LOCUS       HSU24163                1476 bp    mRNA    linear   HUM 17-OCT-1996
DEFINITION  Human Frizzled related protein Frzb precursor (fzrb) mRNA, complete
            cds.
ACCESSION   U24163
VERSION     U24163.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1476)
  AUTHORS   Hoang,B., Moos,M. Jr., Vukicevic,S. and Luyten,F.P.
  TITLE     Primary structure and tissue distribution of FRZB, a novel protein
            related to Drosophila frizzled, suggest a role in skeletal
            morphogenesis
  JOURNAL   J. Biol. Chem. 271 (42), 26131-26137 (1996)
   PUBMED   8824257
REFERENCE   2  (bases 1 to 1476)
  AUTHORS   Hoang,B., Moos,M., Vukicevic,S. and Luyten,F.P.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-APR-1995) Malcolm Moos, Cellular & Gene Therapies,
            FDA/CBER, 1401 Rockville Pike, Suite 200N, HFM-527, Rockville, MD
            20852-1448, USA
FEATURES             Location/Qualifiers
     source          1..1476
                     /db_xref="H-InvDB:HIT000218734"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
     gene            1..1476
                     /gene="frzb"
     regulatory      206..212
                     /regulatory_class="ribosome_binding_site"
                     /gene="frzb"
     CDS             209..1186
                     /gene="frzb"
                     /note="protein present in highly purified fraction from
                     mammalian articular cartilage associated with in vivo
                     chondrogenic/osteogenic activity; it is expressed during
                     human skeletogenesis in a graded pattern suggesting a role
                     in polarity specification; Frizzled related protein;
                     Method: conceptual translation supplied by author"
                     /codon_start=1
                     /product="Frzb precursor"
                     /protein_id="AAC50736.1"
                     /translation="MVCGSPGGMLLLRAGLLALAALCLLRVPGARAAACEPVRIPLCK
                     SLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAPICTIDFQH
                     EPINPCKSVCERARQGCEPILIKYRHSWPENLACEELPVYDRGVCISPEAIVTADGAD
                     FPMDSSNGNCRGASSERCKCKPIRATQKTYFRNNYNYVIRAKVKEIKTKCHDVTAVVE
                     VKEILKSSLVNIPRDTVNLYTSSGCLCPPLNVNEEYIIMGYEDEERSRLLLVEGSIAE
                     KWKDRLGKKVKRWDMKLRHLGLSKSDSSNSDSTQSQKSGRNSNPRQARN"
     mat_peptide     284..1183
                     /gene="frzb"
                     /product="Frzb"
                     /note="Frizzled related protein"
     misc_feature    353..355
                     /gene="frzb"
                     /note="encodes putative N-linked glycosylation site"
     misc_feature    402..404
                     /gene="frzb"
                     /note="encodes putative N-linked glycosylation site"
     misc_feature    431..502
                     /gene="frzb"
                     /note="encodes putative membrane spanning domain"
     misc_feature    480..551
                     /gene="frzb"
                     /note="encodes putative membrane spanning domain"
     misc_feature    536..538
                     /gene="frzb"
                     /note="encodes putative phosphorylation site"
     misc_feature    585..587
                     /gene="frzb"
                     /note="encodes putative phosphorylation site"
     misc_feature    593..595
                     /gene="frzb"
                     /note="encodes putative phosphorylation site"
     misc_feature    704..706
                     /gene="frzb"
                     /note="encodes putative phosphorylation site"
     misc_feature    764..766
                     /gene="frzb"
                     /note="encodes putative phosphorylation site"
     misc_feature    1025..1027
                     /gene="frzb"
                     /note="encodes putative phosphorylation site"
     misc_feature    1103..1105
                     /gene="frzb"
                     /note="encodes putative phosphorylation site"
     misc_feature    1118..1120
                     /gene="frzb"
                     /note="encodes putative phosphorylation site"
     misc_feature    1139..1141
                     /gene="frzb"
                     /note="encodes putative phosphorylation site"
     misc_feature    1148..1150
                     /gene="frzb"
                     /note="encodes putative phosphorylation site"
     regulatory      1456..1461
                     /regulatory_class="polyA_signal_sequence"
                     /gene="frzb"
     polyA_site      1476
                     /gene="frzb"
                     /note="8 A nucleotides"
BASE COUNT          349 a          379 c          389 g          358 t
ORIGIN      
        1 acggggcctg ggcggsaggg gcggtggctg gagctcggta aagctcgtgg gaccccattg
       61 ggggaatttg atccaaggaa gcggtgattg ccgggggagg agaagctccc agatccttgt
      121 gtccacttgc agcgggggag gcggagacgc ggagcgggcc ttttggcgtc cactgcgcgg
      181 ctgcaccctg ccccatcctg ccgggatcat ggtctgcggc agcccgggag ggatgctgct
      241 gctgcgggcc gggctgcttg ccctggctgc tctctgcctg ctccgggtgc ccggggctcg
      301 ggctgcagcc tgtgagcccg tccgcatccc cctgtgcaag tccctgccct ggaacatgac
      361 taagatgccc aaccacctgc accacagcac tcaggccaac gccatcctgg ccatcgagca
      421 gttcgaaggt ctgctgggca cccactgcag ccccgatctg ctcttcttcc tctgtgccat
      481 gtacgcgccc atctgcacca ttgacttcca gcacgagccc atcaacccct gtaagtctgt
      541 gtgcgagcgg gcccggcagg gctgtgagcc catactcatc aagtaccgcc actcgtggcc
      601 ggagaacctg gcctgcgagg agctgccagt gtacgacagg ggcgtgtgca tctctcccga
      661 ggccatcgtt actgcggacg gagctgattt tcctatggat tctagtaacg gaaactgtag
      721 aggggcaagc agtgaacgct gtaaatgtaa gcctattaga gctacacaga agacctattt
      781 ccggaacaat tacaactatg tcattcgggc taaagttaaa gagataaaga ctaagtgcca
      841 tgatgtgact gcagtagtgg aggtgaagga gattctaaag tcctctctgg taaacattcc
      901 acgggacact gtcaacctct ataccagctc tggctgcctc tgccctccac ttaatgttaa
      961 tgaggaatat atcatcatgg gctatgaaga tgaggaacgt tccagattac tcttggtgga
     1021 aggctctata gctgagaagt ggaaggatcg actcggtaaa aaagttaagc gctgggatat
     1081 gaagcttcgt catcttggac tcagtaaaag tgattctagc aatagtgatt ccactcagag
     1141 tcagaagtct ggcaggaact cgaacccccg gcaagcacgc aactaaatcc cgaaatacaa
     1201 aaagtaacac agtggacttc ctattaagac ttacttgcat tgctggacta gcaaaggaaa
     1261 attgcactat tgcacatcat attctattgt ttactataaa aatcatgtga taactgatta
     1321 ttacttctgt ttctcttttg gtttctgctt ctctcttctc tcaacccctt tgtaatggtt
     1381 tgggggcaga ctcttaagta tattgtgagt tttctatttc actaatcatg agaaaaactg
     1441 ttcttttgca ataataataa attaaacatg ctgtta
//