LOCUS HSU31973 2969 bp mRNA linear HUM 09-APR-1996
DEFINITION Human phosphodiesterase A' subunit (PDE6C) mRNA, complete cds.
ACCESSION U31973
VERSION U31973.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2969)
AUTHORS Piriev,N.I., Viczian,A.S., Ye,J., Kerner,B., Korenberg,J.R. and
Farber,D.B.
TITLE Gene structure and amino acid sequence of the human cone
photoreceptor cGMP-phosphodiesterase alpha' subunit (PDEA2) and its
chromosomal localization to 10q24
JOURNAL Genomics 28 (3), 429-435 (1995)
PUBMED 7490077
REFERENCE 2 (bases 1 to 2969)
AUTHORS Viczian,A.S., Piriev,N.I. and Farber,D.B.
TITLE Isolation and characterization of a cDNA encoding the alpha'
subunit of human cone cGMP-phosphodiesterase
JOURNAL Gene 166 (2), 205-211 (1995)
PUBMED 8543163
REFERENCE 3 (bases 1 to 2969)
AUTHORS Viczian,A.S.
TITLE Direct Submission
JOURNAL Submitted (21-JUL-1995) Andrea S. Viczian, Jules Stein Eye
Institute, UCLA School of Medicine, 100 Stein Plaza, Los Angeles,
CA 90095, USA
FEATURES Location/Qualifiers
source 1..2969
/db_xref="H-InvDB:HIT000219180"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="10"
/map="10q24"
/cell_type="photoreceptor cell"
/tissue_type="retina"
/dev_stage="adult"
gene 1..2969
/gene="PDE6C"
CDS 139..2715
/gene="PDE6C"
/note="cGMP-phosphodiesterase activity; membrane
associated protein"
/codon_start=1
/product="phosphodiesterase A' subunit"
/protein_id="AAA96392.1"
/translation="MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPV
QSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCR
SRNGIPEVASRLLVVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKK
NSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLN
FVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCER
YSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVI
PTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFPKGPVDETGWVIKNVLSLPI
VNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKD
IAQEMLMNQTKATLEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYE
FRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWQH
GFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARL
HGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRT
MFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALM
VANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEI
TPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCL
ML"
regulatory 2880..2885
/regulatory_class="polyA_signal_sequence"
/gene="PDE6C"
regulatory 2947..2952
/regulatory_class="polyA_signal_sequence"
/gene="PDE6C"
polyA_site 2969
/gene="PDE6C"
/note="11 A nucleotides"
BASE COUNT 943 a 593 c 683 g 750 t
ORIGIN
1 ctttggaagt cctatgaggg accatttacg gtttcctcag taatttccac caggatgaat
61 ttccttctca tcactctgcc tcaggtagtg ctctgaaggt cgtcctttct gaacaaacgc
121 agcaaagcaa gccacaccat gggtgagatc aaccaagttg ccgtggagaa atacctggag
181 gagaaccctc agtttgccaa ggagtacttt gacaggaagt tgcgggtgga ggtgctggga
241 gaaatcttca agaacagcca ggtgccagtc cagtccagca tgtccttctc tgagctgacc
301 caggtggagg agtcagccct gtgcttggag ctgctgtgga ccgtgcagga ggaggggggc
361 accccagagc agggggttca cagggcccta cagaggctgg cccacctgct ccaggctgac
421 cgctgcagca tgttcctgtg ccggtcccgg aacggcatac ctgaggtggc ctctaggttg
481 ctggtagtca cccccacctc caagtttgag gacaacctgg tgggccctga caaagaagtt
541 gtgtttccat tggacattgg gatagtgggt tgggctgctc acacgaagaa aactcataat
601 gtcccagatg tgaaaaagaa cagccatttt tctgacttca tggacaagca aactgggtat
661 gtcactaaga acctgctggc aaccccgatc gtggtgggca aggaggttct tgctgtgatc
721 atggcagtta acaaagtaaa tgcatctgaa ttttccaaac aggatgaaga ggtcttttcc
781 aaatacctca actttgtgtc tatcatccta aggcttcatc acaccagcta catgtacaat
841 attgaatccc gaagaagcca gatccttatg tggtcagcca ataaagtatt tgaagaactc
901 acagatgttg agcgacagtt tcacaaagcg ctctacacgg ttagatcata tctgaactgt
961 gaacgatact ccattggact gctggacatg accaaggaga aggaattcta cgatgaatgg
1021 ccaatcaagc ttggagaagt agagccttat aaaggtccaa agacacctga tggcagggaa
1081 gtcaactttt ataaaatcat tgattacatt ttacatggaa aagaagagat caaagtgatt
1141 ccgacgcctc ctgcagacca ctggacactc attagtgggt tgccaacata tgttgctgaa
1201 aatggattta tctgtaacat gatgaatgcc cctgcggatg aatacttcac atttccgaaa
1261 ggacctgtag acgaaactgg ttgggtcatt aagaatgttt tgtccctgcc tattgtcaac
1321 aagaaagaag atattgtggg agtggctaca ttttacaaca ggaaggatgg aaaacctttc
1381 gatgagcatg atgaatacat taccgagact ctcacacaat ttcttggatg gtctctttta
1441 aatactgaca cctacgataa gatgaataag ctagaaaaca gaaaggacat tgctcaggaa
1501 atgctcatga accaaaccaa agccactctt gaagaaatta agtccatttt gaaatttcaa
1561 gagaagttaa atgttgatgt aattgacgac tgtgaagaaa aacaacttgt tgcaattttg
1621 aaagaggact tgccagaccc acgctcagca gaactgtacg aattccgctt cagtgacttc
1681 ccccttacag agcacggatt gattaaatgt ggaatacgac tgttttttga aataaatgtg
1741 gtggagaaat tcaaagtacc tgtagaggtt cttaccagat ggatgtacac tgtgaggaaa
1801 gggtaccgag ctgtcactta ccacaattgg cagcatgggt tcaacgtggg gcagaccatg
1861 tttactttgc tgatgacagg aagattaaag aagtactaca cagatctcga agcctttgcc
1921 atgcttgctg ctgctttctg ccatgatatt gaccacagag gcaccaataa tttgtaccag
1981 atgaaatcca cgtctccatt agcaagactt catggttctt ctattttgga gaggcaccac
2041 ctggagtaca gtaagactct gttgcaggat gagagtttaa acatcttcca gaacctaaat
2101 aagcggcagt ttgaaacagt tattcatttg ttcgaggtcg caataatagc aactgacctg
2161 gctttatatt tcaagaagag gaccatgttt caaaaaattg ttgatgcctg tgaacaaatg
2221 caaacggaag aagaagccat caaatatgta actgttgatc caaccaagaa agagattatc
2281 atggcaatga tgatgacggc atgtgacttg tctgctatta ccaagccctg ggaggtgcaa
2341 agtcaggtag cacttatggt tgcaaatgaa ttttgggaac aaggagatct ggagagaaca
2401 gtgttgcagc aacaacccat tcctatgatg gacagaaaca aaagagatga attacctaaa
2461 cttcaagttg gatttattga ttttgtttgt acttttgtat ataaggagtt ctcacggttt
2521 cacaaagaaa tcacacctat gctgagtggt cttcagaata acagagtaga atggaaatca
2581 ctagctgatg agtatgatgc aaagatgaag gtcattgaag aggaggcaaa aaagcaagaa
2641 ggaggagccg aaaaagctgc tgaagattca ggaggtggtg atgacaaaaa gtccaaaaca
2701 tgtttaatgt tgtaatatta tctaactggt ctaaacttca aatatcattt tacctttgaa
2761 gaaaaccaga aaacattcaa aagaacttca acaaatcatc acgtaacagg atcttcagaa
2821 aaactaccct gtgactatga agaaaatata tattgctagc ccaaaaatcc caggggcaaa
2881 ataaagttca acaaaagtgc aaaatatgac aaaaataggt acatttttgg tgccaattta
2941 ttttaaatta aaaaatcatg caatcctga
//