LOCUS HSU33428 2620 bp mRNA linear HUM 31-JAN-1997
DEFINITION Human K+ channel beta 1a subunit mRNA, alternatively spliced,
complete cds.
ACCESSION U33428
VERSION U33428.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 28 to 1233)
AUTHORS McCormack,T. and McCormack,K.
TITLE Shaker K+ channel beta subunits belong to an NAD(P)H-dependent
oxidoreductase superfamily
JOURNAL Cell 79 (7), 1133-1135 (1994)
PUBMED 8001150
REFERENCE 2 (bases 1 to 2620)
AUTHORS McCormack,K., McCormack,T., Tanouye,M., Rudy,B. and Stuhmer,W.
TITLE Alternative splicing of the human Shaker K+ channel beta 1 gene and
functional expression of the beta 2 gene product
JOURNAL FEBS Lett. 370 (1-2), 32-36 (1995)
PUBMED 7649300
REFERENCE 3 (bases 1 to 2620)
AUTHORS Schultz,D., Litt,M., Smith,L., Thayer,M. and McCormack,K.
TITLE Localization of two potassium channel beta subunit genes, KCNA1B
and KCNA2B
JOURNAL Genomics 31 (3), 389-391 (1996)
PUBMED 8838324
REMARK Localized beta 1a to chromosome 3
REFERENCE 4 (bases 1 to 2620)
AUTHORS McCormack,K.
TITLE Direct Submission
JOURNAL Submitted (08-AUG-1995) Ken McCormack, Department of Genetics,
University of Wisconsin, 445 Henry Mall, Madison, WI 53706, USA
FEATURES Location/Qualifiers
source 1..2620
/db_xref="H-InvDB:HIT000219319"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3q.26.1"
/tissue_type="hippocampus"
CDS 28..1233
/function="modulates gating and expression of K+ channels"
/function="putative enzymatic function"
/note="alternative splice product of the Shaker beta 1
gene, see GenBank Accession Numbers U16953 and L39833;
member of the NAD(P)H-dependent aldo-keto reductase
superfamily"
/citation=[1]
/codon_start=1
/product="K+ channel beta 1a subunit"
/protein_id="AAC50953.1"
/translation="MQVSIACTEHNLKSRNGEDRLLSKQSSTAPNVVNAARAKFRTVA
IIARSLGTFTPQHHISLKESTAKQTGMKYRNLGKSGLRVSCLGLGTWVTFGGQISDEV
AERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVITTKLYWGGKAE
TERGLSRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNTPMEEIVRAMTHVINQGMAMY
WGTSRWSAMEIMEAYSVARQFNMIPPVCEQAEYHLFQREKVEVQLPELYHKIGVGAMT
WSPLACGIISGKYGNGVPESSRASLKCYQWLKERIVSEEGRKQQNKLKDLSPIAERLG
CTLPQLAVAWCLRNEGVSSVLLGSSTPEQLIENLGAIQVLPKMTSHVVNEIDNILRNK
PYSKKDYRS"
BASE COUNT 811 a 513 c 581 g 715 t
ORIGIN
1 agggaccgtg cgctgcctgg ggaagcaatg caagtctcca tagcctgcac agagcacaat
61 ttgaagagtc ggaatggtga ggaccgactt ctgagcaagc agagctccac cgcccccaat
121 gtggtgaacg cagcccgggc caaattccgc acggtcgcta tcatcgcgcg cagcctgggg
181 acgttcacgc ctcagcatca catttctctc aaagagtcca ccgcaaagca gactggcatg
241 aaatatagga atcttggaaa atcaggactc agagtttctt gcttgggtct tggaacatgg
301 gtgacatttg gaggtcaaat ttcagatgag gttgctgaac ggctgatgac catcgcctat
361 gaaagtggtg ttaacctctt tgatactgcc gaagtctatg ctgctggaaa ggctgaagtg
421 attctgggga gcatcatcaa gaagaaaggc tggaggaggt ccagtctggt cataacaacc
481 aaactctact ggggtggaaa agctgaaaca gaaagagggc tgtcaagaaa gcatattatt
541 gaaggattga agggctccct ccagaggctg cagctcgagt atgtggatgt ggtctttgca
601 aatcgaccgg acagtaacac tcccatggaa gaaattgtcc gagccatgac acatgtgata
661 aaccaaggca tggcgatgta ctggggcacc tcgagatgga gtgctatgga gatcatggaa
721 gcctattctg tagcaagaca gttcaatatg atcccaccgg tctgtgaaca agctgagtac
781 catcttttcc agagagagaa agtggaggtc cagctgccag agctctacca caaaataggt
841 gttggcgcaa tgacatggtc tccacttgcc tgtggaatca tctcaggaaa atacggaaac
901 ggggtgcctg aaagttccag ggcttcactg aagtgctacc agtggttgaa agaaagaatt
961 gtaagtgaag aagggagaaa acagcaaaac aagctaaaag acctttcccc aattgcggag
1021 cgtctgggat gcacactacc tcagctagct gttgcgtggt gcctgagaaa tgaaggtgtg
1081 agttctgtgc tcctgggatc atccactcct gaacaactca ttgaaaacct tggtgccatt
1141 caggttctcc caaagatgac atcacatgtg gtaaatgaga ttgataacat actgcgcaac
1201 aagccctaca gcaagaagga ctatagatca taaggcaatg catgaaccac agaagctgca
1261 tggttaaaat agcggcctgt gcccagtaca gaaaggtgtt actaaccagt cttttgaatc
1321 acttagcagc ttgctcgtca acctctagtg tccctccctg gattctttga ggtgtctgct
1381 gtcgctacca ctgtgcacat ctgaaaactc acaaccaaga aaatccattc tattttctta
1441 tcttggactg gagtcaccta ttcttgcatt gctgtataca cctcatgctt atgcaatggg
1501 aagaatatgg gggccagggg gtgtggtact accttcaggc atttggtaac tcaaagaagg
1561 ctgtacagat atattttttc aaaaagaaca aaatccacag atgcaatgtg agttgcgtaa
1621 gaaacagagt agatagacta aattcagtga aggaaaggaa ttgagagatt tttcttagta
1681 aatagattat tgttaagtaa atagttatta aaaatatatc tcactgcaaa aaaaaaaaaa
1741 gcagtatctt cactcaaaag tcttgcttgg aagaataagc agaaagaatt ttatatattt
1801 tttttctatt ttcacattca tactaacaag ttttgttcca tttgttattc aataaaacaa
1861 aaatttctag gtatttgctt tattaccttt caaatattta ctgttgcttg gccccaagaa
1921 tggccttgta caacttatcc agaatgtcta ttaggattct aatgttatgt ccacttacaa
1981 gtagagacag taaaaggatg aatacccaat ctttagtgac aatgcagctg atttatgaaa
2041 gagagggcta cactgctatg gaaacttagc ttcaaagaaa atgcaatgta tctgcaatta
2101 ggtgttcatt ttttactaca ttttattaaa acctgcttta tactttcaac tgcttgtagg
2161 cacaacttct gcaagtttaa atatttgagc tttacaaata aacatacaca tgctgttttt
2221 taagtaaacc tgtaaaatac ccaggaaggc aaatgttcat tgtttaatta gcactgggat
2281 tttataatat aatgtttggt atttttgagg cattgttaac atgaaagtca accactggct
2341 ttgtgaaaaa tgctatgtca ctattcagaa tatgctgggt aaattaactt gcctagtgaa
2401 aagcaaaatg ttaaagaaag aacttctggt tctataatca tattatatgc actaaactat
2461 atgcatgaaa gttctttgca tggattaatg gggcttaccc ttgttgcact cgaaatctga
2521 ggtgtatcta gccctgccac tattggctac ttaccctcat taatatccca cttgagaaaa
2581 attgtgagac tatactgtgt caatatctgt aaaaagagag
//