LOCUS HSU31345 1837 bp mRNA linear HUM 24-AUG-1995
DEFINITION Human calpastatin mRNA, partial cds, short 3'UTR.
ACCESSION U31345
VERSION U31345.1
KEYWORDS calpastatin.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1837)
AUTHORS El-Amine,M., Talbot,G., Despres,N., Asselin,C., Boire,G. and
Menard,H.A.
TITLE Differential expression of two calpastatin mRNAs with different
3'UTRs
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 1837)
AUTHORS Asada,K., Ishino,Y., Shimada,M., Shimojo,T., Endo,M., Kimizuka,F.,
Kato,I., Maki,M., Hatanaka,M. and Murachi,T.
TITLE cDNA cloning of human calpastatin: sequence homology among human,
pig, and rabbit calpastatins
JOURNAL J. Enzym. Inhib. 3 (1), 49-56 (1989)
PUBMED 2577276
REFERENCE 3 (bases 1 to 1837)
AUTHORS Despres,N., Talbot,G., Plouffe,B., Boire,G. and Menard,H.A.
TITLE Detection and expression of a cDNA clone that encodes a polypeptide
containing two inhibitory domains of human calpastatin and its
recognition by rheumatoid arthritis sera
JOURNAL J. Clin. Invest. 95 (4), 1891-1896 (1995)
PUBMED 7706496
REFERENCE 4 (bases 1 to 1837)
AUTHORS El-Amine,M.
TITLE Direct Submission
JOURNAL Submitted (10-JUL-1995) Moustapha El-Amine, Rheumatic Diseases
Unit, Universite de Sherbrooke, 3001, 12e avenue Nord, Sherbrooke,
Quebec J1H-5N4, Canada
FEATURES Location/Qualifiers
source 1..1837
/db_xref="H-InvDB:HIT000219135"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="placental"
/clone_lib="lambda gt11"
CDS <1..1396
/function="proteinase inhibitor; calpain endogenous
inhibitor"
/codon_start=2
/product="calpastatin"
/protein_id="AAB60371.1"
/translation="PTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMS
DQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPAT
DKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPV
SEAVSRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEK
AKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDF
SGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSSDKDLDDALDKLSDSL
GQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTK
KSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKD
SAKTTEETSKPKDD"
variation 954^955
/replace="cag"
variation 1044
/replace="g"
3'UTR 1397..1837
polyA_site 1837
/note="25 A nucleotides"
BASE COUNT 639 a 373 c 411 g 414 t
ORIGIN
1 gcctacagct gctggaaaga aaactgaaaa agaggaatct acagaagttt taaaagctca
61 gtcagcaggg acagtcagaa gtgctgctcc accccaagag aagaaaagaa aggtggagaa
121 ggatacaatg agtgatcaag cactcgaggc tctgtcggct tcactgggca cccggcaagc
181 agaacctgag ctcgacctcc gctcaattaa ggaagtcgat gaggcaaaag ctaaagaaga
241 aaaactagag aagtgtggtg aggatgatga aacaatccca tctgagtaca gattaaaacc
301 agccacggat aaagatggaa aaccactatt gccagagcct gaagaaaaac ccaagcctcg
361 gagtgaatca gaactcattg atgaactttc agaagatttt gaccggtctg aatgtaaaga
421 gaaaccatct aagccaactg aaaagacaga agaatctaag gccgctgctc cagctcctgt
481 gtcggaggct gtgtctcgga cctccatgtg tagtatacag tcagcacccc ctgagccggc
541 taccttgaag ggcacagtgc cagatgatgc tgtagaagcc ttggctgata gcctggggaa
601 aaaggaagca gatccagaag atggaaaacc tgtgatggat aaagtcaagg agaaggccaa
661 agaagaagac cgtgaaaagc ttggtgaaaa agaagaaaca attcctcctg attatagatt
721 agaagaggtc aaggataaag atggaaagcc actcctgcca aaagagtcta aggaacagct
781 tccacccatg agtgaagact tccttctgga tgctttgtct gaggacttct ctggtccaca
841 aaatgcttca tctcttaaat ttgaagatgc taaacttgct gctgccatct ctgaagtggt
901 ttcccaaacc ccagcttcaa cgacccaagc tggagcccca ccccgtgata cctcgagtga
961 caaagacctc gatgatgcct tggataaact ctctgacagt ctaggacaaa ggcagcctga
1021 cccagatgag aacaaaccaa tggaagataa agtaaaggaa aaagctaaag ctgaacatag
1081 agacaagctt ggagaaagag atgacactat cccacctgaa tacagacatc tcctggatga
1141 taatggacag gacaaaccag tgaagccacc tacaaagaaa tcagaggatt caaagaaacc
1201 tgcagatgac caagacccca ttgatgctct ctcaggagat ctggacagct gtccctccac
1261 tacagaaacc tcacagaaca cagcaaagga taagtgcaag aaggctgctt ccagctccaa
1321 agcacctaag aatggaggta aagcgaagga ttcagcaaag acaacagagg aaacttccaa
1381 gccaaaagat gactaaagaa atacaagtta aggtatctgg tatctgcatg taaaatcttc
1441 agctggtgga tggtgacttt tgaagaacaa aaggctttgg caacagaaaa caattgttct
1501 gggtgatttc tagaatggtt tttgttgagt ctctgaacat cctaaatatt ggtttgttat
1561 tcttttccag aaagaaaatg aatttgactg gttcacctgt gtactgagta ttgataaact
1621 ttgaattttt ttaattgcct tcaattggga gagaaagctt tatatttgta agaaatatat
1681 ttgataaagt ttcttaaagc aacaccaaaa aaacaaaaga aaagctaagt gaatttttgc
1741 acattcctac acacagtgcc tgtaaatctc atttgtattt tcagtttgcc cttaattttt
1801 tttgttagtg tttagaaaac aatgttttaa acattca
//