LOCUS       HSU33632                1882 bp    mRNA    linear   HUM 05-JUN-1996
DEFINITION  Human two P-domain K+ channel TWIK-1 mRNA, complete cds.
ACCESSION   U33632
VERSION     U33632.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1882)
  AUTHORS   Lesage,F., Guillemare,E., Fink,M., Duprat,F., Lazdunski,M.,
            Romey,G. and Barhanin,J.
  TITLE     TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with
            a novel structure
  JOURNAL   EMBO J. 15 (5), 1004-1011 (1996)
   PUBMED   8605869
REFERENCE   2  (bases 1 to 1882)
  AUTHORS   Lesage,F.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-AUG-1995) Florian Lesage, Institut de Pharmacologie
            Moleculaire et Cellulaire-CNRS, 660 Route des Lucioles, Valbonne
            06560, France
FEATURES             Location/Qualifiers
     source          1..1882
                     /db_xref="H-InvDB:HIT000219324"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="pBS-HORK"
                     /tissue_type="kidney"
                     /dev_stage="adult"
     5'UTR           1..182
     CDS             183..1193
                     /function="two P-domain K+ channel"
                     /codon_start=1
                     /product="TWIK-1"
                     /protein_id="AAB01688.1"
                     /translation="MLQSLAGSSCVRLVERHRSAWCFGFLVLGYLLYLVFGAVVFSSV
                     ELPYEDLLRQELRKLKRRFLEEHECLSEQQLEQFLGRVLEASNYGVSVLSNASGNWNW
                     DFTSALFFASTVLSTTGYGHTVPLSDGGKAFCIIYSVIGIPFTLLFLTAVVQRITVHV
                     TRRPVLYFHIRWGFSKQVVAIVHAVLLGFVTVSCFFFIPAAVFSVLEDDWNFLESFYF
                     CFISLSTIGLGDYVPGEGYNQKFRELYKIGITCYLLLGLIAMLVVLETFCELHELKKF
                     RKMFYVKKDKDEDQVHIIEHDQLSFSSITDQAAGMKEDQKQNEPFVATQSSACVDGPA
                     NH"
     3'UTR           1194..1882
BASE COUNT          449 a          435 c          512 g          486 t
ORIGIN      
        1 gggcaggaag acggcgctgc ccggaggagc ggggcgggcg ggcgcgcggg ggagcgggcg
       61 gcgggcggga gccaggcccg ggcgggggcg ggggcggcgg ggccagaaga ggcggcgggc
      121 cgcgctccgg ccggtctgcg gcgttggcct tggctttggc tttggcggcg gcggtggaga
      181 agatgctgca gtccctggcc ggcagctcgt gcgtgcgcct ggtggagcgg caccgctcgg
      241 cctggtgctt cggcttcctg gtgctgggct acttgctcta cctggtcttc ggcgcagtgg
      301 tcttctcctc ggtggagctg ccctatgagg acctgctgcg ccaggagctg cgcaagctga
      361 agcgacgctt cttggaggag cacgagtgcc tgtctgagca gcagctggag cagttcctgg
      421 gccgggtgct ggaggccagc aactacggcg tgtcggtgct cagcaacgcc tcgggcaact
      481 ggaactggga cttcacctcc gcgctcttct tcgccagcac cgtgctctcc accacaggtt
      541 atggccacac cgtgcccttg tcagatggag gtaaggcctt ctgcatcatc tactccgtca
      601 ttggcattcc cttcaccctc ctgttcctga cggctgtggt ccagcgcatc accgtgcacg
      661 tcacccgcag gccggtcctc tacttccaca tccgctgggg cttctccaag caggtggtgg
      721 ccatcgtcca tgccgtgctc cttgggtttg tcactgtgtc ctgcttcttc ttcatcccgg
      781 ccgctgtctt ctcagtcctg gaggatgact ggaacttcct ggaatccttt tatttttgtt
      841 ttatttccct gagcaccatt ggcctggggg attatgtgcc tggggaaggc tacaatcaaa
      901 aattcagaga gctctataag attgggatca cgtgttacct gctacttggc cttattgcca
      961 tgttggtagt tctggaaacc ttctgtgaac tccatgagct gaaaaaattc agaaaaatgt
     1021 tctatgtgaa gaaggacaag gacgaggatc aggtgcacat catagagcat gaccaactgt
     1081 ccttctcctc gatcacagac caggcagctg gcatgaaaga ggaccagaag caaaatgagc
     1141 cttttgtggc cacccagtca tctgcctgcg tggatggccc tgcaaaccat tgagcgtagg
     1201 atttgttgca ttatgctaga gcaccagggt cagggtgcaa ggaagaggct taagtatgtt
     1261 catttttatc agaatgcaaa agcgaaaatt atgtcacttt aagaaatagc tactgtttgc
     1321 aatgtcttat taaaaaacaa caaaaaaaga cacatggaac aaagaagctg tgaccccagc
     1381 aggatgtcta atatgtgagg aaatgagatg tccacctaaa attcatatgt gacaaaatta
     1441 tctcgacctt acataggagg agaatacttg aagcagtatg ctgctgtggt tagaagcaga
     1501 ttttatactt ttaactggaa actttggggt ttgcatttag atcatttagc tgatggctaa
     1561 atagcaaaat ttatatttag aagcaaaaaa aaaaagcata gagatgtgtt ttataaatag
     1621 gtttatgtgt actggtttgc atgtacccac ccaaaatgat tatttttgga gaatctaagt
     1681 caaactcact atttataatg cataggtaac cattaactat gtacatataa agtataaata
     1741 tgtttatatt ctgtacatat ggtttaggtc accagatcct agtgtagttc tgaaactaag
     1801 actatagata ttttgtttct tttgatttct ctttatacta aagaatccag agttgctaca
     1861 ataaaataag gggaataata aa
//