LOCUS U24105 4692 bp mRNA linear HUM 10-SEP-2007
DEFINITION Homo sapiens coatomer protein (COPA) mRNA, complete cds.
ACCESSION U24105
VERSION U24105.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 360 to 4692)
AUTHORS Chow,V.T. and Quek,H.H.
TITLE HEP-COP, a novel human gene whose product is highly homologous to
the alpha-subunit of the yeast coatomer protein complex
JOURNAL Gene 169 (2), 223-227 (1996)
PUBMED 8647451
REFERENCE 2 (bases 1 to 359)
AUTHORS Quek,H.H. and Chow,V.T.
TITLE Genomic organization and mapping of the human HEP-COP gene (COPA)
to 1q
JOURNAL Cytogenet. Cell Genet. 76 (3-4), 139-143 (1997)
PUBMED 9186507
REFERENCE 3 (bases 1 to 4692)
AUTHORS Quek,H.H. and Chow,V.T.
TITLE Molecular and cellular studies of the human homolog of the 160-kD
alpha-subunit of the coatomer protein complex
JOURNAL DNA Cell Biol. 16 (3), 275-280 (1997)
PUBMED 9115636
REFERENCE 4 (bases 1 to 4692)
AUTHORS Quek,H.-H.
TITLE Direct Submission
JOURNAL Submitted (04-APR-1995) Hung-Hiang Quek, The National University of
Singapore, Microbiology, Lower Kent Ridge Road, Kent Ridge,
Singapore, 0511, Singapore
COMMENT On Oct 26, 1996 this sequence version replaced gi:1002368.
FEATURES Location/Qualifiers
source 1..4692
/db_xref="H-InvDB:HIT000218731"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/sex="male"
/cell_line="Hep 3B hepatocellular carcinoma"
gene 1..4692
/gene="COPA"
/note="HEP-COP"
exon 1..506
/gene="COPA"
/number=1
5'UTR 1..466
/gene="COPA"
/experiment="experimental evidence, no additional details
recorded"
CDS 467..4141
/gene="COPA"
/note="similar to alpha subunit of yeast coatomer complex,
PIR Accession Number A55288"
/codon_start=1
/product="coatomer protein"
/protein_id="AAB70879.1"
/translation="MLTKFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLI
DKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFH
HEYPWILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVR
VWDISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMP
LIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVW
DMSKRTGVQTFRRDHDRFWVLAAHPNLNLFAAGHDGGMIVFKLERERPAYAVHGNMLH
YVKDRFLRQLDFNSSKDVAVMQLRSGSKFPVFNMSYNPAENAVLLCTRASNLENSTYD
LYTIPKDADSQNPDAPEGKRSSGLTAVWVARNRFAVLDRMHSLLIKNLKNEITKKVQV
PNCDEIFYAGTGNLLLRDADSITLFDVQQKRTLASVKISKVKYVIWSADMSHVALLAK
HAIVICNRKLDALCNIHENIRVKSGAWDESGVFIYTTSNHIKYAVTTGDHGIIRTLDL
PIYVTRVKGNNVYCLDRECRPRVLTIDPTEFKFKLALINRKYDEVLHMVRNAKLVGQS
IIAYLQKKGYPEVALHFVKDEKTRFSLALECGNIEIALEAAKALDDKNCWEKLGEVAL
LQGNHQIVEMCYQRTKNFDKVSFLYLITGNLEKLRKMMKIAEIRKDMSGHYQNALYLG
DVSERVRILKNCGQKSLAYLTAATHGLDEEAESLKETFDPEKETIPDIDPNAKLLQPP
APIMPLDTNWPLLTVSKGFFEGTIASKGKGGALAADIDIDTVGTEGWGEDAELQLDED
GFVEATEGLGDDALGKGQEEGGGWDVEEDLELPPELDISPGAAGGAEDGFFVPPTKGT
SPTQIWCNNSQLPVDHILAGSFETAMRLLHDQVGVIQFGPYKQLFLQTYARGRTTYQA
LPCLPSMYGYPNRNWKDAGLKNGVPAVGLKLNDLIQRLQLCYQLTTVGKFEEAVEKFR
SILLSVPLLVVDNKQEIAEAQQLITICREYIVGLSVETERKKLPKETLEQQKRICEMA
AYFTHSNLQPVHMILVLRTALNLFFKLKNFKTAATFARRLLELGPKPEVAQQTRKILS
ACEKNPTDAYQLNYDMHNPFDICAASYRPIYRGKPVEKCPLSGACYSPEFKGQICRVT
TVTEIGKDVIGLRISPLQFR"
repeat_region 470..1315
/gene="COPA"
/note="total of 6 WD-40 repeats within this repeat region"
/rpt_family="WD-40"
/rpt_type=tandem
repeat_region 470..595
/gene="COPA"
/rpt_family="WD-40"
exon 507..620
/gene="COPA"
/number=2
repeat_region 596..721
/gene="COPA"
/rpt_family="WD-40"
exon 621..694
/gene="COPA"
/number=3
exon 695..775
/gene="COPA"
/number=4
repeat_region 722..847
/gene="COPA"
/rpt_family="WD-40"
exon 776..852
/gene="COPA"
/number=5
repeat_region 848..973
/gene="COPA"
/rpt_family="WD-40"
exon 853..962
/gene="COPA"
/number=6
exon 963..1072
/gene="COPA"
/number=7
repeat_region 1058..1183
/gene="COPA"
/rpt_family="WD-40"
exon 1073..1172
/gene="COPA"
/number=8
exon 1173..1308
/gene="COPA"
/number=9
repeat_region 1190..1315
/gene="COPA"
/rpt_family="WD-40"
exon 1309..1391
/gene="COPA"
/number=10
exon 1392..1542
/gene="COPA"
/number=11
exon 1543..1609
/gene="COPA"
/number=12
exon 1610..1685
/gene="COPA"
/number=13
exon 1686..1768
/gene="COPA"
/number=14
exon 1769..1908
/gene="COPA"
/number=15
exon 1909..1994
/gene="COPA"
/number=16
exon 1995..2133
/gene="COPA"
/number=17
exon 2134..2296
/gene="COPA"
/number=18
exon 2297..2443
/gene="COPA"
/number=19
exon 2444..2633
/gene="COPA"
/number=20
exon 2634..2729
/gene="COPA"
/number=21
exon 2730..2818
/gene="COPA"
/number=22
exon 2819..2942
/gene="COPA"
/number=23
exon 2943..3032
/gene="COPA"
/number=24
exon 3033..3142
/gene="COPA"
/number=25
exon 3143..3220
/gene="COPA"
/number=26
exon 3221..3289
/gene="COPA"
/number=27
exon 3290..3426
/gene="COPA"
/number=28
exon 3427..3613
/gene="COPA"
/number=29
exon 3614..3724
/gene="COPA"
/number=30
exon 3725..3886
/gene="COPA"
/number=31
exon 3887..4081
/gene="COPA"
/number=32
exon 4082..4692
/gene="COPA"
/number=33
BASE COUNT 1213 a 1125 c 1230 g 1124 t
ORIGIN
1 gagaagggga ccttcaggtc caggcaaagg gggaacttct gtcgtgggaa cgaaaaagaa
61 agaggattta cagggtgggg ggacagaggg gcagcaggaa ccagaaggga gacagtggcg
121 gtcgcaccgg ggccgatccg agagttcccc ttagagaacg gagctcacgg gcggggaggc
181 ctcacctgct agtaggacgc agaaagacag aaggcgaagg agaccccctg ccgtagccat
241 cttgcctctc tgctgagcgg aagcccccgt tcggctcctg tctgttagcg gcctctctag
301 gctaccactg acaccgtctc tgtggcccgg agcctaagag accggaagtt cgtgtttcca
361 ggcgcttccg gaaaccgcgg gagagggtcg ctgacgtgga ggcgtccgaa gggcagcagg
421 gtgtgtcggg gctcggatta agacatcgga gtcggagacc tgagagatgt taaccaaatt
481 cgagaccaag agcgcgcggg tcaaagggct cagctttcac cccaaaagac cttggatcct
541 gactagttta cataatgggg tcatccagtt atgggactat cggatgtgca ctctcattga
601 caagtttgat gaacatgatg gtccagtgcg aggcattgac ttccataagc agcagccact
661 gttcgtctct ggaggagatg actataagat taaggtttgg aattacaagc ttcggcgctg
721 tcttttcaca ttgcttgggc acttagatta tattcgcacc acgttttttc atcatgaata
781 tccctggatt ctgagtgcct ccgatgatca gaccatccga gtgtggaatt ggcaatctag
841 aacctgtgtt tgtgtgttaa cagggcacaa ccattatgtg atgtgtgctc agttccaccc
901 cacagaagac ttggtagtat cagccagcct ggaccagact gtgcgcgttt gggatatttc
961 tggtctgagg aaaaaaaacc tgtcccctgg tgcggtggaa tcggatgtga gaggaataac
1021 tggggttgat ctatttggaa ctacagatgc agtggtgaag catgtactag agggtcacga
1081 tcgtggagta aactgggctg ccttccaccc cactatgccc cttattgtat ctggggcaga
1141 tgatcgtcaa gtgaagatct ggcgcatgaa tgaatcaaag gcatgggagg ttgatacctg
1201 ccggggccat tacaacaatg tatcttgtgc cgtcttccac cctcgccaag agttgatcct
1261 cagcaattct gaggacaaga gtattcgagt ctgggatatg tctaagcgga ctggggttca
1321 gactttccgc agagaccatg atcgtttctg ggtcctagct gctcacccta accttaacct
1381 ctttgcagca ggccatgatg gtggtatgat tgtgtttaag ctggaacggg aacggccagc
1441 ctatgctgtt catggcaata tgctacacta tgtcaaggac cgattcttac gacagctgga
1501 tttcaacagc tccaaagatg tagctgtgat gcagttgcgg agtggttcca agtttccagt
1561 attcaatatg tcatacaatc cagcagaaaa tgcagtcctg ctttgtacaa gagctagcaa
1621 tctagagaat agtacctatg acctgtacac catccctaaa gatgctgact cccagaatcc
1681 tgatgcgcct gaagggaaac gatcctcagg cctgacagcc gtttgggtcg ctcgaaatcg
1741 gtttgctgtc ctagatcgga tgcattcgct tctgatcaag aatctgaaga atgagatcac
1801 caaaaaggta caggtgccca actgtgatga gatcttctat gctggcacag gcaatctcct
1861 gcttcgagat gcggactcta tcacactctt tgacgtacag cagaagcgga ctctggcatc
1921 tgtgaagatt tctaaagtga aatacgttat ctggtcagca gacatgtcac atgtagcact
1981 actagccaaa cacgccattg tgatctgtaa ccgcaaactg gatgctttat gtaacattca
2041 tgagaacatt cgtgtcaaga gtggggcctg ggatgagagt ggggtattta tctataccac
2101 aagcaaccac atcaaatatg ctgtcaccac tggggaccac gggatcattc gaactctgga
2161 tttacccatc tatgtcacac gggtgaaggg caacaatgta tactgcctag acagggagtg
2221 tcgtccccgg gtactcacca ttgatcccac tgagttcaaa ttcaagctgg ccctgatcaa
2281 cagaaaatat gatgaggtac tgcacatggt gaggaatgcc aaactagttg gccagtctat
2341 tattgcttat ctccagaaga agggctatcc tgaagtggca ctgcattttg tcaaggatga
2401 gaaaactcgc tttagtctgg cactggagtg tggaaacatt gagattgctc tggaagcagc
2461 caaagcactg gatgacaaga actgctggga aaagctggga gaagtggccc tgctgcaggg
2521 gaaccaccag attgtggaaa tgtgctatca gcgtaccaaa aactttgaca aagtttcctt
2581 cctgtatctt atcactggca acttagaaaa acttcgcaag atgatgaaga ttgctgagat
2641 cagaaaggac atgagtggcc actatcagaa tgccctatac ctgggtgatg tgtcagagcg
2701 tgtgcggatc ctgaagaact gtggacagaa gtccctggcc tatctcacag ctgctaccca
2761 tggcttagat gaagaagctg agagcctaaa ggagacattt gacccagaga aggagacaat
2821 cccagacatt gaccctaatg ccaagctgct ccagccacct gcacctatca tgccattgga
2881 taccaattgg cctttattga ctgtatccaa aggatttttt gaaggcacca ttgccagcaa
2941 agggaaggga ggagcactgg ctgctgacat tgacattgac actgttggta cagagggctg
3001 gggagaggat gcagagctgc agttggatga agatgggttt gtggaggcta cagaaggttt
3061 gggggatgat gctcttggca agggacagga agaaggaggt ggctgggatg tagaagaaga
3121 tctggagctc cctcctgagc tggatatatc ccctggggca gctggtgggg ctgaagatgg
3181 tttctttgtg cccccaacca agggaacaag tccaactcag atctggtgta ataactctca
3241 gcttccagtt gatcacatcc tggcaggctc tttcgaaaca gccatgcggc tccttcatga
3301 ccaagtaggg gtaatccagt ttggccccta caagcaactg ttcctacaga catacgcccg
3361 aggccgcaca acctatcagg ctctgccctg cctaccctcc atgtatggct atcctaatcg
3421 caactggaag gatgcagggc tgaagaatgg tgtaccagct gtgggcctga agcttaatga
3481 cctcatccaa cggttgcagc tgtgctacca gctcaccaca gttggcaaat ttgaggaggc
3541 tgtggaaaaa ttccgttcca tccttctcag tgtgccactt cttgttgtgg acaataaaca
3601 agagattgca gaggcccagc agctcatcac catttgccgt gagtacattg tgggtttgtc
3661 cgtggagaca gaaaggaaga agctgcccaa agagactcta gaacagcaga agcgcatctg
3721 tgagatggca gcctatttca cccactcaaa cctgcagcct gtgcacatga tcctggtgct
3781 gcgtacagcc ctcaatctgt tcttcaagct caagaacttc aagacagctg ccacctttgc
3841 tcggcgccta ctagaactcg ggcccaagcc tgaggtggcc caacagaccc gaaaaatcct
3901 gtctgcctgt gagaagaatc ccacagatgc ctaccagctc aattatgaca tgcacaaccc
3961 ctttgacatt tgtgctgcat catatcggcc catctaccgt ggaaagccag tagaaaagtg
4021 tccactcagt ggggcctgct attcccctga gttcaaaggt caaatctgca gggtcaccac
4081 agtgacagag attggcaaag atgtgattgg tttaaggatc agtcctctgc agtttcgcta
4141 aggccccctt tgtgtgcatg ggtcagtcac catatgttcc ccccagagaa tgtgtctata
4201 tcctccttct aacagcacct tccccctgca gctactcttc agatctggct ctctgtaccc
4261 taaaacctag tatctttttc tcttctatgg aaaatccgaa ggtctaaact tgactttttt
4321 gaggtcttct caacttgact acagttgtgc tcataattgt ccttgccttt ccagcttaat
4381 tattttaagg aacaaatgaa aactctgggc tgggtggagt ggctcatacc tgtaatccca
4441 gcactttggg aggctacggt gggcagatca tctgaggcca ggagttcgag acctgcctgg
4501 ccaacatggc aacaccccgt ctctaataaa aatataaaaa ttagcctggc atggtagcat
4561 gcgcctatag tcccagctgc tcaggaggct gaggcatgag aatcgcttga acctaggagg
4621 tggaggttgc attcaactga gatcatacca cttcattcca gcctgggtga cagagcaaga
4681 ctctgtctca aa
//