LOCUS       HSU28043                2584 bp    mRNA    linear   HUM 10-MAR-1997
DEFINITION  Human plasma membrane Na+/H+ exchanger isoform 3 (NHE3) mRNA,
            complete cds.
ACCESSION   U28043
VERSION     U28043.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2584)
  AUTHORS   Brant,S.R., Yun,C.H., Donowitz,M. and Tse,C.M.
  TITLE     Cloning, tissue distribution, and functional analysis of the human
            Na+/N+ exchanger isoform, NHE3
  JOURNAL   Am. J. Physiol. 269 (1 Pt 1), C198-C206 (1995)
   PUBMED   7631746
REFERENCE   2  (bases 1 to 2584)
  AUTHORS   Brant,S.R.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-MAY-1995) Steve R. Brant, Medicine, Gastroenterology
            Division, The Johns Hopkins University School of Medicine, 720
            Rutland Avenue, Baltimore, MD 21205, USA
FEATURES             Location/Qualifiers
     source          1..2584
                     /db_xref="H-InvDB:HIT000218904"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="23-3, HKC-3, and HKC-5"
                     /tissue_type="kidney, cortex"
                     /clone_lib="lamda gt10 human kidney cortex cDNA library of
                     Graeme I. Bell, The University of Chicago, Chicago, IL"
     gene            1..2584
                     /gene="NHE3"
     CDS             11..2515
                     /gene="NHE3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /codon_start=1
                     /product="plasma membrane Na+/H+ exchanger isoform 3"
                     /protein_id="AAB48990.1"
                     /translation="MWGLGARGPDRGLLLALALGGLARAGGVEVEPGGAHGESGGFQV
                     VTFEWAHVQDPYVIALWILVASLAKIGFHLSHKVTSVVPESALLIVLGLVLGGIVWAA
                     DHIASFTLTPTVFFFYLLPPIVLDAGYFMPNRLFFGNLGTILLYAVVGTVWNAATTGL
                     SLYGVFLSGLMGDLQIGLLDFLLFGSLMAAVDPVAVLAVFEEVHVNEVLFIIVFGESL
                     LNDAVTVVLYNVFESFVALGGDNVTGVDCVKGIVSFFVVSLGGTLVGVVFAFLLSLVT
                     RFTKHVRIIEPGFVFIISYLSYLTSEMLSLSAILAITFCGICCQKYVKANISEQSATT
                     VRYTMKMLASSAETIIFMFLGISAVNPFIWTWNTAFVLLTLVFISVYRAIGVVLQTWL
                     LNRYRMVQLEPIDQVVLSYGGLRGAVAFALVVLLDGDKVKEKNLFVSTTIIVVFFTVI
                     FQGLTIKPLVQWLKVKRSEHREPRLNEKLHGRAFDHILSAIEDISGQIGHNYLRDKWS
                     HFDRKFLSRVLMRRSAQKSRDRILNVFHELNLKDAISYVAEGERRGSLAFIRSPSTDN
                     VVNVDFTPRSSTVEASVSYLLRENVSAVCLDMQSLEQRRRSIRDAEDMVTHHTLQQYL
                     YKPRQEYKHLYSRHELTPTEDEKQDREIFHRTMRKRLESFKSTKLGLNQNKKAAKLYK
                     RERAQKRRNSSIPNGKLPMESPAQNFTIKEKDLELSDTEEPPNYDEEMSGGIEFLASV
                     TKDTASDSPAGIDNPVFSPDEALDRSLLARLPPWLSPGETVVPSQRARTQIPYSPGTF
                     RRLMPFRLSSKSVDSFLQADGPEERPPAALPESTHM"
BASE COUNT          455 a          846 c          789 g          494 t
ORIGIN      
        1 gcaggcggca atgtggggac tcggggcccg gggccccgac cgggggctgc tgctggcgct
       61 ggcgctgggc gggctggcgc gggccggggg cgtcgaggtg gagcccggcg gcgcgcacgg
      121 cgagagcggg ggcttccagg tggtcacctt cgagtgggcc cacgtgcagg atccctacgt
      181 catcgcgctc tggatcctcg tggccagctt ggccaagatc gggttccacc tgtcccacaa
      241 ggtcaccagc gtggttcccg agagcgccct gctcatcgtg ctgggcctgg tgctgggcgg
      301 catcgtctgg gcggccgacc acatcgcgtc cttcacactg acgcccaccg tcttcttctt
      361 ctacctgctg ccccccatcg tgctggacgc cggctacttc atgcccaacc gcctcttctt
      421 cggcaacctg gggaccatcc tgttgtacgc cgtcgtgggt accgtgtgga acgcggccac
      481 caccgggctg tccctctacg gcgtcttcct cagtgggctc atgggcgacc tgcagattgg
      541 gctgctggac ttcctcctgt ttggcagcct catggcggct gtggacccgg tggccgtcct
      601 ggccgtgttt gaggaggtcc atgtcaacga ggtcctgttc atcatcgtct tcggggagtc
      661 gctgctgaac gacgcagtca ccgtggttct gtacaatgtg tttgaatctt tcgtggcgct
      721 gggaggtgac aacgtgactg gcgtggactg cgtgaagggc atagtgtcct tcttcgtggt
      781 gagcctgggg ggcacgctgg tgggggtggt cttcgccttc ctgctgtcgc tggtgacgcg
      841 cttcaccaag catgtgcgta tcatcgagcc cggcttcgtg ttcatcatct cctacctgtc
      901 ctacctgacg tccgagatgc tgtcgctgtc ggccatcctc gccatcacct tctgtggcat
      961 ctgctgtcag aagtatgtga aggccaacat ctcggagcag tcggccacca ccgtgcgcta
     1021 caccatgaag atgctggcca gcagcgccga gaccatcatc ttcatgttcc tgggtatctc
     1081 ggccgtgaac ccgttcatct ggacctggaa cacggccttc gtgctcctga cgctggtctt
     1141 catctccgtg taccgggcca tcggtgtggt cctgcagacc tggcttctga accgctaccg
     1201 catggtgcag ctggagccca ttgaccaggt ggtcctgtcc tacgggggcc tgcgcggggc
     1261 cgtggccttt gccctggtgg tgcttctgga tggagacaag gtcaaggaga agaacctgtt
     1321 cgtcagcacc accatcatcg tagtgttctt caccgtcatc ttccagggcc tgaccatcaa
     1381 gcctctggtg cagtggctga aggtgaagag gagcgagcac cgggaacctc ggctcaacga
     1441 gaagctgcac ggccgcgctt tcgaccacat cctctcggcc atcgaggaca tatccggaca
     1501 gatcgggcac aattatctca gagacaagtg gtcccacttc gacaggaagt tcctcagcag
     1561 ggtcctcatg agacggtcgg cccagaagtc tcgagaccgg atcctgaatg tcttccacga
     1621 gctgaacctg aaggatgcca tcagctacgt ggctgaggga gagcgccgcg ggtccctggc
     1681 cttcatccgc tcccccagca ccgacaacgt ggtcaacgtg gacttcacgc cacgatcgtc
     1741 caccgtggag gcctctgtct cctacctcct gagagaaaat gtcagcgctg tctgcctgga
     1801 catgcagtct ctggagcagc gacggcggag catccgggac gcggaggaca tggtcacgca
     1861 ccacacgcta cagcagtacc tgtacaagcc gcggcaggag tacaagcatc tgtacagccg
     1921 acacgagctc acgcccacgg aggacgagaa acaggaccgg gaaatcttcc acaggaccat
     1981 gcggaagcgc ctggagtcct tcaagtcgac caagctgggg ctcaaccaga acaagaaggc
     2041 agccaagctg tacaagcggg agcgtgccca gaagcggaga aacagcagca tccccaatgg
     2101 gaagctgccc atggagagcc ctgcgcagaa tttcaccatc aaggagaaag acttggaact
     2161 ttcagacacc gaggagcccc ccaactatga tgaggagatg agtgggggga tcgagttcct
     2221 ggctagtgtc accaaggaca cagcgtccga ctcccctgca ggaattgaca accctgtgtt
     2281 ttctccggac gaggccctgg accgcagcct cctggccagg ctgccgccct ggctgtctcc
     2341 cggggagacg gtggtcccct cgcagagggc ccgcacgcag attccctact ctcccggcac
     2401 cttccgccgc ctgatgccct tccgcctcag cagcaagtcc gtggactcct tcctgcaggc
     2461 agacggcccc gaggagcggc cccccgccgc cctccccgag tccacacaca tgtgacaccg
     2521 gctccgacac gccgctaacc ggccgctcgt ccccgcgcca cggtccgccc accgccgccg
     2581 ccgc
//