LOCUS HSU29615 1633 bp mRNA linear HUM 03-NOV-1995
DEFINITION Human chitotriosidase precursor mRNA, complete cds.
ACCESSION U29615
VERSION U29615.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1633)
AUTHORS Boot,R.G., Renkema,G.H., Strijland,A., van Zonneveld,A.J. and
Aerts,J.M.
TITLE Cloning of a cDNA encoding chitotriosidase, a human chitinase
produced by macrophages
JOURNAL J. Biol. Chem. 270 (44), 26252-26256 (1995)
PUBMED 7592832
REFERENCE 2 (bases 1 to 1633)
AUTHORS Boot,R.G.
TITLE Direct Submission
JOURNAL Submitted (21-JUN-1995) Rolf G. Boot, Department of Biochemistry,
AMC, E.C. Slater, Institute, University of Amsterdam, Meibergdreef
15, 1105 AZ, Amsterdam, The Netherlands
FEATURES Location/Qualifiers
source 1..1633
/db_xref="H-InvDB:HIT000218980"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="Ch1.1"
/cell_type="macrophage"
/clone_lib="macrophage-1 cDNA library of Rolf G. Boot"
CDS 13..1413
/codon_start=1
/product="chitotriosidase precursor"
/protein_id="AAC50246.1"
/translation="MVRSVAWAGFMVLLMIPWGSAAKLVCYFTNWAQYRQGEARFLPK
DLDPSLCTHLIYAFAGMTNHQLSTTEWNDETLYQEFNGLKKMNPKLKTLLAIGGWNFG
TQKFTDMVATANNRQTFVNSAIRFLRKYSFDGLDLDWEYPGSQGSPAVDKERFTTLVQ
DLANAFQQEAQTSGKERLLLSAAVPAGQTYVDAGYEVDKIAQNLDFVNLMAYDFHGSW
EKVTGHNSPLYKRQEESGAAASLNVDAAVQQWLQKGTPASKLILGMPTYGRSFTLASS
SDTRVGAPATGSGTPGPFTKEGGMLAYYEVCSWKGATKQRIQDQKVPYIFRDNQWVGF
DDVESFKTKVSYLKQKGLGGAMVWALDLDDFAGFSCNQGRYPLIQTLRQELSLPYLPS
GTPELEVPKPGQPSEPEHGPSPGQDTFCQGKADGLYPNPRERSSFYSCAAGRLFQQSC
PTGLVFSNSCKCCTWN"
sig_peptide 13..75
mat_peptide 76..1410
/product="chitotriosidase"
/note="human chitinase"
regulatory 1605..1610
/regulatory_class="polyA_signal_sequence"
polyA_site 1633
/note="10 A nucleotides"
BASE COUNT 354 a 489 c 443 g 347 t
ORIGIN
1 ctgagctgca tcatggtgcg gtctgtggcc tgggcaggtt tcatggtcct gctgatgatc
61 ccatggggct ctgctgcaaa actggtctgc tacttcacca actgggccca gtacagacag
121 ggggaggctc gcttcctgcc caaggacttg gaccccagcc tttgcaccca cctcatctac
181 gccttcgctg gcatgaccaa ccaccagctg agcaccactg agtggaatga cgagactctc
241 taccaggagt tcaatggcct gaagaagatg aatcccaagc tgaagaccct gttagccatc
301 ggaggctgga atttcggcac tcagaagttc acagatatgg tagccacggc caacaaccgt
361 cagacctttg tcaactcggc catcaggttt ctgcgcaaat acagctttga cggccttgac
421 cttgactggg agtacccagg aagccagggg agccctgccg tagacaagga gcgcttcaca
481 accctggtac aggacttggc caatgccttc cagcaggaag cccagacctc agggaaggaa
541 cgccttcttc tgagtgcagc ggttccagct gggcagacct atgtggatgc tggatacgag
601 gtggacaaaa tcgcccagaa cctggatttt gtcaacctta tggcctacga cttccatggc
661 tcttgggaga aggtcacggg acataacagc cccctctaca agaggcaaga agagagtggt
721 gcagcagcca gcctcaacgt ggatgctgct gtgcaacagt ggctgcagaa ggggacccct
781 gccagcaagc tgatccttgg catgcctacc tacggacgct ccttcacact ggcctcctca
841 tcagacacca gagtgggggc cccagccaca gggtctggca ctccaggccc cttcaccaag
901 gaaggaggga tgctggccta ctatgaagtc tgctcctgga agggggccac caaacagaga
961 atccaggatc agaaggtgcc ctacatcttc cgggacaacc agtgggtggg ctttgatgat
1021 gtggagagct tcaaaaccaa ggtcagctat ctgaagcaga agggactggg cggggccatg
1081 gtctgggcac tggacttaga tgactttgcc ggcttctcct gcaaccaggg ccgatacccc
1141 ctcatccaga cgctacggca ggaactgagt cttccatact tgccttcagg caccccagag
1201 cttgaagttc caaaaccagg tcagccctct gaacctgagc atggccccag ccctggacaa
1261 gacacgttct gccagggcaa agctgatggg ctctatccca atcctcggga acggtccagc
1321 ttctacagct gtgcagcggg gcggctgttc cagcaaagct gcccgacagg cctggtgttc
1381 agcaactcct gcaaatgctg cacctggaat tgagtcgtaa agcccctcca gtccagcttt
1441 gaggctgggc ccaggatcac tctacagcct gcctcctggg ttttcctggg ggccgcaatc
1501 tggctcctgc aggcctttct gtggtcttcc tttatccagg ctttctgctc tcagccttgc
1561 cttccttttt tctgggtctc ctgggctgcc cctttcactt gcaaaataaa tctttggttt
1621 gtgcccctct tca
//