LOCUS HSU34349 1705 bp mRNA linear HUM 29-NOV-1995
DEFINITION Human seven trans-membrane domain protein (AD3LP/AD5) mRNA,
complete cds.
ACCESSION U34349
VERSION U34349.1
KEYWORDS Alzheimer's disease.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1673)
AUTHORS Li,J., Ma,J. and Potter,H.
TITLE Identification and expression analysis of a potential familial
Alzheimer disease gene on chromosome 1 related to AD3
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (26), 12180-12184 (1995)
PUBMED 8618867
REFERENCE 2 (bases 1 to 1673)
AUTHORS Li,J.
TITLE Direct Submission
JOURNAL Submitted (21-AUG-1995) Jinhe Li, Neurobiology, Harvard Medical
School, 220 Longwood Ave., B2-502, Boston, MA 02115, USA
FEATURES Location/Qualifiers
source 1..1705
/db_xref="H-InvDB:HIT000219377"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="Contig WC-516, 289 cM from centromere"
gene 1..1705
/gene="AD3LP/AD5"
5'UTR 1..91
/gene="AD3LP/AD5"
CDS 92..1420
/gene="AD3LP/AD5"
/note="A potential familial Alzheimer's disease gene
related to AD3; Similar to the Mus musculus product
encoded by S182 gene, GenBank Accession Number L42110"
/codon_start=1
/product="seven trans-membrane domain protein AD3LP/AD5"
/protein_id="AAC50290.1"
/translation="MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENT
AQWRSQENEEDGEEDPDRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVV
VATIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLY
KYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVC
IHWKGPLVLQQAYLIMISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRM
LVETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQLPYDPEMEDSYDSFGEPS
YPEVFEPPLTGYPGEELEEEEESQGGVKLGLGDFIFYSVLVGKAAATGSGDWNTTLAC
FVAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDRKHSRFIQMN"
3'UTR 1421..1705
/gene="AD3LP/AD5"
regulatory 1666..1671
/regulatory_class="polyA_signal_sequence"
/gene="AD3LP/AD5"
BASE COUNT 369 a 455 c 488 g 389 t
ORIGIN
1 ncaatcttaa cttntngaga anaaaccaag tgtccgggat tcagacctct ctgcggcccc
61 aagtgttcgt ggtgcttcca gaggcagggc tatgctcaca ttcatggcct ctgacagcga
121 ggaagaagtg tgtgatgagc ggacgtccct aatgtcggcc gagagcccca cgccgcgctc
181 ctgccaggag ggcaggcagg gcccagagga tggagagaac actgcccagt ggagaagcca
241 ggagaacgag gaggacggtg aggaggaccc tgaccgctat gtctgtagtg gggttcccgg
301 gcggccgcca ggcctggagg aagagctgac cctcaaatac ggagcgaagc acgtgatcat
361 gctgtttgtg cctgtcactc tgtgcatgat cgtggtggta gccaccatca agtctgtgcg
421 cttctacaca gagaagaatg gacagctcat ctacacgcca ttcactgagg acacaccctc
481 ggtgggccag cgcctcctca actccgtgct gaacaccctc atcatgatca gcgtcatcgt
541 ggttatgacc atcttcttgg tggtgctcta caagtaccgc tgctacaagt tcatccatgg
601 ctggttgatc atgtcttcac tgatgctgct gttcctcttc acctatatct accttgggga
661 agtgctcaag acctacaatg tggccatgga ctaccccacc ctcttgctga ctgtctggaa
721 cttcggggca gtgggcatgg tgtgcatcca ctggaagggc cctctggtgc tgcagcaggc
781 ctacctcatc atgatcagtg cgctcatggc cctagtgttc atcaagtacc tcccagagtg
841 gtccgcgtgg gtcatcctgg gcgccatctc tgtgtatgat ctcgtggctg tgctgtgtcc
901 caaagggcct ctgagaatgc tggtagaaac tgcccaggag agaaatgagc ccatattccc
961 tgccctgata tactcatctg ccatggtgtg gacggttggc atggcgaagc tggacccctc
1021 ctctcagggt gccctccagc tcccctacga cccggagatg gaagactcct atgacagttt
1081 tggggagcct tcataccccg aagtctttga gcctcccttg actggctacc caggggagga
1141 gctggaggaa gaggaggaaa gtcaaggggg cgtgaagctt ggcctcgggg acttcatctt
1201 ctacagtgtg ctggtgggca aggcggctgc cacgggcagc ggggactgga ataccacgct
1261 ggcctgcttc gtggccatcc tcattggctt gtgtctgacc ctcctgctgc ttgctgtgtt
1321 caagaaggcg ctgcccgccc tccccatctc catcacgttc gggctcatct tttacttctc
1381 cacggacagg aagcacagca ggtttatcca gatgaactga gaaggtcaga ttagggcggg
1441 gagaagagca tccggcatga gggctgagat gcgcaaagag tgtgctcggg agtggcccct
1501 ggcacctggg tgctctggct ggagaggaaa aaccagttcc ctacgaggag tgttcccaat
1561 gctttgtcca tgatgtcctt gttattttat tgcctttaga aactgagtcc tgttcttgtt
1621 acggcagtca cactgctggg aagtggctta atactaatat caataaatag atgagtcctg
1681 ttagaaaaaa aaaaaaaaaa aaaaa
//