LOCUS HSU26592 1964 bp mRNA linear HUM 18-NOV-1996 DEFINITION Human clone IS4 diabetes mellitus type I autoantigen (ICAp69) mRNA, complete cds. ACCESSION U26592 VERSION U26592.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1964) AUTHORS Pietropaolo,M., Castano,L., Babu,S., Buelow,R., Kuo,Y.-L.S., Martin,S., Martin,A., Powers,A.C., Prochazka,M., Naggert,J., Leiter,E.H. and Eisenbarth,G.S. TITLE Islet cell autoantigen 69 kD (ICA69). Molecular cloning and characterization of a novel diabetes-associated autoantigen JOURNAL J. Clin. Invest. 92 (1), 359-371 (1993) PUBMED 8326004 REFERENCE 2 (bases 1 to 1964) AUTHORS Gaedigk,R., Duncan,A.M., Miyazaki,I., Robinson,B.H. and Dosch,H.M. TITLE ICA1 encoding p69, a protein linked to the development of type 1 diabetes, maps to human chromosome 7p22 JOURNAL Cytogenet. Cell Genet. 66 (4), 274-276 (1994) PUBMED 8162706 REFERENCE 3 (bases 1 to 1964) AUTHORS Miyazaki,I., Gaedigk,R., Hui,M.F., Cheung,R.K., Morkowski,J., Rajotte,R.V. and Dosch,H.M. TITLE Cloning of human and rat p69 cDNA, a candidate autoimmune target in type 1 diabetes JOURNAL Biochim. Biophys. Acta 1227 (1-2), 101-104 (1994) PUBMED 7918678 REFERENCE 4 (bases 1 to 1964) AUTHORS Miyazaki,I., Cheung,R.K., Gaedigk,R., Hui,M.F., Van der Meulen,J., Rajotte,R.V. and Dosch,H.M. TITLE T cell activation and anergy to islet cell antigen in type I diabetes JOURNAL J. Immunol. 154 (3), 1461-1469 (1995) PUBMED 7822811 REFERENCE 5 (bases 1 to 1964) AUTHORS Karges,W.J.P., Gaedigk,R., Hui,M.F., Cheung,R.K. and Dosch,H.M. TITLE Direct Submission JOURNAL Submitted (08-MAY-1995) Hans-Michael Dosch, Immunology and Cancer, The Hospital for Sick Children, 555 University Ave., Toronto, Ontario M5G 1X8, Canada FEATURES Location/Qualifiers source 1..1964 /db_xref="H-InvDB:HIT000218806" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="7" /map="7p22" /clone="IS4" /cell_type="islet cell" gene 1..1964 /gene="ICAp69" CDS 125..388 /gene="ICAp69" /codon_start=1 /product="diabetes mellitus type I autoantigen" /protein_id="AAB19034.1" /translation="MSGHKCSYPWDLQDRYAQDKSVVNKMQQKYWETKQAFIKATGKK EDEHVVASDADLDAKLELFHSIQRTCLDLSKAIVLYQKRICSF" BASE COUNT 616 a 436 c 471 g 441 t ORIGIN 1 gcgctccgac ctcggccggg aggctcctgg ggccggggct ccgaggttat aatataactt 61 atcctctcat gcttttttcc tgccccttct ccccaaatca tcaacaatag aagaagaaga 121 aaacatgtca ggacacaaat gcagttatcc ctgggactta caggatcgat atgctcaaga 181 taagtcagtt gtaaataaga tgcaacagaa atattgggag acgaagcagg cctttattaa 241 agccacaggg aagaaggaag atgaacatgt tgttgcctct gacgcggacc tggatgccaa 301 gctagagctg tttcattcaa ttcagagaac ctgtctggac ttatcgaaag caattgtact 361 ctatcaaaag aggatatgtt cattttagga ggccaaggca ggaggatcac ttggagccag 421 gagtttgaga ccagcctggg caacaaagtg agacccccat ctctacaaaa aataaaaaca 481 cttaaaaatt atccgggtac cgtgcatgtg cagtcccagc tactcaggag gctgaggcag 541 gaggatcaca gtgacctata atgagccgtt gtgctccagc ctgggcgaca gaagtcttgt 601 ctcaagaaga aaacgaactg ggaaaatttc ttcgatccca aggtttccaa gataaaacca 661 gagcaggaaa gatgatgcaa gcgacaggaa aggccctctg cttttcttcc cagcaaaggt 721 tggccttacg aaatcctttg tgtcgatttc accaagaagt ggagactttt cggcatcggg 781 ccatctcaga tacttggctg acggtgaacc gcatggaaca gtgcaggacg gaatatagag 841 gagcactatt atggatgaag gacgtgtctc aggagcttga tccagacctc tacaagcaaa 901 tggagaagtt caggaaggta caaacacaag tgcgccttgc aaaaaaaaac tttgacaaat 961 tgaagatgga tgtttgtcaa aaagtggatc ttcttggagc gagcagatgc aatctcttgt 1021 ctcacatgct agcaacatac cagaccactc tgcttcattt ttgggagaaa acttctcaca 1081 ctatggcagc catccatgag agtttcaaag gttatcaacc atatgaattt actactttaa 1141 agagcttaca agaccctatg aaaaaattag ttgagaaaga agagaagaag aaaatcaacc 1201 agcaggaaag tacagatgca gccgtgcagg agccgagcca attaatttca ttagaggaag 1261 aaaaccagcg caaggaatcc tctagtttta agactgaaga tggaaaaagt attttatctg 1321 ccttagacaa aggctctaca catactgcat gctcaggacc catagatgaa ctattagaca 1381 tgaaatctga ggaaggtgct tgcctgggac cagtggcagg gaccccggaa cctgaaggtg 1441 ctgacaaaga tgacctgctg ctgttgagtg agatcttcaa tgcttcctcc ttggaagagg 1501 gcgagttcag caaagagtgg gccgctgtgt ttggagacgg ccaagtgaag gagccagtgc 1561 ccactatggc cctgggagag ccagacccca aggcccagac aggctcaggt ttccttcctt 1621 cgcagctttt agaccaaaat atgaaagact tacaggcctc gctacaagaa cctgctaagg 1681 ctgcctcaga cctgactgcc tggttcagcc tcttcgctga cctcgaccca ctctcaaatc 1741 ctgatgctgt tgggaaaacc gataaagaac acgaattgct caatgcatga atctgtaccc 1801 ttcgggaggg cactcacatg ccgcccccag cagctcccct gggggctagc agaagtataa 1861 agtgatcagt atgctgtttt aataattatg tgccatttta ataaaatgaa agggtcaacg 1921 gccctgttta tattggtata aaaaaaaaaa aaaaaaaaaa aaaa //