LOCUS HSU24163 1476 bp mRNA linear HUM 17-OCT-1996 DEFINITION Human Frizzled related protein Frzb precursor (fzrb) mRNA, complete cds. ACCESSION U24163 VERSION U24163.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1476) AUTHORS Hoang,B., Moos,M. Jr., Vukicevic,S. and Luyten,F.P. TITLE Primary structure and tissue distribution of FRZB, a novel protein related to Drosophila frizzled, suggest a role in skeletal morphogenesis JOURNAL J. Biol. Chem. 271 (42), 26131-26137 (1996) PUBMED 8824257 REFERENCE 2 (bases 1 to 1476) AUTHORS Hoang,B., Moos,M., Vukicevic,S. and Luyten,F.P. TITLE Direct Submission JOURNAL Submitted (05-APR-1995) Malcolm Moos, Cellular & Gene Therapies, FDA/CBER, 1401 Rockville Pike, Suite 200N, HFM-527, Rockville, MD 20852-1448, USA FEATURES Location/Qualifiers source 1..1476 /db_xref="H-InvDB:HIT000218734" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" gene 1..1476 /gene="frzb" regulatory 206..212 /regulatory_class="ribosome_binding_site" /gene="frzb" CDS 209..1186 /gene="frzb" /note="protein present in highly purified fraction from mammalian articular cartilage associated with in vivo chondrogenic/osteogenic activity; it is expressed during human skeletogenesis in a graded pattern suggesting a role in polarity specification; Frizzled related protein; Method: conceptual translation supplied by author" /codon_start=1 /product="Frzb precursor" /protein_id="AAC50736.1" /translation="MVCGSPGGMLLLRAGLLALAALCLLRVPGARAAACEPVRIPLCK SLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAPICTIDFQH EPINPCKSVCERARQGCEPILIKYRHSWPENLACEELPVYDRGVCISPEAIVTADGAD FPMDSSNGNCRGASSERCKCKPIRATQKTYFRNNYNYVIRAKVKEIKTKCHDVTAVVE VKEILKSSLVNIPRDTVNLYTSSGCLCPPLNVNEEYIIMGYEDEERSRLLLVEGSIAE KWKDRLGKKVKRWDMKLRHLGLSKSDSSNSDSTQSQKSGRNSNPRQARN" mat_peptide 284..1183 /gene="frzb" /product="Frzb" /note="Frizzled related protein" misc_feature 353..355 /gene="frzb" /note="encodes putative N-linked glycosylation site" misc_feature 402..404 /gene="frzb" /note="encodes putative N-linked glycosylation site" misc_feature 431..502 /gene="frzb" /note="encodes putative membrane spanning domain" misc_feature 480..551 /gene="frzb" /note="encodes putative membrane spanning domain" misc_feature 536..538 /gene="frzb" /note="encodes putative phosphorylation site" misc_feature 585..587 /gene="frzb" /note="encodes putative phosphorylation site" misc_feature 593..595 /gene="frzb" /note="encodes putative phosphorylation site" misc_feature 704..706 /gene="frzb" /note="encodes putative phosphorylation site" misc_feature 764..766 /gene="frzb" /note="encodes putative phosphorylation site" misc_feature 1025..1027 /gene="frzb" /note="encodes putative phosphorylation site" misc_feature 1103..1105 /gene="frzb" /note="encodes putative phosphorylation site" misc_feature 1118..1120 /gene="frzb" /note="encodes putative phosphorylation site" misc_feature 1139..1141 /gene="frzb" /note="encodes putative phosphorylation site" misc_feature 1148..1150 /gene="frzb" /note="encodes putative phosphorylation site" regulatory 1456..1461 /regulatory_class="polyA_signal_sequence" /gene="frzb" polyA_site 1476 /gene="frzb" /note="8 A nucleotides" BASE COUNT 349 a 379 c 389 g 358 t ORIGIN 1 acggggcctg ggcggsaggg gcggtggctg gagctcggta aagctcgtgg gaccccattg 61 ggggaatttg atccaaggaa gcggtgattg ccgggggagg agaagctccc agatccttgt 121 gtccacttgc agcgggggag gcggagacgc ggagcgggcc ttttggcgtc cactgcgcgg 181 ctgcaccctg ccccatcctg ccgggatcat ggtctgcggc agcccgggag ggatgctgct 241 gctgcgggcc gggctgcttg ccctggctgc tctctgcctg ctccgggtgc ccggggctcg 301 ggctgcagcc tgtgagcccg tccgcatccc cctgtgcaag tccctgccct ggaacatgac 361 taagatgccc aaccacctgc accacagcac tcaggccaac gccatcctgg ccatcgagca 421 gttcgaaggt ctgctgggca cccactgcag ccccgatctg ctcttcttcc tctgtgccat 481 gtacgcgccc atctgcacca ttgacttcca gcacgagccc atcaacccct gtaagtctgt 541 gtgcgagcgg gcccggcagg gctgtgagcc catactcatc aagtaccgcc actcgtggcc 601 ggagaacctg gcctgcgagg agctgccagt gtacgacagg ggcgtgtgca tctctcccga 661 ggccatcgtt actgcggacg gagctgattt tcctatggat tctagtaacg gaaactgtag 721 aggggcaagc agtgaacgct gtaaatgtaa gcctattaga gctacacaga agacctattt 781 ccggaacaat tacaactatg tcattcgggc taaagttaaa gagataaaga ctaagtgcca 841 tgatgtgact gcagtagtgg aggtgaagga gattctaaag tcctctctgg taaacattcc 901 acgggacact gtcaacctct ataccagctc tggctgcctc tgccctccac ttaatgttaa 961 tgaggaatat atcatcatgg gctatgaaga tgaggaacgt tccagattac tcttggtgga 1021 aggctctata gctgagaagt ggaaggatcg actcggtaaa aaagttaagc gctgggatat 1081 gaagcttcgt catcttggac tcagtaaaag tgattctagc aatagtgatt ccactcagag 1141 tcagaagtct ggcaggaact cgaacccccg gcaagcacgc aactaaatcc cgaaatacaa 1201 aaagtaacac agtggacttc ctattaagac ttacttgcat tgctggacta gcaaaggaaa 1261 attgcactat tgcacatcat attctattgt ttactataaa aatcatgtga taactgatta 1321 ttacttctgt ttctcttttg gtttctgctt ctctcttctc tcaacccctt tgtaatggtt 1381 tgggggcaga ctcttaagta tattgtgagt tttctatttc actaatcatg agaaaaactg 1441 ttcttttgca ataataataa attaaacatg ctgtta //