LOCUS HSU26711 3241 bp mRNA linear HUM 30-SEP-1996
DEFINITION Human cbl-b truncated form 1 lacking leucine zipper mRNA, complete
cds.
ACCESSION U26711
VERSION U26711.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3241)
AUTHORS Keane,M.M., Rivero-Lezcano,O.M., Mitchell,J.A., Robbins,K.C. and
Lipkowitz,S.
TITLE Cloning and characterization of cbl-b: a SH3 binding protein with
homology to the c-cbl proto-oncogene
JOURNAL Oncogene 10 (12), 2367-2377 (1995)
PUBMED 7784085
REFERENCE 2 (bases 1 to 3241)
AUTHORS Lipkowitz,S., Keane,M.M. and Mitchell,J.A.
TITLE Direct Submission
JOURNAL Submitted (10-MAY-1995) Stan Lipkowitz, Navy Medical Oncology
Branch, National Cancer Institute, Blg 8, Rm 5101, Bethesda Naval
Hospital, Bethesda, MD 20889, USA
FEATURES Location/Qualifiers
source 1..3241
/db_xref="H-InvDB:HIT000218819"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3q"
/cell_line="breast cancer cell line ZR75-1"
CDS 323..2755
/note="binds SH3 proteins; similar to c-cbl proto-oncogene
product, Swiss-Prot Accession Number P22681"
/codon_start=1
/product="cbl-b truncated form 1"
/protein_id="AAB09292.1"
/translation="MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRR
TVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLS
ENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAI
FPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSSLEAMALKS
TIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKY
STKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDG
RSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLM
CTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLD
DDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVP
PRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIP
PDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSN
VNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLP
SIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGH
CMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRT
PSDYDLLIPPLG"
misc_feature 668..679
/note="encodes nuclear localization signal"
misc_feature 1439..1558
/note="encodes ring finger"
misc_feature 2751
/note="alternative splice at nucleotide 2751 truncates
protein before leucine zipper"
BASE COUNT 907 a 758 c 720 g 856 t
ORIGIN
1 ctgggtcctg tgtgtgccac aggggtgggg tgtccagcga gcggtctcct cctcctgcta
61 gtgctgctgc ggcgtcccgc ggcctccccg agtcgggcgg gaggggagag cgggtgtgga
121 tttgtcttga cggtaattgt tgcgtttcca cgtctcggag gcctgcgcgc tgggttgctc
181 cttcttcggg agcgagctgt tctcagcgat cccactccca gccggggctc cccacacaca
241 ctgggctgcg tgcgtgtgga gtgggacccg cgcacacgcg tgtctctgga cagctacggc
301 gccgaaagaa ctaaaattcc agatggcaaa ctcaatgaat ggcagaaacc ctggtggtcg
361 aggaggaaat ccccgaaaag gtcgaatttt gggtattatt gatgctattc aggatgcagt
421 tggaccccct aagcaagctg ccgcagatcg caggaccgtg gagaagactt ggaagctcat
481 ggacaaagtg gtaagactgt gccaaaatcc caaacttcag ttgaaaaata gcccaccata
541 tatacttgat attttgcctg atacatatca gcatttacga cttatattga gtaaatatga
601 tgacaaccag aaacttgccc aactcagtga gaatgagtac tttaaaatct acattgatag
661 ccttatgaaa aagtcaaaac gggcaataag actctttaaa gaaggcaagg agagaatgta
721 tgaagaacag tcacaggaca gacgaaatct cacaaaactg tcccttatct tcagtcacat
781 gctggcagaa atcaaagcaa tctttcccaa tggtcaattc cagggagata actttcgtat
841 cacaaaagca gatgctgctg aattctggag aaagtttttt ggagacaaaa ctatcgtacc
901 atggaaagta ttcagacagt gccttcatga ggtccaccag attagctcta gcctggaagc
961 aatggctcta aaatcaacaa ttgatttaac ttgcaatgat tacatttcag tttttgaatt
1021 tgatattttt accaggctgt ttcagccttg gggctctatt ttgcggaatt ggaatttctt
1081 agctgtgaca catccaggtt acatggcatt tctcacatat gatgaagtta aagcacgact
1141 acagaaatat agcaccaaac ccggaagcta tattttccgg ttaagttgca ctcgattggg
1201 acagtgggcc attggctatg tgactgggga tgggaatatc ttacagacca tacctcataa
1261 caagccctta tttcaagccc tgattgatgg cagcagggaa ggattttatc tttatcctga
1321 tgggaggagt tataatcctg atttaactgg attatgtgaa cctacacctc atgaccatat
1381 aaaagttaca caggaacaat atgaattata ttgtgaaatg ggctccactt ttcagctctg
1441 taagatttgt gcagagaatg acaaagatgt caagattgag ccttgtgggc atttgatgtg
1501 cacctcttgc cttacggcat ggcaggagtc ggatggtcag ggctgccctt tctgtcgttg
1561 tgaaataaaa ggaactgagc ccataatcgt ggaccccttt gatccaagag atgaaggctc
1621 caggtgttgc agcatcattg acccctttgg catgccgatg ctagacttgg acgacgatga
1681 tgatcgtgag gagtccttga tgatgaatcg gttggcaaac gtccgaaagt gcactgacag
1741 gcagaactca ccagtcacat caccaggatc ctctcccctt gcccagagaa gaaagccaca
1801 gcctgaccca ctccagatcc cacatctaag cctgccaccc gtgcctcctc gcctggatct
1861 aattcagaaa ggcatagtta gatctccctg tggcagccca acaggttcac caaagtcttc
1921 tccttgcatg gtgagaaaac aagataaacc actcccagca ccacctcctc ccttaagaga
1981 tcctcctcca ccgccacctg aaagacctcc accaatccca ccagacaata gactgagtag
2041 acacatccat catgtggaaa gcgtgccttc cagagacccg ccaatgcctc ttgaagcatg
2101 gtgccctcgg gatgtgtttg ggactaatca gcttgtggga tgtcgactcc taggggaggg
2161 ctctccaaaa cctggaatca cagcgagttc aaatgtcaat ggaaggcaca gtagagtggg
2221 ctctgaccca gtgcttatgc ggaaacacag acgccatgat ttgcctttag aaggagctaa
2281 ggtcttttcc aatggtcacc ttggaagtga agaatatgat gttcctcccc ggctttctcc
2341 tcctcctcca gttaccaccc tcctccctag cataaagtgt actggtccgt tagcaaattc
2401 tctttcagag aaaacaagag acccagtaga ggaagatgat gatgaataca agattccttc
2461 atcccaccct gtttccctga attcacaacc atctcattgt cataatgtaa aacctcctgt
2521 tcggtcctgt gataatggtc actgtatgct gaatggaaca catggtccat cttcagagaa
2581 gaaatcaaac atccctgact taagcatata tttaaaggga gatgtttttg attcagcctc
2641 tgatcccgtg ccattaccac ctgccaggcc tccaactcgg gacaatccaa agcatggttc
2701 ttcactcaac aggacgccct ctgattatga tcttctcatc cctccattag gttgaaacct
2761 ttaaaaaagt tttgaacaac ccacccctcc ttcttttaat ttcagaattt tcagaattca
2821 gagttcagta taacacagac tcactgggtt gtgaatttgc ctgaaatttg aatgggttct
2881 ccaggtgccg gtgactccca agttcacgag accattactc catgtagatg attaaggtag
2941 tagtgtagta gttgggcatc agtcaggttt taagcaagtt gttttgtcca tactaaatgt
3001 agtctaaaaa cacatgagag ctttgtgctc tagtagtttt gaagtgatga cttgaagtgt
3061 tgagattttc tttaagtata ataattctta ataaatatga acttgctttt cttgcagcat
3121 gagcaccagt tccacttacg ctaattaaat tatgcaaaat taaatagttg tatgtagaga
3181 actgataata aattctgttt tattctaatc attacaactg taacacattc aaaaaaaaaa
3241 a
//