LOCUS HSU26644 7515 bp mRNA linear HUM 08-NOV-1995 DEFINITION Human fatty acid synthase (fas) mRNA, complete cds. ACCESSION U26644 VERSION U26644.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 7515) AUTHORS Jayakumar,A., Tai,M.H., Huang,W.Y., al-Feel,W., Hsu,M., Abu-Elheiga,L., Chirala,S.S. and Wakil,S.J. TITLE Human fatty acid synthase: properties and molecular cloning JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (19), 8695-8699 (1995) PUBMED 7567999 REFERENCE 2 (bases 1 to 7515) AUTHORS Jayakumar,A. TITLE Direct Submission JOURNAL Submitted (08-MAY-1995) Arumugam Jayakumar, Biochemistry, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA FEATURES Location/Qualifiers source 1..7515 /db_xref="H-InvDB:HIT000218808" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="17" /map="17q25" /sex="male" /tissue_type="whole cerebral brain" gene 1..7515 /gene="fas" CDS 1..7515 /gene="fas" /EC_number="2.3.1.85" /function="palmitate synthesis" /experiment="experimental evidence, no additional details recorded" /note="encodes region of fatty acid synthase activity; FAS; multifunctional protein" /codon_start=1 /protein_id="AAC50259.1" /translation="MEEVVIAGMFGKLPESENLQEFWDNLIGGVDMVTDDDRRWKAGL YGLPRRSGKLKDLSRFDASFFGVHPKQAHTMDPQLRLLLEATYEAIVDGGINPDSLRG THTGVWVGVSGSETSEALSRDPETLVGYSMVGCQRAMMANRLSFFFDFRGPSIALDTA CSSSLMALQNAYQAIHSGQCPAAIVGGINVLLKPNTSVQFLRLGMLSPEGTCKAFDTA GNGYCRSEGVVAVLLTKKSLARKVYTTILNKGTNTDGFKEQGVTFPQDIQEQPIRSLY QSAGVAPESFEYIEAHGPGTKVGDPQERNGITRALCATRQEPLLIGSTKSNMGHPEPA SGLDALAKVLLSLEHGLWAPNLHFHSPNPEIPALLDGRLQVVDQPLPVRGGNVGINSF GFGGSNMHIILRPNTQSAPAPAPHATLPRLLRASGRTPEAVQKLLEQGLRHSQGLAFL SMLNDIAAVPATAMPFRGYAVLGGETRWPRVQQVPAGERPLWFICSGMGTQWRGMGLS LMRLDRFRDSILRSDEAVNRFGLKVSQLLLSTDESTFDDIVHSFVSLTAIQIGLIDLL SCMGPEADGIVGHSLGEWLSVRDGCLSQEEAVLAAYWRGQCIKEAPLPAGAMAAVGLS WEECKQRCPPAVVPACHNSKDTVTISGPQAPVFEFVEQLRKEGVFAKEVRTGGMAFHS YFMEAIAPPLLQELKKVIREPKPRSARWLSTSIPEAQWHSSLARTSSAEYNVNNLVSP VLFQEALWHVPEHAVVLEIAPTPCPQAVLKRVRKPSCTIIPRMKKDHRDNLEFFLAGI GRLHLSGIDANPNALFPPVESPAPRGTPLISPLIKWDHSLAWDAPAAEDFPNGSGSPS ATIYTCTPSSESPDRYLVDHTIDGRVLFPATGYLSIVWKTLARAWAGLEQLPVVFEDV VQHQATILPKTGTVSLEVRLLEATGAFEVSENGNLVVSGKVYQWDDPDPRLFDHPESP HPNSPRSPLFLAQAEVYKELRLRGYDYGPHFQGILEASLEGDSGRLLWKDNWVSFMDT MLQMSILGSAKHGLYLPTRVTAIHIDPATHRQKLYTLQDKAQVADVVVSRWPRVTVAG GVHISGLHTESAPRRHEEQQVPILEKFCFTPHTEEGCLSEHAALEEELQLCKGLVEAL ETKVTQQGLKMVVPDWTGPRSPRDPSQQELPRLLSAACRLQLNGNLQLELAQVLAQER PKLPEDPLLSGLLDSPALKACLDTAVENMPSLKMKVVEVLAGHGHLYSRIPGLLSPHP LLQLSYTATDRHPQALEAAQAELQQHDVAQGQWDPADPAPSALGSADLLVCNCAVAAL GDPASALSNMVAALREGGFLLLHTLLRGHPRDIVAFLTSTEPQYGQGILSQDAWESLF SRVSLRLVGLKKSFYGATLFLCRRPTPQDSPIFLPVDDTSFRWVESLKGILADEDSSR PVWLKAINCATSGVVGLVNCLRREPGGTVRCVLLSNLSSTSHVPEVDPGSAELQKVLQ GDLVMNVYRDGAWGVFRHFLLEDKPEEPTAHAFVSTLTRGDLSSIRWVCSSLRHAQPT CPGAQLCTVYYASLNFRDIMLATGKLSPDAIPGKWTSQDSLLGMEFSGRDASGKRVMG LVPAKGLATSVLLSPDFLWDVPSNWTLEEAASVPVVYSTAYYALVVRGRVRPGETLLI HSGSGGVGQAAIAIALSLGCRVFTTVGSAEKRAYLQARFPQLDSTSFANSRDTSFEQH VLWHTGGKGVDLVLNSLAEEKLQASVRCFGTHGRFLEIGKFDLSQNHPLGMAIFLKNV TFHGVLLDAFFNESSADWREVWALVEAAIRDGVVRPLKCTVFHGAQVEDAFRYMAQGK HIGKVVVQVLAEEPAVLKGAKPKLMSAISKTFCPAHKSYIIAGGLGGFGLELAQWLIQ RGVQKLVLTSRSGIRTGYQAKQVRRWRRQGLQVQVSTSNISSLEGARGLIAEAAQLGP VGGVFNLAVVLRDGLLENQTPEFFQDVCKPKYSGTLNLDRVTREACPELDYFVVFSSV SCGRGNAGQSNYGFANSAMERICEKRRHEGLPGLAVQWGAIGTVGILVETMSTNDTIV SGTLPTRIGVLGLEVLDLFLNQPHMVLSSFVLAEKAAAYRDRDSQRDLVEAVAHILGI RDLAAVNLGGSLADLGLDSLMSAPVRQTLERELNLVLSVREVRQLTLRKLQELSSKAD EASELACPTPKEDGLAQQQTQLNLRSLLVKPEGPTLMRLNSVQSSERPLFLVHPIEAT TVFHSLGPGLSIPTYGLQCTPAAPLDSIHSLAAYYIDCIRQVQPEGPYRVAGYSYGAC VAFEMCSQLQAQQSPAPTHNSLFLFDGSPTYVLAYTQSYRAKLTPGCKAEAETEAICF FVQQFTDMEHNRVLEALLPLKGLEERVAAAVDLIIKSHQGLDRQELSFAARSFYYRLR AADQYTPKAKYSGNVMLLRAKTGGRYGEDLGADYNLSQVCDGKVSVHIIEGDHRTLLE GSGLESIISIIHSSLAEPRVSREG" misc_feature 1..1218 /gene="fas" /inference="non-experimental evidence, no additional details recorded" /note="encodes region of beta-ketoacyl-synthase activity" /function="condensing reaction" misc_feature 1284..2445 /gene="fas" /inference="non-experimental evidence, no additional details recorded" /note="encodes region of acetyl/malonyl transacylase activity" misc_feature 2490..2910 /gene="fas" /inference="non-experimental evidence, no additional details recorded" /note="encodes region of dehydratase activity" misc_feature 4890..5550 /gene="fas" /inference="non-experimental evidence, no additional details recorded" /note="encodes region of enoyl reductase activity" misc_feature 5610..6300 /gene="fas" /inference="non-experimental evidence, no additional details recorded" /note="encodes region of beta-ketoacyl-reductase activity" misc_feature 6342..6570 /gene="fas" /inference="non-experimental evidence, no additional details recorded" /note="encodes region of acyl carrier protein activity" misc_feature 6600..7512 /gene="fas" /inference="non-experimental evidence, no additional details recorded" /note="encodes region of thioesterase activity" BASE COUNT 1328 a 2491 c 2385 g 1311 t ORIGIN 1 atggaggagg tggtgattgc cggcatgttc gggaagctgc cagagtcgga gaacttgcag 61 gagttctggg acaacctcat cggcggtgtg gacatggtca cggacgatga ccgtcgctgg 121 aaggctgggc tctacggcct gccccggcgg tccggcaagc tgaaggacct gtctaggttt 181 gatgcctcct tcttcggagt ccaccccaag caggcacaca cgatggaccc tcagctgcgg 241 ctgctgctgg aagctaccta tgaagccatc gtggacggag gcatcaaccc agattcactc 301 cgaggaacac acactggcgt ctgggtgggc gtgagcggct ctgagacctc ggaggccctg 361 agccgagacc ccgagacact cgtgggctac agcatggtgg gctgccagcg agcgatgatg 421 gccaaccggc tctccttctt cttcgacttc agagggccca gcatcgcact ggacacagcc 481 tgctcctcca gcctgatggc cctgcagaac gcctaccagg ccatccacag cgggcagtgc 541 cctgccgcca tcgtgggggg catcaacgtc ctgctgaagc ccaacacctc cgtgcagttc 601 ttgaggctgg ggatgctcag ccccgagggc acctgcaagg ccttcgacac agcggggaat 661 gggtactgcc gctcggaggg tgtggtggct gtcctgctga ccaagaagtc cctggcccgg 721 aaggtctaca ccaccatcct gaacaaaggc accaatacag atggcttcaa ggagcaaggc 781 gtgaccttcc ctcaggatat ccaggagcag cctatccgct cgttgtacca gtcggccgga 841 gtggcccctg agtcatttga atacatcgaa gcccacggac caggcaccaa ggtgggcgac 901 ccccaggagc gtaatggcat cacccgagcc ctgtgcgcca cccgccagga gccgctgctc 961 atcggctcca ccaagtccaa catggggcac ccggagccag cctcggggct cgacgccctg 1021 gccaaggtgc tgctgtccct ggagcacggg ctctgggccc ccaacctgca cttccatagc 1081 cccaaccctg agatcccagc gctgttggat gggcggctgc aggtggtgga ccagcccctg 1141 cccgtccgtg gcggcaacgt gggcatcaac tcctttggct tcgggggctc caacatgcac 1201 atcatcctga ggcccaacac gcagtccgcc cccgcacccg ccccacatgc caccctgccc 1261 cgtctgctgc gggccagcgg acgcacccct gaggccgtgc agaagctgct ggagcagggc 1321 ctccggcaca gccagggcct ggctttcctg agcatgctga acgacatcgc ggctgtcccc 1381 gccaccgcca tgcccttccg tggctacgct gtgctgggtg gtgagacgcg gtggcccaga 1441 gtgcagcagg tgcccgctgg cgagcgcccg ctctggttca tctgctctgg gatgggcaca 1501 cagtggcgtg gaatggggct gagccttatg cgcctggacc gcttccgaga ttccatccta 1561 cgctccgatg aggctgtgaa ccgattcggc ctgaaggtgt cacagctgct gctgagcaca 1621 gacgagagca cctttgatga catcgtccat tcgtttgtga gcctgactgc catccagata 1681 ggcctcatag acctgctgag ctgcatggga cctgaggcag atggcatcgt cggccactcc 1741 ctgggggagt ggctgtcggt acgcgacggc tgcctgtccc aggaggaggc cgtcctcgct 1801 gcctactgga ggggacagtg catcaaagaa gccccacttc ccgccggcgc catggcagcc 1861 gtgggcttgt cctgggagga gtgtaaacag cgctgccccc ctgcggtggt gcccgcctgc 1921 cacaactcca aggacacagt caccatctcg ggacctcagg ccccggtgtt tgagttcgtg 1981 gagcagctga ggaaggaggg tgtgtttgcc aaggaggtgc ggaccggcgg tatggccttc 2041 cactcctact tcatggaggc catcgcaccc ccactgctgc aggagctcaa gaaggtgatc 2101 cgggagccga agccacgttc agcccgctgg ctcagcacct ctatccccga ggcccagtgg 2161 cacagcagcc tggcacgcac gtcttccgcc gagtacaatg tcaacaacct ggtgagccct 2221 gtgctgttcc aggaggccct gtggcacgtg cctgagcacg cggtggtgct ggagatcgcc 2281 ccgaccccgt gccctcaggc tgtcctgaag cgggtccgta agccgagctg caccatcatc 2341 ccccgtatga agaaggatca cagggacaac ctggagttct tcctggccgg catcggcagg 2401 ctgcacctct caggcatcga cgccaacccc aatgccttgt tcccacctgt ggagtcccca 2461 gctccccgag gaactcccct catctcccca ctcatcaagt gggaccacag cctggcctgg 2521 gacgcgccgg ccgccgagga cttccccaac ggttcaggtt ccccctcagc caccatctac 2581 acatgcacac caagctccga gtctcctgac cgctacctgg tggaccacac catcgacggt 2641 cgcgtcctct tccccgccac tggctacctg agcatagtgt ggaagacgct ggcccgcgcc 2701 tgggctgggc tcgagcagct gcctgtggtg tttgaggatg tggtgcagca ccaggccacc 2761 atcctgccca agactgggac agtgtccttg gaggtacggc tcctggaggc caccggtgcc 2821 ttcgaggtgt cagagaacgg caacctggta gtgagtggga aggtgtacca gtgggatgac 2881 cctgacccca ggctcttcga ccacccggaa agtccccacc ccaattcccc acggagtccc 2941 ctcttcctgg cccaggcaga agtttacaag gagctgcgtc tgcgtggcta cgactacggc 3001 cctcatttcc agggcatcct ggaggccagc ctggaaggtg actcggggag gctgctgtgg 3061 aaggataact gggtgagctt catggacacc atgctgcaga tgtccatcct gggctcggcc 3121 aagcacggcc tgtacctacc cacccgtgtc accgccatcc acatcgaccc tgccacccac 3181 aggcagaagc tgtacacact gcaggacaag gcccaagtgg ctgacgtggt ggtgagcagg 3241 tggccgaggg tcacagtggc gggaggcgtc cacatctccg ggctccacac tgagtcggcc 3301 ccgcggcggc acgaggagca gcaggtgccc atcctggaga agttttgctt cactccccac 3361 acggaggagg ggtgcctgtc tgagcacgct gccctcgagg aggagctgca actgtgcaag 3421 gggctggtcg aggcactcga gaccaaggtg acccagcagg ggctgaagat ggtggtgccg 3481 gactggacgg ggcccagatc cccccgggac ccctcacagc aggaactgcc ccggctgttg 3541 tcggctgcct gcaggcttca gctcaacggg aacctgcagc tggagctggc gcaggtgctg 3601 gcccaggaga ggcccaagct gccagaggac cctctgctca gcggcctcct ggactccccg 3661 gcactcaagg cctgcctgga cactgccgtg gagaacatgc ccagcctgaa gatgaaggtg 3721 gtggaggtgc tggccggcca cggtcacctg tattcccgca tcccaggcct gctcagcccc 3781 catcccctgc tgcagctgag ctacacggcc accgaccgcc acccccaggc cctggaggct 3841 gcccaggccg agctgcagca gcacgacgtt gcccagggcc agtgggatcc cgcagaccct 3901 gcccccagcg ccctgggcag cgcggacctc ctggtgtgca actgtgctgt ggctgccctc 3961 ggggacccgg cctcagctct cagcaacatg gtggctgccc tgagagaagg gggctttctg 4021 ctcctgcaca cactgctccg ggggcaccct cgggacatcg tggccttcct cacctccact 4081 gagccgcagt atggccaggg catcctgagc caggacgcgt gggagagcct cttctccagg 4141 gtgtcgctgc gcctggtggg cctgaagaag tccttctacg gcgccacgct cttcctgtgc 4201 cgccggccca ccccgcagga cagccccatc ttcctgccgg tggacgatac cagcttccgc 4261 tgggtggagt ctctgaaggg catcctggct gacgaagact cttcccggcc tgtgtggctg 4321 aaggccatca actgtgccac ctcgggcgtg gtgggcttgg tgaactgtct ccgccgagag 4381 cccggcggaa ccgtccggtg tgtgctgctc tccaacctca gcagcacctc ccacgtcccg 4441 gaggtggacc cgggctccgc agaactgcag aaggtgttgc agggagacct ggtgatgaac 4501 gtctaccgcg acggggcctg gggggttttc cgccacttcc tgctggagga caagcctgag 4561 gagccgacgg cacatgcctt tgtgagcacc ctcacccggg gggacctgtc ctccatccgc 4621 tgggtctgct cctcgctgcg ccatgcccag cccacctgcc ctggcgccca gctctgcacg 4681 gtctactacg cctccctcaa cttccgcgac atcatgctgg ccactggcaa gctgtcccct 4741 gatgccatcc cagggaagtg gacctcccag gacagcctgc taggtatgga gttctcgggc 4801 cgagacgcca gcggcaagcg tgtgatggga ctggtgcctg ccaagggcct ggccacctct 4861 gtcctgctgt caccggactt cctctgggat gtgccttcca actggacgct ggaggaggcg 4921 gcctcggtgc ctgtcgtcta cagcacggcc tactacgcgc tggtggtgcg tgggcgggtg 4981 cgccccgggg agacgctgct catccactcg ggctcgggcg gcgtgggcca ggccgccatc 5041 gccatcgccc tcagtctggg ctgccgcgtc ttcaccaccg tggggtcggc tgagaagcgg 5101 gcgtacctcc aggccaggtt cccccagctc gacagcacca gcttcgccaa ctcccgggac 5161 acatccttcg agcagcatgt gctgtggcac acgggcggga agggcgttga cctggtcttg 5221 aactccttgg cggaagagaa gctgcaggcc agcgtgaggt gcttcggtac gcacggtcgc 5281 ttcctggaaa ttggcaaatt cgacctttct cagaaccacc cgctcggcat ggctatcttc 5341 ctgaagaacg tgacattcca cggggtccta ctggatgcgt tcttcaacga gagcagtgct 5401 gactggcggg aggtgtgggc gcttgtcgag gccgccatcc gggatggggt ggtacggccc 5461 ctcaagtgca cggtgttcca tggggcccag gtggaggacg ccttccgcta catggcccaa 5521 gggaagcaca ttggcaaagt cgtcgtgcag gtgcttgcgg aggagccggc agtgctgaag 5581 ggggccaaac ccaagctgat gtcggccatc tccaagacct tctgcccggc ccacaagagc 5641 tacatcatcg ctggtggtct gggtggcttc ggcctggagt tggcgcagtg gctgatacag 5701 cgtggggtgc agaagctcgt gttgacttct cgctccggga tccggacagg ctaccaggcc 5761 aagcaggtcc gccggtggag gcgccagggg ctacaggtgc aggtgtccac cagcaacatc 5821 agctcactgg agggggcccg gggcctcatt gccgaggcgg cgcagcttgg gcccgtgggg 5881 ggcgtcttca acctggccgt ggtcttgaga gatggcttgc tggagaacca gaccccagag 5941 ttcttccagg acgtctgcaa gcccaagtac agcggcaccc tgaacctgga cagggtgacc 6001 cgagaggcgt gccctgagct ggactacttt gtggtcttct cctctgtgag ctgcgggcgt 6061 ggcaatgcgg gacagagcaa ctacggcttt gccaattccg ccatggagcg tatctgtgag 6121 aaacgccggc acgaaggcct cccaggcctg gccgtgcagt ggggcgccat cggcaccgtg 6181 ggcattttgg tggagacgat gagcaccaac gacacgatcg tcagtggcac gctgcccacg 6241 cgcattggcg tccttggcct ggaggtgctg gacctcttcc tgaaccagcc ccacatggtc 6301 ctgagcagct ttgtgctggc tgagaaggct gcggcctata gggacaggga cagccagcgg 6361 gacctggtgg aggccgtggc acacatcctg ggcatccgcg acttggctgc tgtcaacctg 6421 ggcggctcac tggcggacct gggcctggac tcgctcatga gcgcgccggt gcgccagacg 6481 ctggagcgtg agctcaacct ggtgctgtcc gtgcgcgagg tgcggcaact cacgctccgg 6541 aaactgcagg agctgtcctc aaaggcggat gaagccagcg agctggcatg ccccacgccc 6601 aaggaggatg gtctggccca gcagcagact cagctgaacc tgcgctccct gctggtgaaa 6661 ccggagggcc ccaccctgat gcggctcaac tccgtgcaga gctcggagcg gcccctgttc 6721 ctggtgcacc caatcgaggc taccaccgtg ttccacagcc tcggtcccgg tctcagcatc 6781 cccacctatg gcctgcagtg caccccggct gcgccccttg acagcatcca cagcctggct 6841 gcctactaca tcgactgcat caggcaggtg cagcccgagg gcccctaccg cgtggccggc 6901 tactcctacg gggcctgcgt ggcctttgaa atgtgctccc agctgcaggc ccagcagagc 6961 ccagccccca cccacaacag cctcttcctg ttcgacggct cgcccaccta cgtactggcc 7021 tacacccaga gctaccgggc aaagctgacc ccaggctgta aggctgaggc tgagacggag 7081 gccatatgct tcttcgtgca gcagttcacg gacatggagc acaacagggt gctggaggcg 7141 ctgctgccgc tgaagggcct agaggagcgt gtggcagccg ccgtggacct gatcatcaag 7201 agccaccagg gcctggaccg ccaggagctg agctttgcgg cccggtcctt ctactacagg 7261 ctgcgtgccg ctgaccagta tacacccaag gccaagtaca gtggcaacgt gatgctactg 7321 cgggccaaga cgggtggccg ctacggcgag gacctgggcg cggactacaa cctctcccag 7381 gtatgcgacg ggaaagtatc cgtccatatc atcgagggtg accaccgcac gctgctggag 7441 ggcagcggcc tggagtccat catcagcatc atccacagct ccctggctga gccacgtgtg 7501 agtcgggagg gctag //