LOCUS HSU25435 3780 bp mRNA linear HUM 11-SEP-1996 DEFINITION Human transcriptional repressor (CTCF) mRNA, complete cds. ACCESSION U25435 VERSION U25435.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3780) AUTHORS Filippova,G.N., Fagerlie,S., Klenova,E.M., Myers,C., Dehner,Y., Goodwin,G., Neiman,P.E., Collins,S.J. and Lobanenkov,V.V. TITLE An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes JOURNAL Mol. Cell. Biol. 16 (6), 2802-2813 (1996) PUBMED 8649389 REFERENCE 2 (bases 1 to 3780) AUTHORS Filippova,G.N., Neiman,P.E., Collins,S. and Lobanenkov,V.V. TITLE Direct Submission JOURNAL Submitted (20-APR-1995) Victor V. Lobanenkov, Basic Sciences, Fred Hutchinson Ctr, 1124 Columbia Street, Seattle, WA 98104, USA FEATURES Location/Qualifiers source 1..3780 /db_xref="H-InvDB:HIT000218768" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="16" /cell_line="HL-60" gene 1..3780 /gene="CTCF" CDS 292..2475 /gene="CTCF" /function="transcriptional repressor binding to promoters of vertebrate c-myc genes" /note="11-Zn-finger transcription factor" /codon_start=1 /product="CTCF" /protein_id="AAB07788.1" /translation="MEGDAVEAIVEESETFIKGKERKTYQRRREGGQEEDACHLPQNQ TDGGEVVQDVNSSVQMVMMEQLDPTLLQMKTEVMEGTVAPEAEAAVDDTQIITLQVVN MEEQPINIGELQLVQVPVPVTVPVATTSVEELQGAYENEVSKEGLAESEPMICHTLPL PEGFQVVKVGANGEVETLEQGELPPQEDPSWQKDPDYQPPAKKTKKTKKSKLRYTEEG KDVDVSVYDFEEEQQEGLLSEVNAEKVVGNMKPPKPTKIKKKGVKKTFQCELCSYTCP RRSNLDRHMKSHTDERPHKCHLCGRAFRTVTLLRNHLNTHTGTRPHKCPDCDMAFVTS GELVRHRRYKHTHEKPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTY KLKRHMRTHSGEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPHCDTVIARKS DLGVHLRKQHSYIEQGKKCRYCDAVFHERYALIQHQKSHKNEKRFKCDQCDYACRQER HMIMHKRTHTGEKPYACSHCDKTFRQKQLLDMHFKRYHDPNFVPAAFVCSKCGKTFTR RNTMARHADNCAGPDGVEGENGGETKKSKRGRKRKMRSKKEDSSDSENAEPDLDDNED EEEPAVEIEPEPEPQPVTPAPPPAKKRRGRPPGRTNQPKQNQPTAIIQVEDQNTGAIE NIIVEVKKEPDAEPAEGEEEEAQPAATDAPNGDLTPEMILSMMDR" polyA_site 3780 /gene="CTCF" /note="30 A nucleotides" BASE COUNT 1098 a 823 c 960 g 899 t ORIGIN 1 tgtgtctgag cctgtggagc gattaaaccg tgcgcggagc tgcttctttg gcggcagcgg 61 cggcggcggt ggccggtgcg gacgcgcgga gctcgccgga gacgccgggt ggccggagcc 121 gtggagcggc ggcggagcgg gcgccgcggg gggtgtggcg cggagaatga ttacggacct 181 gaagccaaag aacaagatgc gctagtggac agattgctga ccaggggctt gagagctggg 241 ttctattttc cctcctcaaa ctgactttgc agccacggag aggcagggga aatggaaggt 301 gatgcagtcg aagccattgt ggaggagtcc gaaactttta ttaaaggaaa ggagagaaag 361 acttaccaga gacgccggga agggggccag gaagaagatg cctgccactt accccagaac 421 cagacggatg ggggtgaggt ggtccaggat gtcaacagca gtgtacagat ggtgatgatg 481 gaacagctgg accccaccct tcttcagatg aagactgaag taatggaggg cacagtggct 541 ccagaagcag aggctgctgt ggacgatacc cagattataa ctttacaggt tgtaaatatg 601 gaggaacagc ccataaacat aggagaactt cagcttgttc aagtacctgt tcctgtgact 661 gtacctgttg ctaccacttc agtagaagaa cttcaggggg cttatgaaaa tgaagtgtct 721 aaagagggcc ttgcggaaag tgaacccatg atatgccaca ccctaccttt gcctgaaggg 781 tttcaggtgg ttaaagtggg ggccaatgga gaggtggaga cactagaaca aggggaactt 841 ccaccccagg aagatcctag ttggcaaaaa gacccagact atcagccacc agccaaaaaa 901 acaaagaaaa ccaaaaagag caaactgcgt tatacagagg agggcaaaga tgtagatgtg 961 tctgtctacg attttgagga agaacagcag gagggtctgc tatcagaggt taatgcggag 1021 aaagtggttg gtaatatgaa gcctccaaag ccaacaaaaa ttaaaaagaa aggtgtaaag 1081 aagacattcc agtgtgagct ttgcagttac acgtgtccac ggcgttcaaa tttggatcgt 1141 cacatgaaaa gccacactga tgagagacca cacaagtgcc atctctgtgg cagggcattc 1201 agaacagtca ccctcctgag gaatcacctt aacacacaca caggtactcg tcctcacaag 1261 tgcccagact gcgacatggc ctttgtgacc agtggagaat tggttcggca tcgtcgttac 1321 aaacacaccc acgagaagcc attcaagtgt tccatgtgcg attacgccag tgtagaagtc 1381 agcaaattaa aacgtcacat tcgctctcat actggagagc gtccgtttca gtgcagtttg 1441 tgcagttatg ccagcaggga cacatacaag ctgaaaaggc acatgagaac ccattcaggg 1501 gaaaagcctt atgaatgtta tatttgtcat gctcggttta cccaaagtgg taccatgaag 1561 atgcacattt tacagaagca cacagaaaat gtggccaaat ttcactgtcc ccactgtgac 1621 acagtcatag cccgaaaaag tgatttgggt gtccacttgc gaaagcagca ttcctatatt 1681 gagcaaggca agaaatgccg ttactgtgat gctgtgtttc atgagcgcta tgccctcatc 1741 cagcatcaga agtcacacaa gaatgagaag cgctttaagt gtgaccagtg tgattacgct 1801 tgtagacagg agaggcacat gatcatgcac aagcgcaccc acaccgggga gaagccttac 1861 gcctgcagcc actgcgataa gaccttccgc cagaagcagc ttctcgacat gcacttcaag 1921 cgctatcacg accccaactt cgtccctgcg gcttttgtct gttctaagtg tgggaaaaca 1981 tttacacgtc ggaataccat ggcaagacat gctgataatt gtgctggccc agatggcgta 2041 gagggggaaa atggaggaga aacgaagaag agtaaacgtg gaagaaaaag aaagatgcgc 2101 tctaagaaag aagattcctc tgacagtgaa aatgctgaac cagatctgga cgacaatgag 2161 gatgaggagg agcctgccgt agaaattgaa cctgagccag agcctcagcc tgtgacccca 2221 gccccaccac ccgccaagaa gcggagagga cgaccccctg gcagaaccaa ccagcccaaa 2281 cagaaccagc caacagctat cattcaggtt gaagaccaga atacaggtgc aattgagaac 2341 attatagttg aagtaaaaaa agagccagat gctgagcccg cagagggaga ggaagaggag 2401 gcccagccag ctgccacaga tgcccccaac ggagacctca cgcccgagat gatcctcagc 2461 atgatggacc ggtgatggcg gagccttgtg cgtcgccagg acttctctgg gctgtgttta 2521 aacggcccgc atcttaattt ttctcccttc tttctttttt tggctttggg aaaagcatca 2581 ttttaccaaa cataccgaga acgaaaactt caaggatgat gttagaaaaa aatgtgattt 2641 aactagaact tgctgtctga tgttagcaaa tcatggaatg ttctgagtcc ctgagggttt 2701 actgtgaagt gctgaggaca gtgttgacaa ctaactcgtt ttcctagatg gaaacggaga 2761 cattgacccc tccctccatg tggtaaacca ctccagaatg gccaccaggc ttcccagagt 2821 tctatggtct tcttcccaag agagttttta attgtaaatg catacttggg aaggacttag 2881 agttttaaac tgttttttgc ttttgctttt ccctgactcc ctttgcttgg agtcagctgc 2941 acaccagtag tatggcatgc tacgatcagg ttctgtcctg aaagctttgc ctctttcttg 3001 gcaaagtttc tggtatggtc aagcttgtaa ataacttttt ttacatttta atcttttcca 3061 ttaattaaga ggttgaaaag aagtgcagtg taagaaaacc cagcatttta attacttgca 3121 aattaagtta ccacagactc tgtagtgtgt aaatgttgac aaggaattgg atcacaatca 3181 tgtagcagaa tggcacccag accactgccc accagtgacg gacatgcacg tggcagatca 3241 tgatttccag cccacggagc cagcatttga accttgtata attaactttc agttatgatt 3301 tcccatcgac attttctttg ccctgtttgt agctgattgt tgtgttttat aaatcttctg 3361 ttaaggcaga agggtgatta tgagtggttc acagcagccc ttataagctg ggccagaaaa 3421 tttcactagg tcagtaattt aaaccttgga tcttcaaaaa ataaaataat gtgaagcaaa 3481 accaactaaa aagtgattct tgcacatgaa ctgtcacatg tttaaaaatg tgttttttag 3541 agagcctcag tcttactgat ttcaaacact tttttcttct gtgtattgct tttaagagag 3601 ccatcagtta gctatcagac tctaggttga tgcattttgt acttagctgt actgtgtgat 3661 atttttcatt attttaggac gccaacatga gacctgtaat aaaatatgta atggggttga 3721 aagctgggga ggaggatcta ctgctgtaca gctaataaat cataacggat taacaagtga //