LOCUS       HSU25435                3780 bp    mRNA    linear   HUM 11-SEP-1996
DEFINITION  Human transcriptional repressor (CTCF) mRNA, complete cds.
ACCESSION   U25435
VERSION     U25435.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3780)
  AUTHORS   Filippova,G.N., Fagerlie,S., Klenova,E.M., Myers,C., Dehner,Y.,
            Goodwin,G., Neiman,P.E., Collins,S.J. and Lobanenkov,V.V.
  TITLE     An exceptionally conserved transcriptional repressor, CTCF, employs
            different combinations of zinc fingers to bind diverged promoter
            sequences of avian and mammalian c-myc oncogenes
  JOURNAL   Mol. Cell. Biol. 16 (6), 2802-2813 (1996)
   PUBMED   8649389
REFERENCE   2  (bases 1 to 3780)
  AUTHORS   Filippova,G.N., Neiman,P.E., Collins,S. and Lobanenkov,V.V.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-1995) Victor V. Lobanenkov, Basic Sciences, Fred
            Hutchinson Ctr, 1124 Columbia Street, Seattle, WA 98104, USA
FEATURES             Location/Qualifiers
     source          1..3780
                     /db_xref="H-InvDB:HIT000218768"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /cell_line="HL-60"
     gene            1..3780
                     /gene="CTCF"
     CDS             292..2475
                     /gene="CTCF"
                     /function="transcriptional repressor binding to promoters
                     of vertebrate c-myc genes"
                     /note="11-Zn-finger transcription factor"
                     /codon_start=1
                     /product="CTCF"
                     /protein_id="AAB07788.1"
                     /translation="MEGDAVEAIVEESETFIKGKERKTYQRRREGGQEEDACHLPQNQ
                     TDGGEVVQDVNSSVQMVMMEQLDPTLLQMKTEVMEGTVAPEAEAAVDDTQIITLQVVN
                     MEEQPINIGELQLVQVPVPVTVPVATTSVEELQGAYENEVSKEGLAESEPMICHTLPL
                     PEGFQVVKVGANGEVETLEQGELPPQEDPSWQKDPDYQPPAKKTKKTKKSKLRYTEEG
                     KDVDVSVYDFEEEQQEGLLSEVNAEKVVGNMKPPKPTKIKKKGVKKTFQCELCSYTCP
                     RRSNLDRHMKSHTDERPHKCHLCGRAFRTVTLLRNHLNTHTGTRPHKCPDCDMAFVTS
                     GELVRHRRYKHTHEKPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTY
                     KLKRHMRTHSGEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPHCDTVIARKS
                     DLGVHLRKQHSYIEQGKKCRYCDAVFHERYALIQHQKSHKNEKRFKCDQCDYACRQER
                     HMIMHKRTHTGEKPYACSHCDKTFRQKQLLDMHFKRYHDPNFVPAAFVCSKCGKTFTR
                     RNTMARHADNCAGPDGVEGENGGETKKSKRGRKRKMRSKKEDSSDSENAEPDLDDNED
                     EEEPAVEIEPEPEPQPVTPAPPPAKKRRGRPPGRTNQPKQNQPTAIIQVEDQNTGAIE
                     NIIVEVKKEPDAEPAEGEEEEAQPAATDAPNGDLTPEMILSMMDR"
     polyA_site      3780
                     /gene="CTCF"
                     /note="30 A nucleotides"
BASE COUNT         1098 a          823 c          960 g          899 t
ORIGIN      
        1 tgtgtctgag cctgtggagc gattaaaccg tgcgcggagc tgcttctttg gcggcagcgg
       61 cggcggcggt ggccggtgcg gacgcgcgga gctcgccgga gacgccgggt ggccggagcc
      121 gtggagcggc ggcggagcgg gcgccgcggg gggtgtggcg cggagaatga ttacggacct
      181 gaagccaaag aacaagatgc gctagtggac agattgctga ccaggggctt gagagctggg
      241 ttctattttc cctcctcaaa ctgactttgc agccacggag aggcagggga aatggaaggt
      301 gatgcagtcg aagccattgt ggaggagtcc gaaactttta ttaaaggaaa ggagagaaag
      361 acttaccaga gacgccggga agggggccag gaagaagatg cctgccactt accccagaac
      421 cagacggatg ggggtgaggt ggtccaggat gtcaacagca gtgtacagat ggtgatgatg
      481 gaacagctgg accccaccct tcttcagatg aagactgaag taatggaggg cacagtggct
      541 ccagaagcag aggctgctgt ggacgatacc cagattataa ctttacaggt tgtaaatatg
      601 gaggaacagc ccataaacat aggagaactt cagcttgttc aagtacctgt tcctgtgact
      661 gtacctgttg ctaccacttc agtagaagaa cttcaggggg cttatgaaaa tgaagtgtct
      721 aaagagggcc ttgcggaaag tgaacccatg atatgccaca ccctaccttt gcctgaaggg
      781 tttcaggtgg ttaaagtggg ggccaatgga gaggtggaga cactagaaca aggggaactt
      841 ccaccccagg aagatcctag ttggcaaaaa gacccagact atcagccacc agccaaaaaa
      901 acaaagaaaa ccaaaaagag caaactgcgt tatacagagg agggcaaaga tgtagatgtg
      961 tctgtctacg attttgagga agaacagcag gagggtctgc tatcagaggt taatgcggag
     1021 aaagtggttg gtaatatgaa gcctccaaag ccaacaaaaa ttaaaaagaa aggtgtaaag
     1081 aagacattcc agtgtgagct ttgcagttac acgtgtccac ggcgttcaaa tttggatcgt
     1141 cacatgaaaa gccacactga tgagagacca cacaagtgcc atctctgtgg cagggcattc
     1201 agaacagtca ccctcctgag gaatcacctt aacacacaca caggtactcg tcctcacaag
     1261 tgcccagact gcgacatggc ctttgtgacc agtggagaat tggttcggca tcgtcgttac
     1321 aaacacaccc acgagaagcc attcaagtgt tccatgtgcg attacgccag tgtagaagtc
     1381 agcaaattaa aacgtcacat tcgctctcat actggagagc gtccgtttca gtgcagtttg
     1441 tgcagttatg ccagcaggga cacatacaag ctgaaaaggc acatgagaac ccattcaggg
     1501 gaaaagcctt atgaatgtta tatttgtcat gctcggttta cccaaagtgg taccatgaag
     1561 atgcacattt tacagaagca cacagaaaat gtggccaaat ttcactgtcc ccactgtgac
     1621 acagtcatag cccgaaaaag tgatttgggt gtccacttgc gaaagcagca ttcctatatt
     1681 gagcaaggca agaaatgccg ttactgtgat gctgtgtttc atgagcgcta tgccctcatc
     1741 cagcatcaga agtcacacaa gaatgagaag cgctttaagt gtgaccagtg tgattacgct
     1801 tgtagacagg agaggcacat gatcatgcac aagcgcaccc acaccgggga gaagccttac
     1861 gcctgcagcc actgcgataa gaccttccgc cagaagcagc ttctcgacat gcacttcaag
     1921 cgctatcacg accccaactt cgtccctgcg gcttttgtct gttctaagtg tgggaaaaca
     1981 tttacacgtc ggaataccat ggcaagacat gctgataatt gtgctggccc agatggcgta
     2041 gagggggaaa atggaggaga aacgaagaag agtaaacgtg gaagaaaaag aaagatgcgc
     2101 tctaagaaag aagattcctc tgacagtgaa aatgctgaac cagatctgga cgacaatgag
     2161 gatgaggagg agcctgccgt agaaattgaa cctgagccag agcctcagcc tgtgacccca
     2221 gccccaccac ccgccaagaa gcggagagga cgaccccctg gcagaaccaa ccagcccaaa
     2281 cagaaccagc caacagctat cattcaggtt gaagaccaga atacaggtgc aattgagaac
     2341 attatagttg aagtaaaaaa agagccagat gctgagcccg cagagggaga ggaagaggag
     2401 gcccagccag ctgccacaga tgcccccaac ggagacctca cgcccgagat gatcctcagc
     2461 atgatggacc ggtgatggcg gagccttgtg cgtcgccagg acttctctgg gctgtgttta
     2521 aacggcccgc atcttaattt ttctcccttc tttctttttt tggctttggg aaaagcatca
     2581 ttttaccaaa cataccgaga acgaaaactt caaggatgat gttagaaaaa aatgtgattt
     2641 aactagaact tgctgtctga tgttagcaaa tcatggaatg ttctgagtcc ctgagggttt
     2701 actgtgaagt gctgaggaca gtgttgacaa ctaactcgtt ttcctagatg gaaacggaga
     2761 cattgacccc tccctccatg tggtaaacca ctccagaatg gccaccaggc ttcccagagt
     2821 tctatggtct tcttcccaag agagttttta attgtaaatg catacttggg aaggacttag
     2881 agttttaaac tgttttttgc ttttgctttt ccctgactcc ctttgcttgg agtcagctgc
     2941 acaccagtag tatggcatgc tacgatcagg ttctgtcctg aaagctttgc ctctttcttg
     3001 gcaaagtttc tggtatggtc aagcttgtaa ataacttttt ttacatttta atcttttcca
     3061 ttaattaaga ggttgaaaag aagtgcagtg taagaaaacc cagcatttta attacttgca
     3121 aattaagtta ccacagactc tgtagtgtgt aaatgttgac aaggaattgg atcacaatca
     3181 tgtagcagaa tggcacccag accactgccc accagtgacg gacatgcacg tggcagatca
     3241 tgatttccag cccacggagc cagcatttga accttgtata attaactttc agttatgatt
     3301 tcccatcgac attttctttg ccctgtttgt agctgattgt tgtgttttat aaatcttctg
     3361 ttaaggcaga agggtgatta tgagtggttc acagcagccc ttataagctg ggccagaaaa
     3421 tttcactagg tcagtaattt aaaccttgga tcttcaaaaa ataaaataat gtgaagcaaa
     3481 accaactaaa aagtgattct tgcacatgaa ctgtcacatg tttaaaaatg tgttttttag
     3541 agagcctcag tcttactgat ttcaaacact tttttcttct gtgtattgct tttaagagag
     3601 ccatcagtta gctatcagac tctaggttga tgcattttgt acttagctgt actgtgtgat
     3661 atttttcatt attttaggac gccaacatga gacctgtaat aaaatatgta atggggttga
     3721 aagctgggga ggaggatcta ctgctgtaca gctaataaat cataacggat taacaagtga
//