LOCUS HSU29943 2194 bp mRNA linear HUM 25-JUL-1995
DEFINITION Human ELAV-like neuronal protein-2 Hel-N2 mRNA, complete cds.
ACCESSION U29943
VERSION U29943.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2194)
AUTHORS Gao,F.B., Carson,C.C., Levine,T. and Keene,J.D.
TITLE Selection of a subset of mRNAs from combinatorial 3' untranslated
region libraries using neuronal RNA-binding protein Hel-N1
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 91 (23), 11207-11211 (1994)
PUBMED 7972035
REFERENCE 2 (bases 1 to 2194)
AUTHORS Keene,J.D.
TITLE Direct Submission
JOURNAL Submitted (22-JUN-1995) Jack D. Keene, Microbiology, Duke
University Med. Center, Research Drive, Durham, NC 27710, USA
FEATURES Location/Qualifiers
source 1..2194
/db_xref="H-InvDB:HIT000218987"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="medulloblastoma D283"
CDS 585..1625
/note="ELAV-like neuronal protein 2; overexpressed in
medulloblastoma and small cell lung cancer; RNA-binding
protein; differs from Hel-N1 by deletion of 13 amino
acids"
/codon_start=1
/product="Hel-N2"
/protein_id="AAA70417.1"
/translation="METQLSNGPTCNNTANGPTTINNNCSSPVDSGNTEDSKTNLIVN
YLPQNMTQEELKSLFGSIGEIESCKLVRDKITGQSLGYGFVNYIDPKDAEKAINTLNG
LRLQTKTIKVSYARPSSASIRDANLYVSGLPKTMTQKELEQLFSQYGRIITSRILVDQ
VTGISRGVGFIRFDKRIEAEEAIKGLNGQKPPGATEPITVKFANNPSQKTNQAILSQL
YQSPNRRYPGPLAQQAQRFRFSPMTIDGMTSLAGINIPGHPGTGWCIFVYNLAPDADE
SILWQMFGPFGAVTNVKVIRDFNTNKCKGFGFVTMTNYDEAAMAIRSLNGYRLGDRVL
QVSFKTNKTHKA"
misc_feature 702..941
/note="encodes RNA-binding domain 1 (RRM1)"
misc_feature 960..1205
/note="encodes RNA-binding domain 2 (RRM2)"
misc_feature 1374..1613
/note="encodes RNA-binding domain 3 (RRM3)"
BASE COUNT 628 a 430 c 461 g 675 t
ORIGIN
1 ataaaaacat tgtatatagt agaccaaatg gtcatagtta ctgtgagcct ggcagagcag
61 aaaaggcagt tgaaggaggc agagaagggg ttggtgatac ggtgctataa atctgtggtc
121 cagtccacct cccttttaag acgtcctccc cctatttctg ttcttagtta gagatgcagc
181 agcttactcc tgtagcgacc tactaaaaag caacaaggag aaagacatcg tctttttgaa
241 aaaacgttct ttcgtctctt ttctttgttc cttggtttgt ttttcttgcc cctttttgtt
301 tagttgaacg gcaataggag ggtagtctct ccgtcttttt aaactctttt ttaagtttcc
361 cctccccttt catatttttt tgggccattt cttttagctt tggactttgg gggtcgaaag
421 cgtttctttt tatttgcttc ttttaagccg agcacagttt aggtttcgtg ctgtcttaag
481 agaactatcc agcagcttct tgctcatcct tattgggaga actgcaccgt tactttaaaa
541 acacacatac acaaaaacct taagggagaa aggtaattgc tgccatggaa acacaactgt
601 ctaatgggcc aacttgcaat aacacagcca atggtccaac caccataaac aacaactgtt
661 cgtcaccagt tgactctggg aacacagaag acagcaagac caacttaata gtcaactacc
721 ttcctcagaa catgacacag gaggaactaa agagtctctt tgggagcatt ggtgaaatag
781 agtcctgtaa gcttgtaaga gacaaaataa cagggcagag cttgggatat ggctttgtga
841 actacattga ccccaaggat gcagagaaag ctatcaacac cctgaatgga ttgagacttc
901 aaaccaaaac aataaaagtt tcctatgctc gcccaagttc agcttctatc agagatgcaa
961 atttatatgt cagcggactt ccaaaaacaa tgacccagaa ggagttggaa cagctttttt
1021 cacaatatgg acgcattatt acttctcgta ttcttgtcga ccaggtcact ggcatatcaa
1081 ggggtgtagg gtttattcga tttgacaagc gaattgaggc agaagaagct atcaaaggcc
1141 taaatggcca gaaacctccc ggtgccacgg agccaatcac tgtaaagttt gctaataacc
1201 caagccaaaa aaccaatcag gccatccttt cccagctgta ccagtctcca aacagaaggt
1261 atccaggacc gctagctcag caggcacagc gttttaggtt ttctccaatg accattgacg
1321 gaatgaccag tttggctgga attaatatcc ctgggcaccc tggaacaggg tggtgtatat
1381 ttgtgtacaa cctggctcct gacgcagatg agagtatcct gtggcaaatg tttgggcctt
1441 ttggagctgt caccaatgtg aaggtcatcc gtgactttaa caccaataaa tgcaaaggtt
1501 ttggatttgt gactatgaca aactatgatg aggctgccat ggcgatacgt agcctcaatg
1561 gataccgtct gggagacaga gtactgcagg tctcctttaa gacaaacaaa acgcacaaag
1621 cctaatgagc tcttgtcctc agtccattta tatatgaaaa ctatacaaca aaggcaagtt
1681 aagagaaact ttatacatta gtaaatgtct ttgtaagtca gtgttgagat ggggataaaa
1741 tgactactta gcatcctaag aaatatgtga gattttttat tgctagtatt tgaattaaaa
1801 cttcttaaat atcttttatg ttgaatatgg acaagaggta cagggtttta cctgtcacat
1861 tgcattctat tgccttcttt gaagaaggtg gaccttttaa agtgtttcag ctaagggaag
1921 acatttcttt tctttttaca taactgcctt gaacctgtga gtaaatattg aggctttgtg
1981 ttgtaattct tcagttggtt gtgtcttttt tttcccccct ttttcctttt tctgattagc
2041 tttgtgtttg gtttacattt aaagcattgc tgttatgtct gtttaagaaa agtattttga
2101 agtttacatt tttatttatg aagtttaaaa cagtatttat tttgtaatta tgatttgggt
2161 tggggaaggg ggggctacat tataaacgct tagg
//