LOCUS       HSU33286                3147 bp    mRNA    linear   HUM 14-FEB-1996
DEFINITION  Human chromosome segregation gene homolog CAS mRNA, complete cds.
ACCESSION   U33286
VERSION     U33286.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3147)
  AUTHORS   Brinkmann,U., Brinkmann,E. and Pastan,I.
  TITLE     Expression cloning of cDNAs that render cancer cells resistant to
            Pseudomonas and diphtheria toxin and immunotoxins
  JOURNAL   Mol. Med. 1 (2), 206-216 (1995)
   PUBMED   8529099
REFERENCE   2  (bases 1 to 3147)
  AUTHORS   Brinkmann,U., Brinkmann,E., Gallo,M. and Pastan,I.
  TITLE     Cloning and characterization of a cellular apoptosis susceptibility
            gene, the human homologue to the yeast chromosome segregation gene
            CSE1
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 92 (22), 10427-10431 (1995)
   PUBMED   7479798
REFERENCE   3  (bases 1 to 3147)
  AUTHORS   Brinkmann,U.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-AUG-1995) Ulrich Brinkman, Laboratory of Molecular
            Biology, DCBDC, National Cancer Institute, National Institutes of
            Health, Building 37, Room 4E16, 37 Convent Dr., MSC 4255, Bethesda,
            MD 20892-4255, USA
REFERENCE   4  (bases 1 to 3147)
  AUTHORS   Brinkmann,U., Gallo,M., Polymeropoulos,M.H. and Pastan,I.
  TITLE     The human CAS gene maps on chromosome 20q13, is amplified in BT474
            breast cancer cells and part of aberrant chromosomes in breast and
            colon cancer cells
  JOURNAL   Unpublished
COMMENT     On Nov 4, 1995 this sequence version replaced gi:951337.
FEATURES             Location/Qualifiers
     source          1..3147
                     /db_xref="H-InvDB:HIT000219316"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13"
                     /tissue_type="placenta"
     CDS             124..3039
                     /note="yeast chromosome segregation gene CSE1 homolog"
                     /codon_start=1
                     /product="CAS"
                     /protein_id="AAC50367.1"
                     /translation="MELSDANLQTLTEYLKKTLDPDPAIRRPAEKFLESVEGNQNYPL
                     LLLTLLEKSQDNVIKVCASVTFKNYIKRNWRIVEDEPNKICEADRVAIKANIVHLMLS
                     SPEQIQKQLSDAISIIGREDFPQKWPDLLTEMVNRFQSGDFHVINGVLRTAHSLFKRY
                     RHEFKSNELWTEIKLVLDAFALPLTNLFKATIELCSTHANDASALRILFSSLILISKL
                     FYSLNFQDLPEFWEGNMETWMNNFHTLLTLDNKLLQTDDEEEAGLLELLKSQICDNAA
                     LYAQKYDEEFQRYLPRFVTAIWNLLVTTGQEVKYDLLVSNAIQFLASVCERPHYKNLF
                     EDQNTLTSICEKVIVPNMEFRAADEEAFEDNSEEYIRRDLEGSDIDTRRRAACDLVRG
                     LCKFFEGPVTGIFSGYVNSMLQEYAKNPSVNWKHKDAAIYLVTSLASKAQTQKHGITQ
                     ANELVNLTEFFVNHILPDLKSANVNEFPVLKADGIKYIMIFRNQVPKEHLLVSIPLLI
                     NHLQAGSIVVHTYAAHALERLFTMRGPNNATLFTAAEIAPFVEILLTNLFKALTLPGS
                     SENEYIMKAIMRSFSLLQEAIIPYIPTLITQLTQKLLAVSKNPSKPHFNHYMFEAICL
                     SIRITCKANPAAVVNFEEALFLVFTEILQNDVQEFIPYVFQVMSLLLETHKNDIPSSY
                     MALFPHLLQPVLWERTGNIPALVRLLQAFLERGSNTIASAAADKIPGLLGVFQKLIAS
                     KANDHQGFYLLNSIIEHMPPESVDQYRKQIFILLFQRLQNSKTTKFIKSFLVFINLYC
                     IKYGALALQEIFDGIQPKMFGMVLEKIIIPEIQKVSGNVEKKICAVGITNLLTECPPM
                     MDTEYTKLWTPLLQSLIGLFELPEDDTIPDEEHFIDIEDTPGYQTAFSQLAFAGKKEH
                     DPVGQMVNNPKIHLAQSLHMLSTACPGRVPSMVSTSLNAEALQYLQGYLQAASVTLL"
     polyA_site      3147
                     /note="37 A nucleotides"
BASE COUNT          959 a          639 c          621 g          928 t
ORIGIN      
        1 gtcgcgccat tttgccgggg tttgaatgtg aggcggagcg gcggcaggag cggatagtgc
       61 cagctacggt ccgcggctgg ggttccctcc tccgtttctg tatccccacg agatcctata
      121 gcaatggaac tcagcgatgc aaatctgcaa acactaacag aatatttaaa gaaaacactt
      181 gatcctgatc ctgccatccg acgtccagct gagaaatttc ttgaatctgt tgaaggaaat
      241 cagaattatc cactgttgct tttgacatta ctggagaagt cccaggataa tgttatcaaa
      301 gtatgtgctt cagtaacatt caaaaactat attaaaagga actggagaat tgttgaagat
      361 gaaccaaaca aaatttgtga agccgatcga gtggccatta aagccaacat agtgcacttg
      421 atgcttagca gcccagagca aattcagaag cagttaagtg atgcaattag cattattggc
      481 agagaagatt ttccacagaa atggcctgac ttgctgacag aaatggtgaa tcgctttcag
      541 agtggagatt tccatgttat taatggagtc ctccgtacag cacattcatt atttaaaaga
      601 taccgtcatg aatttaagtc aaacgagtta tggactgaaa ttaagcttgt tctggatgcc
      661 tttgctttgc ctttgactaa tctttttaag gccactattg aactctgcag tacccatgca
      721 aatgatgcct ctgccctgag gattctgttt tcttccctga tcctgatctc aaaattgttc
      781 tatagtttaa actttcagga tctccctgaa ttttgggaag gtaatatgga aacttggatg
      841 aataatttcc atactctctt aacattggat aataagcttt tacaaactga tgatgaagag
      901 gaagccggct tattggagct cttaaaatcc cagatttgtg ataatgccgc actctatgca
      961 caaaagtacg atgaagaatt ccagcgatac ctgcctcgtt ttgttacagc catctggaat
     1021 ttactagtta caacgggtca agaggttaaa tatgatttgt tggtaagtaa tgcaattcaa
     1081 tttctggctt cagtttgtga gagacctcat tataagaatc tatttgagga ccagaacacg
     1141 ctgacaagta tctgtgaaaa ggttattgtg cctaacatgg aatttagagc tgctgatgaa
     1201 gaagcatttg aagataattc tgaggagtac ataaggagag atttggaagg atctgatatt
     1261 gatactagac gcagggctgc ttgtgatctg gtacgaggat tatgcaagtt ttttgaggga
     1321 cctgtgacag gaatcttctc tggttatgtt aattccatgc tgcaggaata cgcaaaaaat
     1381 ccatctgtca actggaaaca caaagatgca gccatctacc tagtgacatc tttggcatca
     1441 aaagcccaaa cacagaagca tggaattaca caagcaaatg aacttgtaaa cctaactgag
     1501 ttctttgtga atcacatcct ccctgattta aaatcagcta atgtgaatga atttcctgtc
     1561 cttaaagctg acggtatcaa atatattatg atttttagaa atcaagtgcc aaaagaacat
     1621 cttttagtct cgattcctct cttgattaat catcttcaag ctggaagtat tgttgttcat
     1681 acttacgcag ctcatgctct tgaacggctc tttactatgc gagggcctaa caatgccact
     1741 ctctttacag ctgcagaaat cgcaccgttt gttgagattc tgctaacaaa ccttttcaaa
     1801 gctctcacac ttcctggctc ttcagaaaat gaatatatta tgaaagctat catgagaagt
     1861 ttttctctcc tacaagaagc cataatcccc tacatcccta ctctcatcac tcagcttaca
     1921 cagaagctat tagctgttag taagaaccca agcaaacctc actttaatca ctacatgttt
     1981 gaagcaatat gtttatccat aagaataact tgcaaagcta accctgctgc tgttgtaaat
     2041 tttgaggagg ctttgttttt ggtgtttact gaaatcttac aaaatgatgt gcaagaattt
     2101 attccatacg tctttcaagt gatgtctttg cttctggaaa cacacaaaaa tgacatcccg
     2161 tcttcctata tggccttatt tcctcatctc cttcagccag tgctttggga aagaacagga
     2221 aatattcctg ctctagtgag gcttcttcaa gcattcttag aacgcggttc aaacacaata
     2281 gcaagtgctg cagctgacaa aattcctggg ttactaggtg tctttcagaa gctgattgca
     2341 tccaaagcaa atgaccacca aggtttttat cttctaaaca gtataataga gcacatgcct
     2401 cctgaatcag ttgaccaata taggaaacaa atcttcattc tgctattcca gagacttcag
     2461 aattccaaaa caaccaagtt tatcaagagt tttttagtct ttattaattt gtattgcata
     2521 aaatatgggg cactagcact acaagaaata tttgatggta tacaaccaaa aatgtttgga
     2581 atggttttgg aaaaaattat tattcctgaa attcagaagg tatctggaaa tgtagagaaa
     2641 aagatctgtg cggttggcat aaccaactta ctaacagaat gtcccccaat gatggacact
     2701 gagtatacca aactgtggac tccattatta cagtctttga ttggtctttt tgagttaccc
     2761 gaagatgata ccattcctga tgaggaacat tttattgaca tagaagatac accaggatat
     2821 cagactgcct tctcacagtt ggcatttgct gggaaaaaag agcatgatcc tgtaggtcaa
     2881 atggtgaata accccaaaat tcacctggca cagtcacttc acatgttgtc taccgcctgt
     2941 ccaggaaggg ttccatcaat ggtgagcacc agcctgaatg cagaagcgct ccagtatctc
     3001 caagggtacc ttcaggcagc cagtgtgaca ctgctttaaa ctgcattttt ctaatgggct
     3061 aaacccagat ggtttcctag gaaatcacag gcttctgagc acagctgcat taaaacaaag
     3121 gaagttttcc ttttgaactt gtcacga
//