LOCUS       HSU26644                7515 bp    mRNA    linear   HUM 08-NOV-1995
DEFINITION  Human fatty acid synthase (fas) mRNA, complete cds.
ACCESSION   U26644
VERSION     U26644.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7515)
  AUTHORS   Jayakumar,A., Tai,M.H., Huang,W.Y., al-Feel,W., Hsu,M.,
            Abu-Elheiga,L., Chirala,S.S. and Wakil,S.J.
  TITLE     Human fatty acid synthase: properties and molecular cloning
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 92 (19), 8695-8699 (1995)
   PUBMED   7567999
REFERENCE   2  (bases 1 to 7515)
  AUTHORS   Jayakumar,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-MAY-1995) Arumugam Jayakumar, Biochemistry, Baylor
            College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
FEATURES             Location/Qualifiers
     source          1..7515
                     /db_xref="H-InvDB:HIT000218808"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25"
                     /sex="male"
                     /tissue_type="whole cerebral brain"
     gene            1..7515
                     /gene="fas"
     CDS             1..7515
                     /gene="fas"
                     /EC_number="2.3.1.85"
                     /function="palmitate synthesis"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="encodes region of fatty acid synthase activity;
                     FAS; multifunctional protein"
                     /codon_start=1
                     /protein_id="AAC50259.1"
                     /translation="MEEVVIAGMFGKLPESENLQEFWDNLIGGVDMVTDDDRRWKAGL
                     YGLPRRSGKLKDLSRFDASFFGVHPKQAHTMDPQLRLLLEATYEAIVDGGINPDSLRG
                     THTGVWVGVSGSETSEALSRDPETLVGYSMVGCQRAMMANRLSFFFDFRGPSIALDTA
                     CSSSLMALQNAYQAIHSGQCPAAIVGGINVLLKPNTSVQFLRLGMLSPEGTCKAFDTA
                     GNGYCRSEGVVAVLLTKKSLARKVYTTILNKGTNTDGFKEQGVTFPQDIQEQPIRSLY
                     QSAGVAPESFEYIEAHGPGTKVGDPQERNGITRALCATRQEPLLIGSTKSNMGHPEPA
                     SGLDALAKVLLSLEHGLWAPNLHFHSPNPEIPALLDGRLQVVDQPLPVRGGNVGINSF
                     GFGGSNMHIILRPNTQSAPAPAPHATLPRLLRASGRTPEAVQKLLEQGLRHSQGLAFL
                     SMLNDIAAVPATAMPFRGYAVLGGETRWPRVQQVPAGERPLWFICSGMGTQWRGMGLS
                     LMRLDRFRDSILRSDEAVNRFGLKVSQLLLSTDESTFDDIVHSFVSLTAIQIGLIDLL
                     SCMGPEADGIVGHSLGEWLSVRDGCLSQEEAVLAAYWRGQCIKEAPLPAGAMAAVGLS
                     WEECKQRCPPAVVPACHNSKDTVTISGPQAPVFEFVEQLRKEGVFAKEVRTGGMAFHS
                     YFMEAIAPPLLQELKKVIREPKPRSARWLSTSIPEAQWHSSLARTSSAEYNVNNLVSP
                     VLFQEALWHVPEHAVVLEIAPTPCPQAVLKRVRKPSCTIIPRMKKDHRDNLEFFLAGI
                     GRLHLSGIDANPNALFPPVESPAPRGTPLISPLIKWDHSLAWDAPAAEDFPNGSGSPS
                     ATIYTCTPSSESPDRYLVDHTIDGRVLFPATGYLSIVWKTLARAWAGLEQLPVVFEDV
                     VQHQATILPKTGTVSLEVRLLEATGAFEVSENGNLVVSGKVYQWDDPDPRLFDHPESP
                     HPNSPRSPLFLAQAEVYKELRLRGYDYGPHFQGILEASLEGDSGRLLWKDNWVSFMDT
                     MLQMSILGSAKHGLYLPTRVTAIHIDPATHRQKLYTLQDKAQVADVVVSRWPRVTVAG
                     GVHISGLHTESAPRRHEEQQVPILEKFCFTPHTEEGCLSEHAALEEELQLCKGLVEAL
                     ETKVTQQGLKMVVPDWTGPRSPRDPSQQELPRLLSAACRLQLNGNLQLELAQVLAQER
                     PKLPEDPLLSGLLDSPALKACLDTAVENMPSLKMKVVEVLAGHGHLYSRIPGLLSPHP
                     LLQLSYTATDRHPQALEAAQAELQQHDVAQGQWDPADPAPSALGSADLLVCNCAVAAL
                     GDPASALSNMVAALREGGFLLLHTLLRGHPRDIVAFLTSTEPQYGQGILSQDAWESLF
                     SRVSLRLVGLKKSFYGATLFLCRRPTPQDSPIFLPVDDTSFRWVESLKGILADEDSSR
                     PVWLKAINCATSGVVGLVNCLRREPGGTVRCVLLSNLSSTSHVPEVDPGSAELQKVLQ
                     GDLVMNVYRDGAWGVFRHFLLEDKPEEPTAHAFVSTLTRGDLSSIRWVCSSLRHAQPT
                     CPGAQLCTVYYASLNFRDIMLATGKLSPDAIPGKWTSQDSLLGMEFSGRDASGKRVMG
                     LVPAKGLATSVLLSPDFLWDVPSNWTLEEAASVPVVYSTAYYALVVRGRVRPGETLLI
                     HSGSGGVGQAAIAIALSLGCRVFTTVGSAEKRAYLQARFPQLDSTSFANSRDTSFEQH
                     VLWHTGGKGVDLVLNSLAEEKLQASVRCFGTHGRFLEIGKFDLSQNHPLGMAIFLKNV
                     TFHGVLLDAFFNESSADWREVWALVEAAIRDGVVRPLKCTVFHGAQVEDAFRYMAQGK
                     HIGKVVVQVLAEEPAVLKGAKPKLMSAISKTFCPAHKSYIIAGGLGGFGLELAQWLIQ
                     RGVQKLVLTSRSGIRTGYQAKQVRRWRRQGLQVQVSTSNISSLEGARGLIAEAAQLGP
                     VGGVFNLAVVLRDGLLENQTPEFFQDVCKPKYSGTLNLDRVTREACPELDYFVVFSSV
                     SCGRGNAGQSNYGFANSAMERICEKRRHEGLPGLAVQWGAIGTVGILVETMSTNDTIV
                     SGTLPTRIGVLGLEVLDLFLNQPHMVLSSFVLAEKAAAYRDRDSQRDLVEAVAHILGI
                     RDLAAVNLGGSLADLGLDSLMSAPVRQTLERELNLVLSVREVRQLTLRKLQELSSKAD
                     EASELACPTPKEDGLAQQQTQLNLRSLLVKPEGPTLMRLNSVQSSERPLFLVHPIEAT
                     TVFHSLGPGLSIPTYGLQCTPAAPLDSIHSLAAYYIDCIRQVQPEGPYRVAGYSYGAC
                     VAFEMCSQLQAQQSPAPTHNSLFLFDGSPTYVLAYTQSYRAKLTPGCKAEAETEAICF
                     FVQQFTDMEHNRVLEALLPLKGLEERVAAAVDLIIKSHQGLDRQELSFAARSFYYRLR
                     AADQYTPKAKYSGNVMLLRAKTGGRYGEDLGADYNLSQVCDGKVSVHIIEGDHRTLLE
                     GSGLESIISIIHSSLAEPRVSREG"
     misc_feature    1..1218
                     /gene="fas"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="encodes region of beta-ketoacyl-synthase activity"
                     /function="condensing reaction"
     misc_feature    1284..2445
                     /gene="fas"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="encodes region of acetyl/malonyl transacylase
                     activity"
     misc_feature    2490..2910
                     /gene="fas"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="encodes region of dehydratase activity"
     misc_feature    4890..5550
                     /gene="fas"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="encodes region of enoyl reductase activity"
     misc_feature    5610..6300
                     /gene="fas"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="encodes region of beta-ketoacyl-reductase activity"
     misc_feature    6342..6570
                     /gene="fas"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="encodes region of acyl carrier protein activity"
     misc_feature    6600..7512
                     /gene="fas"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="encodes region of thioesterase activity"
BASE COUNT         1328 a         2491 c         2385 g         1311 t
ORIGIN      
        1 atggaggagg tggtgattgc cggcatgttc gggaagctgc cagagtcgga gaacttgcag
       61 gagttctggg acaacctcat cggcggtgtg gacatggtca cggacgatga ccgtcgctgg
      121 aaggctgggc tctacggcct gccccggcgg tccggcaagc tgaaggacct gtctaggttt
      181 gatgcctcct tcttcggagt ccaccccaag caggcacaca cgatggaccc tcagctgcgg
      241 ctgctgctgg aagctaccta tgaagccatc gtggacggag gcatcaaccc agattcactc
      301 cgaggaacac acactggcgt ctgggtgggc gtgagcggct ctgagacctc ggaggccctg
      361 agccgagacc ccgagacact cgtgggctac agcatggtgg gctgccagcg agcgatgatg
      421 gccaaccggc tctccttctt cttcgacttc agagggccca gcatcgcact ggacacagcc
      481 tgctcctcca gcctgatggc cctgcagaac gcctaccagg ccatccacag cgggcagtgc
      541 cctgccgcca tcgtgggggg catcaacgtc ctgctgaagc ccaacacctc cgtgcagttc
      601 ttgaggctgg ggatgctcag ccccgagggc acctgcaagg ccttcgacac agcggggaat
      661 gggtactgcc gctcggaggg tgtggtggct gtcctgctga ccaagaagtc cctggcccgg
      721 aaggtctaca ccaccatcct gaacaaaggc accaatacag atggcttcaa ggagcaaggc
      781 gtgaccttcc ctcaggatat ccaggagcag cctatccgct cgttgtacca gtcggccgga
      841 gtggcccctg agtcatttga atacatcgaa gcccacggac caggcaccaa ggtgggcgac
      901 ccccaggagc gtaatggcat cacccgagcc ctgtgcgcca cccgccagga gccgctgctc
      961 atcggctcca ccaagtccaa catggggcac ccggagccag cctcggggct cgacgccctg
     1021 gccaaggtgc tgctgtccct ggagcacggg ctctgggccc ccaacctgca cttccatagc
     1081 cccaaccctg agatcccagc gctgttggat gggcggctgc aggtggtgga ccagcccctg
     1141 cccgtccgtg gcggcaacgt gggcatcaac tcctttggct tcgggggctc caacatgcac
     1201 atcatcctga ggcccaacac gcagtccgcc cccgcacccg ccccacatgc caccctgccc
     1261 cgtctgctgc gggccagcgg acgcacccct gaggccgtgc agaagctgct ggagcagggc
     1321 ctccggcaca gccagggcct ggctttcctg agcatgctga acgacatcgc ggctgtcccc
     1381 gccaccgcca tgcccttccg tggctacgct gtgctgggtg gtgagacgcg gtggcccaga
     1441 gtgcagcagg tgcccgctgg cgagcgcccg ctctggttca tctgctctgg gatgggcaca
     1501 cagtggcgtg gaatggggct gagccttatg cgcctggacc gcttccgaga ttccatccta
     1561 cgctccgatg aggctgtgaa ccgattcggc ctgaaggtgt cacagctgct gctgagcaca
     1621 gacgagagca cctttgatga catcgtccat tcgtttgtga gcctgactgc catccagata
     1681 ggcctcatag acctgctgag ctgcatggga cctgaggcag atggcatcgt cggccactcc
     1741 ctgggggagt ggctgtcggt acgcgacggc tgcctgtccc aggaggaggc cgtcctcgct
     1801 gcctactgga ggggacagtg catcaaagaa gccccacttc ccgccggcgc catggcagcc
     1861 gtgggcttgt cctgggagga gtgtaaacag cgctgccccc ctgcggtggt gcccgcctgc
     1921 cacaactcca aggacacagt caccatctcg ggacctcagg ccccggtgtt tgagttcgtg
     1981 gagcagctga ggaaggaggg tgtgtttgcc aaggaggtgc ggaccggcgg tatggccttc
     2041 cactcctact tcatggaggc catcgcaccc ccactgctgc aggagctcaa gaaggtgatc
     2101 cgggagccga agccacgttc agcccgctgg ctcagcacct ctatccccga ggcccagtgg
     2161 cacagcagcc tggcacgcac gtcttccgcc gagtacaatg tcaacaacct ggtgagccct
     2221 gtgctgttcc aggaggccct gtggcacgtg cctgagcacg cggtggtgct ggagatcgcc
     2281 ccgaccccgt gccctcaggc tgtcctgaag cgggtccgta agccgagctg caccatcatc
     2341 ccccgtatga agaaggatca cagggacaac ctggagttct tcctggccgg catcggcagg
     2401 ctgcacctct caggcatcga cgccaacccc aatgccttgt tcccacctgt ggagtcccca
     2461 gctccccgag gaactcccct catctcccca ctcatcaagt gggaccacag cctggcctgg
     2521 gacgcgccgg ccgccgagga cttccccaac ggttcaggtt ccccctcagc caccatctac
     2581 acatgcacac caagctccga gtctcctgac cgctacctgg tggaccacac catcgacggt
     2641 cgcgtcctct tccccgccac tggctacctg agcatagtgt ggaagacgct ggcccgcgcc
     2701 tgggctgggc tcgagcagct gcctgtggtg tttgaggatg tggtgcagca ccaggccacc
     2761 atcctgccca agactgggac agtgtccttg gaggtacggc tcctggaggc caccggtgcc
     2821 ttcgaggtgt cagagaacgg caacctggta gtgagtggga aggtgtacca gtgggatgac
     2881 cctgacccca ggctcttcga ccacccggaa agtccccacc ccaattcccc acggagtccc
     2941 ctcttcctgg cccaggcaga agtttacaag gagctgcgtc tgcgtggcta cgactacggc
     3001 cctcatttcc agggcatcct ggaggccagc ctggaaggtg actcggggag gctgctgtgg
     3061 aaggataact gggtgagctt catggacacc atgctgcaga tgtccatcct gggctcggcc
     3121 aagcacggcc tgtacctacc cacccgtgtc accgccatcc acatcgaccc tgccacccac
     3181 aggcagaagc tgtacacact gcaggacaag gcccaagtgg ctgacgtggt ggtgagcagg
     3241 tggccgaggg tcacagtggc gggaggcgtc cacatctccg ggctccacac tgagtcggcc
     3301 ccgcggcggc acgaggagca gcaggtgccc atcctggaga agttttgctt cactccccac
     3361 acggaggagg ggtgcctgtc tgagcacgct gccctcgagg aggagctgca actgtgcaag
     3421 gggctggtcg aggcactcga gaccaaggtg acccagcagg ggctgaagat ggtggtgccg
     3481 gactggacgg ggcccagatc cccccgggac ccctcacagc aggaactgcc ccggctgttg
     3541 tcggctgcct gcaggcttca gctcaacggg aacctgcagc tggagctggc gcaggtgctg
     3601 gcccaggaga ggcccaagct gccagaggac cctctgctca gcggcctcct ggactccccg
     3661 gcactcaagg cctgcctgga cactgccgtg gagaacatgc ccagcctgaa gatgaaggtg
     3721 gtggaggtgc tggccggcca cggtcacctg tattcccgca tcccaggcct gctcagcccc
     3781 catcccctgc tgcagctgag ctacacggcc accgaccgcc acccccaggc cctggaggct
     3841 gcccaggccg agctgcagca gcacgacgtt gcccagggcc agtgggatcc cgcagaccct
     3901 gcccccagcg ccctgggcag cgcggacctc ctggtgtgca actgtgctgt ggctgccctc
     3961 ggggacccgg cctcagctct cagcaacatg gtggctgccc tgagagaagg gggctttctg
     4021 ctcctgcaca cactgctccg ggggcaccct cgggacatcg tggccttcct cacctccact
     4081 gagccgcagt atggccaggg catcctgagc caggacgcgt gggagagcct cttctccagg
     4141 gtgtcgctgc gcctggtggg cctgaagaag tccttctacg gcgccacgct cttcctgtgc
     4201 cgccggccca ccccgcagga cagccccatc ttcctgccgg tggacgatac cagcttccgc
     4261 tgggtggagt ctctgaaggg catcctggct gacgaagact cttcccggcc tgtgtggctg
     4321 aaggccatca actgtgccac ctcgggcgtg gtgggcttgg tgaactgtct ccgccgagag
     4381 cccggcggaa ccgtccggtg tgtgctgctc tccaacctca gcagcacctc ccacgtcccg
     4441 gaggtggacc cgggctccgc agaactgcag aaggtgttgc agggagacct ggtgatgaac
     4501 gtctaccgcg acggggcctg gggggttttc cgccacttcc tgctggagga caagcctgag
     4561 gagccgacgg cacatgcctt tgtgagcacc ctcacccggg gggacctgtc ctccatccgc
     4621 tgggtctgct cctcgctgcg ccatgcccag cccacctgcc ctggcgccca gctctgcacg
     4681 gtctactacg cctccctcaa cttccgcgac atcatgctgg ccactggcaa gctgtcccct
     4741 gatgccatcc cagggaagtg gacctcccag gacagcctgc taggtatgga gttctcgggc
     4801 cgagacgcca gcggcaagcg tgtgatggga ctggtgcctg ccaagggcct ggccacctct
     4861 gtcctgctgt caccggactt cctctgggat gtgccttcca actggacgct ggaggaggcg
     4921 gcctcggtgc ctgtcgtcta cagcacggcc tactacgcgc tggtggtgcg tgggcgggtg
     4981 cgccccgggg agacgctgct catccactcg ggctcgggcg gcgtgggcca ggccgccatc
     5041 gccatcgccc tcagtctggg ctgccgcgtc ttcaccaccg tggggtcggc tgagaagcgg
     5101 gcgtacctcc aggccaggtt cccccagctc gacagcacca gcttcgccaa ctcccgggac
     5161 acatccttcg agcagcatgt gctgtggcac acgggcggga agggcgttga cctggtcttg
     5221 aactccttgg cggaagagaa gctgcaggcc agcgtgaggt gcttcggtac gcacggtcgc
     5281 ttcctggaaa ttggcaaatt cgacctttct cagaaccacc cgctcggcat ggctatcttc
     5341 ctgaagaacg tgacattcca cggggtccta ctggatgcgt tcttcaacga gagcagtgct
     5401 gactggcggg aggtgtgggc gcttgtcgag gccgccatcc gggatggggt ggtacggccc
     5461 ctcaagtgca cggtgttcca tggggcccag gtggaggacg ccttccgcta catggcccaa
     5521 gggaagcaca ttggcaaagt cgtcgtgcag gtgcttgcgg aggagccggc agtgctgaag
     5581 ggggccaaac ccaagctgat gtcggccatc tccaagacct tctgcccggc ccacaagagc
     5641 tacatcatcg ctggtggtct gggtggcttc ggcctggagt tggcgcagtg gctgatacag
     5701 cgtggggtgc agaagctcgt gttgacttct cgctccggga tccggacagg ctaccaggcc
     5761 aagcaggtcc gccggtggag gcgccagggg ctacaggtgc aggtgtccac cagcaacatc
     5821 agctcactgg agggggcccg gggcctcatt gccgaggcgg cgcagcttgg gcccgtgggg
     5881 ggcgtcttca acctggccgt ggtcttgaga gatggcttgc tggagaacca gaccccagag
     5941 ttcttccagg acgtctgcaa gcccaagtac agcggcaccc tgaacctgga cagggtgacc
     6001 cgagaggcgt gccctgagct ggactacttt gtggtcttct cctctgtgag ctgcgggcgt
     6061 ggcaatgcgg gacagagcaa ctacggcttt gccaattccg ccatggagcg tatctgtgag
     6121 aaacgccggc acgaaggcct cccaggcctg gccgtgcagt ggggcgccat cggcaccgtg
     6181 ggcattttgg tggagacgat gagcaccaac gacacgatcg tcagtggcac gctgcccacg
     6241 cgcattggcg tccttggcct ggaggtgctg gacctcttcc tgaaccagcc ccacatggtc
     6301 ctgagcagct ttgtgctggc tgagaaggct gcggcctata gggacaggga cagccagcgg
     6361 gacctggtgg aggccgtggc acacatcctg ggcatccgcg acttggctgc tgtcaacctg
     6421 ggcggctcac tggcggacct gggcctggac tcgctcatga gcgcgccggt gcgccagacg
     6481 ctggagcgtg agctcaacct ggtgctgtcc gtgcgcgagg tgcggcaact cacgctccgg
     6541 aaactgcagg agctgtcctc aaaggcggat gaagccagcg agctggcatg ccccacgccc
     6601 aaggaggatg gtctggccca gcagcagact cagctgaacc tgcgctccct gctggtgaaa
     6661 ccggagggcc ccaccctgat gcggctcaac tccgtgcaga gctcggagcg gcccctgttc
     6721 ctggtgcacc caatcgaggc taccaccgtg ttccacagcc tcggtcccgg tctcagcatc
     6781 cccacctatg gcctgcagtg caccccggct gcgccccttg acagcatcca cagcctggct
     6841 gcctactaca tcgactgcat caggcaggtg cagcccgagg gcccctaccg cgtggccggc
     6901 tactcctacg gggcctgcgt ggcctttgaa atgtgctccc agctgcaggc ccagcagagc
     6961 ccagccccca cccacaacag cctcttcctg ttcgacggct cgcccaccta cgtactggcc
     7021 tacacccaga gctaccgggc aaagctgacc ccaggctgta aggctgaggc tgagacggag
     7081 gccatatgct tcttcgtgca gcagttcacg gacatggagc acaacagggt gctggaggcg
     7141 ctgctgccgc tgaagggcct agaggagcgt gtggcagccg ccgtggacct gatcatcaag
     7201 agccaccagg gcctggaccg ccaggagctg agctttgcgg cccggtcctt ctactacagg
     7261 ctgcgtgccg ctgaccagta tacacccaag gccaagtaca gtggcaacgt gatgctactg
     7321 cgggccaaga cgggtggccg ctacggcgag gacctgggcg cggactacaa cctctcccag
     7381 gtatgcgacg ggaaagtatc cgtccatatc atcgagggtg accaccgcac gctgctggag
     7441 ggcagcggcc tggagtccat catcagcatc atccacagct ccctggctga gccacgtgtg
     7501 agtcgggagg gctag
//