LOCUS HSU25804 1263 bp mRNA linear HUM 07-FEB-1996
DEFINITION Human Ich-2 cysteine protease mRNA, complete cds.
ACCESSION U25804
VERSION U25804.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1263)
AUTHORS Kamens,J., Paskind,M., Hugunin,M., Talanian,R.V., Allen,H.,
Banach,D., Bump,N., Hackett,M., Johnston,C.G., Li,P.,
Mankovich,J.A., Terranova,M. and Ghayur,T.
TITLE Identification and characterization of ICH-2, a novel member of the
interleukin-1 beta-converting enzyme family of cysteine proteases
JOURNAL J. Biol. Chem. 270 (25), 15250-15256 (1995)
PUBMED 7797510
REFERENCE 2 (bases 1 to 1263)
AUTHORS Kamens,J.
TITLE Direct Submission
JOURNAL Submitted (26-APR-1995) Joanne Kamens, Immunology, BASF Bioresearch
Corporation, 100 Research Drive, Worcester, MA 01605, USA
FEATURES Location/Qualifiers
source 1..1263
/db_xref="H-InvDB:HIT000218779"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="thymus"
/clone_lib="thymus cDNA library from Clontech"
exon 1..55
/note="exon positions based on sequencing of genomic
clones"
CDS 49..1182
/note="member of the IL-1beta converting enzyme cysteine
protease family; ICE and Ced-3 Homolog-2"
/codon_start=1
/product="Ich-2"
/protein_id="AAA86890.1"
/translation="MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKK
YYDAKTEDKVRVMADSMQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGES
TDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDIT
GMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICG
TVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLE
VASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYS
WCCHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN"
exon 56..310
exon 311..420
exon 421..593
exon 594..829
exon 830..974
exon 975..1082
exon 1083..1263
BASE COUNT 394 a 297 c 286 g 286 t
ORIGIN
1 ctctgaggct ctttccaacg ctgtaaaaaa ggacagaggc tgttccctat ggcagaaggc
61 aaccacagaa aaaagccact taaggtgttg gaatccctgg gcaaagattt cctcactggt
121 gttttggata acttggtgga acaaaatgta ctgaactgga aggaagagga aaaaaagaaa
181 tattacgatg ctaaaactga agacaaagtt cgggtcatgg cagactctat gcaagagaag
241 caacgtatgg caggacaaat gcttcttcaa acctttttta acatagacca aatatccccc
301 aataaaaaag ctcatccgaa tatggaggct ggaccacctg agtcaggaga atctacagat
361 gccctcaagc tttgtcctca tgaagaattc ctgagactat gtaaagaaag agctgaagag
421 atctatccaa taaaggagag aaacaaccgc acacgcctgg ctctcatcat atgcaataca
481 gagtttgacc atctgcctcc gaggaatgga gctgactttg acatcacagg gatgaaggag
541 ctacttgagg gtctggacta tagtgtagat gtagaagaga atctgacagc cagggatatg
601 gagtcagcgc tgagggcatt tgctaccaga ccagagcaca agtcctctga cagcacattc
661 ttggtactca tgtctcatgg catcctggag ggaatctgcg gaactgtgca tgatgagaaa
721 aaaccagatg tgctgcttta tgacaccatc ttccagatat tcaacaaccg caactgcctc
781 agtctgaagg acaaacccaa ggtcatcatt gtccaggcct gcagaggtgc aaaccgtggg
841 gaactgtggg tcagagactc tccagcatcc ttggaagtgg cctcttcaca gtcatctgag
901 aacctggagg aagatgctgt ttacaagacc cacgtggaga aggacttcat tgctttctgc
961 tcttcaacgc cacacaacgt gtcctggaga gacagcacaa tgggctctat cttcatcaca
1021 caactcatca catgcttcca gaaatattct tggtgctgcc acctagagga agtatttcgg
1081 aaggtacagc aatcatttga aactccaagg gccaaagctc aaatgcccac catagaacga
1141 ctgtccatga caagatattt ctacctcttt cctggcaatt gaaaatggaa gccacaagca
1201 gcccagccct ccttaatcaa cttcaaggag caccttcatt agtacagctt gcatatttaa
1261 cat
//