LOCUS HSU31601 3620 bp mRNA linear HUM 24-OCT-1995
DEFINITION Human tyrosine protein kinase (Jak3B) splice variant mRNA, complete
cds.
ACCESSION U31601
VERSION U31601.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3620)
AUTHORS Lai,K.S., Jin,Y., Graham,D.K., Witthuhn,B.A., Ihle,J.N. and
Liu,E.T.
TITLE A kinase-deficient splice variant of the human JAK3 is expressed in
hematopoietic and epithelial cancer cells
JOURNAL J. Biol. Chem. 270 (42), 25028-25036 (1995)
PUBMED 7559633
REFERENCE 2 (sites)
AUTHORS Witthuhn,B.A., Silvennoinen,O., Miura,O., Lai,K.S., Cwik,C.,
Liu,E.T. and Ihle,J.N.
TITLE Involvement of the Jak-3 Janus kinase in signalling by interleukins
2 and 4 in lymphoid and myeloid cells
JOURNAL Nature 370 (6485), 153-157 (1994)
PUBMED 8022486
REFERENCE 3 (bases 1 to 3620)
AUTHORS Liu,E.T.
TITLE Direct Submission
JOURNAL Submitted (14-JUL-1995) Edison T. Liu, Lineberger Comprehensive
Cancer Center, University of North Carolina, Chapel Hill, NC
27599-7295, USA
COMMENT Witthuhn, B.A. Nature 370, 153-157, 1994.
FEATURES Location/Qualifiers
source 1..3620
/db_xref="H-InvDB:HIT000219148"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="19"
/map="19p12"
/clone="SKBR-3"
/cell_type="SKBR-3 breast cancer cells"
gene 1..3620
/gene="Jak3B"
CDS 96..3380
/gene="Jak3B"
/function="tyrosine protein kinase"
/codon_start=1
/product="JAK3B"
/protein_id="AAC50226.1"
/translation="MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFS
FGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRI
RFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQG
ECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVR
RALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGD
GGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPG
LPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTG
GSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSL
RELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQL
SQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCM
ESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDIYLRKRGHLVPASWK
LQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLE
MLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYED
RQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAP
RDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQ
LQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFL
QRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAK
LLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSP
SAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVSAAGLASVSQSVDWAGVS
GKPAGA"
BASE COUNT 670 a 1152 c 1076 g 722 t
ORIGIN
1 aattcggcac gaggtgggac tttcctctcg ctgcctcccg gctctgcccg cccttcgaaa
61 gtccagggtc cctgcccgct aggcaagttg cactcatggc acctccaagt gaagagacgc
121 ccctgatccc tcagcgttca tgcagcctct tgtccacgga ggctggtgcc ctgcatgtgc
181 tgctgcccgc tcggggcccc gggccccccc agcgcctatc tttctccttt ggggaccact
241 tggctgagga cctgtgcgtg caggctgcca aggccagcgg catcctgcct gtgtaccact
301 ccctctttgc tctggccacg gaggacctgt cctgctggtt ccccccgagc cacatcttct
361 ccgtggagga tgccagcacc caagtcctgc tgtacaggat tcgcttttac ttccccaatt
421 ggtttgggct ggagaagtgc caccgcttcg ggctacgcaa ggatttggcc agtgctatcc
481 ttgacctgcc agtcctggag cacctctttg cccagcaccg cagtgacctg gtgagtgggc
541 gcctccccgt gggcctcagt ctcaaggagc agggtgagtg tctcagcctg gccgtgttgg
601 acctggcccg gatggcgcga gagcaggccc agcggccggg agagctgctg aagactgtca
661 gctacaaggc ctgcctaccc ccaagcctgc gcgacctgat ccagggcctg agcttcgtga
721 cgcggaggcg tattcggagg acggtgcgca gagccctgcg ccgcgtggcc gcctgccagg
781 cagaccggca ctcgctcatg gccaagtaca tcatggacct ggagcggctg gatccagccg
841 gggccgccga gaccttccac gtgggcctcc ctggggccct tggtggccac gacgggctgg
901 ggctgctccg cgtggctggt gacggcggca tcgcctggac ccagggagaa caggaggtcc
961 tccagccctt ctgcgacttt ccagaaatcg tagacattag catcaagcag gccccgcgcg
1021 ttggcccggc cggagagcac cgcctggtca ctgttaccag gacagacaac cagattttag
1081 aggccgagtt cccagggctg cccgaggctc tgtcgttcgt ggcgctcgtg gacggctact
1141 tccggctgac cacggactcc cagcacttct tctgcaagga ggtggcaccg ccgaggctgc
1201 tggaggaagt ggccgagcag tgccacggcc ccatcactct ggactttgcc atcaacaagc
1261 tcaagactgg gggctcacgt cctggctcct atgttctccg ccgcagcccc caggactttg
1321 acagcttcct cctcactgtc tgtgtccaga acccccttgg tcctgattat aagggctgcc
1381 tcatccggcg cagccccaca ggaaccttcc ttctggttgg cctcagccga ccccacagca
1441 gtcttcgaga gctcctggca acctgctggg atggggggct gcacgtagat ggggtggcag
1501 tgaccctcac ttcctgctgt atccccagac ccaaagaaaa gtccaacctg atcgtggtcc
1561 agagaggtca cagcccaccc acatcatcct tggttcagcc ccaatcccaa taccagctga
1621 gtcagatgac atttcacaag atccctgctg acagcctgga gtggcatgag aacctgggcc
1681 atgggtcctt caccaagatt taccggggct gtcgccatga ggtggtggat ggggaggccc
1741 gaaagacaga ggtgctgctg aaggtcatgg atgccaagca caagaactgc atggagtcat
1801 tcctggaagc agcgagcttg atgagccaag tgtcgtaccg gcatctcgtg ctgctccacg
1861 gcgtgtgcat ggctggagac agcaccatgg tgcaggaatt tgtacacctg ggggccatag
1921 acatatatct gcgaaaacgt ggccacctgg tgccagccag ctggaagctg caggtggtca
1981 aacagctggc ctacgccctc aactatctgg aggacaaagg cctgccccat ggcaatgtct
2041 ctgcccggaa ggtgctcctg gctcgggagg gggctgatgg gagcccgccc ttcatcaagc
2101 tgagtgaccc tggggtcagc cccgctgtgt taagcctgga gatgctcacc gacaggatcc
2161 cctgggtggc ccccgagtgt ctccgggagg cgcagacact tagcttggaa gctgacaagt
2221 ggggcttcgg cgccacggtc tgggaagtgt ttagtggcgt caccatgccc atcagtgccc
2281 tggatcctgc taagaaactc caattttatg aggaccggca gcagctgccg gcccccaagt
2341 ggacagagct ggccctgctg attcaacagt gcatggccta tgagccggtc cagaggccct
2401 ccttccgagc cgtcattcgt gacctcaata gcctcatctc ttcagactat gagctcctct
2461 cagaccccac acctggtgcc ctggcacctc gtgatgggct gtggaatggt gcccagctct
2521 atgcctgcca agaccccacg atcttcgagg agagacacct caagtacatc tcacagctgg
2581 gcaagggcaa ctttggcagc gtggagctgt gccgctatga cccgctaggc gacaatacag
2641 gtgccctggt ggccgtgaaa cagctgcagc acagcgggcc agaccagcag agggactttc
2701 agcgggagat tcagatcctc aaagcactgc acagtgattt cattgtcaag tatcgtggtg
2761 tcagctatgg cccgggccgc cagagcctgc ggctggtcat ggagtacctg cccagcggct
2821 gcttgcgcga cttcctgcag cggcaccgcg cgcgcctcga tgccagccgc ctccttctct
2881 attcctcgca gatctgcaag ggcatggagt acctgggctc ccgccgctgc gtgcaccgcg
2941 acctggccgc ccgaaacatc ctcgtggaga gcgaggcaca cgtcaagatc gctgacttcg
3001 gcctagctaa gctgctgccg cttgacaaag actactacgt ggtccgcgag ccaggccaga
3061 gccccatttt ctggtatgcc cccgaatccc tctcggacaa catcttctct cgccagtcag
3121 acgtctggag cttcggggtc gtcctgtacg agctcttcac ctactgcgac aaaagctgca
3181 gcccctcggc cgagttcctg cggatgatgg gatgtgagcg ggatgtcccc gccctctgcc
3241 gcctcttgga actgctggag gagggccaga ggctgccggc gcctcctgcc tgccctgctg
3301 aggtgagcgc cgcagggcta gcctcagttt cccagtctgt agattgggcc ggggtctcgg
3361 gcaagccagc tggcgcctga gtctctgtac tgagaagaaa ggctagagtg tgaggccgat
3421 gaggatcctg gcccccactt ggctactctc tcactgtggc aagtcagagc actttcagag
3481 cctcagttta cccttttcca aaatgagaat agtaatgcct tatagggtga gggaagatta
3541 gactcctgtt cacctgtgcc tatgagggct cagctcaaag ccgagcacac agtcgatgct
3601 ccataaatgg tggtgacgtt
//