LOCUS HSU31346 1323 bp mRNA linear HUM 24-AUG-1995
DEFINITION Human calpastatin mRNA, partial cds, long 3'UTR.
ACCESSION U31346
VERSION U31346.1
KEYWORDS calpastatin.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1323)
AUTHORS El-Amine,M., Talbot,G., Despres,N., Asselin,C., Boire,G. and
Menard,H.A.
TITLE Differential expression of two calpastatin mRNAs with different
3'UTRs
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 1323)
AUTHORS Asada,K., Ishino,Y., Shimada,M., Shimojo,T., Endo,M., Kimizuka,F.,
Kato,I., Maki,M., Hatanaka,M. and Murachi,T.
TITLE cDNA cloning of human calpastatin: sequence homology among human,
pig, and rabbit calpastatins
JOURNAL J. Enzym. Inhib. 3 (1), 49-56 (1989)
PUBMED 2577276
REFERENCE 3 (bases 1 to 1323)
AUTHORS Despres,N., Talbot,G., Plouffe,B., Boire,G. and Menard,H.A.
TITLE Detection and expression of a cDNA clone that encodes a polypeptide
containing two inhibitory domains of human calpastatin and its
recognition by rheumatoid arthritis sera
JOURNAL J. Clin. Invest. 95 (4), 1891-1896 (1995)
PUBMED 7706496
REFERENCE 4 (bases 1 to 1323)
AUTHORS El-Amine,M.
TITLE Direct Submission
JOURNAL Submitted (10-JUL-1995) Moustapha El-Amine, Rheumatic Diseases
Unit, Universite de Sherbrooke, 3001, 12e avenue Nord, Sherbrooke,
Quebec J1H-5N4, Canada
COMMENT On Aug 24, 1995 this sequence version replaced gi:950213.
FEATURES Location/Qualifiers
source 1..1323
/db_xref="H-InvDB:HIT000219136"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="placental"
/clone_lib="lambda gt11"
CDS <1..612
/function="proteinase inhibitor; calpain endogenous
inhibitor"
/codon_start=1
/product="calpastatin"
/protein_id="AAB60372.1"
/translation="MSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPAS
TTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKL
GERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTT
ETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD"
3'UTR 613..1323
variation 1044
/replace="g"
polyA_site 1322
/note="14 A nucleotides"
BASE COUNT 445 a 283 c 261 g 334 t
ORIGIN
1 atgagtgaag acttccttct ggatgctttg tctgaggact tctctggtcc acaaaatgct
61 tcatctctta aatttgaaga tgctaaactt gctgctgcca tctctgaagt ggtttcccaa
121 accccagctt caacgaccca agctggagcc ccaccccgtg atacctcgca gagtgacaaa
181 gacctcgatg atgccttgga taaactctct gacagtctag gacaaaggca gcctgaccca
241 gatgagaaca aaccaatgga agataaagta aaggaaaaag ctaaagctga acatagagac
301 aagcttggag aaagagatga cactatccca cctgaataca gacatctcct ggatgataat
361 ggacaggaca aaccagtgaa gccacctaca aagaaatcag aggattcaaa gaaacctgca
421 gatgaccaag accccattga tgctctctca ggagatctgg acagctgtcc ctccactaca
481 gaaacctcac agaacacagc aaaggataag tgcaagaagg ctgcttccag ctccaaagca
541 cctaagaatg gaggtaaagc gaaggattca gcaaagacaa cagaggaaac ttccaagcca
601 aaagatgact aaagaaatac aagttaaggt atctggtatc tgcatgtaaa aacttcagct
661 ggtggatggt gacttttgaa gaacaaaagg ctttggcaac agaaaacaat tgttctgggt
721 gatttctaga atggtttttg ttgagtctct gaacatccta aatattggtt tgttattctt
781 ttccagaaag aaaatgaatt tgactggttc acctgtgtac tgagtattga taaactttga
841 atttttttaa ttgccttcaa ttgggagaga aagctttata tttgtgtgag gacttctgca
901 tcttacagtc agcacagaac acactgagac ttgaatcaag tcagcaacag agcaaaataa
961 agatgcaaac ttcgtttttt aaaaacatga tatctaaaaa gcagaatgtg cagagtcttt
1021 tctttgccaa gcaaaacagt ttccaccaca tcttgtctat agatgactac ctttctggtc
1081 aaggctttgg acatctcttc agtcatcaga cagagtatct ctgctctaga cctcgctgga
1141 gttcaagctt gaattattat atgcaagtta attttacaag cctggatgag gctactgaaa
1201 actggaaaaa agctacgaga ctgtaacaac ccttcattct tttcatttcc aaagctctct
1261 ccccatctca agctagaaaa tagtgtaacc agactacaca atggaaccac tcctaaaaaa
1321 ata
//