LOCUS HSU26591 2139 bp mRNA linear HUM 18-NOV-1996
DEFINITION Human clone IS10 diabetes mellitus type I autoantigen (ICAp69)
mRNA, complete cds.
ACCESSION U26591
VERSION U26591.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2139)
AUTHORS Pietropaolo,M., Castano,L., Babu,S., Buelow,R., Kuo,Y.-L.S.,
Martin,S., Martin,A., Powers,A.C., Prochazka,M., Naggert,J.,
Leiter,E.H. and Eisenbarth,G.S.
TITLE Islet cell autoantigen 69 kD (ICA69). Molecular cloning and
characterization of a novel diabetes-associated autoantigen
JOURNAL J. Clin. Invest. 92 (1), 359-371 (1993)
PUBMED 8326004
REFERENCE 2 (bases 1 to 2139)
AUTHORS Gaedigk,R., Duncan,A.M., Miyazaki,I., Robinson,B.H. and Dosch,H.M.
TITLE ICA1 encoding p69, a protein linked to the development of type 1
diabetes, maps to human chromosome 7p22
JOURNAL Cytogenet. Cell Genet. 66 (4), 274-276 (1994)
PUBMED 8162706
REFERENCE 3 (bases 1 to 2139)
AUTHORS Miyazaki,I., Gaedigk,R., Hui,M.F., Cheung,R.K., Morkowski,J.,
Rajotte,R.V. and Dosch,H.M.
TITLE Cloning of human and rat p69 cDNA, a candidate autoimmune target in
type 1 diabetes
JOURNAL Biochim. Biophys. Acta 1227 (1-2), 101-104 (1994)
PUBMED 7918678
REFERENCE 4 (bases 1 to 2139)
AUTHORS Miyazaki,I., Cheung,R.K., Gaedigk,R., Hui,M.F., Van der Meulen,J.,
Rajotte,R.V. and Dosch,H.M.
TITLE T cell activation and anergy to islet cell antigen in type I
diabetes
JOURNAL J. Immunol. 154 (3), 1461-1469 (1995)
PUBMED 7822811
REFERENCE 5 (bases 1 to 2139)
AUTHORS Karges,W.J.P., Gaedigk,R., Hui,M.F., Cheung,R.K. and Dosch,H.M.
TITLE Direct Submission
JOURNAL Submitted (08-MAY-1995) Hans-Michael Dosch, Immunology and Cancer,
The Hospital for Sick Children, 555 University Ave., Toronto,
Ontario M5G 1X8, Canada
FEATURES Location/Qualifiers
source 1..2139
/db_xref="H-InvDB:HIT000218805"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="7"
/map="7p22"
/clone="IS10"
/cell_type="islet cell"
gene 1..2139
/gene="ICAp69"
CDS 68..1519
/gene="ICAp69"
/codon_start=1
/product="diabetes mellitus type I autoantigen"
/protein_id="AAB19033.1"
/translation="MSGHKCSYPWDLQDRYAQDKSVVNKMQQKYWETKQAFIKATGKK
EDEHVVASDADLDAKLELFHSIQRTCLDLSKAIVLYQKRICFLSQEENELGKFLRSQG
FQDKTRAGKMMQATGKALCFSSQQRLALRNPLCRFHQEVETFRHRAISDTWLTVNRME
QCRTEYRGALLWMKDVSQELDPDLYKQMEKFRKVQTQVRLAKKNFDKLKMDVCQKVDL
LGASRCNLLSHMLATYQTTLLHFWEKTSHTMAAIHESFKGYQPYEFTTLKSLQDPMKK
LVEKEEKKKINQQESTDAAVQEPSQLISLEEENQRKESSSFKTEDGKSILSALDKGST
HTACSGPIDELLDMKSEEGACLGPVAGTPEPEGADKDDLLLLSEIFNASSLEEGEFSK
EWAAVFGDGQVKEPVPTMALGEPDPKAQTGSGFLPSQLLDQNMKDLQASLQEPAKAAS
DLTAWFSLFADLDPLSNPDAVGKTDKEHELLNA"
BASE COUNT 621 a 485 c 528 g 505 t
ORIGIN
1 gctgcaggaa gcagcaggag acgcccggca gccgggacgg tcggggacgc ctgaagaaga
61 agaaaacatg tcaggacaca aatgcagtta tccctgggac ttacaggatc gatatgctca
121 agataagtca gttgtaaata agatgcaaca gaaatattgg gagacgaagc aggcctttat
181 taaagccaca gggaagaagg aagatgaaca tgttgttgcc tctgacgcgg acctggatgc
241 caagctagag ctgtttcatt caattcagag aacctgtctg gacttatcga aagcaattgt
301 actctatcaa aagaggatat gtttcttgtc tcaagaagaa aacgaactgg gaaaatttct
361 tcgatcccaa ggtttccaag ataaaaccag agcaggaaag atgatgcaag cgacaggaaa
421 ggccctctgc ttttcttccc agcaaaggtt ggccttacga aatcctttgt gtcgatttca
481 ccaagaagtg gagacttttc ggcatcgggc catctcagat acttggctga cggtgaaccg
541 catggaacag tgcaggacgg aatatagagg agcactatta tggatgaagg acgtgtctca
601 ggagcttgat ccagacctct acaagcaaat ggagaagttc aggaaggtac aaacacaagt
661 gcgccttgca aaaaaaaact ttgacaaatt gaagatggat gtttgtcaaa aagtggatct
721 tcttggagcg agcagatgca atctcttgtc tcacatgcta gcaacatacc agaccactct
781 gcttcatttt tgggagaaaa cttctcacac tatggcagcc atccatgaga gtttcaaagg
841 ttatcaacca tatgaattta ctactttaaa gagcttacaa gaccctatga aaaaattagt
901 tgagaaagaa gagaagaaga aaatcaacca gcaggaaagt acagatgcag ccgtgcagga
961 gccgagccaa ttaatttcat tagaggaaga aaaccagcgc aaggaatcct ctagttttaa
1021 gactgaagat ggaaaaagta ttttatctgc cttagacaaa ggctctacac atactgcatg
1081 ctcaggaccc atagatgaac tattagacat gaaatctgag gaaggtgctt gcctgggacc
1141 agtggcaggg accccggaac ctgaaggtgc tgacaaagat gacctgctgc tgttgagtga
1201 gatcttcaat gcttcctcct tggaagaggg cgagttcagc aaagagtggg ccgctgtgtt
1261 tggagacggc caagtgaagg agccagtgcc cactatggcc ctgggagagc cagaccccaa
1321 ggcccagaca ggctcaggtt tccttccttc gcagctttta gaccaaaata tgaaagactt
1381 acaggcctcg ctacaagaac ctgctaaggc tgcctcagac ctgactgcct ggttcagcct
1441 cttcgctgac ctcgacccac tctcaaatcc tgatgctgtt gggaaaaccg ataaagaaca
1501 cgaattgctc aatgcatgaa tctgtaccct tcgggagggc actcacatgc cgcccccagc
1561 agctcccctg ggggctagca gaagtataaa gtgatcagta tgctgtttta ataattatgt
1621 gccattttaa taaaatgaaa gggtcaacgg ccctgtttat attggtataa ttatttactc
1681 ttatttggta taaagggttt tcgtgtatct ctatgtggat ctaaataata caggattgtg
1741 ctagaagcgg tttccaggcc accgttctcc tgcctacatc ccattcatgg ctgcttgcgg
1801 tgtcactggg ctaccgtgag atccaagttg aaattcagaa gcctactttg atggtaggtt
1861 tgaatgacgt gtcctacagc ctcagaggca gcaggaggct agcaaagctt taaatgcctt
1921 ccttctctgc ccccagcctt ctgtccccct tggaggaggg ctgtaggaag attccctctt
1981 cctgccaagc caccttccag tgagctctgg atgaagctct ggccaaccaa agacactgtc
2041 cccacagcag gtgcctggtg ggccagtgtt ctcacactgg tggaggagct gggcttctct
2101 ccaaggacaa acttactatg gaagcagcca tatttgagt
//