtgcgcgtg ggtgtagctt tgtgcatcct ctcccagtgg agcgatcacc tgtgcctccc
2941 ctcccccttt gtttgcccct gtgtggttgg tcaaggaggg atgtgaggga aatagggacc
3001 ccccgacttg ccctcctgcc tcagtctttc ccccaccctg tctcttcctt gtccttctct
3061 ggaaatgcca aaatacacga tgtgaataaa agtacaacgg ct
//